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Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-omics Integrated Analysis

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Chinese Journal of Integrative Medicine 2022年第1期28卷 28-35页

作者： TANG Yi-shuang GUO Jian-chun XU Lin ZHANG xiao-na SHEN xiao-ping HAI Ya-mei MAO Yu-feng HU Yi-yang ZHAO Yu Key Laboratory of Liver and Kidney Diseases Institute of Liver DiseasesShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(201203)China Department of Integrated Chinese and Western Medicine Hangzhou Xixi HospitalHangzhou(310023)China National Engineering Center for Biochip at Shanghai Shanghai(201203)China Institute of Clinical Pharmacology Shuguang Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai(201203)China Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai(201203)China

Objective:To compare the circular pathological changes of chronic hepatitis B(CHB)patients according to the tongue ***:Totally 41 CHB patients with typical white tongue coating(WTC)or yellow tongue coating(YTC)were enrolled and 14 healthy volunteers with normal tongue manifestation served as *** mRNA expression of peripheral leukocytes was detected by GeneChips,and 9 genes were randomly selected for expression *** metabolites were detected by gas chromatographymass *** information was analyzed based on ingenuity pathways analysis or metabolomics database and the integrated networks were constructed by ***:A total of 945 and 716 differentially expressed genes were found in patients with WTC and YTC relative to healthy volunteers *** biological information analysis indicated that CHB patients had obviously increased functions in cell death,apoptosis and necrosis(Z-score 2,P<0.05)and decreased activation in T lymphocytes(Z-score–2,P<0.05),regardless of the tongue *** to patients with WTC,the YTC patients were predicted to be more active in functions related to virus replication(Z-score 2,P<0.05),and the content of circular fatty acids,such as oleic acid(P=0.098)and lauric acid(P=0.035),and citric acid cycle-related metabolites were higher in the YTC patients(P<0.1).The integrated analysis based on differential genes and metabolites indicated that the most difference in the biological function network between the WTC and YTC patients was tumor necrosis factor receptor associated factor 6 mediated-nuclear factor kappa-B activation ***:CHB patients with YTC had more severe inflammation and fatty acids metabolism aberrant than patients with *** results facilitate the modern pathological annotation of Chinese medicine tongue diagnosis theory and provide a reference for the interpretation of pharmacological mechanisms of Chinese medicine treatment.

关键词： Chinese medicine chronic hepatitis B tongue diagnosis metabolomics transcriptomic

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青海地区自身免疫性肝病重叠综合征患者的抗线粒体抗体差异分析

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肝脏 2024年第4期29卷 448-452页

作者：王春秋陈婷张臻英张晓菲青海省人民医院消化内科西宁810000 青海省人民医院心内科西宁810000 成都京东方医院消化内科 610000

目的总结青海省自身免疫性肝病重叠患者的临床及病理特征,提高临床诊治水平。方法回顾性分析2017年12月—2022年12月青海省人民医院首次确诊为自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征的患者共85例,抗线粒体抗体阳性为A组共58例,... 详细信息

目的总结青海省自身免疫性肝病重叠患者的临床及病理特征,提高临床诊治水平。方法回顾性分析2017年12月—2022年12月青海省人民医院首次确诊为自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征的患者共85例,抗线粒体抗体阳性为A组共58例,抗线粒体抗体阴性为B组27例。分析一般临床特征、合并疾病情况、血清生化学指标、免疫学指标、肝组织的病理情况;计量资料符合正态分布的采用x±s表示,组间比较采用独立样本t检验;不符合正态分布的计量资料采用M(P_(25),P_(75))表示,组间比较采用Wilcoxon秩和检验;计数资料采用构成比(%)表示,组间比较采用χ^(2)检验。结果A、B两组患者在性别、年龄、总胆红素、γ-谷氨酰基转移酶、碱性磷酸酶、免疫球蛋白G的水平及抗Ro52抗体、抗SSA抗体检出率、干燥综合征患病率、肝脏病理炎症分级、肝脏病理纤维化分级的比较上无统计学差异(P>0.05);在丙氨酸氨基转移酶[(115.41±76.63)比(255.90±244.90)U/L]、免疫球蛋白M[4.05(2.75,5.43)比1.99(1.41,3.51)g/L]水平、抗核抗体-G(χ^(2)=9.67)、自身免疫性甲状腺疾病(χ^(2)=5.74)患病率的组间比较差异有统计学意义(P<0.05)。结论A组患者丙氨酸氨基转移酶、免疫球蛋白M及抗核抗体-G水平更高,B组患自身免疫性甲状腺疾病比例更高;两组病理组织学的炎症分级及纤维化分级以中重度为主,提示患者发病隐匿,病程漫长,确诊时病情分期较晚;如确诊为自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征患者,建议完善甲状腺疾病的检查。

关键词：青海地区抗线粒体抗体自身免疫性肝病

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Behavior of adsorbed diphenyl-sulfide on the Pd/C catalyst for o-chloronitrobenzene hydrogenation

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Chinese Chemical Letters 2013年第1期24卷 59-62页

作者： Chang Su xiao-Nian Li Qun-Feng Zhang Lei Ma chun-Shan Lu Feng Feng Industrial Catalysis Institute of Zhejiang University of Technology

A series of diphenyl-sulfide （Ph2S）-immobilized Pd/C catalysts （Pd-Ph2Scx）/C） were prepared using the wetness-impregnation and immobilization method. Pd-Ph2S（x）/C catalysts employed for the hydro- genation of o-chloronitrobenzene showed very high selectivity. The structure of Pd-Ph2Scx）/C with different molar ratio of ligand （x-values） was characterized by XPS and TG-DSC-MS. The results suggest a ＂saturated＂ surface ratio of Ph2S/Pd （about 0.3） was formed on the Pd-Ph2S（x）[C catalysts surface. The Ph2S immobilized on the Pd particle is quite stable, and the desorption of Ph2S or dissociative loss of phenyl group was only found at temperatures above 500 K. The possible catalytic mechanism of the Pd-Ph2S（x）/C catalyst was also discussed.

关键词： Pd-Ph2S(x)/C o-Chloronitrobenzene Hydrogenation

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Bochdalek hernia masquerading as severe acute pancreatitis during the third trimester of pregnancy: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4660-4666页

作者： Yun-Zhi Zou Jin-Pu Yang xiao-Jiang zhou Ke Li xiao-Mei Li Cong-Hua Song Medical College Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Gastroenterology the First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Clinical Research Center Xiamen UniversityXiamen 361102Fujian ProvinceChina

BACKGROUND The occurrence of a diaphragmatic hernia during the third trimester of pregnancy is rare;to our knowledge,there has only been a single case report related to congenital Bochdalek hernia complicated with mild acute pancreatitis during *** symptoms and lack of experience due to its rarity make the diagnosis of this condition very *** report a case of diaphragmatic hernia accompanied by mild acute pancreatitis in the third trimester of pregnancy,which was misdiagnosed as severe acute *** SUMMARY A 19-year-old woman presented at gestation of 31+2 weeks with continuous distension pain for 3 d in the left lumbar region of no obvious *** findings of left ureterectasis,with nonspecific lumbago and abdominal pain,led to the misdiagnosis of renal *** serum amylase and/or lipase levels indicated acute *** the treatment of pancreatitis,her condition *** patient was finally diagnosed with a diaphragmatic hernia complicated with mild acute pancreatitis on magnetic resonance imaging at our *** section was performed at gestation of 31+6 weeks,followed by hernia repair,and the pancreatitis was treated *** patient was discharged in good condition 20 d after the *** In this case,surgical treatment was not the same as that for non-pregnant diaphragmatic hernia *** is important to first perform a cesarean section before commencing the therapy.

关键词： Diaphragmatic hernia Pregnancy Acute pancreatitis Diagnosis Therapy Case report

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Stability of growth periods traits for soybean cultivars across multiple locations

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Journal of Integrative Agriculture 2016年第5期15卷 963-972页

作者： WANG xiao-bo LIU Zhang-xiong YANG chun-yan XU ran LU Wei-guo ZHANG Li-feng WANG Qian WEI Su-hong YANG chun-ming WANG Hui-cai WANG Rui-zhen zhou Rong CHEN Huai-zhu CHANG Ru-zhen QIU Li-juan National Key Facility for Gene Resources and Genetic Improvement/Key Laboratory of Crop Germplasm Utilization Ministry of Agriculture/Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China School of Agronomy Anhui Agricultural University Hefei 230036 P.R. China Institute of Cereal and Oil Crops Hebei Academy of Agriculture and Forestry Sciences/Shijiazhuang Sub-Center National Soybean Improvement Center/Huang-Huai-Hai Key Laboratory for Biology and Genetic Improvement of Soybean Ministry of Agriculture/Hebei Genetic Breeding Laboratory Shijiazhuang 050035 P.R. China Institute of Crop Sciences Shandong Academy of Agricultural Sciences Jinan 250010 P.R. China Institute of Industrial Crops Research Henan Academy of Agricultural Sciences Zhengzhou 450002 P.R.China Crop Breeding Institute Heilongjiang Academy of Agricultural Sciences Harbin 150086 P.R.China Soybean Research Institute Jilin Academy of Agricultural Sciences Changchun 130124 P.R. China Agricultural Science Institute of Chifeng Chifeng 024031 P.R.China Institute of Crop Sciences Jiangxi Academy of Agricultural Sciences Nanchang 330200 P.R. China Oil Crop Research Institute Chinese Academy of Agricultural Sciences Wuhan 430062 P.R.China Institute of Industrial Crops Research Guangxi Academy of Agricultural Sciences Nanning 530007 P.R. China

The growth periods（GPs, from planting/emergence to reproductive stage 8（R8） of soybean cultivars vary in different ecological regions, especially in China with a very complex soybean cropping system. In this study, a 3-yr experimental study was undertaken in three geographical locations of China from 2008 to 2010, including the Northeast（40.66-45.85°N）, Huang-Huai（34.75-38.04°N） and southern（22.82-30.60°N） eco-regions with about 250 accessions in each region to clarify the classification of maturity group（MG） and identify the cultivars with stable GP to increase the knowledge about the GP distribution of soybean cultivars in China. GPs of soybean cultivars in different eco-regions were significant different with a gradual decrease from 115-125 d in the Northeast part to the 85-100 d in the southern part of China. The geographical location was the major factor for GP of cultivars from the Northeast, while the year of planting was the major factor affecting the stability of GPs in Huang-Huai summer and southern summer soybean. AMMI2（additive main effects and multiplicativeinteraction）-Biplot analysis showed that the GPs of soybean cultivars from the Northeast eco-region have a comparatively satisfactory environmental stability. Moreover, soybean cultivars with moderate GP/MG and stable environment adaptability in different eco-regions were identified based on the linear regression and AMMI analysis, which was important for the accurate classification of soybean MGs in future. Taken together, our results reflected the genetic diversity, geographical distribution and environmental stability of the Chinese soybean GP trait. Soybean cultivars with stable GP for various Chinese eco-regions would be beneficial for Chinese soybean genetic improvement, varietal introduction, exchange, and soybean breeding program for wide adaptability.

关键词： soybean growth periods maturity group environmental stability

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Blast responses of polyurea retrofitted utility tunnel reinforced with basalt fibre reinforced polymer bars

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Defence Technology（防务技术） 2022年第5期18卷 755-771页

作者： Jian-nan zhou xiao-shuo Chen Yin-zhi zhou Wen-ye Wang Peng Wang Xin-li Kong Ying Xu Han-sheng Geng Feng-nian Jin State Key Laboratory for Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China

Polyurea coating and carbon fibre reinforced polymer reinforcing techniques were applied to retrofit a severely damaged urban utility tunnel(UUT).The blast responses of the retrofitted UUT were investigated through in-filed explosion experimental tests,and the displacements,strains,accelerations,and damage were *** retrofitted UUT exhibited comparable or even better blast resistance than the intact *** the polyurea coating was flexible,it exhibited excellent performance in improving the blast resistance of the damaged *** the UUT reinforced with basalt fibre reinforce polymer(BFRP)bars has smaller damage compared with the UUT reinforced with steel bars,its retrofitting is simple,and the cost is *** roof was simplified as an elastically simple support one-way *** beam theory was adopted to analyse the dynamic responses of UUT roof considering the interaction between soil and structure,which agree well with the experiments in the first three cases.

关键词： Urban utility tunnel Retrofitting Polyurea CFRP Explosion

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眼外肌功能训练对改善眼眶骨折整复术后复视的影响

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实用临床医学（江西） 2024年第4期25卷 93-96页

作者：何珍李建舞张笑天余其春南昌大学附属眼科医院南昌330006 南昌大学护理学院南昌330006 南昌大学第一附属医院住院服务中心南昌330006

目的评价术后眼外肌功能训练对眼眶骨折整复术后复视症状恢复的效果。方法选取行眼眶骨折整复术患者66例,随机分为对照组和干预组各33例。对照组执行常规治疗与护理,干预组在对照组的基础上指导患者术后眼外肌功能训练。比较2组干预前... 详细信息

目的评价术后眼外肌功能训练对眼眶骨折整复术后复视症状恢复的效果。方法选取行眼眶骨折整复术患者66例,随机分为对照组和干预组各33例。对照组执行常规治疗与护理,干预组在对照组的基础上指导患者术后眼外肌功能训练。比较2组干预前和干预后1周、1个月、3个月、6个月的复视情况与患者对护理的满意度。结果术后1周、1个月、3个月及6个月干预组患者0级复视率均高于对照组(P<0.05)。住院期间,干预组患者对护理的满意度高于对照组(P<0.05)。结论眼外肌功能训练有助于眼眶骨折整复术后患者改善复视症状。

关键词：眼外肌功能训练护理干预眼眶骨折复视

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一种可模态分离的高分辨率频率-波数法及其工程应用

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中国地震 2024年第2期40卷 484-502页

作者：周晓岳子冲刘宏岳郑金伙化希瑞刘铁牟新刚武汉理工大学机电工程学院武汉430070 福建省建筑设计研究院福州350001 中铁第四勘察设计院集团有限公司武汉430063

高分辨率频率-波数法是通过计算F-K谱从能量角度获取主导表面波频散信息的一种常用方法。然而,由于高模态瑞利波的能量通常低于基阶波的能量,因此难以分离多模态频散信息。本文通过建立多模态瑞利波模型,并讨论其相速度、波数和能量特性... 详细信息

高分辨率频率-波数法是通过计算F-K谱从能量角度获取主导表面波频散信息的一种常用方法。然而,由于高模态瑞利波的能量通常低于基阶波的能量,因此难以分离多模态频散信息。本文通过建立多模态瑞利波模型,并讨论其相速度、波数和能量特性,提出一种可模态分离的高分辨率频率-波数法。通过增强F-K谱上的高模态能量,提取其多模态能量的局部极值,进而得到相速度点,对所有相速度点进行概率分布并拟合,得到多模态频散曲线。工程应用表明,改进的高分辨率频率-波数法能够较好地还原多模态瑞利波信息,通过对提取的多模态频散曲线进行联合反演,可以得到与工程钻孔结果匹配较好的剪切波速度结构。

关键词：频率-波数法微动勘探频散曲线多模态面波工程应用

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Numerical Simulation of Independent Advance of Ore Breaking in the Non-pillar Sublevel Caving Method

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Journal of China University of Mining and Technology 2007年第2期17卷 295-300页

作者： zhou Chuan-bo YAO Ying-kang GUO Liao-wu YIN xiao-peng FAN xiao-feng SHANG Ying Engineering College China University of Geosciences Wuhan Hubei 430074 China Ming Company of Wuhan Steel and Iron Unite Company Wuhan Hubei 430080 China

The mechanism of stress generation and propagation by detonation loading in five separate independent advance of ore breaking patterns is discussed in the paper. An elastic numerical model was developed using AN- SYS/LS-DYNA 3D Nonlinear Dynamic Finite Element Software. In this package ANSYS is the preprocessor and LS-DYNA is the postprocessor. Numerical models in the paper to actual were l：10 and the element mesh was dissected in scanning mode utilizing the symmetry characteristics of the numerical model. Five different advance rates were studied. Parameters, such as the time required to maximum stress, the action time of the available stress, the maximum velocity of the nodes, the stress penetration time, the magnitude of the stress peak and the time duration for high stress were numerically simulated. The 2.2 m advance appeared optimum from an analysis of the simulation results. The results from numerical simulation have been validated by tests with physical models.

关键词： non-pillar sublevel caving method independent advance of ore breaking numerical simulation model test

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Asymmetric dynamic behaviors of magnetic domain wall in trapezoid-cross-section nanostrip

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Chinese Physics B 2020年第9期29卷 518-522页

作者： xiao-Ping Ma Hong-Guang Piao Lei Yang Dong-Hyun Kim chun-Yeol You Liqing Pan Research Institute for Magnetoelectric&Weak Magnetic-field Detection College of ScienceChina Three Gorges UniversityYichang 443002China Department of Physics Chungbuk National UniversityCheongju 28644ChungbukRepublic of Korea Department of Emerging Materials Science Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea

Field-driven magnetic domain wall propagation in ferromagnetic nanostrips with trapezoidal cross section has been systematically investigated by means of micromagnetic simulation. Asymmetric dynamic behaviors of domain wall, depending on the propagation direction, were observed under an external magnetic field. When the domain walls propagate in the opposite direction along the long axis of the nanostrip, the Walker breakdown fields as well as the average velocities are different. The asymmetric landscape of demagnetization energies, which arises from the trapezoidal geometry, is the main origin of the asymmetric propagation behavior. Furthermore, a trapezoid-cross-section nanostrip will become a nanotube if it is rolled artificially along its long axis, and thus a two-dimensional transverse domain wall will become a three-dimensional one. Interestingly, it is found that the asymmetric behaviors observed in two-dimensional nanostrips with trapezoidal cross section are similar with some dynamic properties occurring in three-dimensional nanotubes.

关键词： ferromagnetic nanowire magnetic domain wall geometric effect asymmetric Walker breakdown

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