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Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： chun Zhu Yifei Yang Yike Jing Zhen Zeng Xuesong Yi wei Sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu Hui Hong wei Quan Xinyu Qiao chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-Yi Hsiao chung-Yi Nien Ruei-Feng Shiu wei-chun Chin Tzung-Hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

Efficacy and safety of S-1 maintenance therapy in advanced nonsmall- cell lung cancer patients

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World Journal of Clinical Cases 2020年第21期8卷 5172-5179页

作者： Xiao-wei Cheng Wen-Hua leng chun-Ling Mu Department of Respiratory and Critical Care Medicine Panzhihua Central HospitalPanzhihua 617067Sichuan ProvinceChina Department of Ultrasound Panzhihua Central HospitalPanzhihua 617067Sichuan ProvinceChina

BACKGROUND Previous reports have demonstrated that S-1 has remarkable effects in the maintenance treatment of advanced non-small-cell lung cancer(NSCLC),and has less toxic and side effects than conventional *** To investigate the efficacy and safety of S-1 maintenance therapy in patients with advanced *** Ninety-four patients with NSCLC admitted to our hospital from September 2015 to April 2018 were included in the study and divided into the S-1 group(47 cases)and the gemcitabine group(47 cases)by random digital table *** S-1 group was treated with S-1,while the gemcitabine group received gemcitabine *** clinical efficacy and quality of life of the patients after treatment in the two groups were *** There was no significant difference in the total effectiveness rate between the two groups(P=0.519).The quality-of-life scores indicated that there was no significant difference between the two groups in terms of four dimensions of the GQOLI-74 questionnaire(P=0.518,0.094,0.338,0.418).The incidence of nausea and vomiting,granulocytopenia and diarrhea in the S-1 group was significantly lower than that in the gemcitabine group(P=0.001,0.001 and 0.001,respectively).There was no significant difference in the incidence of thrombocytopenia(P=0.366),the progression-free survival(P=0.064),and the survival between the two groups(P=0.050).CONCLUSION S-1 maintenance therapy shows a significant therapeutic effect in patients with advanced *** has the same clinical efficacy as gemcitabine,but with less toxic and side effects than conventional drugs.

关键词： Advanced non-small cell lung cancer Maintenance therapy S-1 Gemcitabine Efficacy Toxic and side effects

Progress in numerical modeling of subducting plate dynamics

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Science China Earth Sciences 2018年第12期61卷 1761-1774页

作者： wei leng Liangzhi HUANG School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China National Geophysical Observatory at Mengcheng Hefei 230026China

The core concerns of plate tectonics theory are the dynamics of subducting plates, which can be studied by integrating multidisciplinary fields such as seismology, mineral physics, rock geochemistry, geological formation studies, sedimentology,and numerical simulations. By establishing a theoretical model and solving it with numerical methods, one can replicate the dynamic effects of a subducting plate, quantifying its evolution and the surface response. Simulations can also explain the observations and experimental results of other disciplines. Therefore, numerical models are among the most important tools for studying the dynamics of subducting plates. This paper provides a review on recent advances in the numerical modeling of subducting plate dynamics. It covers various aspects, namely, the origin of plate tectonics, the initiation process and thermal structure of subducting slab, and the main subduction slab dynamics in the upper mantle, mantle transition zone, and lower mantle. The results of numerical models are based on the theoretical equations of mass, momentum, and energy conservation. To better understand the dynamic progress of subducting plates, the simulation results must be verified in comparisons with the results from natural observations by geology, geophysics and geochemistry. With the substantial increase in computing power and continuous improvement of simulation methods, numerical models will become a more accurate and efficient means of studying the frontier issues of Earth sciences, including subducting plate dynamics.

关键词： Subducting plate Dynamics Numerical simulation

Progress in the numerical modeling of mantle plumes

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Science China Earth Sciences 2023年第4期66卷 685-702页

作者： wei leng Hao LIU Laboratory of Seismology and Physics of Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China State Key Laboratory of Geological Processes and Mineral Resources School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China CAS Center for Excellence in Comparative Planetology Hefei 230026China

The mantle plume model, as an integral part of the Earth’s internal convection system, is complementary to the theory of plate tectonics. They together constitute the key configuration of material circulation and energy transport in the Earth’s interior. Seismology, high-temperature and high-pressure mineralogy, geology, and geodynamic numerical modeling have conducted comprehensive studies on the mantle plume model since it was proposed. In particular, numerical simulation, which investigates the dynamic processes of mantle plumes by establishing a theoretical model, provides a quantitative description of possible mantle plume evolution and the responses of the Earth’s interior and surface, which can be used to explain observations and experimental results from other disciplines. Thus, it is one of the most important means to study plume dynamics. This paper summarizes the research progress in numerical modeling of mantle plumes in past decades, including the origin of mantle plumes, seismological evidence for the existence of plumes, interactions between mantle plumes and the lithosphere, mid-ocean ridges, subduction zones, and the mantle transition zone, as well as the relationship between plumes and large low shear wave velocity provinces. The theoretical results of numerical modeling combined with observations from other disciplines enable us to deeply understand the dynamic process of mantle plumes. With the continuing development of numerical methodology and the improvement of high-performance computing, geodynamic numerical modeling will become a more accurate and efficient approach for studying mantle plume dynamics and related frontier problems in geosciences.

关键词： Mantle plume Dynamics Numerical modeling

Aseismic ridge subduction and flat subduction:Insights from three-dimensional numerical models

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Earth and Planetary Physics 2023年第2期7卷 269-281页

作者： Hui Zhao wei leng Laboratory of Seismology and Physics of Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Hefei 230026China

Flat subduction can significantly influence the distribution of volcanism,stress state,and surface topography of the overriding ***,the mechanisms for inducing flat subduction remain *** two-dimensional(2-D)numerical models and laboratory analogue models suggested that a buoyant impactor(aseismic ridge,oceanic plateau,or the like)may induce flat ***,three-dimensional(3-D)systematic studies on the relationship between flat subduction and buoyant blocks are still ***,we use a 3-D numerical model to investigate the influence of the aseismic ridge,especially its width(which is difficult to consider in 2-D numerical models),on the formation of flat *** model results suggest that the aseismic ridge needs to be wide and thick enough to induce flat subduction,a condition that is difficult to satisfy on the *** also find that the subduction of an aseismic ridge parallel to the trench or a double aseismic ridge normal to the trench has a similar effect on super-wide aseismic ridge subduction in terms of causing flat subduction,which can explain the flat subduction observed beneath regions such as Chile and Peru.

关键词： flat subduction aseismic ridge oceanic plateau 3-D numerical simulation

Thermal structure of continental subduction zone: high temperature caused by the removal of the preceding oceanic slab

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Earth and Planetary Physics 2021年第3期5卷 290-295页

作者： Ting Luo wei leng Laboratory of Seismology and Physics of Earth’s Interior/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Beijing 100049China

The thermal structure of the continental subduction zone can be deduced from high-pressure and ultra-high-pressure rock samples or numerical ***,petrological data indicate that the temperature of subducted continental plates is generally higher than that derived from numerical *** this paper,a two-dimensional kinematic model is used to study the thermal structure of continental subduction zones,with or without a preceding oceanic *** results show that the removal of the preceding oceanic slab can effectively increase the slab surface temperature of the continental subduction zone in the early stage of *** can sufficiently explain the difference between the cold thermal structure obtained from previous modeling results and the hot thermal structure obtained from rock sample data.

关键词： thermal structure continental subduction zone slab breakoff numerical model

A comprehensive review of in-situ polymer gel simulation for conformance control

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Petroleum Science 2022年第1期19卷 189-202页

作者： Baojun Bai Jianqiao leng Mingzhen wei Missouri University of Science and Technology Rolla65409USA

Gel treatment has been widely applied in mature oilfields to improve sweep efficiency and control water *** numerical simulation is of major importance to the optimization design and prediction of a successful gel ***,there exist many problems in current simulation studies in published *** paper first presents a comprehensive review on the major factors that have been considered at different gelation stages during gel treatment,the models used in the commercial/inhouse simulators,and current numerical simulation studies on both laboratory and field *** we classify the current in-situ gel numerical simulation problems as 1,deficient model problem that has published numerical model but has not been applied in simulator and application studies;2,missing model problem that does not have published quantitative model;and 3,inaccurate application problem that does not consider the major factors of gel performance,based on the reasons from some questionable results of current simulation ***,we point out the major research efforts that should be made in the future to better simulate in-situ gel treatment *** review indicates that numerous simulation studies using commercial software packages intend to predigest the gel treatment,many of which,however,ignore important mechanisms and mislead the operation of gel *** fact,a full assessment of simulating in-situ gels cannot be achieved unless the quantitative models can be qualified in terms of transport and plugging mechanisms based on the experimental results.

关键词： In-situ gel Mechanism Simulation model Application studies