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PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification

Acta Pharmaceutica Sinica B 2024年第7期14卷 3049-3067页

作者： Jianming Yang Yawen Xiao Ningning zhao Geng Pei Yan Sun Xinyu Sun Kaiyuan Yu chunhui Miao Ran Liu Junqiang Lv Hongyu Chu Lu Zhou Bangmao Wang Zhi Yao Quan Wang Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Institute of ImmunologyState Key Laboratory of Experimental Hematologythe Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of ImmunologySchool of Basic Medical SciencesTianjin Institute of Urologythe Second Hospital of Tianjin Medical UniversityTianjin Key Laboratory of Cellular and Molecular ImmunologyTianjin Medical UniversityTianjin 300070China Department of Pathology Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center of Cancer/Key Laboratory of Cancer Prevention and TherapyTianjin/Tianjin’s Clinical Research Center of CancerTianjin 30060China Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300070China

The mucosal barrier is crucial for intestinal homeostasis,and goblet cells are essential for maintaining the mucosal barrier *** proviral integration site for Moloney murine leukemia virus-1(PIM1)kinase regulates multiple cellular functions,but its role in intestinal homeostasis during colitis is ***,we demonstrate that PIM1 is prominently elevated in the colonic epithelia of both ulcerative colitis patients and murine models,in the presence of intestinal *** PIM1 leads to decreased goblet cells,thus impairing resistance to colitis and colitis-associated colorectal cancer(CAC)in ***,PIM1 modulates goblet cell differentiation through the Wnt and Notch signaling ***,PIM1 interacts with histone deacetylase 2(HDAC2)and downregulates its level via phosphorylation,thereby altering the epigenetic profiles of Wnt signaling pathway ***,these findings investigate the unknown function of the PIM1-HDAC2 axis in goblet cell differentiation and ulcerative colitis/CAC pathogenesis,which points to the potential for PIM1-targeted therapies of ulcerative colitis and CAC.

关键词： PIM1 HDAC2 Goblet cell Gut microbiota Intestinal homeostasis Epigenetic modification Ulcerative colitis CAC

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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu Yu-Ya Wang Gui-Tao Huo Yan-Wei Yang Nan Xu Hong Wang Yong Wu Yu-Fa Miao Rui Fu Yu-Wei zhao Chang-Fa Fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

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陶瓷与银材料在首饰设计中的结合应用——以首饰实践“欲”为例

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陶瓷 2024年第9期 56-58页

作者：范梦婷陈春赵春雷景德镇陶瓷大学江西景德镇333403

当前市场上部分融合了陶瓷和金属银元素的首饰缺乏创意思维,存在同质化问题,需深入探索其设计领域中的创新潜力。笔者旨在以陶瓷和银材料在首饰设计中崭新应用为课题,并从融合创意设计与工艺技术的角度出发,结合优秀的陶瓷首饰品牌设计... 详细信息

当前市场上部分融合了陶瓷和金属银元素的首饰缺乏创意思维,存在同质化问题,需深入探索其设计领域中的创新潜力。笔者旨在以陶瓷和银材料在首饰设计中崭新应用为课题,并从融合创意设计与工艺技术的角度出发,结合优秀的陶瓷首饰品牌设计之优点,探讨如何在陶瓷首饰领域中既遵循一定艺术理念又能突破创新形式的可能性。通过将陶瓷与银巧妙融合,创造出迎合当代大众审美且具有适应性的现代陶瓷首饰作品,为进一步探索陶瓷和银材料在首饰设计中的应用提供更多设计方法。

关键词：陶瓷首饰银材料工艺技术

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Synthesis and Antibacterial Activities of 1,4-Disubstituted Phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole

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Chemical Research in Chinese Universities 2012年第3期28卷 424-429页

作者： zhao Xu LU Jun-rui XIN chun-wei LU Bo-wei BAO Xiu-rong LI Jian-fa LIU Ya YANG Xu-yun YUAN Yi College of Chemistry and Chemical Engineering Tianjin University of TechnologyTianjin 300384P.R.China College of Chemistry Nankai UniversityTianjin 300071P.R.China

According to the superposition principle of reinforcement of biological activities, 24 novel 1,4- disubstituted phenyl-5-（halo-2-hydroxyphenyl）imino-l,2,3-triazoles was synthesized and characterized by 1H NMR, ^13C NMR, elemental analysis and IR. All the target compounds were screened for their antibacterial potential in vitro against Monilia albican, Escherichia coli and Staphylococcus aureus. It was shown that all the compounds possessed efficient antibacterial activities at a concentration of 0.1 mg/mL, even at a concentration of 0.01 mg/mL, some of the compounds still exhibited antibacterial activities against Escherichia coli and Monilia albican. At last, the struc- ture-activity relationship was discussed based on the antibacterial results.

关键词： 1,4-Disubstituted phenyl-5-(halo-2-hydroxyphenyl)imino-l,2,3-triazole Antibacterial activity Structure-activity relationship

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Extraction Separation of Germanium with Hydroxamic Acid HGS98

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Journal of Central South University 2000年第1期12卷 40-42页

作者： TANG Shu-fang ZHOU chun-shan JIANG Xin-yu zhao chun-lei College of Chemistry and Chemical Engineering Central South University of TechnologyChangsha 410083China

The extraction separation of germanium from indium raffinate in hydrometallurgical zinc process was discussed. The conditions and mechanism of the extraction with hydroxamic acid HGS98 have been investigated in detail. The results show that u sing 2% (mass fraction) hydroxamic acid HGS98 and 5% D 2EHPA as synergist, germanium is extracted (1 stage) over 99% in 5 min at phase ratio ( V o∶ V a) of 1∶5 from indium raffinate with original acidity. Then, using 2 mol·L -1 NH 4F as strip liquor, the stripping recovery is over 98% in 15 min at phase ratio of 1∶1. This process has the following advantages:easy to operate, high recovery and selectivity, and lower investment cost. It provides a new way to recover rare metal-germanium from metallurgical spent residues.

关键词： extraction separation germanium hydroxamic acid HGS98

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中药及天然药物来源的小核酸新药发现与前景展望

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中国中药杂志 2024年第9期49卷 2273-2280页

作者：华桦田韦韦刘俐曾瑾魏平谭蕊蓉王剑波赵军宁四川省中医药转化医学中心国家中医药管理局中药质量生物评价重点研究室中医药转化医学四川省重点实验室四川省道地药材系统开发工程技术研究中心四川省道地药材形成原理与品质评价工程研究中心四川成都610041 国家药品监督管理局药品监管科学全国重点实验室北京100037

小核酸药物主要包括小干扰核糖核酸(small interfering RNA,siRNA)、反义寡核苷酸(antisense oligonucleotide,ASO)、微小RNA(microRNA,miRNA)、信使RNA(messenger RNA,mRNA)以及核酸适配体(aptamer)等,可通过与靶分子的RNA结合,抑制其翻译或调控,具有高度特异性、持久性和可治愈性,近年来颇受关注。新近发现中药动植物来源的miRNA自身稳定并可稳定存在于动物或人体的血液与组织器官,而且可通过参与调控多种靶蛋白的表达发挥药理作用。该文概述了源自中药及天然药物的小核酸药物发现及其跨界调控机制,探讨这类新兴药品带来的技术挑战与监管问题,可为中药复杂性作用机制阐释、中药及天然药物来源的小核酸新药研制及监管科学研究提供新的思路和方法。

关键词：小核酸中药天然药物新药发现监管科学

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基于UNet的翼型可压缩流场机器学习推理方法

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南京航空航天大学学报 2024年第2期56卷 253-263页

作者：朱智杰赵国庆高远招启军南京航空航天大学直升机动力学全国重点实验室南京210016

为进一步提升高雷诺数、大迎角(Angle of attack,AoA)和高马赫数下的翼型可压缩流场预测精度和效率,本文提出了一种基于坐标转换方法和UNet神经网络的机器学习推理方法。首先,提出了用于数据前处理的坐标转换方法,将计算流体力学中的物... 详细信息

为进一步提升高雷诺数、大迎角(Angle of attack,AoA)和高马赫数下的翼型可压缩流场预测精度和效率,本文提出了一种基于坐标转换方法和UNet神经网络的机器学习推理方法。首先,提出了用于数据前处理的坐标转换方法,将计算流体力学中的物理量和网格信息转换成神经网络空间信息,使流场信息的分布更符合神经网络的输入要求。其次,建立了新型深度UNet神经网络,使模型学习到翼型流场精细复杂的局部流动特征。本文将两种方法结合,建立了翼型可压缩流场机器学习推理方法,得到快速高精度的推理模型。最后,对不同种类翼型的流场与气动力进行预测分析,并与传统机器学习方法预测的结果进行比较。结果表明,本文提出的机器学习推理方法能够较好地预测翼型的可压缩流场,并且能够更好地捕捉高雷诺数下的复杂流动行为以及预测大迎角、高马赫数条件下的流动分离和激波现象。

关键词： UNet 机器学习坐标转换翼型流动分离激波

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Plant regeneration in the new era:from molecular mechanisms to biotechnology applications

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Science China(Life Sciences) 2024年第7期67卷 1338-1367页

作者： chunli Chen Yuxin Hu Momoko Ikeuchi Yuling Jiao Kalika Prasad Ying Hua Su Jun Xiao Lin Xu Weibing Yang Zhong zhao Wenkun Zhou Yun Zhou Jian Gao Jia-Wei Wang National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences(CAS)China National Botanical GardenBeijing 100093China Division of Biological Sciences Graduate School of Science and TechnologyNara Institute of Science and TechnologyNara 630-0192Japan State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Center for Quantitative BiologyAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Indian Institute of Science Education and Research Pune 411008IndiaThiruvananthapuram 695551India State Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Sino-German Joint Research Center on Agricultural Biology Shandong Agricultural UniversityTai’an 271018China Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology(IGDB)CASBeijing 100101China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) IGDBCASBeijing 100101China National Key Laboratory of Plant Molecular Genetics CEMPSInstitute of Plant Physiology and Ecology(SIPPE)CASShanghai 200032China CEPAMS SIPPECASShanghai 200032China Hefei National Laboratory for Physical Sciences at the Microscale CEMPSSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China Department of Botany and Plant Pathology and Center for Plant Biology Purdue UniversityWest Lafayette 47907USA School of Life Science and Technology Shang

Plants or tissues can be regenerated through various *** animal regeneration,cell totipotency and pluripotency are the molecular basis of plant *** systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant ***,plant hormones,cell division,epigenetic remodeling,and transcription factors play crucial roles in reprogramming somatic cells and reestablishing meristematic *** research on basal non-vascular plants and monocot crops has revealed that plant regeneration differs among species,with various plant species using distinct mechanisms and displaying significant differences in regenerative *** multi-omics studies at the single-cell level,tracking plant regeneration processes in real-time,and deciphering the natural variation in regenerative capacity will ultimately help understand the essence of plant regeneration,improve crop regeneration efficiency,and contribute to future crop design.

关键词： apical meristem model species regeneration phytohormone plant cell reprogramming somatic embryogenesis

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基于ARM+FPGA的图像采集与存储系统设计

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舰船电子工程 2024年第3期44卷 116-119,129页

作者：刘威宏周春孟令军赵鑫中北大学省部共建动态测试技术国家重点实验室太原030051

针对传统图像在采集传输速度慢,图像处理功耗高的问题,文中提出一种基于ARM+FPGA的图像采集与存储系统,将采集的图像数据输入到FPGA中,利用FPGA并行数据处理方式,提高其传输速度,再利用AXI总线与ARM进行数据间的高速交互,ARM对数据进行... 详细信息

针对传统图像在采集传输速度慢,图像处理功耗高的问题,文中提出一种基于ARM+FPGA的图像采集与存储系统,将采集的图像数据输入到FPGA中,利用FPGA并行数据处理方式,提高其传输速度,再利用AXI总线与ARM进行数据间的高速交互,ARM对数据进行处理,FPGA进行加速。对数据的采集与处理分布进行,有效提升转换速率,降低系统功耗,最后将图像存储到SD卡中,验证了ARM+FPGA平台在图像采集、处理与存储的有效性和准确性。

关键词： ARM FPGA ZYNQ OV5640 图像 VIVADO SD

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One-dimensional Vanadyl Phosphate Containing the Tancoite-like{Ⅴ^(Ⅳ)O(HPO_4)_2}^(2–)Chain

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Chinese Journal of Structural Chemistry 2013年第12期32卷 1821-1828页

作者： WEN Lei HUANG Ya-Xi SUN Wei LIU Biao HUANG chun-Zuo MI Jin-Xiao ZHUANG rong-Chuan TANG Mei-Bo zhao Jing-Tai Fujian Provincial Key Laboratory of Advanced Materials Department of Materials Science and EngineeringCollege of MaterialsXiamen University Xiamen Zijin Mining and Metallurgy Technology Co.Ltd. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences

A vanadyl phosphate containing a new member of tancoite-like single chain, （DAPH2）[VIVO（HPO4）2]·xH20 （x ≈ 0.2, DAP = 1,3-diaminopropane, C3H10N2）, has been synthesized under hydro（solvo）thermal conditions. It crystallizes in orthorhombic space group P21212 （No. 18） with a = 7.1730（14）, b = 19.252（4）, c = 8.6557（17） A, Z= 4, V= 1195.3（4）A3, C3H14.38N2P2VO9.19, Mr = 338.47, Dc = 1.881 g/cm3,μ（MoKa） = 1.138 mm-1 and F（000） = 692. The final full-matrix least-squares refinement converged to R = 0.0408, wR = 0.1046 for 2498 observed reflections with I 〉 2σ（I） and R = 0.0456 and wR = 0.1080 for all data （2750） and S = 1.001. Its one-dimensional 1 structure consists of tancoite-like ∞1 {vIVO（HPO4）2}2- single chains surrounded by DAPH22＋ ions and water molecules. The single chain is built from trans-corner-sharing octahedral {VIV= O…VIV} backbone loop-branched by HPO4 groups like staple forming a new member of tancoite single chain. Due to the special coordination of VIVO6, the ∞1 {VO（HPO4）2-} chain adopts a larger M-O-M angle （V-O-V = 135°） than those of tancoite chains reported before. The corner-sharing linear {VIV = O…VIV} chain structure also leads to a one-dimensional weak antiferromagnetic interaction at low temperature. The magnetic measurements confirm the 4＋ valence state of vanadium. IR and TG results of the title compound are also discussed.

关键词： magnetic properties one-dimensional structure,phosphate tancoite-like single chain vanadium

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