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Successful treatment of refractory lung adenocarcinoma harboring a germline BRCA2 mutation with olaparib:A case report

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World Journal of Clinical Cases 2021年第25期9卷 7498-7503页

作者： Li Zhang Jing wang Ling-Zhi Cui Kai wang Ming-Ming Yuan Rong-Rong Chen Li-jiao Zhang Department of Cadre Health Shanxi Provincial Cancer HospitalTaiyuan 030013Shanxi ProvinceChina Department of Medicine Geneplus-BeijingBeijing 102206China

BACKGROUND In recent years,targeted therapy and immunotherapy have become important treatment strategies for patients with non-small cell lung cancer(NSCLC).However,the clinical evidence for successful off-label use of targeted drugs for patients with NSCLC following progression on multiple lines of treatment is still *** SUMMARY We describe a 62-year-old male patient with a right lung adenocarcinoma who harbored an EGFR exon 19 deletion *** received gefitinib combined with six cycles of vinorelbine,cisplatin,and recombinant human endostatin as the first-line *** gefitinib was administered in combination with recombinant human endostatin as maintenance therapy,resulting in a progression-free survival(PFS)of 14 *** was added following progression(enlarged brain metastases)on maintenance ***,the brain lesions were highly refractory and progressed again after 15 mo,at which time next-generation sequencing(NGS)of 1021 cancer-related genes was performed using peripheral blood to identify potential actionable *** revealed that the patient harbored a BRCA2 germline mutation,the EGFR exon 19 deletion mutation disappeared,and no additional targetable genetic variant was ***,the patient received olaparib combined with gefitinib and recombinant human endostatin,with a rapid and long-lasting clinical response(PFS=13.5 mo).CONCLUSION This is a rare case of lung adenocarcinoma in a patient with a BRCA2 germline mutation who had long-term benefit from olaparib combination treatment,suggesting that NGS-based genetic testing may render the possibility of long-term survival in NSCLC patients after disease progression.

关键词： Non-small cell lung cancer Next-generation sequencing BRCA2 gene Poly(adenosine diphosphate-ribose)polymerase inhibitor Case report

Associations Between Hypertension Status and Increased Heart Rate-China, 2015

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China CDC weekly 2020年第40期2卷 771-775,I0001页

作者： Xiao Zhang Mei Zhang chun Li Linhong wang Jing Wu Zhengjing Huang Limin wang National Center for Chronic and Non-communicable Disease Control and Prevention China CDCBeijingChina

Summary What is already known on this topic?Hypertension is a major public health concern in China,and hypertensive patients have elevated heart rates(HR),which can synergize with higher blood pressure to promote adverse health *** is added by this report?The risk of increased HR was statistically significant but relatively lower in subjects with treated and controlled *** lower impact might be modified by sex,marital status,smoking,and physical activity.

关键词： elevated hypertensive hypertension

Regioselective Electrochemical Hydroalkylations of[60]Fullerene-Fused Furochromenone

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Chinese Journal of Chemistry 2023年第7期41卷 769-775页

作者： Zheng-chun Yin Chuang Niu Mingjie Li Wen-Rui Liu Guan-Wu wang Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of ChinaHefeiAnhui230026 China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhouGansu730000 China

Comprehensive Summary Regioselective electrochemical hydroalkylations of[60]fullerene-fused furochromenone with alky halides under different acidic conditions unexpectedly afford three types of tetra-functionalized[60]fullerene derivatives in high *** acetic acid is used as the proton source,two 1,2,3,4-adducts with retained or rearranged five-membered heterocycle are obtained as major and minor products,*** trifluoroacetic acid is employed as the proton source,1,2,3,16-adducts and 1,2,3,4-adducts,both with the five-membered heterocycle rearranged from[6,6]-junction to[5,6]-junction,are ***,the obtained 1,2,3,16-adducts can be transformed into 1,2,3,4-adducts accompanied by rearrangement of the fused five-membered heterocycle from[5,6]-junction to[6,6]-*** products have been characterized by spectroscopic data and single-crystal X-ray ***,the two 1,2,3,4-adducts with the heterocycle fused to[5,6]-junction or[6,6]-junction show diagnostic UV-vis spectra,which may be useful for the identification of these two types of 1,2,3,4-adducts in the future.A plausible reaction mechanism has been proposed to elucidate the formation of hydroalkylation products in the presence of different acids.

关键词： Fullerenes Electrosynthesis Hydroalkylation Regioselectivity Rearrangement

Co_(a)Sm_(b)O_(x) Catalyst with Excellent Catalytic Performance for NH3 Decomposition

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Chinese Journal of Chemistry 2021年第9期39卷 2359-2366页

作者： Cui-Ping Wu Zhao Jin Kai Xu Wei-Wei wang and chun-Jiang Jia Key Laboratory for Colloid and Interface Chemistry Key Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinanShandong 250100China

Transition metal-rare earth oxide catalysts had the ability to catalyze ammonia decomposition according to recent years'scientific ***,most of those catalysts had their own limitations:the catalytic activity was poor,and/or the active species could not clearly be iden *** we report the Co_(a)Sm_(b)O_(x) catalysts with good dispersi on,con trollable content,and excelle nt catalytic performs nee for amm onia *** various content catalysts were syn thesized by aerosol-assisted self-assembly *** catalysts had high dispersion and great morphology according to the images of the transmission electron microscope(TEM)and the seanning electron microscope(SEM).The temperature-programmed reduction by hydrogen(Hq-TPR)and in-situ X-ray diffraction(XRD)results indicated that the interaction between cobalt oxide and samarium oxide influenced the redox properties of cobalt *** with in-situ Raman,we found that Co0 was an active species of the Co_(a)Sm_(b)O_(x) catalysts in ammonia ***,the temperature-programmed desorption of NH_(3)(NH_(3)-TPD)data illustrated that the addition of Sm was beneficial to the adsorption of *** general,we successfully obtained the Co_(a)Sm_(b)O_(x) catalyst with high activity and good *** im-porta ntly,we have identified the structure-function relation ship of catalysts by exploring the active species in the reaction process.

关键词： NH_(3)decomposition Catalyst Active phase Aerosol-assisted self-assembly approach Rare earth

Surface reconstruction,modification and functionalization of natural diatomites for miniaturization of shaped heterogeneous catalysts

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纳米材料科学:英文版 2023年第3期5卷 293-311页

作者： Bowen Li Tian wang Qiujian Le Runze Qin Yuxin Zhang Hua chun Zeng Department of Chemical and Biomolecular Engineering Faculty of EngineeringNational University of Singapore10 Kent Ridge Crescent119260Singapore State Key Laboratory of Mechanical Transmissions College of Materials Science and EngineeringChongqing UniversityChongqing400044PR China

Since the discovery of mesoporous silica in 1990s,there have been numerous mesoporous silica-based nanomaterials developed for catalytic applications,aiming at enhanced catalytic activity and ***,there have also been considerable interests in endowing them with hierarchical porosities to overcome the diffusional limitation for those with long unimodal *** processes of making mesoporous silica largely rely on chemical sources which are relatively expensive and impose environmental concerns on their *** this regard,it is desirable to develop hierarchical silica supports from natural ***,we present a series of work on surface reconstruction,modification,and functionalization to produce diatomite-based catalysts with original morphology and macro-meso-micro porosities and to test their suitability as catalyst supports for both liquid-and gas-phase *** wet-chemical routes were developed to introduce mesoporosity to both amorphous and crystalline ***,we have used computational modeling to affirm that the diatomite morphology can improve catalytic performance based on fluid dynamics ***,one could obtain this type of catalysts from numerous natural diatoms that have inherently intricate morphologies and shapes in micrometer *** principle,such catalytic nanocomposites acting as miniaturized industrial catalysts could be employed in microfluidic reactors for process intensification.

关键词： Heterogeneous catalysis Diatomites Silica Catalytic materials Miniaturization Sustainable chemistry

Deep eutectic solvents and alkaline extraction of protein from seabuckthorn seed meal: a comparison study

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Food Science and Human Wellness 2022年第4期11卷 1028-1035页

作者： Junjie Lin Huan Xiang Dongxiao Sun-Waterhouse chun Cui Wei wang College of Food Science and Technology South China University of TechnologyGuangzhou 510640China Guangdong Wei-Wei Biotechnology Co. LtdGuangzhou 510640China

Seabuckthorn seed meal(SSM) is a waste of oil extraction industry that rich in protein. In order to seek suitable protein extraction method, three different deep eutectic solvents(DESs)(including choline chlorideglycerol, choline chloride-oxalic acid and choline chloride-urea) were developed for extracting protein from SSM and compared with alkaline. Result indicated that alkaline could effectively extract 56.9% protein from SSM and its protein content was 73.1%, higher than DES at 31.0%-41.4% and 64.3%-67.5%, respectively. However, compared to alkali, DES led to a product with less β-sheet, more β-turn, more essential amino acids, higher total amino acid content, especially choline chloride-urea which extracted protein showing an integrated and similar protein weight distribution compared to SSM. Also, this protein extracted chloride-urea showed a highest digestibility in vitro(by pepsin)(54.2%). These results indicated that choline chloride-urea extraction is better than alkaline extraction for SSM.

关键词： Seabuckthorn seed meal Protein extraction Deep eutectic solvent Alkaline extraction and acid precipitation Amino acids

Successful management of infected right iliac pseudoaneurysm caused by penetration of migrated inferior vena cava filter:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9211-9217页

作者： Cheng-Xin Weng Shu-Min wang Tie-Hao wang Ji-chun Zhao Ding Yuan Department of Vascular Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Indwelling inferior vena cava(IVC)filters might cause various complications,including filter penetration,filter fracture,filter migration,and thrombosis of the *** and migration complications are common,while a caudal migrated double-basket filter with associated infected iliac pseudoaneurysm has seldom been *** SUMMARY We report a 64-year-old female admitted for sudden onset of severe right abdominal pain after IVC filter placement for 3 *** patient had a history of failed endovascular IVC filter *** tomography showed that the retrieval hook of the filter penetrated the right common iliac artery and vein,leading to right iliac artery pseudoaneurysm accompanied by right ureteral obstruction with ipsilateral hydronephrosis,and bilateral iliac veins were *** open repair was performed to remove the IVC filter,the right iliac pseudoaneurysm,and the compromised segments of the iliac veins and IVC with right common iliac artery *** aureus was isolated from the tissue *** patient was discharged on postoperative day 12 with anticoagulation therapy and antibiotic therapy after ***-month follow-up computed tomography revealed that the right common iliac artery was patent,and only mild hydronephrosis was *** An indwelling IVC filter,even‘embedded’within organized thrombus,could still cause life-threatening *** procedures remain the last resort for IVC filters with severe complications.

关键词： Inferior vena cava filter Infected pseudoaneurysm Hydronephrosis Filter migration Open repair Antibiotic therapy Case report

A Relation Between Energy Barrier and Ferroelectricity in Ba_(x)Sr_(l-x)TiO_(3)

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Chinese Physics Letters 1999年第3期16卷 214-216页

作者： wang Feng-xiang ZHANG Lei PENG Yi-ping WNAG chun-lei wang Qun Department of Physics Shandong UniversityJi’nan 250100 Physics Teaching Section of Staff Training Branch Yanzhou Colliery Staff Training CollegeYanzhou 273500

In the Ba_(x)Sr_(l-x)TiO_(3) system,the decrease of the grain size causes the suppression of the ferroelectricity and the increase of the relaxation *** heights increase with the increasing grain *** result is analogo... 详细信息

关键词： grain (3) (x)

Room-temperature and high-temperature magnetic permeability of Co-doped nanocrystalline alloys

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Rare Metals 2018年第5期37卷 427-432页

作者： Bin Fu Jie Han Sheng-Qi Guo Zhi wang Pan Zhang Zi-jiao Pan Qiang Xu Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and Engineering Tianjin University of Technology College of Science Tianjin University of Technology School of Science Tianjin University School of Materials Science and Engineering Tianjin University of Technology

Influence of composition and annealing temperature on structure and magnetic properties of amorphous and nanocrystalline Fe78.4-xCoxSi9B9Nb2.6Cu1 （x=27.4, 40.0, 51.0, 78.4） alloys was investigated by X-ray diffraction （XRD） and the temperature dependence of permeability. According to the initial crystallization temperature （Tx1） from differential scanning calorimetry （DSC） curves of as-quenched amorphous alloys, 490-700 ℃ isothermal annealing was carded out to obtain the characteristic nanocrystalline structure. Furthermore, the soft magnetic properties were measured by temperature evolution of magnetic permeability to obtain the correlation between Co content, annealing temperature and magnetic permeability. The results show that, on the one hand, the annealing temperature exerts a significant effect on phase structure and initial permeability （μi）. The higher-temperature （from 550 to 610 ℃） annealed Co content nanocrystalline samples can remain higher μi at elevated temperature. On the other hand, partial substitution Fe by Co can improve the high-temperature magnetic stability;however, the room-temperature permeability of higher Co content alloys decreases obviously at the same time. This phenomenon was analyzed from the viewpoint of the saturation magnetic induction （Bs）, magnetic anisotropy （〈K〉） and magnetostriction （λs）.

关键词： Nanocrystalline alloys High-temperature soft magnetic properties Initial permeability FeCo-based alloy