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Dopaminergic effects on in vitro osteogenesis

Bone Research 2015年第3期3卷 130-139页

作者： Dong Joon Lee Henry C Tseng Sing wai wong Zhengyan Wang Meng Deng Ching-Chang Ko NC Oral Health Institute School of Dentistry University of North Carolina Duke Eye Center and Department of Ophthalmology Duke University Medical Center Oral Biology Program School of Dentistry University of North Carolina Department of Pediatric Dentistry School of Dentistry University of North Carolina Department of Orthodontics School of Dentistry University of North Carolina

Multiple growth factors（e.g., BMP2, TGF-b1, FGF2） and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine（PDA） and dopamine（DA） monomer have recently been reported to increase osteoblast proliferation and mineralization in vitro. Although a well-characterized neurotransmitter, DA＇s role in the bone is unknown. We hypothesize that DA can directly act on osteoblasts, and examined whether osteoblasts express DA receptors that respond to exogenous DA. m RNAs and protein cell lysates were obtained from MC3T3-E1 cells during osteogenic differentiation phase. Reverse transcription polymerase chain reaction and western blot analysis were used to examine the expression of DA receptors, D1–D5. Dose-response effect and time course of DA treatment on cell proliferation, mineralization, and osteogenic differentiation were investigated at pre-determined days. Real-time PCR was performed to investigate whether DA affects osteogenic gene expression（ALP, BSP, OC, OSX, RUNX2, and Collagen1a2） with or without receptor antagonists（SCH233390 and GR103691）. Two-way ANOVA was used for statistical analysis. All five DA receptors（D1, D2, D3, D4, and D5） m RNAs and proteins were expressed in MC3T3-E1 cells. DA treatment increased cell proliferation for up to 7 days（P, 0.05）. Osteogenic mineralization was significantly greater in the DA-treated group than control group（P, 0.05）. Finally, expression of all the osteogenic genes was inhibited by DA receptor antagonists for D1, D3, and D5. Our findings suggest that MC3T3-E1 osteoblasts express functional DA receptors that enhance proliferation and mineralization. PDA is not biologically inert and has important implications in orthopedic applications. Furthermore, osteoblast differentiation might be regulated by the nervous system, presumably during bone development, remodeling, or repair.

关键词： osteogenic differentiation cell proliferation polymerase chain reaction bone tissue engineering western blot analysis statistical analysis bone development gene expression nervous system growth factors in vitro

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Substitute of Expensive Pt with Improved Electrocatalytic Performance and Higher Resistance to CO Poisoning for Methanol Oxidation: the Case of Synergistic Pt-Co_3O_4 Nanocomposite

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Nano-Micro Letters 2013年第4期5卷 296-302页

作者： Hongxiao Zhao Zhi Zheng Jing Li Huimin Jia Ka-wai wong Yidong Zhang Woon Ming Lau Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province Institute of Surface Micro and Nano Materials Xuchang University Chengdu Green Energy and Green Manufacturing R&D Center

In this paper, Pt-Co_3O_4 nanocomposite was synthesized by a sol gel process combined with electrodeposition method. Its electrocatalytic activity towards methanol oxidation was investigated at room temperature using cyclic voltammetry(CV), electrochemical impedance spectroscopy(EIS) and current density time curve. It is found that the resultant Pt-Co_3O_4 catalysts with minute amount of Pt exhibite attractive electrocatalytic activity for methanol oxidation reaction(MOR) but with a high resistance CO poisoning due to the synergistic effects from Pt and Co_3O_4. Together with the low manufacturing cost of Co_3O_4, the reported nanostructured Pt-Co_3O_4 catalyst is expected to be a promising electrode material for direct methanol fuel cells(DMFC).

关键词： Pt-Co3O4 nanocomposite MOR Electrocatalytic activity

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Recurrent giant fibrovascular polyp of the esophagus

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World Journal of Gastroenterology 2009年第29期15卷 3697-3700页

作者： Ser Yee Lee Weng Hoong Chan Ranjiv Sivanandan Dennis Teck Hock Lim wai Keong wong Department of General Surgery Singapore General Hospital Outram Road Singapore 169608 Singapore Department of Surgical Oncology National Cancer Centre 11 Hospital Drive Singapore 169610 Singapore

Giant fibrovascular polyps of the esophagus and hypopharynx are rare benign esophageal tumors. They arise most commonly in the upper esophagus and may, rarely, originate in the hypopharynx. They can vary significantly in size. Even though they are benign, they may be lethal due to either bleeding or, rarely, asphyxiation if a large polyp is regurgitated. Patients commonly present with dysphagia or hematemesis. The polyps may not be well visualized on endoscopy and imaging plays a vital role in aiding diagnosis as well as providing important information for preoperative planning, such as the location of the pedicle, the vascularity of the polyp and the tissue elements of the mass. They can also be recurrent in rare cases, especially if the resection margins of the base are involved. We review the recent literature and report a case of a 61-year-old man with a recurrent giant esophageal fibrovascular polyp with illustrative contrast barium swallow, CT and intra-operative images, who required several surgeries via a combination of endoscopic, trans-oral, trans-cervical, trans-thoracic and trans-abdominal approaches.

关键词： Giant fibrovascular polyp Esophagus Esophageal polyp Fibroepithelial polyps

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Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy

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World Journal of Gastroenterology 2005年第31期11卷 4865-4868页

作者： wai K Leung Francis KL Chan Sara SL Fung Mei-Yin wong Joseph JY Sung Digestive Diseases Center

AIM： To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy. METHODS： Consecutive patients who underwent capsule endoscopy during the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and small bowel transit time, and the small bowel image quality were compared. RESULTS： Twenty-four patients received oral erythromycin whereas 14 patients were not given any prokinetic agent. Patients who received erythromycin had a significantly lower gastric transit time than control （16 min vs70 min, P= 0.005）, whereas the small bowel transit time was comparable between the two groups （227 rain vs 183 min, P= 0.18）. Incomplete small bowel examination was found in three patients of the control group and in one patient of the erythromycin group. There was no significant difference in the overall quality of small bowel images between the two groups. A marked reduction in gastric transit time was noted in two patients who had repeat capsule endoscopy after oral erythromycin. CONCLUSION： Use of oral erythromycin significantly reduces the gastric transit time of capsule endoscopy.

关键词： Capsule endoscopy Erythromycin Prokinetic

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X-reality for phantom limb management for amputees:A systematic review and meta-analysis

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Engineered Regeneration 2023年第2期4卷 134-151页

作者： James chung-wai Cheung Daphne Sze Ki Cheung Ming Ni Kam-wai Chen Ye-Jiao Mao Lin Feng Wing-Kai Lam Duo wai-Chi wong Aaron Kam-Lun Leung Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong KongChina School of Nursing The Hong Kong Polytechnic UniversityHong KongChina Department of Orthopaedics Ruijin HospitalShanghai Jiao Tong UniversityShanghaiChina Department of Prosthetics and Orthotics Queen Mary HospitalHong KongChina Sports Information and External Affairs Centre Hong Kong Sports InstituteHong KongChina Research Institute for Sports Science and Technology The Hong Kong Polytechnic UniversityHong KongChina Department of Rehabilitation Science The Hong Kong Polytechnic UniversityHong KongChina

Phantom limb is a disabling neuropsychiatric condition among amputees resulting in pain and disturbance that impact their functions,quality of life,and *** pharmacological approaches appeared to be ineffec-tive,the emergence and integration of X-reality,including virtual reality,augmented reality,and mixed reality,might elevate the effectiveness of mirror therapy in managing phantom *** objective of this study is to review X-reality for managing phantom pain.A systematic search was conducted on PubMed,Scopus,Web of Science,PsycINFO,Embase,and ***(n=16)studies containing 66 lower-limb and 53 upper-limb amputees were included for the review over the thematic framework of amputee characteristics and intervention designs,while thirteen(n=13)studies were further proceeded for the *** found eleven studies on virtual reality(n=11),four studies on marker-based augmented reality(n=4)and one study on mixed reality(n=1)with a total of 40 game/task themes involving,motor skills,motor control,and ***,all these interventions adopted the movement representation strategies with different ***,the X-reality interventions reduced the pain level of the amputees(mean difference:-2.30,95%CI,-3.38 to-1.22),especially the virtual reality subgroup(mean difference:-2.83,95%CI,-4.43 to-1.22).However,there were substantial heterogeneity and partially explained by the subgroup analysis on publication *** strength of evidence was limited by case reports and case series in this review.

关键词： Extended reality Limb telescoping Phantom pain Phantom sensation

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Emodin and shikonin(quinones): an overview of their chemistry, plant sources, pharmacology and cytotoxic activities against lung cancer

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Journal of Chinese Pharmaceutical Sciences 2020年第1期29卷 1-12页

作者： Eric Wei Chiang Chan Chen wai wong Siu Kuin wong Yew Woh Hui Joash Ban Lee Tan Faculty of Applied Sciences UCSI University56000 CherasKuala LumpurMalaysia Xiamen University Malaysia Bandar Sunsuria43900 SepangSelangorMalaysia School of Science Monash University MalaysiaBandar Sunway47500 Subang JayaSelangorMalaysia

Emodin and shikonin are quinones that are commonly found in the roots of plant species of the families Polygonaceae and Boraginceae,*** have a wide spectrum of bioactivities,including anti-cancer *** overview on the cytotoxic properties of emodin and shikonin is focused on lung cancer,the leading cause of cancer death in the *** emodin,the-OH groups at C1 and C3 positions,while in shikonin,the-OH groups of the naphthazarin moiety and chiral side-chain,are important for their anti-tumour *** have shown that emodin and shikonin inhibit the growth of lung cancer cells by inducing apoptosis,autophagy,necrosis and early senescence,and by inhibiting proliferation,invasion,migration and *** cytotoxic activities are involved multiple molecular targets and signalling pathways.A clinical trial using shikonin to treat patients with late-stage lung cancer has been *** future perspectives and research needs are *** of information are from Google Scholar,Pub Med,Science Direct,J-Stage,Pub Chem and CNKI.

关键词： Quinones Emodin Shikonin Lung cancer cells Clinical trial

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Seroprevalence of Pteropine orthoreovirus (PRV) Infection among Outpatients in a Clinic in Rembau, Malaysia

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Biomedical and Environmental Sciences 2022年第8期35卷 755-759页

作者： LEONG wai Jing VOON Kenny wong Siew Tung TENG Cheong Lieng LEONG Pooi Pooi WANG Linfa School of Medicine International Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia School of Pharmacy University of Nottingham MalaysiaSemenyih 43500SelangorMalaysia Faculity of Medicine and Health Sciences Universiti Tunku Abdui RahmanKajang 43000SelangorMalaysia Programme in Emerging Infectious Diseases Duke-NUS Medical School169857 Singapore

Pteropine orthoreovirus(PRV)is an emerging zoonotic respiratory virus with the potential to spill over from fruit bats to *** belongs to the family Reoviridae,whose name is derived from an abbreviation of"respiratory enteric orphan".This family of viruses was initially not believed to cause diseases in humans and therefore was named an"orphan virus".PRV infections in humans are characterized by symptoms ranging from mild influenza-like illness to severe acute respiratory distress.

关键词： PRV abbreviation initially

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Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease

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World Journal of Gastroenterology 2006年第18期12卷 2923-2927页

作者： William Ng wai-Man wong wai-Hong Chen Hung-Fat Tse Pui-Yin Lee Kam-Chuen Lai Sheung-wai Li Matthew Ng Kwok-Fai Lam Xi Cheng Chu-Pak Lau Division of Cardiology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Gastroenterology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Rehabilitation Medicine University Department of Medicine Queen Mary Hospital Hong Kong SAR China Department of Statistics and Actuarial Science University of Hong Kong Hong Kong SAR China

AIM： The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding （UGIB） with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. METHODS： A total of 991 patients with coronary artery disease （CAD） on low-dose aspirin were prospectively followed-up for two years for the occurrence and clinical features of first hospitalized episode of UGIB. RESULTS： UGIB had a bimodal presentation with 45% occurring within four months of aspirin initiation and had an overall prevalence of 1.5% per year. There was no UGIB-related death. Hypertension （OR = 4.6, 95%CI 1.5 - 14.7, P = 0.009）, history of peptic ulceration （OR = 3.1, 95%CI 1.1 - 9.0, P = 0.039）, tertiary education （OR = 3.08, 95%CI 1.1 - 9.0, P = 0.039） and higher lean body mass （P = 0.016） were independent factors associated with UGIB. Use of nitrate did not reduce UGIB. CONCLUSION： The incidence of UGIB in patients with CAD on long-term low-dose aspirin is low, but is accompanied with significant morbidity. With prolonged use of aspirin, UGIB continues to be a problem for those with risk factors and especially in patients with a history of peptic ulcers, in which UGIB tends to occur early after aspirin therapy.

关键词： Coronary artery disease, Aspidn Gastrointestinal bleeding

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Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation

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Cellular & Molecular Immunology 2010年第1期7卷 26-34页

作者： Joyce YS Chow chun K wong Phyllis FY Cheung Christopher WK Lam Department of Chemical Pathology The Chinese University of Hong KongPrince of Wales HospitalShatinNTHong KongChina Macao Institute for Applied Research in Medicine and Health Macao University of Science and Technology FoundationMacaoChina

The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in *** the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling ***-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and *** addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and *** found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)***,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and ***-1β,but not IL-18,markedly upregulated cell surface expression of ***-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK *** efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and *** together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation.

关键词： allergy cytokines eosinophils signal transduction

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Digital Rights Management for a Chinese XML Text Centre

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现代图书情报技术 2002年第S1期 172-177页

作者： wai -man wong(The Open University of Hong Kong Library,Hong Kong,China)

The Electronic Text Centre of the OpenUniversity of Hong Kong(OUHK)has been in full operationsince early *** currently houses 7,300+electronictexts,including free electronic titles,electronic titlespurchased directly from the market,and about,1,000 locallyproduced electronic *** locally produced titles are notavailable in the market but require local digitization andnegotiation with publishers with regard to the right to use(RTU)them so as to meet the learning needs of the ***...

关键词： Text Digital Rights Management for a Chinese XML Text Centre XML

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