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World Journal of Clinical Cases 2021年第5期9卷 1175-1183页

作者： Yang Yang Li-Juan Fu chun-mei chen mei-Wei Hu Department of Hematology The Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Conventional therapies for primary plasma cell leukemia(pPCL)are usually ineffective,with a short remission time with the use of multiple myeloma medications,showing aggressiveness of pPCL.B-cell lymphoma-2 inhibitor venetoclax is usually used for relapsed/refractory multiple myeloma(RRMM)with t(11;14).There are very few studies published on the use of venetoclax in pPCL without t(11;14).Similarly,histone deacetylase inhibitors are considered effective for the treatment of RRMM,but there are no reports on their use in *** SUMMARY A 57-year-old woman with severe anemia,thrombocytopenia,multiple bone destruction,impaired renal function,and 42.7%of peripheral plasma cells is *** multiple chemotherapy regimens and chimeric antigen receptor Tcell treatment,the disease progressed *** patient had very good partial response and was maintained for a long time on venetoclax in combination with chidamide and dexamethasone *** The success of venetoclax-chidamide-dexamethasone combination therapy in achieving a very good partial response suggested that it can be used for refractory/relapsed pPCL patients who have been exhausted with the use of various drug combinations and had poor survival outcomes.

关键词： Relapsed/refractory Primary plasma cell leukemia Venetoclax Chidamide Very good partial response Case report

Catalytic conjugate addition of indole toα,β-unsaturated ketones by Co(ClO_4)-2·6H_2O/bis-Schiff base complexes

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Chinese Chemical Letters 2012年第5期23卷 525-528页

作者： Yong Hai Hui chun mei chen Zheng Feng Xie Key Laboratory of Oil and Gas Fine Chemicals Ministry of Education and Xinjiang Uyghur Autonomous RegionCollege of Chemistry and Chemical EngineeringXinjiang UniversityUrumqi 830046China

Co（ClO_4））_2·6H_2O/bis-Schiff base complexes promoted the conjugate addition of indole toα,β-unsaturated ketones under mild conditions,giving the corresponding addition products with high *** the complex has bee... 详细信息

关键词： Conjugate addition Indole α β-Unsaturated ketone Schiff base

Diversified Polyketides and Nitrogenous Compounds from the Mangrove Endophytic Fungus Penicillium steckii SCSIO 41025

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Chinese Journal of Chemistry 2021年第8期39卷 2132-2140页

作者： chun-mei chen Wei-Hao chen Hua-Ming Tao Bin Yang Xue-Feng Zhou Xiao-Wei Luo Yong-Hong Liu CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhouGuangdong 510301China Institute of Marine Drugs Guangxi University of Chinese MedicineNanningGuangxi 530200China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) GuangzhouGuangdong 511458China University of Chinese Academy of Sciences Beijing 100049China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhouGuangdong 510515China

Four new polyketide decalin derivatives,penicisteck acids A-D(1-4),and three new nitrogenous compounds(7-9)z together with eight previously reported compounds,were isolated from the mangrove endophytic fungus Penicill... 详细信息

关键词： Mangrovee ndophytic fungus Penicillium steckii Polyketides Alkaloids Biological activity

Treatment of a dyeing wastewater from a woolen mill using an A/O membrane bio-reactor

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Journal of Environmental Sciences 2000年第3期12卷 344-348页

An anaerobic/oxic membrane bioreactor (A/O MBR) was used for treatment of dyeing wastewater from a woolen mill. COD and color of the wastewater were 54—473 mg/L and 40—400 dilution time (DT) respectively. The ratio of BOD 5/COD was less than 0.13. By the A/O MBR process, the average removal of COD, BOD 5, color and turbidity was 82%, 96%, 71% and 99%, respectively. The average COD, BOD 5, color and turbidity of effluent was 37 mg/L, 0.8 mg/L, 40 DT and 0.44 NUT respectively. The effluent COD met the local standard of reuse water in Beijing, China. The average COD volume load of the anaerobic biological tank was 0.0483 kgCOD/(m 3·d) and that of the aeration tank of the MBR was 0.3589 kgCOD/(m 3·d). The sludge load of the MBR was 0.19 kgCOD/(kg·MLSS·d) on average and the maximum of that was 0.4 kgCOD/(kg·MLSS·d). The flux of the A/O membrane bioreactor could be remained at larger than 50 L/(h·m 2·0.1MPa). The results indicated that A/O membrane bioreactor has technical feasibility for treatment of woolen mill wastewater.

关键词： membrane bioreactor dyeing wastewater biological process membrane technology activated sludge

Hyperisampsins N and O,two new benzoylated phloroglucinol derivatives from Hypericum sampsonii

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Chinese Chemical Letters 2017年第5期28卷 986-990页

作者： Hu-cheng Zhu chun-mei chen Jin-Wen Zhang Yi Guo Dong-Dong Tan Guang-Zheng Wei Jing Yang Jian-Ping Wang Zeng-Wei Luo Yong-Bo Xue Yong-Hui Zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204China

Twenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii,including two new ones named hyperisampsins N and O（1 and 2）.The structures of 1 and 2 were elucidated by extensive NMR and mass spectrometric *** absolute configurations were further determined by using TDDFT ECD *** 2,7,and 8 were evaluated for their cytotoxic activities against five human cancer cell lines,of which,2 and 8 exhibited significant cytotoxic activities toward HL-60 cell and moderate activities against others cell lines.

关键词： Hyperisampsin PPAPs ECD calculation Absolute configuration

Strain rate imaging in assessing the size of acute ischemic myocardium in dogs

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Chinese Medical Journal 2009年第2期122卷 193-198页

作者： MU Yu-ming GUAN Li-na WANG chun-mei TANG Qi chen Xiao-feng HAN Wei EchocardiographicDepartment First Teaching Hospital of Xinjiang Medical University Urumqi Xinjiang 830000 China

Background Since the size of ischemic myocardium is closely related with both global and regional function of the myocardium, it is of great significance to measure the size of ischemic myocardium with non-invasive methods. Methods Eleven mongrel dogs were subjected to occlusion of the left anterior descending coronary artery for acute ischemia. Strain rate imaging had M-mode of strain-rate （CAMM） curve pointed from the basal segment of the anterior wall to the basal segment of the inferior wall to detect the border of ischemia size. The strain rate （SR） defined the cut-off value of ischemic myocardium in a two-chamber apical view, and marked by the anterior and inferior wall on two-dimensional images respectively. Along the endocardium and epicardium, the ischemic size was curved on two-dimensional images by the trackball method and then compared with the pathologically ischemic size. And then longitudinal strain rates were compared in the cut-off value, adjacent non-ischemic and ischemic segments at which the cut-off point was defined by changing the curve M-mode of strain rate after ischemia. Results Linear correlation existed between pathology and strain rate ischemic size （r=0.884, P 〈0.001）. The SR parameters were lower in ischemia and cut-off point than in non-ischemic segments. The peak SRs of systole （SSR）, early diastole （EsR）, late diastole （ASR）, strain during ejection time （εet）, and the maximum length change during the entire heart cycle （Emax） in ischemic segments lowered （P〈0.05）. Time to onset of regional relaxation （TR） was prolonged （P=0.012）. Conclusion SR imaging can accurately assess the size of ischemic myocardium. Chin Med J 2009; 122（2）： 193-198

关键词： size of acute ischemic myocardium strain rate imaging curved M-mode of strain rate

3D Geology Modeling from 2D Prospecting Line Profile Map

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International Journal of Geosciences 2015年第2期6卷 180-189页

作者： Qing-Yuan Li Yang Cui chun-mei chen Qian-Lin Dong Zi-Xiang Ma Key Laboratory of Geo-Informatics Chinese Academy of Surveying & Mapping Beijing China School of Mapping & Geographical Science Liaoning Technical University Fuxin China College of Geoscience & Surveying Engineering China University of Mining and Technology (Beijing) Beijing China

Using prospecting line profile map in combination with drilling and other information for 3D reconstruction of geological model is an important method of 3D geological modeling.?This paper?discusses the theory and implementation method of 2D prospecting line map into 3D prospecting line map and then into 3D model. The authors propose that it needs twice upgrading dimension to reconstruction 3D geology model from prospecting line profile map. The first upgrading dimension is to convert profile from 2D into 3D profile,?i.e.?the 2D points in the 2D profile map upgrading dimensional transformation to 3D points in a 3D profile. The second upgrading dimension is that transform 0D point 1D curve and 2D polygon feature into 1D curve, 2D surface and 3D solid feature. The paper reexamines contents and forms in prospecting line map from the two different viewpoints of geology and geographic information science. The process of 3D geology modeling from 2D prospecting map is summarized as follows. Firstly, profile is divided into several sections by beginning, end and drill point of the prospecting line. Next, a 3D folded upright profile frame is built by 2D folded prospecting line on the plan map. Then, 2D points of features on 2D profile are converted into 3D points on 3D profile section by section. And then, adding switch control points for the long line crossover two segments. Lastly, 1D curve features are upgraded to 2D surface.

关键词： Prospecting Line Profile 3D Geology Modeling Upgrading Dimensional Coordinate Transformation Profile Framework Segmented Convert

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei Zhang Wenhao Li Yangfei chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing chen Shuyuan Bai Qiong Wu Yushan chen Zhen Wei Yufei mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Kinsenoside:A Promising Bioactive Compound from Anoectochilus Species

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 11-18页

作者： Chang-xing QI Qun ZHOU Yuan ZHOU Zeng-wei LUO Chong DAI Hu-cheng ZHU chun-mei chen Yong-bo XUE Jian-ping WANG Ya-fen WANG Ya-ping LIU Ming XIANG Wei-guang SUN Jin-wen ZHANG Yong-hui ZHANG Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 China

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus,and exhibits many biological activities and pharmacological effects,including hepatoprotective,anti-hyperglycemic,anti-hyperliposis,anti-inflammatory,vascular protective and anti-osteoporosis effects and so on,which is contributing to its promising potency in disease *** review aims to recapitulate the pharmacological functions of kinsenoside,as well as its source,extraction,identification,quantitative analysis,pharmacokinetics,synthesis and patent *** data reported in this work can confirm the therapeutic potential of kinsenoside and provide useful information for further new drug development.

关键词： Anoectochilus roxburghii kinsenoside bioactivity synthesis review