检索结果-南通市图书馆

Porous ultrathin-shell microcapsules designed by microfluidics for selective permeation and stimuli-triggered release

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2022年第11期16卷 1643-1650页

作者： Li Chen Yao xiao Zhiming Zhang chun-xia zhao Baoling Guo Fangfu Ye Dong Chen Department of Oncology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000China Zhejiang Key Laboratory of Smart Biomaterials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China Faculty of Engineering Computerand Mathematical SciencesThe University of AdelaideAdelaideSA 5005Australia Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Microcapsules are versatile delivery vehicles and widely used in various areas.Generally,microcapsules with solid shells lack selective permeation and only exhibit a simple release mode.Here,we use ultrathin-shell water-in-oil-in-water double emulsions as templates and design porous ultrathin-shell microcapsules for selective permeation and multiple stimuli-triggered release.After preparation of double emulsions by microfluidic devices,negatively charged shellac nanoparticles dispersed in the inner water core electrostatically complex with positively charged telechelicα,ω-diamino functionalized polydimethylsiloxane polymers dissolved in the middle oil shell at the water/oil interface,thus forming a porous shell of shellac nanoparticles cross-linked by telechelic polymers.Subsequently,the double emulsions become porous microcapsules upon evaporation of the middle oil phase.The porous ultrathin-shell microcapsules exhibit excellent properties,including tunable size,selective permeation and stimuli-triggered release.Small molecules or particles can diffuse across the shell,while large molecules or particles are encapsulated in the core,and release of the encapsulated cargos can be triggered by osmotic shock or a pH change.Due to their unique performance,porous ultrathin-shell microcapsules present promising platforms for various applications,such as drug delivery.

关键词： microcapsule emulsion microfluidics selective permeation stimuli-triggered release

Templating core-shell particles using metal ion-chelating biosurfactants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2022年第5期20卷 145-152页

作者： Ching-Min Yeh Thomas Jarrett Yuan Gao chun-xia zhao Andrew Whittaker Frank Sainsbury Alison L.White Australian Institute of Bioengineering and Nanotechnology The University of QueenslandSt.LuciaQueensland4072Australia ARC Centre of Excellence in Convergent Bio-Nano Science and Technology The University of QueenslandSt Lucia4072Australia CSIRO Probing Biosystems Future Science Platform BrisbaneAustralia Centre for Cell Factories and Biopolymers Griffith Institute for Drug DiscoveryGriffith UniversityBrisbaneQLD4111 Australia

Designer biosurfactants can be used to stabilise and functionalise interfaces.One particularly promising use is the stabilisation of oil-in-water emulsions,enabling fine tuning physical,chemical and biological surface properties.The ability of emulsion systems to carry high payloads makes them attractive for applications in medicine,food and fragrances,and cosmetics.However,they have limited long-term stability.Here we sought to use the metal ion-chelating ability of the biosurfactant peptide,AM1,to precipitate the formation of a gold metal shell on AM1-stabilised emulsions by electroless plating.We found that replacing the commonly used zinc(Ⅱ)with palladium(Ⅱ)for coordination by histidine residues of adjacent AM1 peptides produced interfacial films that maintained elasticity at acidic pH.Proton NMR suggested a coordination mechanism independent of the imidazole ring of the histidines.Nevertheless.stabilisation of emulsions at low pH enabled the deposition of a gold shell,albeit by an unexpected mechanism.We propose that gold nanoparticles forming in bulk are adsorbed onto the peptide-stabilised interface,accumulating into a particulate coating.The resulting one-step method for nanoparticle precipitation and shell formation will be useful for the creation of biocompatible core-shell particles for applications where large payloads of hydrophobic active compounds require stability over long time periods.

关键词： Biosurfactants Emulsion Core-shell particles Electroless plating Histidine Interfacial elasticity

Self-healing,Stretchable,Temperature-Sensitive and Strain-Sensitive Hydrogel-based Flexible Sensors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2023年第3期41卷 334-344,I0005页

作者： chun-xia zhao Min Guo Jie Mao Yun-Tao Li Yuan-Peng Wu Hua Guo Dong xiang Hui Li School of Materials Science and Engineering Southwest Petroleum UniversityChengdu 610500China The Center of Functional Materials for Working Fluids of Oil and Gas Field Sichuan Engineering Technology Research Center of Basalt Fiber Composites Development and ApplicationSouthwest Petroleum UniversityChengdu 610500China State Key Lab of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

Flexible hydrogels have shown promise as strain sensors in medical monitoring,human motion detection and intelligent robotics.For a hydrogel strain sensor,certain challenges need to be urgently addressed for practical applications,such as the damage caused by external effects,leading to equipment failure,and the inability to perceive ambient temperature,resulting in single functionality.Herein,a stretchable,self-healing and dual temperature-strain sensitive hydrogel,with a physically-crosslinked network,is designed by constructing multiple dynamic reversible bonds.Graphene oxide(GO)and iron ions(Fe^(3+))act as dynamic bridges in the cross-linked network and are mediated by the covalent and hydrogen bonding,rendering excellent stretchability to the hydrogel.The reversible features of coordination interactions and hydrogen interactions endow excellent recoverability and self-healing properties.Moreover,the incorporated N-isopropyl acrylamide(NIPAM)provides excellent temperature responsiveness to the hydrogel,facilitating the detection of external temperature changes.Meanwhile,the hydrogels exhibited strain-sensitivity,with a wide working range of 1%-300%,fast response and electrical stability,which can be used as flexible sensors to monitor body motions,e.g.,speaking and the bending of finger,wrist,elbow and knee.Overall,the hydrogel possesses dual sensory capabilities,combining external temperature and strain,for potential applications in wearable multifunctional sensing devices.

关键词： Hydrogel sensor Self-healing Dual temperature-strain sensitive Monitor body motions

Phase separation-induced nanoprecipitation for making polymer nanoparticles with high drug loading Special Collection:Distinguished Australian Researchers

在线全文

学校读者我要写书评

暂无评论

聚集体(英文)

聚集体(英文) 2023年第2期4卷 137-145页

作者： Guangze Yang Yun Liu Song Jin Yue Hui Xing Wang Letao Xu Dong Chen David Weitz chun-xia zhao School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideAdelaideSouth AustraliaAustralia Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia Department of Medical Oncology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhouZhejiangChina John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMassachusettsUSA Department of Physics Harvard UniversityCambridgeMassachusettsUSA

Increasing drug loading remains a critical challenge in the development and translation of nanomedicine.High drug-loading nanoparticles have demonstrated unique advantages such as less carrier material used,better-controlled drug release,and improved efficacy and safety.Herein,we report a simple and efficient salt concentration screening method for making polymer nanoparticles with exceptionally high drug loading(up to 66.5 wt%)based on phase separation-induced nanoprecipitation.Upon addition of salt,phase separation occurs in a miscible solvent-water solution delaying the precipitation time of drugs and polymers to different extents,facilitating their co-precipitation thus the formation of high drug-loading nanoparticles with high encapsulation efficiency(>90%)and excellent stability(>1 month).This technology is versatile and easy to be adapted to various hydrophobic drugs,different polymers,and solvents.This salt-induced nanoprecipitation strategy offers a novel approach to fabricating polymer nanoparticles with tunable drug loading,and opens great potentials for future nanomedicines.

关键词： drug loading liquid-liquid phase separation nanoparticles nanoprecipitation salt

An Improved FastSLAM Algorithm Based on Revised Genetic Resampling and SR-UPF

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2018年第3期15卷 325-334页

作者： Tai-Zhi Lv chun-xia zhao Hao-Feng Zhang School of Computer Science and Technology Nanjing University of Science and Technology

FastSLAM is a popular framework which uses a Rao-Blackwellized particle filter to solve the simultaneous localization and mapping problem（SLAM）. However, in this framework there are two important potential limitations, the particle depletion problem and the linear approximations of the nonlinear functions. To overcome these two drawbacks, this paper proposes a new FastSLAM algorithm based on revised genetic resampling and square root unscented particle filter（SR-UPF）. Double roulette wheels as the selection operator, and fast Metropolis-Hastings（MH） as the mutation operator and traditional crossover are combined to form a new resampling method. Amending the particle degeneracy and keeping the particle diversity are both taken into considerations in this method. As SR-UPF propagates the sigma points through the true nonlinearity, it decreases the linearization errors. By directly transferring the square root of the state covariance matrix, SR-UPF has better numerical stability. Both simulation and experimental results demonstrate that the proposed algorithm can improve the diversity of particles, and perform well on estimation accuracy and consistency.

关键词： Simultaneous localization and mapping （SLAM） genetic algorithm square root unscented particle filter （SR-UPF） fastMetropolis-Hastings （MH） double roulette wheels.

Biocompatible microcapsules with a water core templated from single emulsions

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第9期28卷 1897-1900页

作者： Linlin Kong Esther Amstad Mingtan Hai Xinyou Ke Dong Chen chun-xia zhao David A.Weitz Institute of Process Equipment. College of Energy Engineering. Zhejiang University Hangzbou 310027 China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310027 China John A. Panlson School of Engineer and Applied Science Harvard University Cambridge MA 02138 USA Australian Institute for Bioengineering and Naaotechnology The University of Queensland St Lucia. OLD 4072 Australia

Biocompatible microcapsules with a water core are widely used to encapsulate hydrophilic actives.Here,a facile method to fabricate monodisperse biocompatible microcapsules with a water core in large quantity is reported.Microfluidic technology is utilized to emulsify the inner aqueous phase containing the shell polymer into monodisperse drops in the outer oil phase.As the cosolvent in the inner aqueous phase diffuses into the outer oil phase,the solubility of the shell polymer decreases,which eventually precipitates.Since the shell polymer,shellac,contains both hydrophilic and hydrophobic groups,it tends to wet both the inner aqueous phase and the outer oil phase,thus forming a solid shell at the periphery of the drop.We show that the diffusion rate of hydrophilic molecules encapsulated in the water core decreases as their molecular weight increases and the property of the microcapsules could further be modified by polyelectrolyte multilayer coating.These microcapsules are fabricated using FDA-approved polymer and non-toxic solvents and are of great use in drugs,cosmetics and foods.

关键词： Microcapsule Microfluidic Biocompatible Single emulsion Hydrophilic actives

Development of a concentration-controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading

在线全文

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2023年第6期4卷 71-84页

作者： Letao Xu Xing Wang Guangze Yang Zihan zhao Yilun Weng Yang Li Yun Liu chun-xia zhao Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt.LuciaQueenslandAustralia School of Chemical Engineering Faculty of SciencesEngincering and TechnologyThe University of AdelaideAdelaideSouth AustraliaAustralia

Lipid-based nanostructures have garnered considerable interests over the last two decades,and have achieved tremendous clinical success including theﬁrst clinical approval of a liposome(Doxil)for cancer therapy in 1995 and the recent COVID-19 mRNA lipid nanoparticle vaccines.Compared to liposomes which have a lipid bilayer surrounding an aqueous core,lipid nanoparticles with a particle structure have several attractive advantages for encapsulating poorly water-soluble drugs such as better stability due to the particle structure,high drug encapsulation efﬁciency because of a pre-or co-drug-loading strategy.While many studies have reported the synthesis of lipid nanoparticles for hydrophobic drug encapsulation,the pre-cise control of drug loading and encapsulation efﬁciency remains a signiﬁcant challenge.This work reports a new concentration-controlled nanoprecipitation plat-form technology for fabricating lipid nanoparticles with tunable drug loading up to 70 wt%.This method is applicable for encapsulating a wide range of drugs from very hydrophobic to slightly hydrophilic.Using this facile method,nanoparticles with tunable drug loading exhibited excellent properties such as small particle size,narrow size distribution,good particle stability,showing great promise for future drug delivery applications.

关键词： controlled release drug delivery drug loading lipid nanoparticles nanoprecipitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preface

Particuology 2022年第5期20卷 1-1页

作者： Guanghui Ma Wei Wei chun-xia zhao Institute of Process Engineering Chinese Academy of SciencesChina University of Queensland Australia

Particles exist everywhere.In nature and organisms,there are multiple types of nanoscale/microscale particles,such as viruses,bacteria,cells.Compared with artificial particles,natural particles have shown a great promise in bio-applications due to their unique biological activities,such as catalytic property,targeting delivery,and infective behaviour.These activities have been considered highly associated with their unique biological components and physico-chemical characteristics.

关键词： characteristics. property behaviour.

Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia LIU xia zhao Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis