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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu liu Shuaipeng Ma Tianjin Shen Yuhua Zou chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Ni-catalyzed cross-electrophile alkyl-alkyl coupling reactions

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Science China Chemistry 2025年

作者： Li-Xu You Lan Tian chun-Ling Guo Shun-Xi Li Yu-Cheng liu Yu-Long Li Wei Shu College of Chemistry and Environmental Engineering Key Laboratory of Green Catalysis of Higher Education Institutes of Sichuan Sichuan University of Science and Engineering Guangming Advanced Research Institute Shenzhen Grubbs Institute Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology

Introducing saturated carbon-carbon bonds into organic molecules significantly increases the three-dimensional configuration,thus altering the physical and chemical properties as well as the functions of molecules. Transition-metal-catalyzed carboncarbon cross-couplings represent one of the most straightforward, efficient and modular alternatives to build saturation in a single step. However, the efficient construction of alkyl-alkyl bonds remains a formidable challenge due to the precise manipulation of multiple alkyl metallic intermediates as well as associated competitive side reactions and selectivity control. Over the past years, Ni-catalyzed cross-coupling under reductive conditions has gained more and more attention for alkyl-alkyl crosscoupling partially attributing to the low-valent state of metal centers under reducing conditions, which suppresses the competitive β-hydride elimination process, thus facilitating the formation of alkyl-alkyl bonds. In this review, the initiative and progress of Ni-catalyzed cross-electrophile alkyl-alkyl cross-coupling, including the efforts in racemic and enantioselective formation of alkyl-alkyl bonds, have been summarized and discussed. Moreover, the challenges and further opportunities in this area have also been discussed.

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基于刻蚀处理的池沸腾传热性能实验研究

原子与分子物理学报 2025年第3期42卷 180-188页

作者：王菊萍匡纯纯刘妮上海理工大学制冷技术研究所上海200093

为探究刻蚀处理铜板表面对池沸腾传热性能的改善效果,搭建了可视化实验平台,制备不同刻蚀浓度和刻蚀时间处理的表面,采用去离子水为工质,进行饱和池沸腾实验.结果表明,氨水刻蚀浓度越大,表面的换热性能越强,氨水刻蚀时间越长,表面换热... 详细信息

为探究刻蚀处理铜板表面对池沸腾传热性能的改善效果,搭建了可视化实验平台,制备不同刻蚀浓度和刻蚀时间处理的表面,采用去离子水为工质,进行饱和池沸腾实验.结果表明,氨水刻蚀浓度越大,表面的换热性能越强,氨水刻蚀时间越长,表面换热性能越强.热流密度为43.2 W/cm^(2)时,0.05 mol/L氨水刻蚀4 h表面、0.05 mol/L氨水刻蚀5 h表面、0.05 mol/L氨水刻蚀8 h表面、0.03 mol/L氨水刻蚀4 h表面、0.05 mol/L氨水刻蚀4 h表面和0.10 mol/L氨水刻蚀4 h表面上的换热系数分别提高了46%、92%、105%、36%、45%、78%.此外,对其表面进行表征,结果说明了其优异的沸腾性能.刻蚀处理增强了表面粗糙度,有效面积,从而促进液体的补充,能够在较小的过热度下达到更高的临界热流密度.可视化研究结果表明,刻蚀表面具有更多的成核位点,更小的气泡离开直径和离开频率.这些结果显示出刻蚀表面强化池沸腾换热的潜力.

关键词：池沸腾刻蚀传热性能气泡动力学微纳结构表面

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Effects of water level variations on the water quality of Huayang Lakes, China

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Journal of Geographical Sciences 2025年第1期 173-188页

作者： AN Lesheng liu chun FAN Zhongya LIAO Kaihua WANG Wencai WANG Nan School of Resources and Environment Anqing Normal University South China Institute of Environmental Sciences Ministry of Ecology and Environment The Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyCAS

To explore water level variations and their dynamic influence on the water quality of Huayang Lakes, the water level from 1967 to 2023 and water quality from 2015 to 2023 were analyzed using the Mann–Kendall trend test, box plots, and violin plots. The results show a notable hydrological rhythm of water level alternation between dry and flood seasons in Huayang Lakes, with an average water level of 12.82 m and a monthly range of 11.21–17.24m. Since 2017, the water level of Huayang Rivers has shown a decreasing trend of –0.02 m/*** phosphorus(TP) has become the primary pollutant. The TP concentrations in Longgan Lake(the largest lake) during the dry, rising, flood, and retreating seasons from 2015 to 2023were 0.083, 0.061, 0.050, and 0.059 mg/L, respectively. The effect of water level on TP was mainly observed during the low-water period. When the water level in the dry season rose to 12.25 and 13.00 m, the percentage of TP exceeding 0.1 mg/L in Longgan Lake decreased to 55.8% and 33.3%, respectively. During the dry season, wind and wave disturbances caused the release of endogenous phosphorus in Huayang Lakes. This led to drastic fluctuations in TP concentration, reducing the correlation between water level and TP. When external control is limited, the water level during the dry season should be maintained between 12.25 and 13.0 m. Additionally, it is necessary to accelerate the restoration of submerged macrophyte species(such as Hydrilla verticillata and Vallisneria natans) in the Huayang Rivers.

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绿原酸对中性粒细胞功能及胞外诱捕网形成的影响及机制

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中国药理学通报 2025年第1期41卷 101-107页

作者：杨运刘娅王翠彭春红贵州中医药大学第二临床医学院贵州贵阳550025 七星关区中医妇幼集团医院贵州毕节551700 毕节市中医医院贵州毕节551700 贵州医科大学临床医学院贵州贵阳550025 贵州省人民医院呼吸与危重医学科贵州贵阳550002 国家卫健委肺脏免疫性疾病重点实验室贵州贵阳550002

目的探究绿原酸(chlorogenic acid,CGA)对中性粒细胞(neutrophil,NEU)功能及中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)形成的影响及机制。方法从小鼠骨髓中分离并纯化NEU;将NEU与CGA共培养,通过CCK-8法筛选共培养适合的干预浓度;检测NEU迁移能力、髓过氧化物酶(MPO)以及脱颗粒弹性蛋白酶(NE)、基质金属蛋白酶9(MMP-9)的水平观察CGA对NEU功能的影响;免疫荧光法观察NETs的主要结构组蛋白H3及DNA骨架,以及检测NEU释放的游离DNA(cf-DNA)含量,观察NETs的形成情况;检测NEU产生的活性氧(ROS)水平,以确定CGA是否影响NEU释放NETs过程中的ROS的生成。结果CGA在浓度为100、200、400μmol·L^(-1)时对NEU活性有明显抑制作用(P<0.01)。与空白组(Blank)相比,CGA(100、200、400μmol·L^(-1))干预后,细胞迁移能力及MPO、NE、MMP-9分泌量增加(P<0.05),组蛋白H3及DNA骨架、cf-DNA的释放量明显增加(P<0.01),细胞产生的ROS也明显增加(P<0.01),上述作用在一定范围内具有浓度依赖性。结论CGA能够增强NEU功能及促进NETs的形成,可能与促进细胞内ROS水平增加有关。

关键词：绿原酸中性粒细胞胞外诱捕网免疫抗菌活性氧

Supersymmetry for Fermion Masses

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Communications in Theoretical Physics 2007年第6期47卷 1088-1098页

作者： liu chun Institute of Theoretical Physics the Chinese Academy of Sciences P.O. Box 2735 Beijing 100080 China

It is proposed that supersymmetry （SUSY） may be used to understand fermion mass hierarchies. A family symmetry ZSL is introduced, which is the cyclic symmetry among the three generation SU（2） doublets. SUSY breaks at a high energy scale - 10^11 GeV. The electroweak energy scale- 100 GeV is unnaturally small No additional global symmetry, like the R-parlty, is imposed. The Yukawa couplings and R-parity violating couplings all take their natural values, which are О（10^0 -10^-2）. Under the family symmetry, only the third generation charged ferrnions get their masses. This family symmetry is broken in the soft SUSY breaking terms, which result in a hierarchical pattern of the fermion masses. It turns out that for the charged leptons, the r mass is from the Higgs vacuum expectation value （VEV） and the sneutrino VEVs, the muon mass is due to the sneutrino VEVs, and the electron gains its mass due to both ZZL and SUSY hreaking. The large neutrino mixing are produced with neutralinos playing the partial role of right-handed neutrinos. │Ve3│, which is for Ve-Vr mixing, is expected to be about 0.1. For the quarks, the third generation masses are from the Higgs VEVs, the second generation masses are from quantum corrections, and the down quark mass due to the sneutrino VEVs. It explains me/ms, ms/me, md 〉 mu and so on. Other aspects of the model are discussed.

关键词： fermion mass family symmetry supersymmetry

Multiobjective evolutionary algorithm for dynamic nonlinear constrained optimization problems

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Journal of Systems Engineering and Electronics 2009年第1期20卷 204-210页

作者： liu chun'an Wang Yuping Dept. of Mathematics Baoji Univ. of Arts and Science Baoji 721013 P. R. China School of Computer Engineering and Technology Xidian Univ. Xi'an 710071 P. R. China

A new method to solve dynamic nonlinear constrained optimization problems （DNCOP） is proposed. First, the time （environment） variable period of DNCOP is divided into several equal subperiods. In each subperiod, the DNCOP is approximated by a static nonlinear constrained optimization problem （SNCOP）. Second, for each SNCOP, inspired by the idea of multiobjective optimization, it is transformed into a static bi-objective optimization problem. As a result, the original DNCOP is approximately transformed into several static bi-objective optimization problems. Third, a new multiobjective evolutionary algorithm is proposed based on a new selection operator and an improved nonuniformity mutation operator. The simulation results indicate that the proposed algorithm is effective for DNCOP.

关键词： dynamic optimization nonlinear constrained optimization evolutionary algorithm optimal solutions

The war between wheat and Fusarum: fighting with an alien weapon

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Science China(Life Sciences) 2020年第9期63卷 1425-1427页

作者： chun-Ming liu Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China

Wheat, as one of the most important staple food crops in the world, has been domesticated and cultivated for over5,000 years. The flour of common wheat (Triticum aestivum L.) is used daily to make different types of foods in different regions, typically bread, pizza and pasta for western countries, and noodle, dumpling and steamed bread for Asian countries. Infections of Fusarium species cause impactful diseases for cereal crops including wheat, rice, maize and barley. Outbreaks of devastating infections by Fusarium species may lead to up to 50%yield loss in these crops and the contaminations of trichothecene mycotoxins. Therefore,it is an important issue for both food security and food safety.

关键词： crops Wheat cultivated

Influence of Water Vapor on Silica Membrane： Adsorption Properties and Percolation Effect

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Chinese Journal of Chemical Physics 2015年第3期28卷 345-350,I0002页

作者： chun-lin Song Gang liu Faculty of Materials and Energy Southwest University Chongqing 400715 China Inorganic Membrane Group MESA+ Institute for Nanotechnology Faculty of Science and Technology University of Twente P.O. Box 217 7500 AE Enschede the Netherlands

The influence of water vapor on silica membrane with pore size of ,-4A has been investigated in terms of adsorption properties and percolation effect at 50 and 90 ℃. Two methods are employed： spectroscopic ellipsometry for water vapor adsorption and gas permeation of binary mixture of helium and H2O The adsorption behaviors on the silica membrane comply with the first-order Langmuir isotherm. The investigation demonstrates that helium flux through the silica membrane decreases dramatically in presence of H20 molecules. The transport of gas molecules through such small pores is believed not to be continuous any more, whereas it is reasonably assumed that the gas molecules hop from one occupied site to another unoccupied one under the potential gradient. When the coverage of H20 molecules on the silica surface increases, the dramatic decrease of helium flux could be related to percolation effect, where the adsorbed H20 molecules on the silica surface block the hopping of helium molecules.

关键词： Silica membrane Percolation effect Adsorption