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Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 475-492页

作者： Hong-mei Wu Yuan-Yuan Huang Yu-Qiu Xu Wei-Lai Xiang Chang Yang Ru-Yuan Liu Di Li Xue-Feng Guo Zheng-Bao Zhang chun-Hua Bei Sheng-Kui Tan Xiao-Nian Zhu Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health Guilin Medical UniversityGuilin 541199Guangxi Zhuang Autonomous RegionChina

BACKGROUND B56εis a regulatory subunit of the serine/threonine protein phosphatase 2A,which is abnormally expressed in tumors and regulates various tumor cell *** present,the application of B56εin pan-cancer lacks a comprehensive analysis,and its role and mechanism in hepatocellular carcinoma(HCC)are still *** Cancer Genome Atlas,Genotype-Tissue Expression,Gene Expression Profiling Interactive Analysis,and Tumor Immune Estimation Resource databases were used to analyze B56εexpression,prognostic mutations,somatic copy number alterations,and tumor immune characteristics in 33 *** relationships between B56εexpression levels and drug sensitivity,immuno-therapy,immune checkpoints,and human leukocyte antigen(HLA)-related genes were further *** Set Enrichment Analysis(GSEA)was performed to reveal the role of B56εin *** Cell Counting Kit-8,plate cloning,wound healing,and transwell assays were conducted to assess the effects of B56εinterference on the malignant behavior of HCC *** In most tumors,B56εexpression was upregulated,and high B56εexpression was a risk factor for adrenocortical cancer,HCC,pancreatic adenocarcinoma,and pheochromocytoma and paraganglioma(all P<0.05).B56εexpression levels were correlated with a variety of immune cells,such as T helper 17 cells,B cells,and *** was a positive correlation between B56εexpression levels with immune checkpoint genes and HLA-related genes(all P<0.05).The expression of B56εwas negatively correlated with the sensitivity of most chemotherapy drugs,but a small number showed a positive correlation(all P<0.05).GSEA analysis showed that B56εexpression was related to the cancer pathway,p53 downstream pathway,and interleukin-mediated signaling in *** of B56εexpression in HCC cells inhibited the proliferation,migration,and invasion capacity of tumor *** Tip:The expression of protein phosphatase 2A(PP2A)subunit B56εis up-regulated in most tumors,and its high

关键词： B56ε Prognosis Tumor microenvironment Immune infiltration Immunotherapy Hepatocellular carcinoma

The FAST all sky HI survey(FASHI):The first release of catalog

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 112-133页

作者： Chuan-Peng Zhang Ming Zhu Peng Jiang Cheng Cheng Jing Wang Jie Wang Jin-Long Xu Xiao-Lan Liu Nai-Ping Yu Lei Qian Haiyang Yu mei Ai Yingjie Jing Chen Xu Ziming Liu Xin Guan chun Sun Qingliang Yang Menglin Huang Qiaoli Hao FAST Collaboration Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China National Astronomical Observatories Chinese Academy of Sciences(CAS)Beijing 100101China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

The FAST All Sky HI survey(FASHI)was designed to cover the entire sky observable by the Five-hundred-meter Aperture Spherical radio Telescope(FAST),spanning approximately 22000 square degrees of declination between-14°and+66°,and in the frequency range of 1050-1450 MHz,with the expectation of eventually detecting more than 100000 HI *** August 2020 and June 2023,FASHI had covered more than 7600 square degrees,which is approximately 35%of the total sky observable by *** has a median detection sensitivity of around 0.76 m Jy beam-1and a spectral line velocity resolution of~6.4 km s-1at a frequency of~1.4 *** of now,a total of 41741 extragalactic HI sources have been detected in the frequency range 1305.5-1419.5 MHz,corresponding to a redshift limit of z■*** cross-matching FASHI sources with the Siena Galaxy Atlas(SGA)and the Sloan Digital Sky Survey(SDSS)catalogs,we found that 16972(40.7%)sources have spectroscopic redshifts and 10975(26.3%)sources have only photometric *** of the remaining 13794(33.0%)HI sources are located in the direction of the Galactic plane,making their optical counterparts difficult to identify due to high extinction or high contamination of Galactic stellar *** on current survey results,the FASHI survey is an unprecedented blind extragalactic H I *** has higher spectral and spatial resolution and broader coverage than the Arecibo Legacy Fast ALFA Survey(ALFALFA).When completed,FASHI will provide the largest extragalactic HI catalog and an objective view of HI content and large-scale structure in the local universe.

关键词： surveys redshifts galaxies telescope radio lines HI line

Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer:A bidirectional Mendelian randomization study

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World Journal of Clinical Cases 2024年第25期12卷 5729-5738页

作者： chun-mei Lin Qian Meng Ying-Jun Li Shuang-Xi Zhang Qiong-Xi Luo Zhen-Yu Dai Postgraduate Student Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology Guangzhou University of Chinese Medicine Shunde HospitalFoshan 528300Guangdong ProvinceChina

BACKGROUND Previous epidemiologic investigations have consistently demonstrated a strong association between the ratio of cholesterol to total lipids in medium very-lowdensity lipoprotein(VLDL)and the occurrence of peptic ulcers(PU).However,the precise causal relationship between these factors remains ***,this study aims to elucidate the potential correlation between the ratio of cholesterol to total lipids in medium VLDL and the incidence of peptic *** To investigate the ratio of cholesterol to total lipids in medium very-low-density lipoprotein(VLDL)association with PU via genetic methods,guiding future clinical *** Genome-wide association study(GWAS)datasets for the ratio of cholesterol to total lipids in intermediate VLDL and peptic ulcer were retrieved from the IEU OpenGWAS project(https://***).For the forward Mendelian randomization(MR)analysis,72 single nucleotide polymorphisms(SNPs)were identified as instrumental *** SNPs were selected based on their association with the ratio of cholesterol to total lipids in intermediate VLDL,with peptic ulcer as the outcome ***,for the inverse MR analysis,no SNPs were identified with peptic ulcer as the exposure variable and the ratio of cholesterol to total lipids in intermediate VLDL as the *** MR analyses utilized inverse variance weighted(IVW)as the primary analytical ***,weighted median and MR-Egger methods were employed as supplementary analytical approaches to assess causal *** regression was used as a supplementary method to evaluate potential directional *** and multiplicity tests were conducted using the leave-one-out method to evaluate result stability and mitigate biases associated with multiple *** The genetically predicted ratio of cholesterol to total lipids in medium VLDL was significantly associated with an elevated risk of peptic ulcer(IVW:OR=2.557,95%CI=1.274

关键词： Ratio of cholesterol to total lipids in medium VLDL Peptic ulcer Mendelian randomization Casual effect Single nucleotide polymorphism

含有圆孔平板电极结构的双凸液体透镜的设计与分析

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物理学报 2024年第1期73卷 211-217页

作者：孔梅梅薛银燕徐春生董媛刘悦潘世成赵瑞南京邮电大学电子与光学工程学院、柔性电子(未来技术)学院南京210023 南京南瑞信息通信科技有限公司南京211100

基于平行平板电极的变焦液体透镜的有关研究,通过应用介电泳效应,提出了一种含有圆孔平板电极结构的双凸液体透镜模型,是一种新型的三层液体透镜结构.利用Comsol,Matlab和Zemax软件仿真分析了该模型在不同电压下的面型变化与成像光路,... 详细信息

基于平行平板电极的变焦液体透镜的有关研究,通过应用介电泳效应,提出了一种含有圆孔平板电极结构的双凸液体透镜模型,是一种新型的三层液体透镜结构.利用Comsol,Matlab和Zemax软件仿真分析了该模型在不同电压下的面型变化与成像光路,得出其变焦范围为22.6—15.9 mm,并对制备的器件进行具体的实验分析,获得了不同电压下双凸液体透镜的液滴上下界面面型和该透镜的变焦范围23.8—17.5 mm,与仿真结果基本一致,而且其成像分辨率可达到45.255 lp/mm.结果表明,所提出的这种新型三层液体结构的双凸液体透镜具有结构简单、易于实现的特点,而且具备良好的成像质量.

关键词：双凸液体透镜介电泳效应变焦成像质量

我国数字乡村试点的政策工具偏好及区域差异——基于全国72个试点县域的扎根分析

同方期刊数据库博看期刊评论

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东北师大学报（哲学社会科学版） 2024年第1期 111-125页

作者：谢小芹张春梅西南财经大学公共管理学院四川成都611100

以数字技术赋能乡村建设是推动农业农村现代化转型的必然要求,也是实现乡村振兴、推动共同富裕的重要战略目标。自2020年中央一号文件首次提出数字乡村试点以来,全国各试点地积极推进数字乡村建设实践。已有研究或从乡村发展与变迁视角... 详细信息

以数字技术赋能乡村建设是推动农业农村现代化转型的必然要求,也是实现乡村振兴、推动共同富裕的重要战略目标。自2020年中央一号文件首次提出数字乡村试点以来,全国各试点地积极推进数字乡村建设实践。已有研究或从乡村发展与变迁视角来阐释数字化建设对于乡村高质量发展的战略意义,或从数字治理视角呈现数字化驱动乡村治理的过程和机制,而较少关注“试点”政策本身,更缺乏政策工具的类型学归纳和分析。基于政策工具视角,研究对全国72个数字乡村试点县域的一、二手资料进行扎根分析,最终提炼出能力建设型、协同治理型和创新激励型三类政策工具,并在此基础上构建数字乡村建设的“价值实践张力—动力机制—政策工具选择—政策目标实现”分析框架。研究表明,以政府主导为依托的能力建设型工具处于绝对优势地位,在此基础上叠加协同治理型与创新激励型两类政策工具,共同促进数字乡村建设的纵深发展。具体而言,东部沿海及部分中部地区因其自身物质基础较好,偏重多种政策工具的组合运用,西部及东北地区则更偏好能力建设型工具的运用。然而政策工具的选取并非一成不变,而是随着情境的变化由单一转向动态化与多样化。本研究可为数字乡村试点的深入推进提供工具借鉴,也可为相关部门的决策提供参考。

关键词：政策工具数字乡村政策试点政策环境扎根理论

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Brain development in newborns and infants after ECMO

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World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan Lu-Kun Tang Fei-Fan Xiao Peng Zhang Guo-Qiang Cheng Lai-Shuan Wang chun-mei Lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng Zhou Tian-Tian Xiao Yan Xu Zhao-Qing Yin Gang-Feng Yan Guo-Ping Lu Qi Li Wen-Hao Zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

非线性广义时滞Markov跳变系统的H_(∞)滑模控制

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东北大学学报（自然科学版） 2024年第2期45卷 153-159页

作者：杨冬梅杜玲秀祝春霞东北大学理学院辽宁沈阳110819

研究了一类转移速率部分未知的广义时滞Markov跳变系统的H_(∞)滑模控制问题.首先,对广义时滞Markov跳变系统设计了积分型滑模面,并求出对应的等效控制器.之后,构建Lyapunov泛函,通过线性矩阵不等式方法得到闭环系统随机容许且满足H_(∞... 详细信息

研究了一类转移速率部分未知的广义时滞Markov跳变系统的H_(∞)滑模控制问题.首先,对广义时滞Markov跳变系统设计了积分型滑模面,并求出对应的等效控制器.之后,构建Lyapunov泛函,通过线性矩阵不等式方法得到闭环系统随机容许且满足H_(∞)性能γ的充分条件,运用加减项方法以及引入自由权矩阵,使得到的结果降低了保守性;对滑模力学分析,设计了滑模控制器,使得系统能在有限时间内到达滑模面上.最后,通过数值算例与仿真验证了理论的可行性.

关键词： Markov跳变系统时滞系统滑模控制广义系统线性矩阵不等式

紫云英压青结合稻秸还田对水稻的节肥增效作用

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植物营养与肥料学报 2024年第2期30卷 279-288页

作者：刘彩玲何春梅王飞黄春应福建省农业科学院资源环境与土壤肥料研究所福建福州350013 三明市农田建设与土肥技术推广站福建三明365000

【目的】紫云英压青结合稻秸还田是降低化肥用量、提高肥料利用率的绿色有效措施。在福建灰(黄)泥田多地开展田间试验,以验证该措施的有效性。【方法】田间试验分别在福建沙县、顺昌县、浦城县进行,沙县供试水稻为头茬再生稻,顺昌和浦... 详细信息

【目的】紫云英压青结合稻秸还田是降低化肥用量、提高肥料利用率的绿色有效措施。在福建灰(黄)泥田多地开展田间试验,以验证该措施的有效性。【方法】田间试验分别在福建沙县、顺昌县、浦城县进行,沙县供试水稻为头茬再生稻,顺昌和浦城为单季稻。所有试验均设置5个处理:不施肥(CK)、100%常规化肥(100%CF)、80%常规化肥(80%CF)、种植翻压紫云英+80%常规化肥(CMV+80%CF)、稻秸还田+种植翻压紫云英+80%常规化肥(RS+CMV+80%CF)。在水稻成熟期,调查产量和产量经济性状,分析氮磷钾养分积累量,并计算水稻产量的变异系数和可持续指数。【结果】与100%CF处理相比,CMV+80%CF和RS+CMV+80%CF处理三地稻谷平均产量和稻秸平均产量增加不显著,但在沙县稻秸产量显著增加33.7%和26.1%。100%CF处理对产量的贡献率较80%CF处理增加了2.74个百分点;CMV+80%CF、RS+CMV+80%CF处理对水稻产量的贡献率较80%CF处理分别提高了7.73%、11.30%,三地RS+CMV+80%CF处理稻谷平均产量比CMV+80%CF处理提高3.9%。各处理间水稻产量变异系数表现为RS+CMV+80%CFCMV+80%CF>100%CF>80%CF,翻压紫云英、紫云英与稻秸联合还田均有利于水稻持续性高产稳产,且紫云英与稻秸联合还田的效果明显高于紫云英单独翻压。翻压紫云英、紫云英与稻秸联合还田均有利于水稻氮、磷、钾养分的累积,与100%CF处理相比,CMV+80%CF处理的平均氮、磷、钾养分回收率分别增加了19.1、20.1、29.5个百分点,RS+CMV+CMV+80%CF处理分别增加了19.3、8.8、30.6个百分点,RS+CMV+80%CF处理的氮、钾养分回收率高于CMV+80%CF处理。RS+CMV+80%CF处理的氮肥农学利用率和氮肥偏生产力最大,较100%CF处理分别增加了76.38%和8.99%。【结论】无论再生稻还是单季稻,在减施化肥用量20%的条件下,紫云英压青结合稻秸还田有利于水稻稳产和产量的可持续性,同时提高养分回收率,增强节肥增效作用,可作为灰黄泥田水稻绿色高效生产的管理制度。

关键词：紫云英稻秸联合还田产量养分利用率

Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

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Nano Research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing Joshua M.Little Haochen Yang Tsai-chun chung Po-Yen Chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft ***,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality