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Discovery of ErbB/HDAC inhibitors by combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285

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Chinese Chemical Letters 2017年第6期28卷 1220-1227页

作者： Chao Ding Dan Li Yan-Wei Wang sai-sai Han chun-mei Gao chun-Yan Tan Yu-Yang Jiang Department of Chemistry Tsinghua University Beijing 100084 China The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology The Graduate School at Shenzhen Tsinghua University Shenzhen518055 China Department of Pharmacology and Pharmaceutical Sciences School of Medicine Tsinghua University Beijing 100084 China

By combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285 with 1,2,3-triazole as linker,eight novel 6-substituted-4-aminoquinazolin derivatives were synthesized and characterized by -1H NMR,-（13）C NMR,and high resolution mass *** inhibitory activities against five enzymes（VEGFR2,HER2,EGFR,HDAC1,and HDAC6） and five cancer cell lines（A549,BT-474,A431,SK-BR-3,and NCI-H1975） were *** bioassay results show that the introduction of triazole linked vorinostat-like segment dramatically changed the selectivity profiles of newly synthetic compounds relative to vandetanib,BMS-690514,neratinib,and *** them,compound 6b exerted outstanding enzymatic and cellular activities through its simultaneous and synergistic inhibitions on multiple pathways,which might have the great potential to confer the better benefits than single-targeted inhibitors in cancer therapy.

关键词： Anticancer Kinase HDAC Multitarget Selectivity

Two Weighted Estimates for the Commutators of Multilinear Maximal Singular Integral Operators with Dini-type Kernels

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Acta Mathematica Sinica,English Series 2023年第3期39卷 459-480页

作者： chun mei ZHANG School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China

The main purpose of this paper is to investigate the properties of the higher order commutators of maximal Calderón-Zygmund operators with Dini-type *** weighted estimates have been established for these *** results ... 详细信息

关键词： Commutators sparse domination multlinear maximal singular integral operators Dinitype kenels two weighted boundedness

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Perfect Matching in k-partite k-graphs and 3-uniform HM-bipartite Hypergraphs

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Acta Mathematicae Applicatae Sinica 2020年第3期36卷 636-641页

作者： chun-qiu FANG mei LU Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China

Let H=(V,E)be an n-balanced k-partite k-graph with partition classes V1,...,*** for every legal(k-1)-tuple f contained in V\V1 and for every legal(k-1)-tuple g contained in V\Vk such that f∪g■E(H),we have d(f)+d(g)≥n+*** this paper,we prove that under this condition H must have a perfect *** result of this paper is about the perfect matching in 3-uniform hm-bipartite *** G be a 3-uniform hm-bipartite hypergraph with one of whose sides V1 has the size n,the another side V2 has size 2 *** for all the legal 2-tuple f with|f∩V1|=1 and for all the legal 2-tuple g with|g∩V1|=0,we have d(f)≥n-2 and d(g)>n/2,then G has a perfect matching.

关键词： Perfect matching k-partite k-graph hm-bipartite hypergraph

Robust Correlation Clustering Problem with Locally Bounded Disagreements

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Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： sai Ji Min Li mei Liang Zhenning Zhang Institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations Research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as *** a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected *** goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most ***,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering *** paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with *** parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite ***,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding

Aromatic Polyimides with Tertbutyl-substituted and Pendent Naphthalene Units:Synthesis and Soluble,Transparent Properties

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Chinese Journal of Polymer Science 2015年第8期33卷 1074-1085页

作者： Chan-juan Liu mei mei Xiang-lin Pei 黄孝华 chun Wei Key Laboratory of New Processing Technology for Nonferrous Metal & Materials Ministry of Educationand School of Material Science and EngineeringGuilin University of Technology Ministry of Education Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical ScienceGuangxi Normal University

A novel non-coplanar aromatic diamine monomer, 3,3＇-ditertbutyl-4,4＇-diaminodiphenyl-4＂-naphthylmethane （TAPN） was synthesized by a condensation reaction of 2-tertbutylaniline and 1-naphthaldehyde under catalyst hydrochloric acid. The structure of the monomer was confirmed by FTIR, NMR, elementary analysis and mass spectrometry. A series of aromatic polyimides （PIs） were synthesized via conventional one-step polycondensation from TAPN and various commercial aromatic dianhydrides. All of the PIs exhibit excellent solubility in common organic solvents, even in low boiling point solvents such as chloroform （CHC13）, tetrahydrofuran （THF） and acetone. The PIs present outstanding thermal stability with the glass transition temperature （Tg） ranged from 299 ℃ to 350 ℃, and the temperature at 10% weight loss ranged from 490 ℃ to 504 ℃, and high optical transparency with the cutoff wavelengths of 306-356 nm. Moreover, the flexible and tough PI films have prominent mechanical properties with tensile strengths in the range of 77.6-90.5 MPa, tensile modulus in the range of 1.8-2.4 GPa and elongation at break in the range of 6.3%-9.5%, as well as lower dielectric constant （2.89-3.12 at 1 MHz） and lower moisture absorption （0.35%-0.66%）.

关键词： Polyimides Solubility Dielectric constant Tertbutyl Naphthyl.

A Khovanov Type Link Homology with Geometric Interpretation

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Acta Mathematica Sinica,English Series 2016年第4期32卷 393-405页

作者： mei Li ZHANG Feng chun LEI School of Mathematical Sciences Dalian University of Technology Department of Basis Dalian Naval Academy

We study a Khovanov type homology close to the original Khovanov homology theory from Frobenius *** homology is an invariant for oriented links up to isotopy by applying a tautological functor on the geometric *** homology has also geometric descriptions by introducing the genus generating *** prove that Jones Polynomial is equal to a suitable Euler characteristic of the homology *** an application,we compute the homology groups of（2,k）-torus knots for every k ∈ N.

关键词： Frobenius system TQFT Khovanov homology

Multi-mode Coherent-Entangled State Representation and Its Applications

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Communications in Theoretical Physics 2008年第11期50卷 1081-1088页

作者： LI Heng-mei YUAN Hong-chun Institute for Theoretical Physics and Department of Modern Physics University of Science and Technology of China Hefei 230026 China Department of Physics Huaibei Coal Industry Teachers＇ College Huaibei 235000 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China

We introduce the so-called coherent-entangled state (CES) in the four-mode Fock space,which makesup a new quantum mechanical representation owing to completeness relation and orthogonal *** standardSchmidt decomposition and experimental generation using beam-splitter (BS) are *** addition,its applicationsin quantum optics are ***,we extend it to multi-mode case and discuss some applications,too.

关键词： coherent-entangled state (CES) representation beam splitter (BS)

Loss of fragile histidine triad protein expression in inflammatory bowel disease

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World Journal of Gastroenterology 2006年第45期12卷 7355-7360页

作者： chun-mei Xu Chuan-Hu Qiao Department of Gastrocnterology Xiangfan No.1 Hospital 75 Jiefang Road Xiangfan 441000 Hubei Province China

AIM： To investigate the expression of fragile histidine triad （FHIT） protein in 64 patients with ulcerative colitis （UC） and Crohn＇s disease （CD）, and its relation with clinicopathological data. METHODS： Rabbit-anti-FHIT antibody was used to detect FHIT protein expression in 64 formalin-fixed, paraffin-embedded tissue specimens of inflammatory bowel disease （IBD） by citrate-microwave-streptavidin （SP）-HRP immunohistochemical method. RESULTS： The positive FHIT protein expression was 22.79% ± 16.16%, 42.14% ± 16.82% in active and remittent phases of UC, 36.07% ± 19.23% in CD, and 57.05% ±8.86% in normal colon mucosa. Statistically significant differences in FHIT protein expression were observed between the active and remittent phases of UC, between the active phase of UC and normal colon mucosa, as well as between the remittent phase of UC and normal colon mucosa, and between CD and normal colon mucosa. CONCLUSION： Our results show that FHIT protein expression is completely absent or reduced in IBD, suggesting that the FHIT gene might be associated with the oncogenesis and progression of IBD, an early event from inflammatory conditions to carcinoma in IBD.

关键词： Fragile histidine triad protein expression Ulcerative colitis Crohn's disease Inflammatory bowel disease

Effects of Time Delay on Stability of an Unstable State in a Bistable System with Correlated Noises

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Chinese Physics Letters 2011年第4期28卷 40-42页

作者： LI chun mei Dong-Cheng Department of Computer Science Simao Teachers’CollegePuer 665000 Department of Physics Yunnan UniversityKunming 650091

Effects of time delay on stability of an unstable state in a time-delayed bistable system are *** analytic expression of the transition rate W(x_(u),τ)from unstable state xu to stable state x+is *** numerical calculation results of W(x_(u),τ)indicate that W(x_(u),τ)decreases with the increasing multiplicative noise intensity,the additive noise intensi by and the strength of correlations between the multiplicative and the additive noise increase,but W(x_(u),τ)increases with increasing delay ***,the multiplicative noise,the additive noise and the correlations between the multiplicative and the additive noises enhance the stability of the unstable state in the time-delayed bistable system but the stability is weakened by time delay.

关键词： unstable noise Effects