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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan jiao Lingyan meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

属性集容量确定的夹挤式测度模式及其推算模型

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中国管理科学 2018年第3期26卷 117-125页

作者：李春好李孟姣田硕吉林大学管理学院

迄今,为解决多属性偏好关联决策属性集容量判断指数复杂性难题所提出的λ模糊测度模式与k-可加模糊测度模式,以及建构在它们之上的属性集容量确定的推算模型,尚存在着适用性差的技术不足。为此,以平衡容量判断的可操作性和容量推算的准... 详细信息

迄今,为解决多属性偏好关联决策属性集容量判断指数复杂性难题所提出的λ模糊测度模式与k-可加模糊测度模式,以及建构在它们之上的属性集容量确定的推算模型,尚存在着适用性差的技术不足。为此,以平衡容量判断的可操作性和容量推算的准确性为视角,提出了一种新容量测度模式,即关于容量判断与推算的夹挤式测度模式,并在此基础上通过引入决策者较易判断给出的容量序信息构建了相应的容量推算模型。基于数值模拟的对比分析表明：新模式不仅在应用可行性上高于k-可加模糊测度模式,而且从容量推算的准确性上看也明显优于λ模糊测度模式和k-可加模糊测度模式,因而对实际决策具有更强的适用性。

关键词：多属性决策属性偏好关联属性集容量 λ模糊测度 k-可加模糊测度夹挤式测度模式

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8个矮牵牛品种抗旱性综合评价分析

西北林学院学报 2018年第2期33卷 62-69,187页

作者：关春景焦孟月张彦妮东北林业大学园林学院黑龙江哈尔滨150040

以常用的8种绿化地被矮牵牛(Petunia hybrida)品种为材料,在盆栽条件下测定8个品种不同水分梯度下植株的净光合速率、蒸腾速率、水分利用率、相对含水量、叶绿素含量、超氧化物歧化酶、过氧化物酶和过氧化氢酶等生理指标的变化,同时观... 详细信息

以常用的8种绿化地被矮牵牛(Petunia hybrida)品种为材料,在盆栽条件下测定8个品种不同水分梯度下植株的净光合速率、蒸腾速率、水分利用率、相对含水量、叶绿素含量、超氧化物歧化酶、过氧化物酶和过氧化氢酶等生理指标的变化,同时观察其形态变化。之后利用隶属函数对8个品种耐旱性进行综合评价。结果表明,随着干旱程度的增加各个品种开花率、花径大小、植株高度、净光合速率、蒸腾速率、相对含水量和叶绿素含量均呈逐渐降低的趋势;水分利用率出现先增加后降低的趋势,SOD、POD和CAT酶活性、丙二醛含量和可溶性蛋白含量逐渐升高。根据隶属函数值比较8个品种矮牵牛的抗旱性大小,依次为3号>6号>4号>2号>5号>1号>8号>7号。这为矮牵牛抗旱的筛选提供参考,为抗旱育种和园林应用提理论依据。

关键词：矮牵牛生理指标抗旱性评价隶属函数

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某些激素和药物对小麦叶片衰老的影响

内蒙古大学学报(自然科学版) 1985年第1期 87-93页

作者：张桂春李梦琏焦美俊内蒙古大学生物系内蒙古大学生物系内蒙古农牧学院呼和浩特市环保所

首先测定了不同温度和叶龄对离体小麦叶片衰老的影响。并用不同浓度的 KT、IAA、GA、MH 和 ABA 处理离体小麦叶片,证明前四种具有不同程度的延缓衰老作用,以 KT3ppm处理效果最显著。ABA 则促进衰老。在供试的五种药物中苯巴比妥钠和阿... 详细信息

首先测定了不同温度和叶龄对离体小麦叶片衰老的影响。并用不同浓度的 KT、IAA、GA、MH 和 ABA 处理离体小麦叶片,证明前四种具有不同程度的延缓衰老作用,以 KT3ppm处理效果最显著。ABA 则促进衰老。在供试的五种药物中苯巴比妥钠和阿斯匹林对离体小麦叶片也具有一定的延缓衰老作用。

关键词：小麦叶片日进程离体激素小麦麦类作物药物

Systematic comparison of Kawasaki disease Z-score formulas:Enhancing diagnostic accuracy and clinical applicability across populations

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World Journal of Clinical Pediatrics 2025年第1期14卷 63-68页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children's HospitalShaanxi Provincial People's Hospital of Xi'anJiaotong UniveristyXi'an 710000Shaanxi ProvinceChina

This study aims to evaluate the performance of six distinct Z-score formulas in diagnosing coronary artery dilation in Kawasaki disease(KD)patients,with a focus on their clinical applicability across diverse populations.A retrospective analysis was conducted using comparative statistical methods to assess the sensitivity and specificity of each *** Kobayashi and Dallaire formulas demonstrated the highest sensitivity in China,particularly in younger patients with prolonged fever *** findings provide evidence-based recommend-ations for selecting Z-score formulas to optimize diagnostic precision in KD patients.

关键词： Kawasaki disease Early diagnosis Z-score Children

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert chunhua Zhao jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu Guang Yin Fan‑Zhen jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods