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Risk factors for predicting early variceal rebleeding after endoscopic variceal ligation

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World Journal of Gastroenterology 2011年第28期17卷 3347-3352页

作者： Liang Xu Feng Ji Qin-Wei Xu Mie-qing zhang Departmemof Gastroenterology First Affiliated Hospital Zhejiang Univer-sity School of Medicine 79 Qingchun Road Hangzhou 310003Zhejiang Province China

AIM: To analyze the clinical risk factors for early variceal rebleeding after endoscopic variceal ligation (EVL).METHODS: 342 cirrhotic patients with esophageal varices who received elective EVL to prevent bleeding or rebleeding at our endoscopy center between January 2005 and July *** included in this *** early rebleeding cases after EVL were confirmed by clinical signs or endoscopy.A case-control study was performed comparing the patients presenting with early rebleeding with those without this ***: The incidence of early rebleeding after EVL was 7.60%,and the morbidity of rebleeding was 26.9%.Stepwise multivariate logistic regression analysis showed that four variables were independent risk factors for early rebleeding: moderate to excessive ascites [odds ratio (OR) 62.83,95% CI: 9.39-420.56,P 18 s (OR 11.35,95% CI: 1.93-66.70,P = 0.007).CONCLUSION: The early rebleeding rate after EVL is mainly affected by the volume of ascites,number of rubber bands used to ligate,severity of varices and prolonged *** measures for prevention and treatment should be adopted before and after EVL.

关键词： Esophageal variceal bleeding Endoscopic variceal ligation Loop ligature Early rebleeding Risk factor

利用高密度电阻率法进行多年冻土探测的研究与应用

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地质与资源 2024年第3期33卷 339-348页

作者：杜海双王书明宋庆元周传芳殷启春张天恩孙桐中国地质调查局哈尔滨自然资源综合调查中心黑龙江哈尔滨150000 中国地质大学地球物理与空间信息学院湖北武汉430074

多年冻土退化后,融区周期性冻结和融化作用会严重损害输油管道的稳定性.为查明原油管道埋设区多年冻土分布、发育现状,计划分别采用二维、三维高密度电法进行探测.为了进一步研究高密度电法不同探测方式的有效性和冻土的电阻率响应特征... 详细信息

多年冻土退化后,融区周期性冻结和融化作用会严重损害输油管道的稳定性.为查明原油管道埋设区多年冻土分布、发育现状,计划分别采用二维、三维高密度电法进行探测.为了进一步研究高密度电法不同探测方式的有效性和冻土的电阻率响应特征,首先在管道下部空间建立未融化、半融化、贯穿融化3种模型,采用EarthImager 2D和EarthImager 3D软件进行有限单元法正演和圆滑约束的最小二乘法反演;随后根据数值模拟结果,对比研究3种模型电阻率响应特征及反演结果的差异性,总结二维、三维高密度电法勘探效果;最后利用勘探实例进一步验证.结果表明,高密度电法在多年冻土探测领域是一种行之有效的方法:二维高密度电法对未融化、贯穿融化探测效果优于半融化状态;三维高密度电法采集数据更加丰富,目标体形态展示更加直观精细,反演结果更加接近理论模型,适用各种冻土融化状态.野外实例进一步验证了数值模拟结果,三维高密度电法的应用也对多年冻土精细探测领域提供了新思路.

关键词：高密度电阻率法二维模型三维模型多年冻土原油管道

A new trimeric furanocoumarin from Heracleum rapula

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Chinese Chemical Letters 2009年第9期20卷 1088-1090页

作者： Cun zhang YuanYan Liu Yong qing Xiao Li Li Institute of Chinese Materia Medica China Academy of Traditional Chinese Medicine Beijing 100700 China

A new trimeric linear-type furanocoumarin, rapultririn A （1）, was isolated from the underground part ofHeracleum rapula. The structure of this new compound was elucidated by NMR, MS spectroscopic methods. 2009 Yon... 详细信息

关键词： Heracleum rapula Tricoumarin Rapultririn A

宽胸气雾剂改善冠心病PCI术后心绞痛患者生活质量随机对照研究

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中国中西医结合杂志 2024年第2期44卷 138-142页

作者：林志彬邓运生徐艳如梁桂连李崇信曾庆春南方医科大学南方医院心血管内科广州510515

目的观察宽胸气雾剂对冠心病经皮冠状动脉介入术(PCI)术后心绞痛患者临床疗效及生活质量的影响。方法选取2022年12月—2023年9月在南方医院诊断为冠心病接受PCI治疗后仍有心绞痛的患者72例。将患者随机分为试验组和对照组,每组各36例。... 详细信息

目的观察宽胸气雾剂对冠心病经皮冠状动脉介入术(PCI)术后心绞痛患者临床疗效及生活质量的影响。方法选取2022年12月—2023年9月在南方医院诊断为冠心病接受PCI治疗后仍有心绞痛的患者72例。将患者随机分为试验组和对照组,每组各36例。对照组给予常规药物治疗,试验组在常规药物治疗的基础上给予宽胸气雾剂舌下喷服,每次2喷,每日3次,连续喷服1个月。比较两组患者治疗前后的生活质量量表(SF-36)、西雅图心绞痛量表(SAQ)评分以及心绞痛缓解临床疗效。结果最终试验组35例和对照组34例患者完成试验。与本组治疗前比较,两组治疗后心绞痛发作频次、心绞痛发作持续时间降低,SAQ各维度评分增高(P0.05),但试验组有升高趋势。结论宽胸气雾剂能降低冠心病PCI术后心绞痛发作次数及持续时间,并改善患者的生活质量。

关键词：宽胸气雾剂冠心病心绞痛生活质量中成药中西医结合随机对照试验

Mercury bioaccumulation in fish in an artificial lake used to carry out cage culture

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Journal of Environmental Sciences 2019年第4期31卷 352-359页

作者： Yongmin Wang qing Xie Qinqin Xu Jinping Xue Cheng zhang Dingyong Wang College of Resources and Environment Southwest University Chongqing Key Laboratory of Agricultural Resources and Environment

As a global toxic pollutant,mercury(Hg)bioaccumulation within food chain could be influenced by human *** typical fish species were collected from Changshou Lake,an artificial lake used to carry out cage fish culture,to investigate the C/N isotopic compositions and Hg bioaccumulation in *** results showed that the total Hg(THg)and methylmercury(MeHg)levels in fish muscles((56.03±43.96)and(32.35±29.57)ng/g,wet weight),comparable with those in most studies in China,were significantly lower than the international marketing limit(0.5 mg/kg).Past human input for cage culture in this lake led to abnormal^(15)N enrichment in food chain,as the quantitative trophic levels based onδ^(15)N were different with that classified by feeding *** phenomenon subsequently demonstrated that it should be considered thoughtfully with respect to the application of the traditional method for understanding Hg bioaccumulation power by the slope of log_(10)[Hg]withδ^(15)N regression in specific water body(i.e.,Changshou Lake).In addition,no significant linear correlation between Hg and body weight or length of some fish species was observed,suggesting that the fish growth in the eutrophic environment was disproportionate with Hg bioaccumulation,and fish length or weight was not the main factor affecting Hg transfer with food *** occurrence of human disturbance in aquatic system presents a challenge to a better understanding of the Hg bioaccumulation and biomagnification within the food chain.

关键词： Mercury Methylmercury Human disturbed lake Bioaccumulation N enrichment

铸态Mg-9Gd-1.5Zn-xAl合金的显微组织和力学性能

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材料热处理学报 2024年第4期45卷 40-47页

作者：张震陈君陈晓亚李全安郭希宽王春阳河南科技大学材料科学与工程学院河南洛阳471023 有色金属新材料与先进加工技术省部共建协同创新中心河南洛阳471023

采用铸造法制备了Mg-9Gd-1.5Zn-xAl(x=0、0.3、0.8和1.3 mass%)合金,通过X射线衍射仪、光学显微镜、扫描电镜等研究了不同Al含量对Mg-9Gd-1.5Zn合金物相和显微组织的影响,并采用电子拉伸试验机测试了室温下4种合金的力学性能。结果表明... 详细信息

采用铸造法制备了Mg-9Gd-1.5Zn-xAl(x=0、0.3、0.8和1.3 mass%)合金,通过X射线衍射仪、光学显微镜、扫描电镜等研究了不同Al含量对Mg-9Gd-1.5Zn合金物相和显微组织的影响,并采用电子拉伸试验机测试了室温下4种合金的力学性能。结果表明:铸态Mg-9Gd-1.5Zn合金的组织由α-Mg基体和沿晶界分布的Mg_(5)Gd和(Mg,Zn)_(3)Gd相组成,加入Al元素后,合金组织中Mg_(5)Gd相逐渐减少,并产生了新相Al_(2)Gd、Al_(11)Gd_(3)和LPSO(Mg_(12)Gd(Al,Zn))。Al元素促进了有效异质形颗粒(Al_(2)Gd)的产生,抑制了晶粒长大,合金的组织明显细化,起到了细晶强化的效果。当Al添加量为0.8%时,合金的抗拉强度、屈服强度和伸长率分别为192.2 MPa、154.8 MPa和16.6%,与不含Al的Mg-9Gd-1.5Zn合金相比,分别提升了47.1%、64.8%和121.3%。

关键词： Mg-Gd-Zn合金 LPSO相显微组织力学性能

Towards an Accurate and Robust Roe-Type Scheme for All Mach Number Flows

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Advances in Applied Mathematics and Mechanics 2019年第1期11卷 132-167页

作者： Wenjia Xie Ye zhang qing Chang Hua Li College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073HunanChina

We propose an accurate and robust Roe-type scheme applied to the compressible Euler system at all Mach *** study the occurrence of unstable modes during the shock wave computation,a shock instability analysis of several Roe-type schemes is carried *** analysis approach allows to propose a simple and effective modification to eliminate shock instability of the Roe method for hypersonic flows.A desirable feature of this modification is that it does not resort to any additional numerical dissipation on linear degenerate waves to suppress the shock *** an all Mach correction strategy,the modified Roe-type scheme is further extended to solve flow problems at all Mach *** results that are obtained for various test cases indicate that the new scheme has a good performance in terms of accuracy and robustness.

关键词： Roe scheme low Mach number numerical shock instability

A facile phototheranostic nanoplatform integrating NIR-Ⅱ fluorescence/PA bimodal imaging and image-guided surgery/PTT combinational therapy for improved antitumor efcacy

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Journal of Materials Science & Technology 2022年第35期130卷 208-218页

作者： Xiuping Han Wenyou Fang Tianqi zhang Xuan Zhong Kun Qian Zhitao Jiang Rongfeng Hu Guoqiang Shao Lei zhang qing zhang Department of Pharmaceutics and Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Department of Nuclear Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 211166China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui Province Engineering Technology Research Center of Modern Pharmaceutical PreparationAnhui University of Chinese MedicineHefei 230012China Department of Nuclear Medicine Taizhou People’s HospitalNanjing University of Chinese MedicineTaizhou 225300China Center for Molecular Imaging Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Phototheranostic with highly integrated functions is an attractive platform for cancer management. It remains challenging to develop a facile phototheranostic platform with complementary bimodal imaging and combinational therapy capacity. Herein, the small-molecule cyanine IR780 loaded liposomes have been harnessed as a nanoplatform to simultaneously realize photoacoustic(PA)/the second near-infrared window(NIR-Ⅱ) fluorescence imaging and image-guided surgery/adjuvant photothermal therapy(PTT).This nanoplatform exhibits attractive properties like uniform controllable size, stable dispersibility, NIR-Ⅱ fluorescence emission, photothermal conversion, and biocompatibility. Benefiting from the complementary PA/NIR-Ⅱ fluorescence bimodal imaging, this nanoplatform was successfully applied in precise vasculature delineation and tumor diagnosis. Interestingly, the tumor was clearly detected by NIR-Ⅱ fluorescence imaging with the highest tumor-to-normal-tissue ratio up to 12.69, while signal interference from the liver was significantly reduced, due to the difference in the elimination rate of the nanoplatform in the liver and tumor. Under the precise guidance of the image, the tumor was accurately resected, and the simulated residual lesion after surgery was completely ablated by adjuvant PTT. This combined therapy showed improved antitumor efcacy over the individual surgery or PTT. This work develops a facile phototheranostic nanoplatform with great significance in accurately diagnosing and effectively treating tumors using simple NIR light irradiation.

关键词： NIR-Ⅱfluorescence imaging Photoacoustic imaging Image-guided surgery Adjuvant photothermal therapy Phototheranostics

异甘草酸镁注射液对肝恶性肿瘤的疗效及对肝功能、炎症因子的影响

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中国药物应用与监测 2024年第4期21卷 372-375页

作者：张莉张宇魏曼玉赵冰清樊敏安徽中医药大学附属太和县中医院药事科阜阳236600 安徽中医药大学附属太和县中医院肝病科阜阳236600

目的探讨异甘草酸镁注射液对肝恶性肿瘤患者的疗效及其对肝功能、炎症因子的影响。方法纳入2022年1月至2024年1月安徽中医药大学附属太和县中医院住院部收治的98例肝恶性肿瘤患者,以随机数字表法分为两组,每组49例,患者均接受肝动脉... 详细信息

目的探讨异甘草酸镁注射液对肝恶性肿瘤患者的疗效及其对肝功能、炎症因子的影响。方法纳入2022年1月至2024年1月安徽中医药大学附属太和县中医院住院部收治的98例肝恶性肿瘤患者,以随机数字表法分为两组,每组49例,患者均接受肝动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)治疗,对照组术后应用还原型谷胱甘肽注射液治疗,观察组术后采取还原型谷胱甘肽注射液联合异甘草酸镁注射液治疗,各治疗10 d,比较两组的临床疗效、肝损伤发生率、不良反应、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)等血清炎症因子水平、甲胎蛋白(AFP)。结果观察组与对照组的总有效率分别为71.43%和63.27%,差异无统计学意义(χ^(2)=0.742,P>0.05);观察组肝损伤发生率(28.57%)低于对照组(59.18%),差异具有统计学意义(χ^(2)=9.324,P0.05);治疗后,观察组TNF-α及IL-6水平分别为(41.25±4.23)μg·m L^(-1)、(35.49±5.23)μg·m L^(-1),均低于对照组[分别为(69.23±6.62)μg·m L^(-1)、(57.73±4.23)μg·m L^(-1)],差异具有统计学意义(t=24.931、48.908,均P<0.05);治疗后,观察组AFP水平为(77.63±6.93) pg·m L^(-1),低于对照组(122.65±9.54) pg·m L^(-1),差异具有统计学意义(t=26.726,P<0.05)。结论异甘草酸镁注射液可较好保护TACE治疗的肝恶性肿瘤患者的肝功能,还可一定程度抑制肿瘤,提升治疗效果,且治疗安全可靠,利于患者病情好转。

关键词：肝恶性肿瘤异甘草酸镁注射液肝功能疗效肿瘤标志物药品不良反应