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New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report

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World Journal of Gastroenterology 2020年第5期26卷 550-561页

作者： chun-shan wei Naja Becher Jenny Blechingberg Friis Peter Ott Ida Vogel Henning Grønbæk Department of Clinical Medicine-Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus N DK-8200Denmark Department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina Department of Clinical Genetics Aarhus University HospitalAarhus N DK-8200Denmark

BACKGROUND Progressive familial intrahepatic cholestasis(PFIC)encompasses a group of autosomal recessive disorders with high morbidity and *** in the gene encoding tight junction protein-2(TJP2)have been linked to PFIC type 4(PFIC4),which predominantly presents in ***,there are only limited data from adults with TJP2-related *** report a family with an autosomal recessive disorder with a novel variant in the TJP2 gene in adults with very variable expression of *** SUMMARY The index patient presented at 19 years old with liver cirrhosis and variceal bleeding and was treated with endoscopic banding and *** 2018,he developed primary liver cancer that was treated with radiofrequency ablation followed by liver transplantation in *** testing revealed a novel homozygous TJP2 variant causing PFIC4(TJP2([NM_004817.3]:c.[3334C>T];[3334C>T])).The consanguineous family consists of the father and mother(both heterozygous)and their 12 children,of which five carry the variant in a homozygous state;however,these five siblings have highly variable expression of *** homozygous brothers had cirrhosis and portal hypertension at diagnosis at the ages of 19 and *** other homozygous brothers,age 23 and 19,and the homozygous sister,age 21,have elevated liver enzymes but presently no cirrhosis,which may suggest an age-dependent *** addition,five sisters had severe and mild intrahepatic cholestasis of pregnancy and carry the TJP2 variant in a homozygous and heterozygous state,*** This novel TJP2 variant is associated with PFIC4 causing severe liver disease with cirrhosis and primary liver cancer in adolescents/adults.

关键词： Progressive familial intrahepatic cholestasis Tight junction protein 2 Genetic variants Liver cirrhosis Liver cancer Case report

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Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-Wen Sun Fu-shan Wang Yan Gao Fu-Qing wei Jia-chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

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Long-term follow-up of cumulative incidence of hepatocellular carcinoma in hepatitis B virus patients without antiviral therapy

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World Journal of Gastroenterology 2021年第11期27卷 1101-1116页

作者： Xiao-Yan Jiang Bing Huang Dan-Ping Huang chun-shan wei wei-Chao Zhong De-Ti Peng Fu-Rong Huang Guang-Dong Tong Department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina Department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina

BACKGROUND China has a high prevalence of hepatitis B virus(HBV),but most chronic hepatitis B(CHB)patients do not receive standardized antiviral *** are few relevant reports addressing the outcomes of the large number of CHB patients who do not receive antiviral *** To observe the outcomes of long-term follow-up of patients with CHB without antiviral *** This study included 362 patients with CHB and 96 with hepatitis B cirrhosis without antiviral treatment and with only liver protection and anti-inflammatory treatment from 1993 to *** median follow-up times were 10 and 7 years,respectively.A total of 203 CHB and 129 hepatitis B cirrhosis patients receiving antiviral therapy were selected as the control *** median follow-up times were 8 and 7 years,***-Meier curves were used to analyze the cumulative incidence of hepatocellular carcinoma(HCC),and the Cox regression model was used to analyze the risk factors for *** Among the patients in the non-antiviral group,16.9%had spontaneous decreases(HBeAg)*** the antiviral group,87.2%of patients had undetectable HBV DNA,and 52%showed HBeAg *** CHB and hepatitis B cirrhosis patients,the cumulative incidence rates of HCC were 14.9%and 53.1%,respectively,in the non-antiviral group and were 10.7%and 31.9%,respectively,in the antiviral *** was no difference between the two groups regarding the CHB patients(P=0.842),but there was a difference between the groups regarding the hepatitis B cirrhosis patients(P=0.026).The cumulative incidence rates of HCC were 1.6%and 22.3%(P=0.022)in the groups with and without spontaneous HBeAg seroconversion,*** incidence rates of HCC among patients with and without spontaneous declines in HBV DNA to undetectable levels were 1.6%and 19.1%,respectively(P=0.051).There was no difference in the cumulative incidence of HCC between the two groups regarding the patients with drug-resistan

关键词： Chronic hepatitis B Anti-inflammatory therapy Hepatoprotective therapy Cumulative incidence Hepatocellular carcinoma Antiviral therapy

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The role of m^(6)A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

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Genes & Diseases 2024年第1期11卷 252-267页

作者： Yunan shan wei Chen Yanbin Li The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinanShandong 250013China Department of Neurology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qjanfoshan HospitalShandong Institute of NeuroimmunologyShandong Key Laboratory of Rheumatic Disease and Translational MedicineJinanShandong 250013China Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

N6-methyladenosine m^(6)A modifications,as one of the most common forms of in-ternal RNA chemical modifications in eukaryotic cells,have gained increasing attention in recent *** m^(6)A RNA modifications exert various crucial roles in various biological pro-cesses,such as embryonic development,neurogenesis,circadian rhythms,and *** advances have highlighted that m^(6)A RNA modification plays an important role in im-mune response,especially in the initiation and progression of autoimmune *** this re-view,we summarized the regulatory mechanisms of m^(6)A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the po-tential role of m^(6)A RNA methylation in the pathogenesis of autoimmune diseases,thus providing possible biomarkers and potential targets for the prevention and treatment of auto-immunediseases.

关键词： Adaptive immunity Autoimmune diseases Innate immunity Immune response m^(6)A RNA methylation

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An artificial intelligence diabetes management architecture based on 5G

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Digital Communications and Networks 2024年第1期10卷 75-82页

作者： Ruochen Huang wei Feng shan Lu Tao shan Changwei Zhang Yun Liu Department of Geriatrics The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Information The First Afliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Medical Informatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing211166China Department of Outpatient The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing210003China

Along with the development of 5G network and Internet of Things technologies,there has been an explosion in personalized healthcare *** the 5G and Artificial Intelligence(Al)is introduced into diabetes management architecture,it can increase the efficiency of existing systems and complications of diabetes can be handled more effectively by taking advantage of *** this article,we propose a 5G-based Artificial Intelligence Diabetes Management architecture(AIDM),which can help physicians and patients to manage both acute complications and chronic *** AIDM contains five layers:the sensing layer,the transmission layer,the storage layer,the computing layer,and the application *** build a test bed for the transmission and application ***,we apply a delay-aware RA optimization based on a double-queue model to improve access efficiency in smart hospital wards in the transmission *** application layer,we build a prediction model using a deep forest *** on real-world data show that our AIDM can enhance the efficiency of diabetes management and improve the screening rate of diabetes as well.

关键词： Diabetes 5G Artificial intelligence Deep forest Smart hospital ward

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Proteomics Study of Benzene Metabolite Hydroquinone Induced Hematotoxicity in K562 Cells

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Biomedical and Environmental Sciences 2024年第4期37卷 341-353页

作者： JIN Yi shan YI Zong chun ZHANG Yu Jing RONG Long YU chun Hong School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China School of Engineering Medicine Beihang UniversityBeijing 100191China

Objective Hydroquinone(HQ),one of the phenolic metabolites of benzene,is widely recognized as an important participant in benzene-induced ***,there are few relevant proteomics in HQ-induced hematotoxicity and the mechanism hasn’t been fully understood *** In this study,we treated K562 cells with 40μmol/L HQ for 72 h,examined and validated protein expression changes by Label-free proteomic analysis and Parallel reaction monitoring(PRM),and performed bioinformatics analysis to identify interaction *** One hundred and eighty-seven upregulated differentially expressed proteins(DEPs)and 279 downregulated DEPs were identified in HQ-exposed K562 cells,which were involved in neutrophilmediated immunity,blood microparticle,and other GO terms,as well as the lysosome,metabolic,cell cycle,and cellular senescence-related *** on the 23 DEGs and 5 DEPs in erythroid differentiation-related pathways,we constructed the network of protein interactions and determined 6 DEPs(STAT1,STAT3,CASP3,KIT,STAT5B,and VEGFA)as main hub proteins with the most interactions,among which STATs made a central impact and may be potential biomarkers of HQ-induced *** Our work reinforced the use of proteomics and bioinformatic approaches to advance knowledge on molecular mechanisms of HQ-induced hematotoxicity at the protein level and provide a valuable basis for further clarification.

关键词： Hydroquinone Proteomics Hematotoxicity K562 cells

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Facet effects on bimetallic ZnSn hydroxide microcrystals for selective electrochemical CO2 reduction

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Green Energy & Environment 2024年第8期9卷 1314-1320页

作者： Liu Han Cheng-wei Wang shan-shan Luo Ying-tang Zhou Bing Li Ming Liu School of Chemistry and Chemical Engineering Harbin Institute of Technology National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean University

Employing crystal facets to regulate the catalytic properties in electrocatalytic carbon dioxide reduction reaction（eCO2RR） has been well demonstrated on electrocatalysts containing single metals but rarely explored for bimetallic systems. Here, we synthesize Zn Sn（OH）6（ZSO）microcrystals（MCs） with distinct facets and investigate the facet effects in eCO2RR. Electrochemical studies and in situ Fourier Transform Infrared Spectroscopy（in situ-FTIR） reveal that ZSO MCs produce mainly C1 products of HCOOH and CO. The {111} facet of the ZSO MCS exhibits higher selectivity and faradaic efficiency（FE） than that of the {100} facet over a wide range of potentials（-0.9 V ～-1.3 V versus RHE）. Density Functional Theory（DFT） calculations elucidate that the {111} facet is favorable to the adsorption/activation of CO2molecules,the formation of intermediate in the rate-determining step, and the desorption of C1 products of CO and HCOOH molecules.

关键词： ZnSn(OH) 6 Crystal facets Electrochemical carbon dioxide reduction C1 product Density functional theory

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ControlService: a containerized solution for control-algorithm-as-a-service in cloud control systems

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Science China(Information Sciences) 2024年第8期67卷 172-189页

作者： Chenggang shan Runze GAO Zhen YANG wei ZHANG Yuanqing XIA School of Artificial Intelligence Zaozhuang University School of Automation Beijing Institute of Technology

As an extension of networked control systems, cloud control systems(CCSs) have emerged as a new control paradigm to improve the service quality of emerging control missions, such as data-driven modeling and automated vehicles. Existing studies have used the workflow-based restructured method to optimize the computation-intensive algorithms in the CCSs. However, the challenges here are how to define and submit these algorithms' workflows as cloud services and execute these algorithms' workflows in a containerized manner. Based on these challenges, we propose a containerized solution for the control-algorithm-as-a-service(C3aS) in the CCSs, namely Control Service. It offers the control algorithm as a cloud workflow service and uses a customized workflow engine to realize the containerized execution. First, we employ a cloud workflow representation method to define a control algorithm into an abstract cloud workflow form. Afterward, we provide a cloud service representation of the abstract cloud workflow. Next, we design a workflow engine and submit the cloud service to this workflow engine to implement containerized execution of this cloud service in the CCSs. In the experiment, we discuss the cloud service form and containerized implementation of the subspace identification method. Experimental results show that the proposed Control Service has significant performance advantages in computational time, reduction percentage, and speedup ratio compared with the baseline method.

关键词： cloud control systems control-algorithm-as-a-service containerization workflow engine cloud workflow service subspace identification

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Analysis on unit maximum capacity of orthogonal multiple watermarking for multimedia signals in B5G wireless communications

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Digital Communications and Networks 2024年第1期10卷 38-44页

作者： Mianjie Li Senfeng Lai Jiao Wang Zhihong Tian Nadra Guizani Xiaojiang Du chun shan School of Electronics and Information Guangdong Polytechnic Normal UniversityGuangzhou510665China Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China Schoolof Electrical Engineering and Computer Science Washington State UniversityPullmanWA99164USA Department of Computer and Information Science Temple UniversityPhiladelphiaPA19122USA

Beyond-5G(B5G)aims to meet the growing demands of mobile traffic and expand the communication *** that intelligent applications to B5G wireless communications will involve security issues regarding user data and operational data,this paper analyzes the maximum capacity of the multi-watermarking method for multimedia signal hiding as a means of alleviating the information security problem of *** multiwatermarking process employs spread transform dither *** the watermarking procedure,Gram-Schmidt orthogonalization is used to obtain the multiple spreading ***,multiple watermarks can be simultaneously embedded into the same position of a multimedia ***,the multiple watermarks can be extracted without affecting one another during the extraction *** analyze the effect of the size of the spreading vector on the unit maximum capacity,and consequently derive the theoretical relationship between the size of the spreading vector and the unit maximum capacity.A number of experiments are conducted to determine the optimal parameter values for maximum robustness on the premise of high capacity and good imperceptibility.

关键词： B5G Multimedia information security Spread transform dither modulation Spreading vector measurement Unit maximum capacity

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Insight into the Role of Isolated Gold Atoms-Ceria Conjunction in Catalyzing the Water-Gas Shift Reaction

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Chinese Journal of Chemistry 2024年第6期42卷 636-644页

作者： Xin-Pu Fu Hui-Zhao wei-wei Wang chun-Jiang Jia Key Laboratory for Colloid and Interface Chemistry Key Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinanShandong250100 China

As the promising catalysts for the water-gas shift(WGS)reaction,the activity of Au-CeO_(2) composites is susceptible to the aggregation size and electronic state of Au *** reports were extensively focused on the discrepancy between nonmetallic Au and metallic Au nanoparticles,whereas the understanding of the authentic role of the isolated Au atoms was ***,we investigated the catalytic behavior and structural information over two types of Au/CeO_(2) catalysts,in which the predominant conjunctions were isolated Au1-CeO_(2) and Aun-CeO_(2),*** on comprehensive characterizations,particularly by in-situ Raman and in-situ DRIFTS,we found that the isolated Au atoms were responsible for enhancing the reducibility of the CeO_(2) *** CO adsorption ability on the isolated Au sites was significantly inferior to clustered Au atoms,especially at relatively high temperatures(>200°C).As a result,the boosted O vacancy on the isolated Au1-CeO_(2) conjunctions could improve the H2O activation ability for the Au-CeO_(2) catalysts and demonstrate a comparable activity to the clustered Aun-CeO_(2) *** work might deepen understanding of the catalytic function for the isolated Au1 site within Au/CeO_(2) systems while catalyzing the WGS reaction.

关键词： Isolated Au atoms Ceria-based catalysts Water-gas shift reaction Defect Adsorption

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