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A short-term study of corneal collagen cross-linking with hypo-osmolar riboflavin solution in keratoconic corneas

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 94-97页

作者： Shao-Feng Gu Zhao-Shan Fan Li-Hua wang Xiang-Chen Tao Yong Zhang chun-qin wang Ya wang Guo-Ying Mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University

AIM: To report the 3mo outcomes of collagen crosslinking(CXL) with a hypo-osmolar riboflavin in thin corneas with the thinnest thickness less than 400 μm without ***: Eight eyes in 6 patients with age 26.2±4.8y were included in the study. All patients underwent CXL using a hypo-osmolar riboflavin solution after its de-epithelization. Best corrected visual acuity, manifest refraction, the thinnest corneal thickness, and endothelial cell density were evaluated before and 3mo after the ***: The mean thinnest thickness of the cornea was 408.5 ±29.0 μm before treatment and reduced to369.8 ±24.8 μm after the removal of epithelium. With the application of the hypo-osmolar riboflavin solution, the thickness increased to 445.0 ±26.5 μm before CXL and recover to 412.5 ±22.7 μm at 3mo after treatment, P =0.659). Before surgery, the mean K-value of the apex of the keratoconus corneas was 57.6 ±4.0 diopters, and slightly decreased(54.7±4.9 diopters) after surgery(P =0.085). Mean best-corrected visual acuity was 0.55 ±0.23 logarithm of the minimal angle of resolution, and increased to 0.53±0.26 logarithm after surgery(P =0.879).The endothelial cell density was 2706.4 ±201.6 cells/mm2 before treatment, and slightly decreased( 2641. 2 ±218.2 cells/mm2) at last fellow up(P =0.002).CONCLUSION: Corneal collagen cross-linking with a hypo-osmolar riboflavin in thin corneas seems to be a promising treatment. Further study should be done to evaluate the safety and efficiency of CXL in thin corneas for the long-term.

关键词： corneal collagen cross-linking keratoconus hypo-osmolar riboflavin thin corneas

Stroke-like Migraine Attacks after Radiation Therapy Syndrome

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Chinese Medical Journal 2015年第15期128卷 2097-2101页

作者： Qian Zheng Li Yang Li-Ming Tan Li-Xia qin chun-Yu wang Hai-Nan Zhang Department of Neurology Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Objective：To summarize the clinical presentation,pathogenesis,neuroimaging,treatment,and outcome of stroke-like migraine attacks after radiation therapy （SMART） syndrome,and to propose diagnostic criteria for this *** Sources：We searched the PubMed database for articles in English published from 1995 to 2015 using the terms of ＂stroke-like AND migraine AND radiation.＂ Reference lists of the identified articles and reviews were used to retrieve additional *** Selection：Data and articles related to late-onset effects of cerebral radiation were selected and ***：SMART is a rare condition that involves complex migraines with focal neurologic deficits following cranial irradiation for central nervous system *** recovery,which ranges from hours to days to weeks,can be partial or *** propose the following diagnostic criteria for SMART：（1） Remote history of therapeutic external beam cranial irradiation for malignancy;（2） prolonged,reversible clinical manifestations mostly years after irradiation,which may include migraine,seizures,hemiparesis,hemisensory deficits,visuospatial defect,aphasia,confusion and so on;（3） reversible,transient,unilateral cortical gadolinium enhancement correlative abnormal T2 and fluid-attenuated inversion recovery signal of the affected cerebral region;（4） eventual complete or partial recovery,the length of duration of recovery ranging from hours to days to weeks;（5） no evidence of residual or recurrent tumor;（6） not attributable to another *** date,no specific treatment has been identified for this ***：SMART is an extremely rare delayed complication of brain ***,improvements in cancer survival rates have resulted in a rise in its ***,awareness and recognition of the syndrome is important to make a rapid diagnosis and avoid aggressive interventions such as brain biopsy and cerebral angiography.

关键词： Cranial Irradiation Epilepsy Migraine Stroke-like Migraine Attacks after Radiation Therapy

Difference of antiepileptic drug concentrations in epileptic foci and the adjacent tissues,and its relationship with blood drug concentrations in patients with intractable epilepsy

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Difference of antiepileptic drug concentrations in epileptic...

CORMIX与二维数模、物模在滨海核电厂温排水近区模拟中的比对研究

中国药理学会第十次全国学术会议

作者： Jiang-Hua Shen,De-chun Jiang,Yu-qin wang~* (Pharmacy department of Xuanwu Hospital of Capital Medical University,Beijing,100053)

Objective Comparing the differences between epileptic foci and the adjacent tissues,establishing the relationship between the blood serum and the brain tissue,and clarify the resistance mechanism of intractable epilepsy. Materials and Methods The cases are collected from functional neurosurgery of Xuanwu Hospital of Capital Medical University from April 2007 to March 2009,who were all with refractory epilepsy and did the surgery of"excision of epileptic foci".We used the intraoperative electrophysiological method to distinguish the epileptic foci and the adjacent *** patients were informed consent before surgery.(1) To determine the drug concentration in blood serum and brain tissue of patients with intractable epilepsy(IE).(2) Comparing the drug concentration between the epileptic foci and the adjacent tissue,and comparing the drug concentration between the brain tissue and the blood serum,then clarify the mechanism of drug-resistant ***:(1) There are 49 patients were collected totally(31 males and 18 females,the age ranged from 12 to 47,and the average age is 27.14), they all took lamotrigine,phenobarbital,carbamazepine and phenytoin alone or in *** the method we set up to determine four drug concentrations in serum,there is one case who took lamotrigine,8 took phenobarbital, 41 took carbamazepine and 9 took *** resulets are all in the normal *** are 23 cases of patients with brain tissue were collected totally(15 males,8 females,the age ranged from 11 to 46,the average age is 23.13).Because two cases of phenytoin concentrations in brain tissue exceeded the standard curve range,so ***’ s more,one case of phenobarbital concentration is too high,and there is great difference comparing with others,so deleted *** there are 20 cases left,including 4 cases of phenobarbital and 16 cases of carbamazepine. The average drug concentration of epileptogenic foci is 1.83 tμg/ml and the adjacent tissue is 2.11μg

关键词： intractable epilepsy drug concentration brain tissue HPLC drug-resistance mechanism

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海洋科学进展 2017年第1期35卷 117-123页

作者：张琨张爱玲覃春丽王韶伟环境保护部核与辐射安全中心北京100082 中广核集团苏州热工研究院江苏苏州215004

我国一般采用二维数值模型和物理模型相结合的方式对滨海核电厂的温排水影响范围进行评价,二维数值模型难以模拟近区水流和温排水的分布规律,而开展物理模型试验所需费用高、周期长。CORMIX是在浮射流理论分析和物理模型试验的基础上开... 详细信息

我国一般采用二维数值模型和物理模型相结合的方式对滨海核电厂的温排水影响范围进行评价,二维数值模型难以模拟近区水流和温排水的分布规律,而开展物理模型试验所需费用高、周期长。CORMIX是在浮射流理论分析和物理模型试验的基础上开发的,对近区的稀释扩散特征模拟结果较好,且使用简单快捷、成本低。本文以我国某滨海核电厂温排水影响范围的模拟为算例,对CORMIX与二维数模、物模进行比较,结果表明,CORMIX对于近区的模拟结果优于二维数模,与物模试验结果的一致性较好。同时,本文还对CORMIX在滨海地区的适用性进行探讨,对于岸线规律、水下地形开阔的区域,CORMIX可作为温排水近区模拟的首选方法。

关键词：滨海核电厂温排水扩散器 CORMIX

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儿童压力后成长量表的编制及信效度检验

中国儿童保健杂志 2016年第9期24卷 900-902页

作者：覃春望吴素梅广西师范大学教育学部认知神经科学与应用心理学广西高校重点实验室广西桂林541004

目的编制适用于我国儿童群体的压力后成长量表,并检验其信效度。方法分别对412名和423名儿童组成的样本进行项目分析、探索性因素分析、验证性因素分析及信效度检验。结果 1）儿童压力后成长量表支持三维结构理论,验证性因素分析结果表... 详细信息

目的编制适用于我国儿童群体的压力后成长量表,并检验其信效度。方法分别对412名和423名儿童组成的样本进行项目分析、探索性因素分析、验证性因素分析及信效度检验。结果 1）儿童压力后成长量表支持三维结构理论,验证性因素分析结果表明各项拟合指标良好（RMSEA=0.013,IFI=0.99,CFI=0.99,χ2/df=1.069）。2）量表的内部一致性信度在0.695~0.816之间,重测信度为0.737,校标关联效度为0.727。结论儿童压力后成长量表符合心理测量学的标准,可以用于测量我国儿童压力后成长的情况。

关键词：压力后成长儿童量表编制信度效度

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剑尾鱼侏儒突变的骨骼异常及其遗传

水产学报 2011年第6期35卷 809-815页

作者：李凯彬刘春常藕琴王芳马必勇吴淑勤中国水产科学研究院珠江水产研究所

以侏儒剑尾鱼为母本,与正常体型的雄性剑尾鱼进行交配,发现其后代的体型表现呈连续分布,部分与父本类似,部分与母本相仿,且存在中间类型,很难有明确的差别界限以区分个体表型的不同。后代中的侏儒个体主要表现为体型短,身体臃肿,游动笨... 详细信息

以侏儒剑尾鱼为母本,与正常体型的雄性剑尾鱼进行交配,发现其后代的体型表现呈连续分布,部分与父本类似,部分与母本相仿,且存在中间类型,很难有明确的差别界限以区分个体表型的不同。后代中的侏儒个体主要表现为体型短,身体臃肿,游动笨拙,其体长和体高的比例出现了明显的变化。F1自交和回交,结果显示:不同组合后代的体型也呈连续分布。剑尾鱼的侏儒性状可遗传,但后代的性状表现不只是一种表型,而是影响一组表型,符合数量性状遗传的基本特征,推测或为多个数量性状基因控制。通过对突变剑尾鱼骨骼形态的分析发现:侏儒剑尾鱼的脊柱长度明显变短,但脊椎骨数量与正常个体并无差异,都在26～29之间;突变体的椎体明显变短,脊椎的纵向发育受阻,髓棘、脉棘等排列紧密,发育也受影响。因而推测,剑尾鱼的侏儒突变是由于脊椎的发育缺陷所致,椎体异常是其体型变化的结构基础。鱼类是低等脊椎动物的代表,剑尾鱼侏儒突变个体不仅可育,其性状也能遗传,且与脊椎的发育关系密切,或可作为模型材料进行系统研究。

关键词：剑尾鱼突变椎体遗传

温湿度和食物对暗黑鳃金龟幼虫存活及生长发育的影响

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昆虫学报 2017年第8期60卷 920-926页

作者：冯晓洁席国成刘福顺吴娱刘春琴王庆雷沧州市农林科学院河北沧州061001

【目的】明确重要生态因素对暗黑鳃金龟Holotrichia parallela幼虫种群的影响,从而为预测预报其发生提供理论依据。【方法】在室内采用自动控制温度、人工控制湿度的方法,观察温度、湿度和食物对暗黑鳃金龟幼虫存活率及发育历期的影响... 详细信息

【目的】明确重要生态因素对暗黑鳃金龟Holotrichia parallela幼虫种群的影响,从而为预测预报其发生提供理论依据。【方法】在室内采用自动控制温度、人工控制湿度的方法,观察温度、湿度和食物对暗黑鳃金龟幼虫存活率及发育历期的影响。【结果】结果表明,20~28℃适宜暗黑鳃金龟1-2龄幼虫的存活,其中24℃时存活率最高,达到74.9%±3.1%;12℃时发育历期最长,32℃时发育历期最短,20℃和24℃下发育历期适中。土壤含水量为7%~19%时暗黑鳃金龟1-2龄幼虫均能存活;其中在7%和19%时,幼虫存活率低于50%,在25%时幼虫全部死亡;在土壤含水量为16%时存活率最高,达到76.4%±2.5%。在供试的6种食物(小麦根、玉米根、棉花根、花生根、大豆根和马铃薯块)中,喂饲花生根的暗黑鳃金龟幼虫存活率最高,达到68.7%±3.2%。取食不同食物的幼虫发育历期差异显著,其中取食花生根的暗黑鳃金龟幼虫期最短,整个幼虫期仅为259 d(3龄幼虫期为227 d);而取食棉花根的幼虫期最长,整个幼虫期为346 d(3龄幼虫期为303 d)。【结论】温度、土壤含水量和食物对暗黑鳃金龟幼虫的存活和生长发育均具有显著影响;在幼虫期调控温湿度及改变其寄主植物结构可有效控制其发生危害。

关键词：暗黑鳃金龟幼虫温度土壤湿度食物存活率发育历期

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光谱判断田间鲜烟叶成熟度的影响因子研究

山地农业生物学报 2016年第4期35卷 88-94页

作者：徐兴阳何春荣秦春丽王锋劳彩莲云南省烟草公司昆明市公司云南昆明650051 中国农业大学信息与电气工程学院北京100083

利用便携式地物波谱仪Field Spec 3测量烤烟成熟期烟叶的反射光谱,针对采收成熟度M2、M3,分析比较同一时间不同测量位点、及同一位点不同测量时间的反射光谱差异。结果表明：反射光谱的差异在不同测量位点主要体现在350~780 nm可见光波... 详细信息

利用便携式地物波谱仪Field Spec 3测量烤烟成熟期烟叶的反射光谱,针对采收成熟度M2、M3,分析比较同一时间不同测量位点、及同一位点不同测量时间的反射光谱差异。结果表明：反射光谱的差异在不同测量位点主要体现在350~780 nm可见光波段和780~1300 nm近红外波段,在不同测量时间主要体现在780~1300 nm近红外波段。因此,利用光谱仪判断鲜烟叶成熟度,受测量位点的影响较大,而受测量时间的影响较小,但若测量烟叶生理生化组分、厚度和水分等内在指标,时间及天气状况是必须考虑的重要因素。

关键词：烤烟光谱法鲜烟叶成熟度影响因子

Synthesis and Characterization of Fine Grained High Density La_2Mo_2O_9-based Oxide-ion Conductors

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Journal of Materials Science & Technology 2008年第5期24卷 761-765页

作者： Jianxin wang qin wang Xianping wang chun LI Qianfeng FANG Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China Ningbo Institute of Material Technology and Engineering Chinese Academy of Sciences Ningbo 315040 China

A cost-efFective technique, including nanocrystalline powder preparation using a modified Pechini method and a two-step low-temperature sintering route, was developed for the synthesis of high performance La2Mo2O9- based oxide-ion conductors. The optimum parameters of the compaction pressure, the first step and ＇the second step sintering temperatures for the synthesis of fine grained, high density and uniform La2Mo2O9- based oxide-ion conductors were determined by a series of sintering experiments. High density and uniform sintered La2Mo2O9 samples with average grain size from 0.8 to 5 μm and La1.96K0.04Mo2O8.96 sample with average grain size as small as 500 nm were synthesized by using this cost-efFective method. The impedance measurement results show that the as-fabricated La2Mo2O9-based ceramics possess much higher ionic conductivity than that obtained by solid state reaction method. It is found that in the range of 0.8-5μm the grain size of dense La2Mo2O9 samples prepared from the nanocrystalline powders has little influence on their conductivities.

关键词： Oxide ion conductor La2MoO9 Nanocrystalline Two-stage sintering