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医学教育探索 2006年第2期5卷 155-156页

作者：夏春红张万敏沈阳药科大学辽宁沈阳110016

研究生在德育教育过程中起着非常重要的作用,它的地位和作用将愈加显现,而社会对于研究生教育的期望也会更高,因此,加强德育教育势在必行。

关键词：德育智育思想教育

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信息网络环境下学生的思想道德教育

医学教育探索 2006年第3期5卷 276-277页

作者：张万敏夏春红沈阳药科大学辽宁沈阳110016

从三个方面分析了信息网络发展给学校思想道德教育带来的机遇以及带来的挑战,针对这些现象,提出了网络环境下思想道德教育的四点思考。

关键词：信息网络思想道德教育信息道德伦理网络文化

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang hong-Yu Tang chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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碳纤维布加固水工构件抗弯试验研究

施工技术 2004年第6期33卷 13-15页

作者：夏春红王步王溥上海市建筑科学研究院上海200032 长安大学陕西西安710061

介绍用碳纤维布抗弯加固水工构件的性能,考察胶粘剂、施工工艺对加固效果的影响。

关键词：碳纤维布水工构件抗弯加固

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碳纤维布加固混凝土框架抗震性能试验研究

施工技术 2004年第6期33卷 6-8,15页

作者：王步夏春红王溥长安大学陕西西安710061 上海市建筑科学研究院上海200032

通过2榀1∶2 52层2跨混凝土框架低周反复加载试验,对应用碳纤维布加固混凝土框架方法进行了探索性研究,从滞回性能、节点核心区剪切变形、耗能能力以及强度、刚度退化等多个方面对加固后框架结构抗震性能的改善效果进行了分析评价。

关键词：碳纤维布加固混凝士框架抗震性能

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三剪式泪点切开术

眼外伤职业眼病杂志 2008年第9期30卷 712-713页

作者：杨朝山杨惠春于红霞郑可可鲁山县人民医院眼科河南鲁山467300

目的探讨三剪式泪点切开术的效果。方法对26例（35眼）施行三剪式泪点切开并置入长12mm，直径0．66mm的硅胶支撑管，其外端用10—0缝线固定在睑缘上，不包扎，不冲洗泪道，术后1周拆线拔管。结果26例35眼中除1眼烧伤所致的泪点闭塞，在... 详细信息

目的探讨三剪式泪点切开术的效果。方法对26例（35眼）施行三剪式泪点切开并置入长12mm，直径0．66mm的硅胶支撑管，其外端用10—0缝线固定在睑缘上，不包扎，不冲洗泪道，术后1周拆线拔管。结果26例35眼中除1眼烧伤所致的泪点闭塞，在拔管后泪点狭小，行2次手术后成功外，其余25例34眼均1次成功。术后观察2～18月，平均11月，均未再复发，溢泪症状均消失。结论三剪式泪点切开术，手术方法简便，成功率高。

关键词：泪点阻塞泪点成形术,三剪式支撑管,硅胶

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阶梯件拉伸挤压复合模设计

金属成形工艺 2001年第5期19卷 37-38页

作者：张春侠郭红利西北轻工业学院陕西咸阳712081

通过分析零件的工艺特点 ,设计了拉伸挤压复合模 ,不仅可提高零件质量 ,而且可提高生产效率。

关键词：阶梯套冲压力模具结构拉伸挤压复合模设计冲压

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-Jie Quan Hao Liang Yong-hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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中国社区老年人衰弱发生率的meta分析

职业与健康 2017年第20期33卷 2767-2770页

作者：廖春霞马红梅徐旭吴佼佼武汉大学人民医院老年科湖北武汉430060

目的采用meta分析的方法综合评价我国社区老年人的衰弱发生率。方法系统检索中文数据库(中国知网、万方数据库和维普网)和英文数据库(Pub Med,Embase,Medline,Cochrane Library)中1997—2016年所有公开发表的关于老年人衰弱发生率的文... 详细信息

目的采用meta分析的方法综合评价我国社区老年人的衰弱发生率。方法系统检索中文数据库(中国知网、万方数据库和维普网)和英文数据库(Pub Med,Embase,Medline,Cochrane Library)中1997—2016年所有公开发表的关于老年人衰弱发生率的文献。纳入合格文献后按Loney标准评价文献质量;最后采用Stata软件对数据进行meta分析。结果最终纳入12篇文献,总样本量为11 024人,我国社区老年人衰弱发生率为7.4%~14.2%。合并分析后衰弱发生率为10.5%(95%CI:9.1%~11.9%)。亚组分析显示,老年衰弱发生率随着年龄的增高而增高(60~69岁:4.9%;70~79岁:9.3%;≥80岁:20.5%)。女性衰弱率(11.3%)高于男性(8.0%)。内地(11.5%)高于香港(10.1%)和台湾地区(9.2%)。结论我国社区老年人衰弱发生率较高,应加以重视并探索有效方法进行预防和干预。

关键词：衰弱发生率 meta分析

CoTCPP integrates with BiOBr microspheres for improved solar-driven CO_(2)reduction performance

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Green Energy & Environment 2025年第1期10卷 193-202页

作者： Lina Li Yi Zhang Gaopeng Liu Tiange Wei Junze Zhao Bin Wang Mengxia Ji Yuanbin She Jiexiang xia Huaming Li School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu University301 Xuefu RoadZhenjiang212013China State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

CO_(2) photoreduction into carbon-based chemicals has been considered as an appropriate way to alleviate the energy issue and greenhouse ***,the 5,10,15,20-tetra(4-carboxyphenyl)porphyrin cobalt(II)(CoTCPP)has been integrated with BiOBr microspheres and formed the CoTCPP/BiOBr *** as-prepared CoTCPP/BiOBr-2 composite shows optimized photocatalytic performance for CO_(2) conversion into CO and CH_(4) upon irradiation with 300 W Xe lamp,which is 2.03 and 2.58 times compared to that of BiOBr,*** introduced CoTCPP significantly enhanced light absorption properties,promoted rapid separation of photogenerated carriers and boosted the chemisorption of CO_(2) *** metal Co^(2+) at the center of the porphyrin molecules also acts as adsorption center for CO_(2) molecules,accelerating the CO_(2) conversion into CO and *** possible mechanism of CO_(2) photoreduction was explored by in-situ FT-IR *** work offers a new possibility for the preparation of advanced photocatalysts.

关键词： BiOBr CoTCPP CO_(2)photoreduction Carriers transfer CO_(2)adsorption-activation