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Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration

Regenerative Biomaterials 2017年第1期4卷 21-30页

作者： Xiaoli Wu Liumin He Wen Li Heng Li wai-Man wong Seeram Ramakrishna Wutian Wu Department of Anatomy School of Biomedical ScienceLKS Faculty of MedicineThe University of Hong Kong21 Sassoon RoadHong Kong SARChina State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam21 Sassoon RoadHong Kong SARChina Joint Laboratory of Jinan University and the University of Hong Kong GHM Institute of CNS RegenerationJinan University601 Huangpu Avenue WestGuangzhou510632China Department of Mechanical Engineering Faculty of EngineeringCenter for Nanofibers and NanotechnologyNational University of Singapore117576SingaporeSingapore.

Peripheral nerves are fragile and easily damaged,usually resulting in nervous tissue loss,motor and sensory function *** in neuroscience and engineering have been significantly contributing to bridge the damage nerve and create permissive environment for axonal regrowth across *** have successfully designed two self-assembling peptides by modifying RADA 16-I with two functional motifs IKVAV and *** hydrogel formed when combing the two neutral solutions together,defined as RADA 16-Mix that overcomes the main drawback of RADA16-I associated with low *** the present study,we transplanted the RADA 16-Mix hydrogel into the transected rat sciatic nerve gap and effect on axonal regeneration was examined and compared with the traditional RADA16-I *** regenerated nerves were found to grow along the walls of the large cavities formed in the graft of RADA16-I hydrogel,while the nerves grew into the RADA 16-Mix hydrogel toward distal *** 16-Mix hydrogel induced more axons regeneration and Schwann cells immigration than RADA16-I hydrogel,resulting in better functional recovery as determined by the gait-stance duration percentage and the formation of new neuromuscular junction ***,our results indicated that the functional SAP RADA16-Mix nanofibrous hydrogel provided a better environment for peripheral nerve regeneration than RADA16-I hydrogel and could be potentially used in peripheral nerve injury repair.

关键词： Peripheral nerve regeneration self-assembling peptide IKVAV RGD nanofibrous hydrogel

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Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2022年第15期28卷 1563-1573页

作者： Thaninee Prasoppokakorn Wah-Kheong Chan Vincent wai-Sun wong Panyavee Pitisuttithum Sanjiv Mahadeva Nik Raihan Nik Mustapha Grace Lai-Hung wong Howard Ho-wai Leung Pimsiri Sripongpun Sombat Treeprasertsuk Department of Medicine Division of GastroenterologyFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Medicine Division of GastroenterologyDivision of Gastroenterology and Hepatology UnitFaculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Medicine Division of General Internal MedicineFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Pathology Hospital Sultanah BahiyahAlor SetarKedah 05460Malaysia Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong KongChina Department of Internal Medicine Prince of Songkla UniversityHat Yai 90110Thailand Department of Medicine Division of Gastroenterology and HepatologyStanford University School of MedicinePalo AltoCA 94305United States

BACKGROUND Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease(NAFLD)*** fibrosis-8(FIB-8)score,recently developed by incorporating four additional variables into the fibrosis-4(FIB-4)score,showed better performance in predicting significant fibrosis in *** To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score(NFS)for predicting significant *** We collected the data of biopsy-proven NAFLD patients from three Asian centers in three *** the patients with available variables for the FIB-4 score(age,platelet count,and aspartate and alanine aminotransferase levels)and FIB-8 score(the FIB-4 variables plus 4 additional parameters:The body mass index(BMI),albumin to globulin ratio,gamma-glutamyl transferase level,and presence of diabetes mellitus)were *** fibrosis stage was scored using nonalcoholic steatohepatitis CRN criteria,and significant fibrosis was defined as at least fibrosis stage *** A total of 511 patients with biopsy-proven NAFLD and complete data were included for *** these 511 patients,271(53.0%)were female,with a median age of 51(interquartile range:41,58)*** median BMI was 29(26.3,32.6)kg/m2,and 268(52.4%)had *** the 511 NAFLD patients,157(30.7%)had significant fibrosis(≥F2).The areas under the receiver operating characteristic curves of the FIB-8 and FIB-4 scores and NFS for predicting significant fibrosis were 0.774,0.743,and 0.680,*** FIB-8 score demonstrated significantly better performance for predicting significant fibrosis than the NFS(P=0.001)and was also clinically superior to FIB-4,although statistical significance was not reached(P=0.073).The low cutoff point of the FIB-8 score for predicting significant fibrosis of 0.88 showed 92.36%sensitivity,and the high cutoff point of the FIB-8 score for predicting significant fibrosis of 1.

关键词： Nonalcoholic fatty liver disease Fibrosis-8 score Fibrosis-4 score Nonalcoholic fatty liver disease fibrosis score

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Corneal blindness and current major treatment concerngraft scarcity

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1154-1162页

作者： Kah Hie wong Ka wai Kam Li Jia Chen Alvin L.Young Department of Ophthalmology and Visual Sciences Chinese University of Hong Kong Department of Ophthalmology and Visual Sciences Prince of Wales Hospital

According to World Health Organization, the global prevalence of blindness in 2010 was 39 million people, among which 4% were due to corneal opacities. Often, the sole resort for visual restoration of patients with damaged corneas is corneal transplantation. However, despite rapid developments of surgical techniques, instrumentations and immunosuppressive agents, corneal blindness remains a prevalent global health issue. This is largely due to the scarcity of good quality corneal grafts. In this review, the causes of corneal blindness, its major treatment options, and the major contributory factors of corneal graft scarcity with potential solutions are discussed.

关键词： corneal blindness keratoplasty corneal graft corneal donation eye banking

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Laparoscopic excision of Meckel's diverticulum in children:What is the current evidence?

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World Journal of Gastroenterology 2014年第41期20卷 15158-15163页

作者： Kin wai Edwin Chan Kim Hung Lee Hei Yi Vicky wong Siu Yan Bess Tsui Yuen Shan wong Kit Yi Kristine Pang Jennifer wai Cheung Mou Yuk Him Tam Division of Paediatric Surgery and Paediatric Urology Department of SurgeryThe Prince of Wales HospitalThe Chinese University of Hong Kong

Complications aroused from Meckel’s diverticulum tend to developed in children. Children presented with abdominal pain, intestinal obstruction, intussusception or gastrointestinal bleeding may actually suffered from complicated Meckel’s diverticulum. With the advancement of minimally invasive surgery (MIS) in children, the use of laparoscopy in the diagnosis and subsequent laparoscopic excision of Meckel’s diverticulum has gained popularity. Recently, single incision laparoscopic surgery (SILS) has emerged as a new technique in minimally invasive surgery. This review offers the overview in the development of MIS in the management of children suffered from Meckel’s diverticulum. The current evidence in different laparoscopic techniques, including conventional laparoscopy, SILS, the use of special laparoscopic instruments, intracorporeal diverticulectomy and extracorporeal diverticulectomy in the management of Meckel’s diverticulum in children were revealed.

关键词： Laparoscopy Meckel’ s diverticulum Children

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The use of animal sensor data for predicting sheep metabolisable energy intake using machine learning

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Information Processing in Agriculture 2021年第4期8卷 494-504页

作者： Hari Suparwito Dean T.Thomas Kok wai wong Hong Xie Shri Rai Murdoch University MurdochWA 6150Australia CSIRO Agriculture and Food Private Bag 5WembleyWA 6913Australia

The use of sensors for monitoring livestock has opened up new possibilities for the management of livestock in extensive grazing *** work presented in this paper aimed to develop a model for predicting the metabolisable energy intake(MEI)of sheep by using temperature,pitch angle,roll angle,distance,speed,and grazing time data obtained directly from wearable sensors on the sheep.A Deep Belief Network(DBN)algorithm was used to predict MEI,which to our knowledge,has not been attempted *** results demonstrated that the DBN method could predict the MEI for sheep using sensor data *** mean square error(MSE)values of 4.46 and 20.65 have been achieved using the DBN model for training and testing datasets,*** also evaluated the influential sensor data variables,i.e.,distance and pitch angle,for predicting the *** study demonstrates that the application of machine learning techniques directly to on-animal sensor data presents a substantial opportunity to interpret biological interactions in grazing systems directly from sensor *** expect that further development and refinement of this technology will catalyse a step-change in extensive livestock management,as wearable sensors become widely used by livestock producers.

关键词： Energy intake Livestock behaviour Machine learning Predictions Sensor data

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Microglia activation,classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage

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Neural Regeneration Research 2022年第7期17卷 1404-1411页

作者： Junfan Chen Zhiyuan Vera Zheng Gang Lu wai Yee Chan Yisen Zhang George Kwok Chu wong Division of Neurosurgery Department of SurgeryThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Neurosurgery Hainan Branch of Chinese People’s Liberation Army General HospitalSanyaHainan ProvinceChina CUHK-SDU Joint Laboratory on Reproductive Genetics School of Biomedical Sciencesthe Chinese University of Hong KongHong Kong Special Administrative RegionChina Bioinformatics Unit SDIVF R&D CentreHong Kong Science and Technology ParksHong Kong Special Administrative RegionChina Department of Interventional Neuroradiology Beijing Neurosurgical InstituteBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Subarachnoid hemorrhage is a devastating disease with significant mortality and morbidity,despite advances in treating cerebral *** has been recent progress in the intensive care management and monitoring of patients with subarachnoid hemorrhage,but the results remain ***,the resident immune cells of the brain,are increasingly recognized as playing a significant role in neurological diseases,including subarachnoid *** early brain injury following subarachnoid hemorrhage,microglial activation and neuroinflammation have been implicated in the development of disease complications and *** understand the disease processes following subarachnoid hemorrhage,it is important to focus on the modulators of microglial activation and the pro-inflammatory/anti-inflammatory cytokines and *** this review,we summarize research on the modulators of microglia-mediated inflammation in subarachnoid hemorrhage,including transcriptome changes and the neuroinflammatory signaling *** also describe the latest developments in single-cell transcriptomics for microglia and summarize advances that have been made in the transcriptome-based classification of microglia and the implications for microglial activation and neuroinflammation.

关键词： activation inflammation microglia modulator neuroinflammation sequencing signal pathway single-cell analysis stroke subarachnoid hemorrhage treatment

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Anaerobic biodegradation of PAHs in mangrove sediment with amendment of NaHCO_3

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Journal of Environmental Sciences 2015年第4期27卷 148-156页

作者： chun-Hua Li Yuk-Shan wong Hong-Yuan Wang Nora Fung-Yee Tam State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Department of Biology and Chemistry City University of Hong Kong Department of Biology The Hong Kong University of Science and Technology Key Laboratory of Nonpoint Source Pollution Control Ministry of Agriculture/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences State Key Laboratory on Marine Pollution City University of Hong Kong

Mangrove sediment is unique in chemical and biological properties. Many of them suffer polycyclic aromatic hydrocarbon（PAH） contamination. However, the study on PAH biological remediation for mangrove sediment is deficient. Enriched PAH-degrading microbial consortium and electron acceptor amendment are considered as two effective measures. Compared to other electron acceptors, the study on CO2, which is used by methanogens, is still seldom. This study investigated the effect of Na HCO3 amendment on the anaerobic biodegradation of four mixed PAHs, namely fluorene（Fl）, phenanthrene（Phe）,fluoranthene（Flua） and pyrene（Pyr）, with or without enriched PAH-degrading microbial consortium in mangrove sediment slurry. The trends of various parameters, including PAH concentrations, microbial population size, electron-transport system activities, electron acceptor and anaerobic gas production were monitored. The results revealed that the inoculation of enriched PAH-degrading consortium had a significant effect with half lives shortened by 7–13 days for 3-ring PAHs and 11–24 days for 4-ring PAHs. While Na HCO3 amendment did not have a significant effect on the biodegradation of PAHs and other parameters, except that CO2 gas in the headspace of experimental flasks was *** of the possible reasons is that mangrove sediment contains high concentrations of other electron acceptors which are easier to be utilized by anaerobic bacteria, the other one is that the anaerobes in mangrove sediment can produce enough CO2 gas even without adding Na HCO3.

关键词： Anaerobic biodegradation Electron acceptor amendment Mangrove sediment Na HCO3amendment Polycyclic aromatic hydrocarbon

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Asymmetric Tris-Heteroleptic Cyclometalated Phosphorescent Iridium(III)Complexes:An Emerging Class of Metallophosphors

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Accounts of Materials Research 2022年第8期3卷 830-842页

作者： Peng Tao Xingqiang Lü Guijiang Zhou wai-Yeung wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHong KongP.R.China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057P.R.China School of Chemical Engineering Northwest UniversityXi’an 710069P.R.China School of Chemistry State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049P.R.China

CONSPECTUS:The rapid developments of cutting-edge research on photofunctional organic semiconductor materials are greatly promoting the progress of science and *** one of the most important organic semiconductor materials,phosphorescent iridium(III)complexes are a promising class of organometallic emitters because of their rich emissive excited states together with excellent chemical stability,which have been widely used in various fields,such as organic electroluminescence,solar cells,photo-catalysis,biosensing,bioimaging,cancer therapy,*** exploration of highly efficient phosphorescent iridium(III)complexes showing various structural features is blooming *** general,the traditional iridium(III)phosphors usually contain at least two identical cyclometalating bidentate *** iridophosphors with two identical bidentate ligands are termed as the bis-heteroleptic complex Ir((L1)2L2),where L denotes the free ligand or the deprotonated form of the free *** with three identical ligands are called homoleptic complex Ir(L)***,the iridium(III)complexes Ir(L1L2L3)supported by three different(cyclometalating)ligands are emerging as a novel and interesting category of *** class of iridophosphors usually refers to tris-heteroleptic cyclometalated phosphorescent iridium(III)complexes,and they usually show the asymmetry in their molecular *** with the case for the traditional iridium(III)phosphors,the independent ligand control provides tris-heteroleptic iridium(III)phosphors with more flexible molecular design/synthesis and excited-state fine-tuning ability,thereby resulting in more rich and appealing excited states and potential multifunctional *** this Account,we will highlight our recent efforts on the asymmetric tris-heteroleptic cyclometalated iridium(III)phosphors including the molecular design strategies,chemical synthesis,excited-state tuning,and structure−property relationships as well as

关键词： excited complexes substituent

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Consensus scoring systems for nonalcoholic fatty liver disease: an unmet clinical need

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 388-390页

作者： Yu-Jie Zhou Vincent wai-Sun wong Ming-Hua Zheng NAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthShanghai Institute of Digestive DiseaseRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouChin

Noninvasive diagnosis of nonalcoholic fatty liver disease(NAFLD)has received increasing attention(1,2).Nowadays,when we search the item‘scoring system and fatty liver’in PubMed,we can see a sharp increase in the number of related papers in the past few *** fact,an era of‘information explosion’of noninvasive tests(NITs)for NAFLD is coming.

关键词： NAFLD diagnosis liver

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A monolithic InP/SOI platform for integrated photonics

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Light(Science & Applications) 2021年第11期10卷 2143-2152页

作者： Zhao Yan Yu Han Liying Lin Ying Xue Chao Ma wai Kit Ng Kam Sing wong Kei May Lau Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Physics and William Mong Institute of Nano Science and Technology Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

The deployment of photonic integrated circuits(PICs)necessitates an integration platform that is scalable,high-throughput,cost-effective,and *** we present a monolithic InP on SOI platform to synergize the advantages of two mainstream photonic integration platforms:Si photonics and InP *** monolithic InP/SOI platform is realized through the selective growth of both InP sub-micron wires and large dimension InP membranes on industry-standard(001)-oriented silicon-on-insulator(SOI)*** epitaxial InP is in-plane,dislocation-free,site-controlled,intimately positioned with the Si device layer,and placed right on top of the buried oxide layer to form“InP-on-insulator”.These attributes allow for the realization of various photonic functionalities using the epitaxial InP,with efficient light interfacing between the III-V devices and the Si-based *** exemplify the potential of this InP/SOI platform for integrated photonics through the demonstration of lasers with different cavity designs including subwavelength wires,square cavities,and *** results here mark a critical step forward towards fully-integrated Si-based PICs.

关键词： SOI monolithic integration

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