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Effects of arginine supplementation on splenocyte cytokine mRNA expression in rats with gut-derived sepsis

World Journal of Gastroenterology 2005年第45期11卷 7091-7096页

作者： Huey-Fang Shang chun-sen hsu Chiu-Li Yeh Man-Hui Pai Sung-Ling Yeh Department of Microbiology and Immunology Taipei Medical University Taipei Taiwan China Department of Obstetrics and Gynecology TaipeiMedical University Municipal Wan Fang Hospital Taipei TaiwanChina Department of Anatomy Taipei Medical UniversityTaipei Taiwan China School of Nutrition and HealthSciences Taipei Medical University Taipei Taiwan China

AIM： To investigate the effects of arginine （Arg）-enriched diets before sepsis and/or Arg-containing total parenteral nutrition （TPN） after sepsis or both on cytokine mRNA expression levels in splenocytes of rats with gut-derived sepsis. METHODS： Rats were assigned to four experimental groups. Groups 1 and 2 were fed with a semipurified diet, while groups 3 and 4 had part of the casein replaced by Arg which provided 2% of the total calories. After the rats were fed with these diets for 10 d, sepsis was induced by cecal ligation and puncture （CLP）, at the same time an internal jugular vein was cannulated. All rats were maintained on TPN for 3 d. Groups 1 and 3 were infused with conventional TPN, while groups 2 and 4 were supplemented with Arg which provided 2% of the total calories in the TPN solution. All rats were killed 3 d after CLP to examine their splenocyte subpopulation distribution and cytokine expression levels. RESULTS： Plasma interleukin （IL）-2, IL-4, tumor necrosis factor-α （TNF-α） and interferon （IFN-γ） were not detectable 3 d after CL.P. There were no differences in the distributions of CD45Ra＋, CD3＋, CD4＋, and CD8＋ cells in whole blood and splenocytes among the four groups. The splenocyte IL-2 mRNA expression in the Arg-supplemented groups was significantly higher than that in group 1. IL-4 mRNA expression in groups 3 and 4 was significantly higher than that in groups 1 and 2. The mRNA expression of IL-10 and IFN-γ was significantly higher in group 4 than in the other three groups. There was no difference in TNF-α mRNA expression among thefour groups CONCLUSION： The influence of Arg on the whole blood and splenic lymphocyte subpopulation distribution is not obvious. However, Arg administration, especially before and after CLP, significantly enhances the mRNA expression levels of Thl and Th2 cytokines in the spleen of rats with gut-derived sepsis.

关键词： Arginine Sepsis Cytokine mRNA expression

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Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi hsu Lin Chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

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Predictive factors for lymph node metastasis in early gastric cancer

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World Journal of Gastroenterology 2010年第41期16卷 5252-5256页

作者： Chang-Mu Sung Chen-Ming hsu Jun-Te hsu Ta-sen Yeh chun-Jung Lin Tse-Ching Chen Cheng-Tang Chiu Department of Gastroenterologyand Hepatology Chang Gung Memorial Hospital College of Medicine Chang Gung University Department of Surgery Chang Gung Memorial Hospital Chang Gung University Department of Pathology Chang Gung Me-morial Hospital Chang Gung University

AIM: To analyze the predictive factors for lymph node metastasis (LNM) in early gastric cancer (EGC). METHODS: Data from patients surgically treated for gastric cancers between January 1994 and December 2007 were retrospectively collected. Clinicopathological factors were analyzed to identify predictive factors for LNM. RESULTS: Of the 2936 patients who underwent gas-trectomy and lymph node dissection, 556 were diag-nosed with EGC and included in this study. Among these, 4.1% of patients had mucosal tumors (T1a) with LNM while 24.3% of patients had submucosal tumorswith LNM. Univariate analysis found that female gen-der, tumors ≥ 2 cm, tumor invasion to the submucosa, vascular and lymphatic involvement were significantly associated with a higher rate of LNM. On multivariate analysis, tumor size, lymphatic involvement, and tumor with submucosal invasion were associated with LNM. CONCLUSION: Tumor with submucosal invasion, size ≥ 2 cm, and presence of lymphatic involvement are predictive factors for LNM in EGC.

关键词： Early gastric cancer Lymph node metasta-sis Endoscopic treatment Endoscopic submucosa dis-section Depth of tumor invasion

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Prognosis and feasibility of en-bloc vascular resection in stage Ⅱ pancreatic adenocarcinoma

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World Journal of Gastroenterology 2010年第8期16卷 997-1002页

作者： K Dilip Chakravarty Jun-Te hsu chun-Nan Yeh Ta-sen Yeh Tsann-Long Hwang Miin-Fu Chen Department of General Surgery Chang Gung Memorial Hospital

AIM:To establish the prognosis and feasibility of en-bloc vascular resection of stage pancreatic adenocarcinoma of the head and uncinate ***:We retrospectively analyzed 87 patients with stage pancreatic adenocarcinoma,who were subjected to pancreaticoduodenectomy (PD) and pylo-rus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital,Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV),***:The overall 1-and 3-year survival rates of patients undergoing PD/PPPD with and without vas-cular resection were 50.0% and 16.7%,and 44.4% and 12.2%,respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%,and 40.0% and 2.7%,respectively. In multivariate analysis,serum bilirubin,histological differentiation and adjuvant chemotherapy were independent prognostic factors that influenced ***:In stage adenocarcinoma of the pancreatic head and uncinate process,serum bilirubin,histological differentiation and adjuvant chemotherapy were independent prognostic factors,and en-bloc vascular resection is a feasible option in carefully selected patients.

关键词： Pancreatic neoplasms Adenocarcinoma Portal vein Superior mesenteric vein Pancreaticoduo-denectomy Chemotherapy

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Successful endoscopic sclerotherapy for cholecystojejunostomy variceal bleeding in a patient with pancreatic head cancer

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World Journal of Gastroenterology 2010年第1期16卷 123-125页

作者： Yu-chun hsu hsu-Heng Yen Maw-Soan Soon Department of Gastroenterology Changhua Christian Hospital

Variceal bleeding outside the esophagus and stomach is rare but important because of its difficult diagnosis and *** from cholecystojejunostomy varices has been reported to be a late complication of palliative biliary surgery for chronic *** ectopic variceal bleeding has never been reported after palliative surgery for pancreatic cancer,probably because of the limited lifespan of these patients. Herein,we report our successful experience using endoscopic cyanoacrylate sclerotherapy to treat bleeding from cholecystojejunostomy varices in a 57-year-old man with pancreatic head *** our knowledge,this is the first case report in the literature of this rare complication.

关键词： Ectopic varix Pancreatic cancer Cholecystojejunostomy Sclerotherapy

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Acute cholangitis detected ectopic ampulla of Vater in the antrum incidentally: A case report

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World Journal of Clinical Cases 2021年第14期9卷 3379-3384页

作者： hsu-Lin Lee chun-Kai Fu Department of Internal Medicine Taichung Armed Forces GeneralHospitalTaichung 411Taiwan Department of Internal Medicine National Defense Medical CenterTaipei 114Taiwan

BACKGROUND The ampulla of Vater is an opening at the confluence of the common bile duct and pancreatic *** is located in the second portion of the *** ectopic papilla of Vater is an anomalous *** cases have been *** report the rare case of a man with an ectopic ampulla of Vater in the *** SUMMARY An 82-year-old man had experienced abdominal pain and fever with chills 1 d before his presentation.A computed tomography scan of the abdomen demonstrated dilatation of the common bile duct approximately 2.2 cm in *** retention was found in his intrahepatic *** cholangitis with pneumobilia was identified,and he was *** and endoscopic retrograde cholangiopancreatography disclosed no ampulla of Vater in the second portion of the ***,a capsule-like foreign body(pharmaceutical desiccant)approximately 1 cm×2 cm in size was found at the gastric antrum and peri-pyloric *** the foreign body was removed,one orifice presented over the pyloric ring in the stomach,a suspected ectopic ampulla of ***,sludge in the common bile duct was cleaned,and balloon dilatation was *** general condition improved *** patient was discharged in a stable condition and followed in our outpatient *** This case involved an ampulla of Vater in an unusual *** retrograde cholangiopancreatography with balloon dilatation is the main treatment recommended and performed.

关键词： Ectopic papilla of Vater Ectopic ampulla of Vater Pneumobilia Endoscopic retrograde cholangiopancreatography Acute cholangitis Case report

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Theoretical and Experimental Study of Breaking Wave on Sloping Bottoms

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China Ocean Engineering 2013年第6期27卷 737-750页

作者： YANG Kuei-sen CHEN Yang-Yih LI Meng-Syue hsu Hung-Chu Department of Marine Environment and Engineering National Sun Yat-Sen University International Wave Dynamics Research Center National Cheng Kung University Tainan Hydraulics Laboratory National Cheng Kung University

This paper studies the continuous evolution of breaking wave for the surface water waves propagating on a sloping beach. A Lagrangian asymptotic solution is derived. According to the solution coupled with the wave breaking criteria and the equations of water particles motion, the wave deformation and the continuous wave breaking processes for the progressive water waves propagating on a sloping bottom can be derived. A series of experiments are also conducted to compare with the theoretical solution. The results show that the present solution can reasonably describe the plunging or spilling wave breaking phenomenon.

关键词： Eulerian Lagrangian waves breaking plunging spilling

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Inter-granular liquid phase aiding grain boundary sliding in superplastic deformation of fine-grained ZK60 Mg alloy

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Transactions of Nonferrous Metals Society of China 2010年第B7期20卷 576-579页

作者： LEE Shyong CHIANG Chih-te CHU chun-lin hsu Chang-chuan Department of Mechanical Engineering National Central University Jhong-li Taiwan China chun-Shan Institute of Science Lung-tan Taiwan China

For 7475 Al alloy,there were micrographs showing filaments or whiskers formation during the separation stage of superplastic *** indicates the presence of liquid phase which accommodates grain boundary sliding to reach *** the other hand,there is no such phenomenon reported regarding Mg alloy in *** electron microscopic(SEM)fractography exceptionally exhibits a mark of grain boundary sliding and its accommodating mechanism of inter-granular liquid *** the testing conditions of 350℃ and 1×10- 4s -1,the initially fine-grained structure(3.7μm)yields 642%superplastic elongation and exhibits fluffy appearance on the fractured *** other specimens showing less superplasticity,their fractured surfaces exhibit partial fluffy appearance.

关键词： Mg alloy inter-granular phase grain boundary sliding superplastic deformation

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Conservative management of chronic gastric volvulus:44 cases over 5 years

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World Journal of Gastroenterology 2010年第33期16卷 4200-4205页

作者： Yao-chun hsu Chin-Lin Perng Jai-Jen Tsai Hwai-Jeng Lin chun-Ku Chen Division of Gastroenterology Department of MedicineLotung Poh-Ai HospitalIlan 26546TaiwanChina Division of Gastroenterology Department of MedicineVeterans General Hospital-Taipeiand School of MedicineNational Yang-MingUniversityTaipei 11217TaiwanChina Depar tment of Radiology Veterans General Hospital-TaipeiTaipei 11217TaiwanChina Department of Medicine NationalYang-Ming University HospitalIlan 26042TaiwanChina Division of Gastroenterology Department of MedicineChanghuaChristian HospitalChanghua 50006TaiwanChina

AIM:To investigate clinical outcomes of patients with chronic gastric volvulus(GV)who were managed conservatively over a 5-year ***:A total of 44 consecutive patients with chronic GV,as diagnosed by barium study between October 2002 and July 2008 were *** of these patients received conservative management initially without anatomical *** clinical manifestations,diagnostic work-ups,and clinical outcomes were *** sought to identify independent risk factors for poor outcome by using the Cox proportional hazards ***:The enrolled patients were predominantly male(n=37,84%)and of advanced age(median: 71 years old,interquartile range:57.5-78 years).Abdominal pain and fullness were the most common *** the follow-up period(median:16 mo,up to 69 mo),there was no severe complication,but symptomatic recurrence was noted in 28 patients(64%).Only one patient turned to elective surgery for frequent *** adhesion was the only independent risk factor associated with recurrence(hazard ratio:2.58,95%CI:1.08-6.13,P=0.033).CONCLUSION:Symptomatic recurrence of chronic GV is very common although serious complications infrequently occur with conservative *** adhesion is independently associated with recurrence.

关键词： Conservative treatment Gastric volvulus Upper gastrointestinal tract Barium study Peritoneal adhesion

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Management of chronic pancreatitis complicated with a bleeding pseudoaneurysm

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World Journal of Gastroenterology 2014年第43期20卷 16132-16137页

作者： Kun-chun Chiang Tsung-Hsing Chen Jun-Te hsu Department of Surgery Chang Gung Memorial Hospital at KeelungChang Gung University College of Medicine Department of Gastroenterology Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine Department of Surgery Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine

Chronic pancreatitis is an ongoing disease characterized by persistent inflammation of pancreatic tissues. With disease progression, patients with chronic pancreatitis may develop troublesome complications in addition to exocrine and endocrine pancreatic functional loss. Among them, a pseudoaneurysm, mainly induced by digestive enzyme erosion of vessels in proximity to the pancreas, is a rare and life-threatening complication if bleeding of the pseudoaneurysm occurs. At present, no prospective randomized trials have investigated the therapeutic strategy for this rare but critical situation. The role of arterial embolization, the timing of surgical intervention and even surgical procedures are still controversial. In this review, we suggest that dynamic abdominal computed tomography and angiography should be performed first to localize the bleeders and to evaluate the associated complications such as pseudocyst formation, followed by arterial embolization to stop the bleeding and to achieve early stabilization of the patient’s condition. With advances and improvements in endoscopic devices and techniques, therapeutic endoscopy for pancreatic pseudocysts is technically feasible, safe and effective. Surgical intervention is recommended for a bleeding pseudoaneurysm in patients with chronic pancreatitis who are in an unstable condition, for those in whom arterial embolization of the bleeding pseudoaneurysm fails, and when endoscopic management of the pseudocyst is unsuccessful. If a bleeding pseudoaneurysm is located over the tail of the pancreas, resection is a preferential procedure, whereas if the lesion is situated over the head or body of the pancreas, relatively conservative surgical procedures are recommended.

关键词： Chronic pancreatitis Pseudocyst Pseudoaneurysm bleeding Arterial embolization Endoscopy Surgery

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