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Association of XRCC1 gene polymorphisms with idiopathic azoospermia in a Chinese population

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Asian Journal of Andrology 2007年第6期9卷 781-786页

作者： Ai-Hua Gu, Jie Liang, Ning-Xia lu, Bin Wu, Yan-Kai Xia, chun-Cheng lu, lin Song, Shou-lin Wang, Xin-Ru WangAi-Hua Gu Jie Liang Ning-Xia lu Bin Wu Yan-Kai Xia chun-Cheng lu lin Song Shou-lin Wang Xin-Ru Wang Jiangsu Key Laboratory of Reproductive Medicine Institute of Toxicology Nanjing Medical University Nanjing 210029 China

Aim： To assess the possible role of genetic polymorphisms in DNA repair gene XRCC 1 （X-ray repair cross-comple- menting group l） during spermatogenesis by investigating the associations of one promoter polymorphism （T-77C） and two exonic polymorphisms （Argl94Trp and Arg399Gln） in XRCC1 gene with risk of idiopathic azoospermia in a Chinese population. Methods： The genotype and allele frequencies of three observed polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism based on a Chinese population consisting of 171 idiopathic azoospermia subjects and 247 normal-spermatogenesis controls. Results： In our study, all the observed genotype frequencies were in agreement with Hardy-Weinberg equilibrium. The 399A （GA＋AA） allele frequency for idiopathic azoospermia subjects and controls was 0.216 and 0.269, respectively. Compared with GG genotype, the AA genotype of Arg399Gln showed a significant association with a decreased risk of idiopathic azoospermia （odds ratio = 0.315; 95% confidence interval = 0.12-0.86）. However, no significant differences were found between the cases and controls for T-77C and Arg194Trp polymorphisms. The major haplotypes of XRCC1 gene were TCG, TrG and TCA, whereas no haplotypes appeared to be significantly associated with idiopathic azoospermia based on the cutoff of P 〈 0.05. Conclusion： In a selected Chinese population, AA genotype of Arg399Gln appears to contribute to a decreased risk of idiopathic azoospermia, while we have not any evidence of involvement of XRCC1 T-77C and Arg194Trp polymorphisms in idiopathic azoospermia. （Asian J Androl 2007 Nov; 9： 843-848）

关键词： DNA repair XRCC1 polymorphism male infertility idiopathic azoospermia

Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

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Journal of Thermal Science 2025年第1期34卷 24-33页

作者： lin Yongjie ZHANG Cancan WU Yuting ZHANG Yi lu Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of TechnologyBeijing 100124China

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings(φ),i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/(Δp)^(1/3)was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29%to 17.18%over the unopened-hole solution.

关键词： molten salt electric heater perforated baffles heat transfer

K-GCN for Identifying Key Nodes in Complex Networks

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Journal of Mathematical Research with Applications 2025年第2期 260-274页

作者： lin DONG Yufeng lu Department of Artificial Intelligence Dalian University of Technology School of Mathematical Sciences Dalian University of Technology

Accurately identifying key nodes is essential for evaluating network robustness and controlling information propagation in complex network analysis. However, current research methods face limitations in applicability and accuracy. To address these challenges, this study introduces the K-GCN model, which integrates neighborhood k-shell distribution analysis with Graph Convolutional Network(GCN) technology to enhance key node identification in complex networks. The K-GCN model first leverages neighborhood k-shell distributions to calculate entropy values for each node, effectively quantifying node importance within the network. These entropy values are then used as key features within the GCN, which subsequently formulates intelligent strategies to maximize network connectivity disruption by removing a minimal set of nodes, thereby impacting the overall network architecture. Through iterative interactions with the environment, the GCN continuously refines its strategies, achieving precise identification of key nodes in the network. Unlike traditional methods, the K-GCN model not only captures local node features but also integrates the network structure and complex interrelations between neighboring nodes, significantly improving the accuracy and efficiency of key node *** validation in multiple real-world network scenarios demonstrates that the K-GCN model outperforms existing methods.

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi lin Ruian Xu lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Lagrangian Modelling and Motion Stability of Synchronous Generator-based Power Systems

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 13-23页

作者： Feng Ji lu Gao Chang lin State Key Laboratory of Advanced Transmission Technology China Electric Power Research InstituteBeijing102209China

This paper proposes to analyze the motion stability of synchronous generator-based power systems using a Lagrangian model derived in the configuration space of generalized position and speed.A Lagrangian model of synchronous generators is derived based on Lagrangian *** generalized potential energy of inductors and the generalized kinetic energy of capacitors are *** mechanical and electrical dynamics can be modelled in a unified manner by constructing a Lagrangian *** the first benchmark model of sub-synchronous oscillation as an example,a Lagragian model is constructed,and a numerical solution of the model is obtained to validate the accuracy and effectiveness of the *** with the traditional EMTP model in PSCAD,the obtained Lagrangian model is able to accurately describe the electromagnetic transient process of the ***,the Lagrangian model is analytical,which enables the analysis of the motion stability of the system using Lyapunov's motion stability *** Lagrangian model can not only be used for discussing the power angle stability but also for analyzing the stability of node voltages and system *** provides the feasibility for studying the unified stability of power systems.

关键词： Lagrangian mechanics Lyapunov's first method motion stability sub-synchronous resonance

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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政治关联与社会责任报告披露

山西财经大学学报 2018年第4期40卷 75-85页

作者：陈浩刘春林鲁悦南京大学商学院

以企业社会责任报告的发布为研究情境,考察政治关联对企业响应政府合法性信号的影响,以及响应方式如何受政治关联层级属性的制约。研究发现,拥有中央政府政治关联的企业不仅发布社会责任报告的可能性较高,而且报告质量也较高;拥有地方... 详细信息

以企业社会责任报告的发布为研究情境,考察政治关联对企业响应政府合法性信号的影响,以及响应方式如何受政治关联层级属性的制约。研究发现,拥有中央政府政治关联的企业不仅发布社会责任报告的可能性较高,而且报告质量也较高;拥有地方政府政治关联的企业不仅发布社会责任报告的可能性较低,而且报告质量也较低;同时拥有两级政府政治关联的企业会采取解耦策略来应对社会责任报告的要求,即积极发布社会责任报告,同时降低报告质量。

关键词：政治关联企业社会责任企业政治行为非市场战略制度理论

Carbon interconnected microsized Si film toward high energy room temperature solid-state lithium-ion batteries

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Chinese Chemical Letters 2025年第2期36卷 531-535页

作者： Xin Li ling Zhang Yunyan Fan Shaojing lin Yong lin Yongsheng Ying Meijiao Hu Haiying Gao Xianri Xu Zhongbiao Xia Xinchuan lin Junjie lu Xiang Han School of Information Engineering Fujian Business University College of Artificial Intelligence Yango University College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University

Solid-state batteries （SSBs） with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potential high energy ***,Si suffers from poor electrical conductivity and huge volume change and particles fracture during lithiaiotn and delithiation,which induces low practical energy *** addition,the SSBs are often operated at high temperature due to the poor physical contact and huge resistance between Si and solid-state electrolyte （SSE）.To improve the bulk electronic/ionic conductivity of Si and its interfacial compatibility with SSE,herein,a binder free and self-supporting Si/C film was *** monolithic carbon not only enhance the electric conductivity but also release huge stress during lithiation and *** addition,paired with the flexible and soft poly（vinylidene fluoride）-co-hexafluoropropylene （PVDF-HFP） and Li1.3Al0.3Ti1.7（PO4）3（LATP） solid-state electrolyte,a LiF-rich and electrochemical stable solid-electrolyte interphase （SEI） layer is in-situ *** fast bulk and interfacial ionic transportation as well as the mechanical integrity of MSi enable high performance SSBs at room *** a result,high specific capacity of 2137 m Ah/g with an initial Coulombic efficiency of 83.2%is obtained at a rate of 0.5 A/*** at a high rate of 3 A/g,the specific capacity is1793 m Ah/*** a rate of 1 A/g,the Si/C anode delivers a long cycling performance over 500 cycles while maintains a capacity of 1135 mAh/*** work provides a new strategy that combines charge transfer kinetics and interfacial chemistry design toward high energy density Si-based SSBs.

关键词： Carbon coating Interphase Lithium-ion battery Silicon anode Solid-state electrolyte

Surface ligand-promoted heterogeneous CO_(2) catalysis

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Science China Chemistry 2025年第2期68卷 444-457页

作者： Zhe lu lu Wang School of Science and Engineering The Chinese University of Hong KongShenzhenShenzhen 518172China

Heterogeneous CO_(2) catalysis towards the synthesis of high-value products provides a potent pathway for achieving carbon *** distinctive attributes of surface ligands allow for highly effective tuning of the kinetics and mechanisms to enhance CO_(2) conversion *** this review,the catalytic contributions of surface ligands from the view of structure modulation,mechanism modulation,mass transfer,and energy transfer were *** relationships between surface ligands and the performance of functionalized catalysts were further ***,the applications of hydrocarbon chain spacer,hydroxyl and amino as terminal,and SiOx ligand in thermal,photo,and photothermal CO_(2) conversion were *** examining the current limitations and advancements,we concluded with insights into potential future research directions that focus on the development of precisely tuned active sites for highly efficient CO_(2) conversion.

关键词： heterogeneous catalysis CO_(2) conversion surface ligands