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Clinical application of individualized total arterial coronary artery bypass grafting in coronary artery surgery

World Journal of Clinical Cases 2021年第19期9卷 5073-5081页

作者： Wei-Guang Chen Bai-chun wang Yong-Ri Jiang Ye-Yang wang Yang Lou Second Ward Department of Heart and Great Arteries SurgeryFourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Total arterial revascularization is associated with increased patency and long-term efficacy and decreased perioperative morbidity and mortality and incidence of cardiac-related events and sternal wound infection compared with conventional coronary artery bypass surgery(CABG),in which the left internal mammary artery(LIMA)is typically grafted to the left anterior descending artery with additional saphenous vein grafts often *** study determined whether these favorable clinical results could be realized at the authors’*** To summarize the early efficacy and clinical experience of individualized total arterial coronary artery bypass grafting *** CABG was performed on 35 patients with non-single-vessel coronary artery disease by adopting total arterial grafts at Fourth Affiliated Hospital of Harbin Medical University between April 2016 and December *** was used in 35 patients,radial artery(RA)was used in 35 patients,and right gastroepiploic artery(RGEA)was used in 9 *** complications were observed,short-term graft patency rate was followed-up,and quality of life was *** All patients underwent off-pump coronary artery bypass and the surgeries were *** of them were discharged without any complications or *** the follow-up,it was found that patients’angina symptoms were relieved and New York Heart Association classification for cardiac function was class I to class II.A total of 90 vessels were grafted with no occlusion for internal mammary artery,three occlusions for RA,and one occlusion for *** The individualized total arterial strategy based on the vessels targeting individual anatomic characteristics can achieve complete revascularization with satisfactory short-term grafting patency rate.

关键词： Total arterial revascularization Coronary artery bypass grafting Radial artery Right gastroepiploic artery

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基于失效模式与效应模型的康复护理对急性心肌梗死合并心律失常患者的干预效果

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四川解剖学杂志 2024年第4期32卷 169-171,178页

作者：田银凤李军娜王春艳平煤神马集团总医院心内科平顶山467000

目的:探讨基于失效模式与效应(FMEA)模型的康复护理对急性心肌梗死(AMI)合并心律失常患者的干预效果.方法:选取2021年3月至2023年9月于本院收治的122例AMI合并心律失常患者作为研究对象.采用随机数字表法,将其分为观察组(n=61,给予基于F... 详细信息

目的:探讨基于失效模式与效应(FMEA)模型的康复护理对急性心肌梗死(AMI)合并心律失常患者的干预效果.方法:选取2021年3月至2023年9月于本院收治的122例AMI合并心律失常患者作为研究对象.采用随机数字表法,将其分为观察组(n=61,给予基于FMEA模型的康复护理)和对照组(n=61,给予常规康复护理).比较两组急救效率、干预前后心功能、不良事件发生率.结果:观察组患者入院后首份心电图完成时长、血肌钙蛋白T(TNT)检测结果出具时间、进医院到球囊扩张操作完成时长,以及冠状动脉开通治疗总时长均短于对照组,差异具有统计学意义(P<0.05).干预后,观察组患者心率、QT间期离散度低于对照组,左心室射血分数高于对照组,差异具有统计学意义(P<0.05).观察组患者不良事件发生率(3/61,4.92%)低于对照组(12/61,19.69%),差异具有统计学意义(P<0.05).结论:基于FMEA模型的康复护理对AMI合并心律失常患者具有显著干预效果,可提高急救效率,能够有效改善心功能.

关键词：失效模式与效应康复护理急性心肌梗死心律失常

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Effect of microRNA-155 on angiogenesis after cerebral infarction of rats through AT1R/VEGFR2 pathway

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Asian Pacific Journal of Tropical Medicine 2015年第10期8卷 810-816页

作者： Ying-chun Meng Zhen-Ying Ding Hai-Quan wang Li-Ping Ning Chao wang Department of Rehabilitation Affiliated Shandong Provincial Hospital of Shandong University Department of Neurology Shandong Qixia People's Hospital

Objective:To explore the function and mechanism of microRNA-155 to regulate the angiogenesis after the cerebral infarction of rats through the angiotensin Ⅱ receptor 1(AT1R)/vascular endothelial growth factor(VEGF) signaling ***:Female SD rats were chosen for the construction of cerebral infarction model of rats using the modified right middle cerebral artery *** real-time PCR(RT-PCR) method was employed to detect the expression of microRNA-155 in each group at different time points after the cerebral infarction(1 h,I d,3 d and 7 d).SD rats were randomly divided into four groups(n=20 rats):sham operation group(Sham group),MACO group,MACO+microRNA-155 mimic group,and MACO+microRNA-155 inhibitor *** group was given the free graft,while MACO+microRNA-155 mimic group and MACO+microRNA-155 inhibitor group were treated with microRNA-155 mimic and microRNA-155 inhibitor *** Zea Longa5-point scale was used to score the neurologic impairment of rats in each group;2,3,5-triphenyl tetrazolium chloride staining to evaluate the volume of cerebral infarction of rats in each group;the immunohistochemistry to detect the expression of CD31;Western blot and RT-PCR to detect the expression of AT1 R and VEGF receptor 2(VEGFR2).Results:The expression of microRNA-155 was increased in the cerebral ischemia tissue after the cerebral *** was significantly increased at 1 d of ischemia and maintained at the high level for a long *** in the Sham group had no symptom of neurologic impairment while rats in the MACO group had the obvious neurologic *** being treated with microRNA-155 inhibitor,the neural function of MACO rats had been improved,with the decreased area of cerebral *** after being treated with microRNA-155 mimic,the neural function was further worsened,with the increased area of cerebral *** of immunohistoehemical assay indicated that microRNA-155 inhibitor could up-regulate the expressi

关键词： microRNA-155 Cerebral infarction Angiogenesis AT1R

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DESC: enabling secure data exchange based on smart contracts

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Science China(Information Sciences) 2018年第4期61卷 262-264页

作者： jiao LIANG Weili HAN Zeqing GUO Yaoliang CHEN Chang CAO Xiaoyang Sean wang Fenghua LI Software School Fudan University Institute of Information Engineering Chinese Academy of Sciences

Dear editor,As data are one of the most important factors of today’s intelligent systems but are relatively scarce,people try exchanging data with other organizations or public ***,data exchange is now lack of a secu... 详细信息

关键词： enabling secure data exchange based on smart contracts

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Diagnostic value of controlled attenuation parameter for liver steatosis in patients with chronic hepatitis B

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World Journal of Gastroenterology 2014年第30期20卷 10585-10590页

作者： chun-Yan wang Wei Lu Dong-Sheng Hu Guang-Dong wang Xiao-Jing Cheng Tianjin Second People’s Hospital Rizhao People’s Hospital Tianjin Medical University

AIM: To study the diagnostic value of controlled attenuation parameter (CAP), evaluated by transient elastography, for liver steatosis in patients with chronic hepatitis B (CHB).

关键词： Transient elastography Controlled attenuation parameter Chronic hepatitis B Liver steatosis

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Targeting mitochondrial transcription factor A sensitizes pancreatic cancer cell to gemcitabine

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国际肝胆胰疾病杂志:英文版 2023年第5期22卷 519-527页

作者： Wei wang chun-Fan Jiang Hai-Sen Yin Shan Gao Bao-Ping Yu Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gastroenterology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Department of Pathology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China

Background:The survival of pancreatic cancer cells,particularly cancer stem cells which are responsible for tumor relapse,depends on mitochondrial *** transcription factor A(TFAM)is critical for the regulation of mitochondrial DNA and thus mitochondrial ***,the possible involvement of TFAM in pancreatic cancer is ***:Human samples were obtained from pancreatic cancers and their adjacent tissues;human pancreatic cell lines were cultured in RPMI1640 *** expressions in pancreatic tissues and cultured cells were determined using immunohistochemistry,ELISA,and reverse transcription polymerase chain reaction(RT-PCR).The effect of TFAM on cell growth,migration,colony formation and apoptosis were *** biogenesis in pancreatic cancer and normal cells were ***:The majority of pancreatic cancer tissues exhibited higher TFAM expression compared to the adjacent ***,TFAM mRNA and protein levels were higher in pancreatic cancer cell lines than in immortalized normal pancreatic epithelial *** was no difference on TFAM level between gemcitabine-sensitive and resistant pancreatic cancer *** analysis demonstrated that TFAM overexpression activated pancreatic normal and tumor cells whereas TFAM inhibition effectively inhibited the growth of pancreatic cancer *** inhibition enhanced gemcitabine’s cytotoxicity and suppressed growth,anchorage-independent colony formation and survival of gemcitabine-resistant pancreatic cancer *** studies showed that TFAM inhibition resulted in remarkable mitochondrial dysfunction and energy crisis followed by oxidative *** basal mitochondrial biogenesis level correlated well with TFAM level in pancreatic cancer ***:TFAM played essential roles in pancreatic cancer via regulating mitochondrial functions which highlighted the therapeutic value of inhibiting TFAM to overcome gemcitabine resist

关键词： TFAM Mitochondrial respiration and biogenesis Pancreatic cancer Gemcitabine

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锡含量对富Zr型Ti-Zr-Nb合金显微组织及性能的影响

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材料热处理学报 2024年第3期45卷 130-139页

作者：程尊鹏炊鹏飞李春梅王晶郭婉莹景然李江华陕西理工大学材料科学与工程学院陕西汉中723000 陕西理工大学矿渣综合利用环保技术国家地方联合工程实验室陕西汉中723000

采用非自耗真空电弧炉制备了Ti-49Zr-21Nb-xSn(x=0、0.5、1.0、2.0和4.0 mass%)合金。借助X射线衍射仪(XRD)、扫描电镜(SEM)、万能试验机、电化学工作站及X射线光电子能谱(XPS)等研究了不同含量Sn元素对合金显微组织、力学性能及腐蚀性... 详细信息

采用非自耗真空电弧炉制备了Ti-49Zr-21Nb-xSn(x=0、0.5、1.0、2.0和4.0 mass%)合金。借助X射线衍射仪(XRD)、扫描电镜(SEM)、万能试验机、电化学工作站及X射线光电子能谱(XPS)等研究了不同含量Sn元素对合金显微组织、力学性能及腐蚀性能的影响。结果表明:随着Sn元素含量的增加,合金的晶粒明显细化,相组成主要为β相,当Sn元素含量超过2%时,在晶界析出(Ti+Zr)_(5)(Nb+Sn)_(3)相。合金的强度随Sn元素含量的增加先升高后降低,当Sn元素含量为1%时,合金的抗拉强度和屈服强度达到最大,分别为1121和1085 MPa,且伸长率为23.9%。未添加Sn元素时,合金的耐蚀性最佳,添加Sn元素后,合金的耐蚀性逐渐降低,当Sn含量为1%时,合金的自腐蚀电流密度较低,耐蚀性较好。因此,Ti-49Zr-21Nb-1Sn合金具有高的力学性能和较好的腐蚀性能,作为生物医用材料表现出了良好的综合性能。

关键词： Ti-Zr-Nb-Sn合金显微组织力学性能腐蚀性能

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Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

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动物学研究 2024年第2期 233页

作者： Peng Li Ting Zhang Ruo Wu Jun-Yu Zhang Yan Zhuo Shan-Gang Li jiao-Jian wang Wen-Ting Guo Zheng-Bo wang Yong-Chang Chen

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T_(2)WI 3D-SPACE+RS-EPI DWI检查对直肠癌术前肿瘤淋巴结分期诊断准确率的影响

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中国CT和MRI杂志 2024年第6期22卷 142-144页

作者：王俊波王晋君丁建峰张崇杰焦玉泉运城市中心医院影像科山西运城044000

目的探究T_(2)WI 3D-SPACE联合RS-EPI DWI检查在直肠癌术前肿瘤淋巴分期诊断准确率的影响。方法收集2020年7月-2022年2月在本院确诊直肠癌并进行影像学检查的96名患者作为此次的研究对象,将所有的研究对象随机进行分组,对照组选择T_(2... 详细信息

目的探究T_(2)WI 3D-SPACE联合RS-EPI DWI检查在直肠癌术前肿瘤淋巴分期诊断准确率的影响。方法收集2020年7月-2022年2月在本院确诊直肠癌并进行影像学检查的96名患者作为此次的研究对象,将所有的研究对象随机进行分组,对照组选择T_(2)WI 3D-SPACE进行检查,研究组采用T_(2)WI3D-SPACE联合RS-EPI DWI进行检查,由盲选形式经检查结果呈现给2位资历较高的临床医师对直肠癌术前肿瘤淋巴分期的结果进行鉴别,分析两组肿瘤淋巴结分期阳性诊断的准确性的差异。结果研究组在直肠癌术前是肿瘤淋巴结分期的准确率高于对照组,尤其是在T3期和T4期,对照组的准确率分别为75.61%和84.38%,研究组为97.56%和100%,有差异纳入统计(P<0.05);对照组的总准确率和淋巴结阳性准确率分别为70%和79.55%,研究组的总淮确率和淋巴结阳性准确率分别为95%和97.73%,研究组总准确率和淋巴结阳性准确率高于对照组,有差异纳入统计(P<0.05)。结论 T_(2)WI 3D-SPACE联合RS-EPI DWI检查能提高直肠癌术前肿瘤淋巴分期诊断的准确性,具有较高的诊断价值,可用于直肠癌术前的肿瘤淋巴结的扫描,为临床医生的确诊提供了重要的理论依据。

关键词： T_(2)WI 3D-SPACE RS-EPI DWI 直肠癌肿瘤淋巴分期诊断准确率

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RESEARCH ON CONTROL METHOD OF HYDRAULIC TORQUE SIMULATOR

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Chinese Journal of Mechanical Engineering 2001年第1期14卷 36-39页

作者： wang Shaoping jiao Zongxia Hua Qing Institute of Automation Science and Electronic Enginearing, Beijing University of Aeronautics and Astronautics 北京航空航天大学自动控制系北京

An effective controller and compensator is designed by using the system identification and constant structure theory to realize the effective control. The experimental results indicate the extraneous torque can be dec... 详细信息

关键词： Hydraulic torque simulator Extraneous torque Compensating network

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