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Fault Ride-Through(FRT)Behavior in VSC-HVDC as Key Enabler of Transmission Systems Using SCADA Viewer Software

Energy Engineering 2022年第6期119卷 2369-2406页

作者： Samuel Bimenyimana Chen Wang Godwin Norense Osarumwense Asemota Aphrodis Nduwamungu Francis Mulolani Jean De Dieu Niyonteze Shilpi Bora chun-ling ho Noel Hagumimana Theobald Habineza Waqar Bashir Yiyi Mo Intelligence and Automation in Construction Provincial Higher-Educational Engineering Research Centre Huaqiao UniversityXiamen361021China African Centre of Excellence in Energy for Sustainable Development University of RwandaKigali4285Rwanda Fujian Province Key Laboratory of Automotive Electronics and Electric Drive Fujian University of TechnologyFuzhou350118China Department of Climate Change Observatory Secretariat Ministry of EducationKigali4285Rwanda School of Electrical Engineering and Automation Tianjin Polytechnic UniversityTianjin300000China Department of Electrical and Electronics Engineering Copperbelt UniversityKitwe23456Zambia Ajeenkya D Y PatilUniversity LohegaonPune412105India Carnegie Mellon University-Kigali Rwanda Campus Kigali4285Rwanda

The world’s energy consumption and power generation demand will continue to ***,the bulk of the energy resources needed to satisfy the rising demand is far from the load *** aforementioned requires long-distance transmission systems and one way to accomplish this is to use high voltage direct current(HVDC)transmission *** main technical issues for HVDC transmission systems are loss of synchronism,variation of quadrature currents,amplitude,the inability of station 1(rectifier),and station 2(inverter)to either inject,or absorb active,or reactive power in the network in any circumstances(before a fault occurs,during having a fault in network and after a fault cleared),and the variations of power transfer ***,faults impact power quality such as voltage dips and power line outage *** paper presents a method of overcoming the aforementioned technical issues using voltage-source converter(VSC)based HVDC transmission systems with SCADA VIEWER software and dynamic grid *** benefits include having a higher capacity transmission system and proposed best method for control of active and reactive power transfer *** results obtained using MATLAB validated the experimental results from SCADA Viewer *** results indicate that the station’s rectifier or inverter can either inject or absorb either active power or reactive power in any ***,the reverse power flow under different modes of operation can ride through *** a 100.0%power transfer rate,the rectifier injected 775.0 W into the *** a 0.0%power transfer rate,the rectifier injected 164.0 W into the *** a-100.0%rated power,the rectifier injected 1264.0 W into the network and direction was also changed.

关键词： Fault ride through capability dynamic grid fault simulator asymmetric components negative sequence control

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Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-ho ho Stacia Tsun-Tsun chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-ho Ip Ada Tsui-Lin Ng Yiu-chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary hospital and Princess Margaret hospital,hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health index<25.0,7.4%in prostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(P<0.01).Among the patients,26.9%could have avoided a biopsy with a prostate health index<25.0,at the expense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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(Lu_(1/7)Yb_(1/7)Sc_(1/7)Er_(1/7)Y_(1/7)ho_(1/7)Dy_(1/7))_(2)Si_(2)O_(7)high entropy rare-earth disilicate with low thermal conductivity and excellent resistance to CMAS corrosion

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Journal of Advanced Ceramics 2024年第5期13卷 549-560页

作者： Xu Wang Mingyu Meng Feihan Xu ling Liu Lihong Gao Shizhen Zhu Zhuang Ma School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing 100081China Tangshan Research Institute Beijing Institute of TechnologyTangshan 063000China

Low thermal conductivity,compatible thermal expansion coefficient,and good calcium–magnesium–aluminosilicate(CMAS)corrosion resistance are critical requirements for environmental barrier coatings used on silicon-based ***2Si2O7(RE=rare earth)has been widely recognized as one of the most promising candidates for environmental barrier coatings due to its good water vapor corrosion ***,the relatively high thermal conductivity and poor resistance to CMAS corrosion have limited its practical *** by the high entropy effect,in this work,a novel rare earth disilicate(Lu_(_(1/7))Yb_(_(1/7))Sc_(_(1/7))Er_(_(1/7))Y_(_(1/7))ho_(_(1/7))Dy_(_(1/7)))2Si2O7((7RE_(_(1/7)))2Si2O7)has been designed and synthesized by a solid reaction process.(7RE_(_(1/7)))2Si2O7 showed a low thermal conductivity of 1.81 W·m^(−1)·K^(−1)at 1273 ***,the thermal expansion coefficient of(7RE_(_(1/7)))_(2)Si_(2)O_(7)(4.07×10^(−6)℃^(−1)from room temperature(RT)to 1400℃)is close to that of the SiC-based ceramic matrix composites(SiC-CMCs)((4.5–5.5)×10^(−6)℃^(−1)).Additionally,(7RE_(_(1/7)))2Si2O7 exhibited excellent resistance to CMAS *** exposed to CMAS at 1300℃for 48 h,the reaction layer thickness was 22μ*** improved performance of(7RE_(_(1/7)))2Si2O7 highlights its potential as a promising candidate for thermal/environmental barrier coatings.

关键词： high entropy disilicate (Lu_(1/7)Yb_(1/7)Sc_(1/7)Er_(1/7)Y_(1/7)ho_(1/7)Dy_(1/7))_(2)Si_(2)O_(7)((7RE_(1/7))_(2)Si_(2)O_(7)) high-temperature thermal properties calcium-magnesium-aluminosilicate(CMAS)corrosion

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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha Eun Shin Jun-Hyeok Han Seungyong Shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee ho Park chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

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Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo Young Cho Dong Hae ho Sae Byeok Jo Jeong ho Cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

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A prospective cohort of men with localized prostate cancer on active surveillance protocol in hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-ho Ko Cindy Yeuk-Lam hong Samuel Chi-Hang Yee Jeremy Yuen-chun Teoh Samson Yun-Sang Chan ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter Ka-Fung Chiu SH ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH ho Urology Centre,Prince of Wales hospital,hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer

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Science China Chemistry 2024年第2期67卷 652-663页

作者： Chong Li Minghao Han Ji Gao Shuxian Wang Song-Bo Lu Yaxi Li Zhao Liu Chen Zhang Zhaojin Wang Fangliang Wang Yuang Sun chun Loong ho Kai Wang Yun Shen Kai Li Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen518055China Department of Chemical and Environmental Engineering University of California RiversideRiverside92521USA Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen518055China

The critical factor of spatial constraint,provided by the external confinement(e.g.,matrix),is often overlooked during photodynamic inactivation,despite playing a crucial role in determining the molecular photophysical process and subsequent antipathogen ***,as a proof-of-concept model,we employed two types of polymers with varying interaction energies with dopants to investigate the intrinsic relationship between spatial constraint and the essential excited-state behaviors of doped photosensitizer(4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)ethyl)-1-methylquinolin-1-ium iodine,TPP).Through experimental investigation and theoretical calculations,we found that TPP tends to remain in the excited state for a shorter dwell time under weaker spatial constraints due to less restricted molecular motion in polyurethane(PU) ***,the singlet oxygen(^(1)O_(2)) generated from doped-TPP shows a 9.23-fold enhancement in PU than in the polyvinylchloride(PVC) *** light irradiation,the PU@TPP nanofiber can efficiently eliminate the coronavirus MHV-A59(≥99.9997%) at a 220,000-fold higher concentration than the infected *** antibacterial efficacy has also been demonstrated,with a killing rate of ≥99%.

关键词： photodynamic antibacterial singlet oxygen triphenylamine nanofiber

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Inferior vena cava reconstruction in extended right hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 533-534页

作者： Karin KY ho Sui ling Sin Kin Pan Au Henry HY Lee Daniel TL Chan Albert Chan Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Surgery Yan Chai Hospital7 Yan Chai StreetHong KongChina State Key Laboratory of Liver Research(Li Ka Shing Faculty of Medicine The University of Hong Kong)102 Pok Fu Lam RoadHong KongChina

To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. however, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.

关键词： invasion vena Liver

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Label-free biosensing with singular-phaseenhanced lateral position shift based on atomically thin plasmonic nanomaterials

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Light(Science & Applications) 2024年第5期13卷 810-822页

作者： Shaodi Zhu Rodolphe Jaffiol Aurelian Crunteanu Cyrille Vézy Sik-To Chan Wu Yuan ho-Pui ho Shuwen Zeng Light Nanomaterials&Nanotechnologies(L2n)CNRS-EMR 7004University of Technology of Troyes10000 TroyesFrance. Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongChina XLIM Research Institute UMR 7252 CNRS/University of Limoges123Avenue Albert ThomasLimogesFrance

Rapid plasmonic biosensing has attracted wide attention in early disease diagnosis and molecular biology ***,it was still challenging for conventional angle-interrogating plasmonic sensors to obtain higher sensitivity without secondary amplifying labels such as plasmonic *** address this issue,we developed a plasmonic biosensor based on the enhanced lateral position shift by phase *** singularity presents as a sudden phase retardation at the dark point of reflection from resonating plasmonic substrate,leading to a giant position shift on reflected ***,for the first time,the atomically thin layer of Ge2Sb2Te5(GST)on silver nanofilm was demonstrated as a novel phase-response-enhancing plasmonic *** GST layer was not only precisely engineered to singularize phase change but also served as a protective layer for active silver *** new configuration has achieved a record-breaking largest position shift of 439.3μm measured in calibration experiments with an ultra-high sensitivity of 1.72×10^(8)nm RIU−1(refractive index unit).The detection limit was determined to be 6.97×10^(−7)RIU with a 0.12μm position ***,a large figure of merit(FOM)of 4.54×10^(11)μm(RIU∙°)^(−1)was evaluated for such position shift interrogation,enabling the labelfree detection of trace amounts of *** targeted biosensing experiments,the optimized sensor has successfully detected small cytokine biomarkers(TNF-αand IL-6)with the lowest concentration of 1×10^(−16)*** two molecules are the key proinflammatory cancer markers in clinical diagnosis,which cannot be directly screened by current clinical *** further validate the selectivity of our sensing systems,we also measured the affinity of integrin binding to arginylglycylaspartic acid(RGD)peptide(a key protein interaction in cell adhesion)with different Mn2+ion concentrations,ranging from 1 nM to 1 mM.

关键词： diagnosis protective silver

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Apple polyphenol phloretin inhibits type II glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer

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Food Science and Human Wellness 2024年

作者： Han-Sheng Chang Tzu-chun Cheng Shih-Hsin Tu Pei-Han Liao Yu-Ching Lee Chi-Tang ho Min-Hsiung Pan Li-Ching Chen Yuan-Soon ho Department of Biological Science & Technology College of Life Sciences China Medical University Institute of Biochemistry and Molecular Biology College of Life Sciences China Medical University Department of Surgery School of Medicine College of Medicine Taipei Medical University Research Center of Cancer Translational Medicine Taipei Medical University Department of Food Science Rutgers University New Jersey USA Institute of Food Sciences and Technology Taiwan University

This study presents novel findings on the potential of phloretin， an apple polyphenol， to enhance the effectiveness of anti-HER2 antibody therapy in HER2-positive breast cancer patients. Our research reveals that phloretin inhibits type II glucose transporter (GLUT2) activity， significantly reducing cancer cell glucose uptake. We confirmed the overexpression of GLUT1 and GLUT2 mRNA in paired human breast tumor tissues， with GLUT2 overexpression associated explicitly with poorer survival rates in breast cancer patients. Treatment with phloretin was observed to increase the interaction between GLUT2 and HER2 proteins， attenuate glycolysis， and enhance the binding affinity of anti-HER2 antibody drugs to target human breast cancer cells. Furthermore， the efficacy of the combination therapy involving phloretin and antibody drugs was reaffirmed in a cell-derived xenograft (CDX) tumor animal model， particularly in suppressing the growth of Trastuzumab-resistant HER2+ breast cancer. These significant findings suggest that targeting GLUT2 activity with phloretin in combination with anti-HER2 antibody drugs may help mitigate the development of drug-resistant breast cancer， offering valuable insights for enhancing tumor treatment strategies and contributing to developing more effective therapies.

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