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Benefits and drawbacks of radiofrequency ablation via percutaneous or minimally invasive surgery for treating hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第11期16卷 3400-3407页

作者： Ching-Lung Hsieh cheng-Ming Peng chun-wen chen Chang-Hsien Liu Chih-Tao Teng Yi-Jui Liu Department of Computer Science and Information Engineering Feng Chia UniversityTaichung 40724Taiwan Department of Surgery Chung Shan Medical University HospitalTaichung 40201Taiwan School of Medicine Chung Shan Medical UniversityTaichung 40201Taiwan Department of Radiology Taichung Armed Forces General HospitalTaichung 406Taiwan Department of Medical Imaging and Radiological Sciences Central Taiwan University of Science and TechnologyTaichung 406Taiwan Department of Radiology School of MedicineNational Defense Medical CenterTaipei 11490Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital and China Medical UniversityHsinchu 302Taiwan Institute of Nuclear Engineering and Science National Tsing Hua UniversityHsinchu 300Taiwan Department of Radiology Nantou Hospital of the Ministry of Health and WelfareNantou 540Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia UniversityTaichung 407Taiwan Department of Automatic Control Engineering Feng Chia UniversityTaichung 407Taiwan

The management of early stage hepatocellular carcinoma(HCC)presents significant *** radiofrequency ablation(RFA)has shown safety and effectiveness in treating HCC,with lower mortality rates and shorter hospital stays,its high recurrence rate remains a significant ***,achieving improved survival solely through RFA is challenging,particularly in retrospective studies with inherent *** is commonly used for guiding percutaneous RFA,but its low contrast can lead to missed tumors and the risk of HCC *** enhance the efficiency of ultrasound-guided percutaneous RFA,various techniques such as artificial ascites and contrast-enhanced ultrasound have been developed to facilitate complete tumor *** invasive surgery(MIS)offers advantages over open surgery and has gained traction in various surgical *** studies suggest that laparoscopic intraoperative RFA(IORFA)may be more effective than percutaneous RFA in terms of survival for HCC patients unsuitable for surgery,highlighting its ***,combining MIS-IORFA with these enhanced percutaneous RFA techniques may hold greater significance for HCC treatment using the MIS-IORFA *** article reviews liver resection and RFA in HCC treatment,comparing their merits and proposing a trajectory involving their combination in future therapy.

关键词： Percutaneous radiofrequency ablation Minimally invasive surgery Hepatocellular carcinoma Intraoperative radiofrequency ablation Contrast-enhanced ultrasound

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基于仿生设计的风力机塔架力学性能分析

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热能动力工程 2018年第5期33卷 126-132页

作者：孙瑞李春陈文朴上海理工大学能源与动力工程学院

为提高塔架力学性能,提出一种仿生结构塔架并研究静态和动态结构特性。建立了1.5 MW风力机塔架有限元模型,通过仿棕榈植物的结构,将传统塔架模型设计成带类维管束腹板的锥筒塔架和带类维管束腹板多段式仿生塔架,并将计算结果与传统塔架... 详细信息

为提高塔架力学性能,提出一种仿生结构塔架并研究静态和动态结构特性。建立了1.5 MW风力机塔架有限元模型,通过仿棕榈植物的结构,将传统塔架模型设计成带类维管束腹板的锥筒塔架和带类维管束腹板多段式仿生塔架,并将计算结果与传统塔架进行了对比分析。结果表明：类维管束腹板使仿生塔架具有更强的抗弯性能,可有效降低塔架的塔尖位移,较之传统塔架减小了68%;传统塔架的应力集中在塔架根部,而仿生塔架能高效地分散载荷,最大应力下降19%,起到减载作用;仿生塔架的一阶固有频率较传统塔架下降0.246 Hz,能够避开塔架的共振频率范围。

关键词：风力机塔架仿生模态分析减载力学性能

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福建省大学生创业路径研究

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闽南师范大学学报（哲学社会科学版） 2017年第1期31卷 31-35页

作者：陈春华陈阿文闽南师范大学商学院福建漳州363000 闽南师范大学图书馆福建漳州363000

创业环境碎片化导致大学生无法有效地识别创业机会和整合创业资源并最终实现创业。实证分析证实,创业环境可以让大学生创业者捕获到更多创业机会,创业资源和创业机会是大学生成功创业的主要抓手。因此,政府应该营造好创业氛围,大学生创... 详细信息

创业环境碎片化导致大学生无法有效地识别创业机会和整合创业资源并最终实现创业。实证分析证实,创业环境可以让大学生创业者捕获到更多创业机会,创业资源和创业机会是大学生成功创业的主要抓手。因此,政府应该营造好创业氛围,大学生创业者要立足市场需求并通过利益机制有效获取创业资源和创业机会。

关键词：创业路径大学生创业过程

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变工况下高低齿迷宫密封泄漏特性及结构优化

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热能动力工程 2018年第5期33卷 33-39页

作者：张尧张万福李春陈文朴上海理工大学能源与动力工程学院

高低齿迷宫密封是透平机械中抑制流体泄漏的关键部件。以某机组隔板密封为对象建立高低齿迷宫的计算流体力学（CFD）模型,研究由变工况引起的转子轴向偏移对密封泄漏特性的影响,并通过调整转子凸台宽度和密封腔高度对密封结构进行优化... 详细信息

高低齿迷宫密封是透平机械中抑制流体泄漏的关键部件。以某机组隔板密封为对象建立高低齿迷宫的计算流体力学（CFD）模型,研究由变工况引起的转子轴向偏移对密封泄漏特性的影响,并通过调整转子凸台宽度和密封腔高度对密封结构进行优化。结果表明：原始结构设计下,转子轴向偏移±3 mm内,泄漏量并未发生大幅度的上升;在-2-1.5 mm范围内泄漏量有所下降,说明在工况变动不大时,密封性能有所提高,但超出±3 mm的范围,泄漏量呈突增趋势;泄漏量分别随转子凸台宽度和密封腔高度呈二次非线性变化,存在一个最佳值使泄漏量达到最小,最佳凸台宽度和密封腔高度分别为5.13和7.5 mm;结构优化后密封泄漏量在正常工况及变工况下均小于原始结构,密封性能得到提高。

关键词：迷宫密封轴向偏移泄漏特性变工况 CFD

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma wen Ma Peng Zang Ying chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu Yi-Sheng chen Yu-chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan Fang wen-Jie Fan chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

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集群信任、社会网络与小微企业融资——以广东澄海玩具行业为例

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科技和产业 2017年第4期17卷 40-47页

作者：张春娇陈文川中山大学新华学院广东东莞523133

小微企业是解决就业问题的根本之策。探讨集群信任、社会网络与小微企业融资在小微企业发展中应用的理论基础,并以广东澄海玩具行业为例,进一步验证和揭示三者之间的关系及其背后的作用机制,结合"供给侧改革"政策,对澄海玩具行业进行展... 详细信息

小微企业是解决就业问题的根本之策。探讨集群信任、社会网络与小微企业融资在小微企业发展中应用的理论基础,并以广东澄海玩具行业为例,进一步验证和揭示三者之间的关系及其背后的作用机制,结合"供给侧改革"政策,对澄海玩具行业进行展望。借鉴其发展经验,提出从舆论宣传和社会监督力度、金融市场体系、小微企业家成长环境以及交通、通信等基础设施这四个路径优化小微企业创新环境,为小微企业创造更好的外部环境提供建议。

关键词：集群信任社会网络小微企业

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