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Klebsiella pneumoniae infections after liver transplantation:Drug resistance and distribution of pathogens,risk factors,and influence on outcomes

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World Journal of Hepatology 2024年第4期16卷 612-624页

作者： Long Guo peng peng Wei-Ting peng Jie zhao Qi-Quan Wan Department of Respiratory and Critical Care Medicine The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Clinical Laboratory Medicine Center Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 421007Hunan ProvinceChina The Second Affiliated Hospital Class Xiangya School of MedicineCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China Department of Transplant Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Engineering and Technology Research Center for Transplantation Medicine of National Health Commission The Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina

BACKGROUND Liver transplantation(LT)is the only curative treatment for end-stage liver ***,LT recipients are susceptible to infection,which is the leading cause of early mortality after *** pneumoniae infections(KPIs)in the bloodstream are common in LT *** hypothesized that KPIs and carbapenemresistant Klebsiella pneumoniae(CRKP)infections may affect the outcomes of LT *** To assess KPI incidence,timing,distribution,drug resistance,and risk factors following LT and its association with *** This retrospective study included 406 patients undergoing LT at The Third Xiangya Hospital of Central South University,a tertiary hospital,from January 2015 to January *** investigated the risk factors for KPIs and assessed the impact of KPIs and CRKP infections on the prognosis of LT recipients using logistic regression *** KPI incidence was 7.9%(n=32),with lung/thoracic cavity the most frequent site of infection;the median time from LT to KPI onset was 7.5 *** 44 Klebsiella pneumoniae isolates,43(97.7%)and 34(77.3%)were susceptible to polymyxin B or ceftazidime/avibactam and tigecycline,respectively;>70%were resistant to piperacillin/tazobactam,ceftazidime,cefepime,aztreonam,meropenem,and *** sex[odds ratio(OR)=2.827,95%confidence interval(CI):1.256-6.364;P=0.012],pre-LT diabetes(OR=2.794,95%CI:1.070-7.294;P=0.036),day 1 post-LT alanine aminotransferase(ALT)levels≥1500 U/L(OR=3.645,95%CI:1.671-7.950;P=0.001),and post-LT urethral catheter duration over 4 d(OR=2.266,95%CI:1.016-5.054;P=0.046)were risk factors for *** infections,but not KPIs,were risk factors for 6-month all-cause mortality *** KPIs occur frequently and rapidly after *** factors include female sex,pre-LT diabetes,increased post-LT ALT levels,and urethral catheter *** infections,and not KPIs,affect mortality.

关键词： Liver transplantation Klebsiella pneumoniae infections Carbapenem-resistant Klebsiella pneumoniae Risk factors Outcomes

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CSST Dense Star Field Preparation:A Framework for Astrometry and Photometry for Dense Star Field Images Obtained by the China Space Station Telescope(CSST)

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Research in Astronomy and Astrophysics 2024年第7期24卷 158-169页

作者： Yining Wang Rui Sun Tianyuan Deng Chenghui zhao Peixuan zhao Jiayi Yang peng Jia Huigen Liu Jilin Zhou College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Astronomy&Space Science Nanjing UniversityNanjing 210093China peng Cheng Lab Shenzhen 518066China

The China Space Station Telescope(CSST)is a telescope with 2 m diameter,obtaining images with high quality through wide-field *** its first observation cycle,to capture time-domain observation data,the CSST is proposed to observe the Galactic halo across different *** data have significant potential for the study of properties of stars and ***,the density of stars in the Galactic center is high,and it is a well-known challenge to perform astrometry and photometry in such a dense star *** paper presents a deep learning-based framework designed to process dense star field images obtained by the CSST,which includes photometry,astrometry,and classifications of targets according to their light curve *** simulated CSST observation data,we demonstrate that this deep learning framework achieves photometry accuracy of 2%and astrometry accuracy of 0.03 pixel for stars with moderate brightness mag=24(i band),surpassing results obtained by traditional ***,the deep learning based light curve classification algorithm could pick up celestial targets whose magnitude variations are 1.7 times larger than magnitude variations brought by Poisson photon *** anticipate that our framework could be effectively used to process dense star field images obtained by the CSST.

关键词： techniques photometric-methods data analysis-astrometry

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Advanced Electrical Motors and Control Strategies for High-quality Servo Systems-A Comprehensive Review

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Chinese Journal of Electrical Engineering 2024年第1期10卷 63-85页

作者： Ming Cheng Jiawei Zhou Wei Qian Bo Wang Chenchen zhao peng Han School of Electrical Engineering Southeast UniversityNanjing 210096China ESTUN Automation Co. Ltd.Nanjing 211106China Ansys Inc.San JoseCA 95134USA

Recent technological advancements have propelled remarkable progress in servo systems,resulting in their extensive utilization across various high-end applications.A comprehensive review of high-quality servo system technologies,focusing specifically on electrical motor topologies and control strategies is *** terms of motor topology,this study outlines the mainstream servo motors used across different periods,as well as the latest theories and technologies surrounding contemporary servo *** terms of control strategies,two well-established approaches are presented:field-oriented control and direct torque ***,it discusses advanced control strategies employed in servo systems,such as model predictive control(MPC)and fault tolerance control,among others.

关键词： Servo system servo motor control strategy magnetic field modulation

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The influence of proxy selection on global annual mean temperature reconstructions during the Common Era

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Science China Earth Sciences 2024年第8期67卷 2522-2534页

作者： Bao YANG Xia LI Minhui HE Feng WANG Yesi zhao peng ZHANG Jianglin WANG Frontiers Science Center for Critical Earth Material Cycling School of Geography and Ocean ScienceNanjing UniversityNanjing 210023China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Centre Eau Terre Environnement Institut National de la Recherche ScientifiqueQuébecQCG1K 9A9Canada GEOTOP Research Centre in the Dynamics of the Earth System MontréalQC H2X 3Y7Canada

The reconstruction of global annual mean temperatures made by the PAGES 2k Consortium in 2019 represents one of the most influential sequences of global climate variability over the Common ***,it is still not clear how the reconstruction can be influenced by the selection of reconstruction methods and the selection of proxy records with different temporal resolutions over different *** adopt a widely used Composite-Plus-Scale method to elucidate the effects of the selection of the proxy records on temperature *** ensure the uniformity of data,different types of proxy records spanning the past~2000 years from the PAGES 2k proxy network were used to investigate the potential effects of proxy selection in hemispheric and global temperature reconstructions during the past two *** long-term trends,spectral characteristics,and volcanic responses of the annual temperatures were studied based on the *** results reveal a significant cooling trend in the global annual mean temperature using both tree-ring and non-tree-ring records during the 1–1850CE period,and show that the cooling exhibits a stronger trend in the Southern Hemisphere(SH)than that in the Northern Hemisphere(NH).Yet,the long-term trends vary according to different combinations of proxy *** reconstructions based on different types of proxies also exhibit different features in terms of volcanic responses and spectral ***-ring-based temperature reconstructions show stronger cooling responses to tropical volcanic eruptions,while non-tree-ring-based reconstructions suggest less robust volcanic responses,which may be related to dating uncertainties and low temporal resolution of the ***-ring width records tend to preserve a substantial proportion of high-frequency(200 years)*** are needed to reduce uncertainti

关键词： Millennial cooling trend Global climate change Proxy records Volcanic eruptions Spectral properties Common Era

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Low‑light enhancement method with dual branch feature fusion and learnable regularized attention

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Frontiers of Optoelectronics 2024年第3期17卷 93-111页

作者： Yixiang Sun Mengyao Ni Ming zhao Zhenyu Yang Yuanlong peng Danhua Cao School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China State Grid Information&Telecommunication Branch Beijing 100761China

Restricted by the lighting conditions,the images captured at night tend to sufer from color aberration,noise,and other unfavorable factors,making it difcult for subsequent vision-based *** solve this problem,we propose a two-stage size-controllable low-light enhancement method,named Dual Fusion Enhancement Net(DFEN).The whole algorithm is built on a double U-Net structure,implementing brightness adjustment and detail revision respectively.A dual branch feature fusion module is adopted to enhance its ability of feature extraction and *** also design a learnable regularized attention module to balance the enhancement efect on diferent ***,we introduce a cosine training strategy to smooth the transition of the training target from the brightness adjustment stage to the detail revision stage during the training *** proposed DFEN is tested on several low-light datasets,and the experimental results demonstrate that the algorithm achieves superior enhancement results with the similar *** is worth noting that the lightest DFEN model reaches 11 FPS for image size of 1224×10^(24)in an RTX 3090 GPU.

关键词： Power inspection Low-light enhancement Feature fusion Learnable regularized attention

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Effect of Phase Separation Size on the Properties of Self-healing Elastomer

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Chinese Journal of Polymer Science 2024年第6期42卷 798-804页

作者： Jun Xu Lei Zhu Xian-Qi Feng Cong Sui Wen-peng zhao Shou-Ke Yan School of Chemical Engineering Qingdao University of Science&TechnologyQingdao266042China College of Engineering Yanching institute of TechnologyLangfang065210China Key Laboratory of Rubber-plastics Qingdao University of Science&TechnologyQingdao266042China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Regulation of phase structure has been recognized as one of the most effective ways to fabricate self-healing polymers with high mechanical *** mechanical properties of the resultant polymers are certainly affected by the size of separated phase ***,the study on this aspect is absence,because it can hardly exclude the influence of variation in monomer proportion required for tuning the separated phase ***,we report the first study on tuning the phase size through reversible addition-fragmentation chain transfer(RAFT)polymerization without changing the proportion of *** expected,the size of separated phase has been successfully mediated from 15 nm to 9 nm by tuning the molecular weight of the chain transfer *** is found that the mechanical strength and the self-healing efficiency of the resultant polymers increase simultaneously with the decrease of phase *** study on the formation kinetics of hydrogen bonds reveals that the decrease of phase size can facilitate the re-bonding rate of hydrogen bonds,even if the migration of polymer chains is restricted.

关键词： Self-healing polymers Phase separation Reversible addition-fragmentation chain transfer

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Activable Photodynamic DNA Probe with an“AND”Logic Gate for Precision Skin Cancer Therapy

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Research 2024年第3期2024卷 735-750页

作者： Jiaojiao Zhu Lanyuan peng Shah Jehan Haiyang Wang Xiang Chen Shuang zhao Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangshaHunan 410013China Department of Dermatology Hunan Engineering Research Center of Skin Health and DiseaseHunan Key Laboratory of Skin Cancer and PsoriasisXiangya HospitalCentral South UniversityChangshaHunan 410008China Key Laboratory of Biological Nanotechnology of National Health Commission ChangshaHunan 410008China. Furong Laboratory ChangshaHunanChina Department of Vascular Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China.

Photodynamic therapy(PDT)has emerged as a promising approach for squamous cell carcinoma treatment but hindered by tumor hypoxia,acquired resistance,phototoxicity,and so *** address these issues,we developed a smart strategy utilizing activable photosensitizers delivered by an aptamer-functionalized DNA probe(ADP).The ADP incorporated an AS1411 aptamer for tumor targeting and a linear antisense oligonucleotide(ASO)for recognition of Survivin *** the absence of the target,PDT remained quenched,thereby avoiding phototoxicity during circulation and nonselective *** the aid of the aptamer,ADP achieved selective targeting of *** internalization,ADP targeted recognized Survivin mRNA,triggering PDT activation,and releasing ASO to down-regulate Survivin expression and reverse tumor ***,the activable photosensitizers exhibited an“AND”logic gate,combining tumor-targeting delivery and tumor-related gene activation,thus enhancing its ***,the incorporation of hemin into the ADP provided catalase activity,converting tumor-abundant H_(2)O_(2) into O_(2),thereby ameliorating tumor *** resulting functionalized G-quadruplex/hemin–DNA probe complex demonstrated targeted delivery and activation,minimized side effects,and enhanced PDT efficacy in both xenograft tumor-bearing mice and patient-derived xenograft *** study offers a unique and promising platform for efficient and safe PDT,thus holding great potential for future clinical translation and improved cancer therapy.

关键词： specificity thereby Skin

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Stress Concentration Effect in Interface Between Conductor and Epoxy Resin in Coaxial Components of Power Equipment

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 412-420页

作者： Chuang Wang Kang Lei Qing Sun Hui Li Jiawei Zhang Lang zhao Zongren peng School of Electrical Engineering Xi’an University of TechnologyXi’an 710054China Xi’an Power Supply Company State Grid Shaanxi Electric Power CompanyXi’an 710032China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

The spacer used in gas insulated switchgear(GIS)plays a vital role in its safe *** mismatch of mechanical properties between conductor and insulating material in spacers results in stress concentration at the interface between *** a hydrostatic test,mechanical damages are often initiated from the *** this paper,the stress between aluminum conductors and epoxy resin is studied by using a simplified coaxial structure *** measurement system and finite element simulation are used to explore the generation of stress and strain during curing and *** real-time measurement of strain at the interface shows that the residual strain in the entire process is primarily generated during the cooling ***,the temperature and stress/strain distribution at the interface during the cooling stage are further studied,and combined with experiments and *** consistency between the finite element simulation and the experimental measurement results verifies the validity of the simulation method *** results show that the maximum of the first principal stress generated during the cooling stage of the production process is concentrated on the upper and lower edges of the interface which is critical to the impact of the production quality of the spacer.

关键词： Epoxy resin GIS interface stress/strain distribution

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Feasible Synthesis of N,O-Bidentate Difluoroboron Chromophores through Direct Functionalization of Quinoxalin-2(1H)-ones with Ketones in One Shot

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Chinese Journal of Chemistry 2024年第13期42卷 1481-1486页

作者： Shuaichen Zhang Jing Zhang Xiang Ling Yifan zhao Yue Ma peng Sun State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityState Key Laboratory of Natural MedicinesNanjingJiangsu 210009China

Organic difluoroboron complexes are a kind of potential platforms for a wide range of applications owing to their excellent photophysical ***,we have explored a simple and direct synthesis methodology for a library of N,O-bidentate difluoroboron complexes from quinoxalin-2(1H)-ones and ketones in one *** photophysical properties of the generated complexes were evaluated and the application potential of these compounds on subcellular imaging was also explored.

关键词： N,O-Bidentate difluoroboron Chromophores Quinoxalin-2(1H)-ones Ketones/Green chemistry Synthetic method C-CcouplingI Boron

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Towards experimental studying the airborne sound insulation of light frame walls with staggered studs

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Science China(Technological Sciences) 2024年第7期67卷 2230-2243页

作者： ZHANG YuCai YUE Kong XIE YiFan CHENG XiangYu SHI XinLei WU peng zhao Hui College of Civil Engineering Nanjing Tech UniversityNanjing 211800China Key Laboratory of Architectural Acoustic Environment of Anhui Higher Education Institutes Hefei 230601China Nanjing Gongda Construction Technology Co.Ltd. Nanjing 211800China

Light frame walls(LFWs) serve as common partition walls in prefabricated buildings due to their lightweight nature, costeffectiveness, energy efficiency, and adaptability for rapid on-site assembly. However, their acoustic insulation capability is hindered by issues such as sound bridges, resonance, and coincidence dips, resulting in inadequate sound insulation. This study aims to propose LFW designs with superior acoustic insulation suitable for practical engineering while meeting prevailing national standards. Nine full-scale LFW configurations were subjected to laboratory testing to evaluate the impact of staggered stud arrangements, stud types, and incorporation of compounded materials. The tests were performed between 100 and 5000 Hz,and the sound pressure level and reverberation time at 1/3 octave band were measured and used to calculate the weighted sound insulation index(Rw). Results demonstrated that the outlined design modifications significantly enhanced the sound insulation of the LFW. These modifications effectively mitigate the influence of sound bridges while addressing resonance and coincidence dips inherent in the wall system. Particularly noteworthy was the superior sound insulation achieved by staggered-stud LFWs with compounded materials, surpassing that of autoclaved lightweight concrete walls commonly used in prefabricated constructions despite having lesser thickness and surface density. Rwvalues increased from 43 to 54 dB compared to conventional LFWs, translating to a notable elevation in airborne sound insulation level from 4 to 7 as an internal separation component,meeting the requisite standards for most applications.

关键词： light frame wall staggered stud airborne sound insulation weighted sound insulation index

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