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Outcome of lamivudine-resistant hepatitis B virus is generally benign except in cirrhotics

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World Journal of Gastroenterology 2005年第28期11卷 4344-4350页

作者： Yock-Young Dan chun-tao wai Yin-Mei Lee Dede Selamat Sutedja Bee-Leng Seer Seng-Gee Lim Division of Gastroenterology National University Hospital Singapore

AIM： We set to determine factors that determine clinical severity after the development of resistance.METHODS： Thirty-five Asian patients with genotypic lamivudine resistance were analyzed in three groups： 13/35 （37%） were non-cirrhotics with normal pre-treatment ALT （Group IA）, 12/35 （34%） were non-cirrhotics with elevated pre-treatment ALT （Group IB）, and 10/35 （29%） were cirrhotics （Group II）. Patients were followed for a median of 98 wk （range 26-220） after the emergence of genotypic resistance.RESULTS： Group IA patients tended to retain normal ALT. Group IB patients showed initial improvement of ALT with lamivudine but 9/12 patients （75%） developed abnormal ALT subsequently. On follow-up however, this persisted in only 33%. Group II patients also showed improvement while on treatment, but they deteriorated with the emergence of resistance with 30% death from decompensated liver disease. Pretreatment ALT levels and CPT score （in the cirrhotic group） were predictive of clinical resistance and correlated with peak ALT levels and CPT score.CONCLUSION： The phenotype of lamivudine-resistant HBV correlated with the pretreatment phenotype. The clinical course was generally benign in non-cirrhotics. However, cirrhotics had a high risk of progression and death （30%） with the development of lamivudine resistance.

关键词： Lamivudine resistance YMDD mutants Hepatitis B treatment Nucleoside analog

Misperceptions among patients with chronic hepatitis B in Singapore

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World Journal of Gastroenterology 2005年第32期11卷 5002-5005页

作者： chun-tao wai Belinda Mak Winnie Chua Mei-Hua Tan Seline Ng Amelia Cheok Mee-Lian Wong Seng-Gee Lira Division of GastroenterologyNational University Hospital Singapore Department of Community Occupational andFamily Medicine National University of Singapore Singapore

AIM： To identify the misperceptions among CHB patients,as well as to determine the factors associated with ***： A telephone interview was conducted on 292 adult CHB patients, who earlier responded to an advertisement for free screening. The questionnaire included items about socio-demographic factors and a24-item quiz on knowledge of general aspects,transmission, and management of HBV ***： The mean knowledge score on HBV was 10.4/14. Common misperceptions included availability of treatment for HBV infection and early liver cancer, as well as on transmission. Having completed tertiary education was the only independent factor associated with a high knowledge score, after controlling other demographic ***： More educational efforts should be focused on patients＇ misperceptions and target the less educated HBV carriers.

关键词： Knowledge Hepatitis B virus Public health Education

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

SMA molecular line survey towards the massive star-forming region G10.6-0.4in W31complex

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Research in Astronomy and Astrophysics 2018年第11期18卷 29-42页

作者： wai-Ho Wong tao An Key Laboratory of Radio Astronomy Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

Line surveys of complex molecules with millimeter and sub-millimeter telescopes are important for probing the physical and chemical environments of massive star forming regions(MSFRs).We present a molecular line survey with the Submillimeter Array(SMA) in the frequency ranges of 220.3–222.3 GHz and 230.3–232.3 GHz toward G10.6-0.4, the brightest star forming core in the W31 complex. Ninety-nine transitions from 22 molecular species and their isotopologues are identified. The moment 0 images of typical molecules show a compact core which is concentrated at the continuum peak position. Based on the local thermodynamic equilibrium assumption, the molecular line data are modeled. The rotational temperatures of those molecular species range from 96 to 178 K and their column densities range from 2.0×1014to 3.7×1017cm-2. The observational data suggest that all complex molecules are located in a warm environment. Chemical environments of the molecules are discussed. We compared molecular abundances and gas temperatures in G10.6-0.4 with those in other MSFRs, and found that gas temperatures and fractional abundances of specific molecules in G10.6-0.4 are similar to the typical MSFR W51 North, suggesting that there are similar physical and chemical environments in these two MSFRs.

关键词： stars: formation ISM: abundances ISM: individual objects: G10.6-0.4 ISM: molecules radio lines: ISM

Economic and Political Factors that Lead to the Budget Deficit in Hong Kong from 1998 to 2003

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Chinese Journal of Population,Resources and Environment 2006年第4期4卷 9-17页

作者： Fan chun wai The Centre for Information and Communication Technology in Education (CICTE) University of Macao Ay. Padre Tomas Pereira S.J. Taipa Macao China

Despite the adverse impact of the budget deficit in Hong Kong has been alleviated since the economic recovery from 2003, the fiscal deficit may return when there is another downturn in the economy if the problem is not handled *** on the economic and political situation from 1998 to 2003,the factors that lead to the budget deficit in Hong Kong are analyzed in four perspectives,including(a)increase in public expenditure;(b)decrease in public revenues;(c)poor management of public money and(d) weak *** a better understanding on these factors, possible solutions to the fiscal problem faced by the government may be developed.

关键词： government budget budget deficit fiscal policy government revenue

New taxa of Clitumninae from Vietnam(Phasmatodea: Phasmatidae)

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Zoological Systematics 2020年第2期45卷 104-117页

作者： wai-chun George Ho Hong Kong Entomological Society Hong KongChina

In this study,one new genus and seven new species from the Clitumninae of Vietnam are described and illustrated,namely Interphasma lineatum ***.,Medauroidea cattienensis ***.,*** ***.,*** ***.,Neomedaura yokdonensis g... 详细信息

关键词： Stick insects new genus new species Vietnam

Contribution to the knowledge of Chinese PhasmatodeaⅪ:New taxa and new nomenclature of Medaurini(Phasmatidae:Clitumninae)from China

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Zoological Systematics 2021年第3期46卷 234-239页

作者： wai-chun George Ho Hong Kong Entomological Society P.O.Box No.73749Kowloon Central Post OfficeHong KongChina

This paper describes two new genera and two new species,Megacnipsomorpha gen nov.,Parapachymorpha granulata ***.,Parapachymorpha parvicorne ***.,and Spinoparapachymorpha gen nov.,from Medaurini of China.

关键词： Stick insects new genus new species new combination China

Contribution to the knowledge of Chinese PhasmatodeaⅨ:First report of Xeroderinae(Phasmatodea:Phasmatidae)from China

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Zoological Systematics 2021年第2期46卷 187-190页

作者： wai-chun George Ho Hong Kong Entomological Society P.O.Box No.73749Kowloon Central Post OfficeHong KongChina

This paper reports the subfamily Xeroderinae Günther,1953 and the genus Xenophasmina Uvarov,1940 for the first time from China;describes a new genus and a new species,Sinoxenophasmina abbreviatum gen.&***.,from Yunnan,China;suggests a new combination and a new synonym,***(Redtenbacher,1908)***.(=*** Redtenbacher,1908 ***.);and reports two new record species,***(Redtenbacher,1908)*** ***(Redtenbacher,1908),from China.

关键词： Stick insects new genus new species new combination new synonym China

Rotational properties of the odd-Z transfermium nucleus ^(255)Lr by a particle-number-conserving method in the cranked shell model

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 25-32页

作者： Yu-chun Li Xiao-tao He College of Material Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

Experimentally observed ground state band based on the 1/2-[521] Nilsson state and the first exited band based on the 7/2-[514] Nilsson state of the odd-Z nucleus 255Lr are studied by the cranked shell model （CSM） with the paring correlations treated by the particle-number-conserving （PNC） method. This is the first time the detailed theoretical investigations are performed on these rotational bands. Both experimental kinematic and dynamic moments of inertia （f^（1） and ,f^（2） versus rotational frequency are reproduced quite well by the PNC-CSM calculations. By comparing the theoretical kinematic moment of inertia f（1） with the experimental ones extracted from different spin assignments, the spin 17/2- →13/2- is assigned to the lowest-lying 196.6（5） keV transition of the 1/2- [521 ] band, and 15/2→11/2- to the 189（1） keV transition of the 7/2- [514] band, respectively. The proton N = 7 major shell is included in the calculations. The intruder of the high-j low→lj15/2 （1/2-[770]） orbital at the high spin leads to band-crossings at hω = 0.20 （hω~=0.25） MeV for the 7/2-[514]ω= -1/2 （ω= ＋1/2） band, and at hω=0.175 MeV for the 1/2- [521 ] ω= - 1/2 band, respectively. Further investigations show that the band-crossing frequencies are quadrupole deformation dependent.

关键词： rotational band spin assignment band-crossing high-j orbital transfermium nuclei