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Abrasive Wear Behavior and Mechanism of High Chromium Cast Iron

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Journal of Iron and Steel Research International 2015年第1期22卷 84-90页

作者： Ting SUN Ren-bo SONG Xu wang Peng DENG chun-jing WU School of Materials Science and Engineering University of Science and Technology Beijing

The abrasive wear behavior of high chromium cast iron （containing 12.9 mass% chromium） austenitized at 1 050 ℃ for 2 h and austempered in salt bath at 320 ℃ for 4 h was evaluated. Abrasive wear was performed using alumina abrasive under four different loads, namely 50, 100, 150, and 200 N, for 36000 cycles. The worn surfaces and wear debris were analyzed by scanning electron microscopy, laser confocal microscopy and X-ray diffraction. Micro hard- ness profiles were also obtained in order to analyze the strain-hardening effects beneath the contact surfaces. Results indicate that the retained austenite in high chromium cast iron has experienced induced martensitic transformation af- ter tests, for small amounts of retained austenite could be detected by X-ray diffraction. In addition, there is a close relationship between wear mechanism and test load. Under the condition of lower test load, the wear mechanism is an uninterrupted and repeated process, during which matrix is cut at first and then fine carbides flake off. As to high- er test load, scratching and spalling induced by cleavage fracture of blocky carbide are the wear mechanism.

关键词： high chromium cast iron abrasive wear wear mechanism wear behavior martensitic transformation

Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation

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World Journal of Gastroenterology 2014年第40期20卷 14821-14830页

作者： Xing-chun wang Aaron M Gusdon Huan Liu Shen Qu Department of Endocrinology and Metabolism Shanghai 10th People’s Hospital Tongji University Nanjing Medical University Department of Neurology and Neuroscience Weill Cornell Medical College New York NY 10065 United States

Glucagon-like peptide1 (GLP-1) is secreted from Langerhans cells in response to oral nutrient intake. Glucagon- like peptide-1 receptor agonists (GLP-1RAs) are a new class of incretin-based anti-diabetic drugs. They function to stimulate insulin secretion while suppressing glucagon secretion. GLP-1-based therapies are now well established in the management of type 2 diabetes mellitus (T2DM), and recent literature has suggested potential applications of these drugs in the treatment of obesity and for protection against cardiovascular and neurological diseases. As we know, along with change in lifestyles, the prevalence of non-alcoholic fatty liver disease (NAFLD) in China is rising more than that of viral hepatitis and alcoholic fatty liver disease, and NAFLD has become the most common chronic liver disease in recent years. Recent studies further suggest that GLP-1RAs can reduce transaminase levels to improve NAFLD by improving blood lipid levels, cutting down the fat content to promote fat redistribution, directly decreasing fatty degeneration of the liver, reducing the degree of liver fibrosis and improving inflammation. This review shows the NAFLD-associated effects of GLP-1RAs in animal models and in patients with T2DM or obesity who are participants in clinical trials. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Glucagon-like peptide-1 receptor agonists Liver function Fat content Non-alcoholic fatty liver disease Inflammation

运脾1号方治疗幽门螺杆菌感染湿热质临床观察

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山西中医 2024年第2期40卷 25-26页

作者：宋政昌田淼元王春花山西省孝义市中医院孝义032300

目的:观察运脾1号方治疗幽门螺杆菌感染湿热质患者的临床疗效。方法:将幽门螺杆菌感染湿热质患者100例随机分为两组各50例,对照组予抗幽门螺杆菌感染常规四联疗法,治疗组予运脾1号方,两组均治疗14天。结果:治疗后,两组幽门螺杆菌感染情... 详细信息

目的:观察运脾1号方治疗幽门螺杆菌感染湿热质患者的临床疗效。方法:将幽门螺杆菌感染湿热质患者100例随机分为两组各50例,对照组予抗幽门螺杆菌感染常规四联疗法,治疗组予运脾1号方,两组均治疗14天。结果:治疗后,两组幽门螺杆菌感染情况较治疗前均有改善,治疗组转阴率92.0%高于对照组的76.0%(P<0.05),且治疗组的复发率及不良反应发生率均低于对照组(P<0.0.5)。结论:运脾1号方治疗幽门螺杆菌感染湿热质患者疗效确切,能提高根治率,降低复发率,减少不良反应。

关键词：幽门螺旋杆菌感染湿热质运脾1号中医药疗法

CO_(2)storage with enhanced gas recovery(CSEGR):A review of experimental and numerical studies

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Petroleum Science 2022年第2期19卷 594-607页

作者： Shu-Yang Liu Bo Ren Hang-Yu Li Yong-Zhi Yang Zhi-Qiang wang Bin wang Jian-chun Xu Ramesh Agarwal Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Bureau of Economic Geology The Jackson School of GeosciencesThe University of Texas at AustinAustinTXUSA Research Institute of Petroleum Exploration and Development Beijing100083China Tsinghua-Berkeley Shenzhen Institute Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055GuangdongChina Washington University in St.Louis St.LouisMO63130USA

CO_(2)emission mitigation is one of the most critical research *** a promising option of carbon capture,utilization and storage(CCUS),CO_(2)storage with enhanced gas recovery(CSEGR)can reduce CO_(2)emission by sequestrating it into gas reservoirs and simultaneously enhance natural gas *** the past decades,the displacement behaviour of CO_(2)—natural gas has been extensively studied and demonstrated to play a key role on both CO_(2)geologic storage and gas recovery *** work thoroughly and critically reviews the experimental and numerical simulation studies of CO_(2)displacing natural gas,along with both CSEGR research and demonstration projects at various *** physical property difference between CO_(2)and natural gas,especially density and viscosity,lays the foundation of *** experiments on displacement behaviour and dispersion characteristics of CO_(2)/natural gas revealed the fundamental mixing characteristics in porous media,which is one key factor of gas recovery efficiency and warrants further *** numerical simulations demonstrated that it is technically and economically feasible to apply CSEGR in depleted gas ***,CO_(2)preferential flow pathways are easy to form(due to reservoir heterogeneity)and thus adversely compromise CSEGR *** preferential flow can be slowed down by connate or injected ***,the optimization of CO_(2)injection strategies is essential for improving gas recovery and CO_(2)storage,which needs further *** successful K12—B pilot project provides insightful field-scale knowledge and experience,which paves a good foundation for commercial *** experiments,simulations,research and demonstration projects are needed to facilitate the maturation of the CSEGR technology.

关键词： Carbon capture Utilization and storage(CCUS) Enhanced gas recovery CO_(2)geologic storage Miscible displacement Dispersion

新医科背景下课程思政融入临床药理学教学的探索和思考

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科教文汇 2024年第4期 116-120页

作者：常艳王春汪庆童张玲玲严尚学安徽医科大学临床药理研究所抗炎免疫药物教育部重点实验室安徽省抗炎免疫药物协同创新中心安徽医科大学类风湿关节炎研究中心安徽合肥230032 安徽医科大学实验动物中心安徽合肥230032

该文探索了在新医科背景下临床药理学课程实施课程思政建设的途径,通过挖掘课程思政元素、明确课程思政目标、打造跨学科优质师资团队、优化教学内容和方法等途径,全方位把爱国情怀、人文精神、社会责任等思政元素融入教学,以期培育新... 详细信息

该文探索了在新医科背景下临床药理学课程实施课程思政建设的途径,通过挖掘课程思政元素、明确课程思政目标、打造跨学科优质师资团队、优化教学内容和方法等途径,全方位把爱国情怀、人文精神、社会责任等思政元素融入教学,以期培育新时代具备综合素养能力的创新型医学人才。

关键词：临床药理学新医科课程思政通识教育

An improved impedance tube test method based on multi-modal decomposition to determine the sound absorption coefficients at high frequencies

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Chinese Journal of Acoustics 2023年第2期42卷 182-203页

作者： SUN Zhongzheng jiao Rong HAN Xu wang Yufei Celanese(China)Holding Co. Ltd.Shanghai 201203 DuPont Electronics and Industrial Applied EngineeringWilmington 19805 DuPont China Research&Development and Management Co. LtdShanghai 201203

In this study,an improved impedance tube test method is proposed to determine the sound absorption coefficients of materials at high frequencies up to 10 ***,a multi-modal decomposition method is used to measure the sound absorption coefficients above the cut-off frequency of plane waves in the impedance *** the measurement process,an array of microphones is placed in the circumferential and axial directions of the ***,the first three acoustic circumferential modes are decomposed,and the corresponding axial incident and reflected waves at each mode are recorded by the array of *** accuracy and feasibility of the proposed multi-modal decomposition method are validated by comparing the measurement results with those obtained using the conventional impedance tube method.

关键词： method impedance modal

中药在控制耐药菌Acinetobacter baumannii繁殖中的研究进展

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中南药学 2024年第6期22卷 1602-1608页

作者：杨运刘娅彭春红金涛王翠贵州中医药大学贵阳550025 毕节市中医医院贵州毕节551700 贵州省人民医院贵阳550002 贵州大学贵阳550025 贵州医科大学贵阳550004

鲍曼不动杆菌存在多重耐药性,感染后可选择抗菌药物有限,病死率高,抗鲍曼不动杆菌感染是目前临床研究领域的重点和难点。部分中药表现出抑制鲍曼不动杆菌生长的作用,但是其抗菌机制尚不清楚。基于此,本文系统综述了近年来中草药在控制... 详细信息

鲍曼不动杆菌存在多重耐药性,感染后可选择抗菌药物有限,病死率高,抗鲍曼不动杆菌感染是目前临床研究领域的重点和难点。部分中药表现出抑制鲍曼不动杆菌生长的作用,但是其抗菌机制尚不清楚。基于此,本文系统综述了近年来中草药在控制鲍曼不动杆菌感染方面的研究进展,以期为中药抗菌药物的研发提供依据。

关键词：鲍曼不动杆菌多重耐药中药研究进展

C_2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates

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Chinese Chemical Letters 2015年第6期26卷 744-748页

作者： Shi Tang Zhi-yong wang Bin Liu chun-E.Dong State Key Laboratory of Virology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(Wuhan University)Ministry of EducationWuhan University School of Pharmaceutical Sciences

The asymmetric α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates has been achieved by C2-symmetric BINOL-squaramide bearing multiple hydrogen bond donors to provide the desired products in excell... 详细信息

关键词： Asymmetric amination 1 3-Dicarbonyl compound Dialkyl azodicarboxylates

Roxadustat for treatment of anemia in a cancer patient with endstage renal disease:A case report

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World Journal of Clinical Cases 2022年第19期10卷 6587-6594页

作者： Qiao-Qiao Zhou Jing Li Bin Liu chun-Li wang Hemodialysis Room Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610042Sichuan ProvinceChina Department of Internal Medicine-Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610042Sichuan ProvinceChina

BACKGROUNDMost cancer patients are accompanied by anemia, which will be more seriouswhen combined with end-stage renal disease (ESRD). At present, cancer-relatedanemia and renal anemia treatments mainly include erythropoiesis-stimulatingagents (ESAs), iron supplementation, and blood transfusion, but their effects areoften poor with several safety concerns. We have used roxadustat to treat anemiain a cancer patient with ESRD and achieved a successful outcome for the *** SUMMARYA 64-year-old man was diagnosed with right renal cancer (clear cell renal cellcarcinoma). He did not receive surgery or radiotherapy before admission. He wastreated with oral soltan (sunitinib malate) on April 18, 2017. During oral chemotherapy,he had numerous complications, including anemia, hypertension,thyroid hypofunction, skin pigment loss, and renal function deterioration. At last,he progressed to ESRD and began hemodialysis treatment. We initially treated thepatient with high-dose ESAs, iron supplementation, adequate dialysis, and evenblood transfusion, but his anemia did not improve. Roxadustat is a newlydeveloped drug for renal anemia treatment, but not for cancer-related anemia, letalone to treat anemia in cancer patients with ESRD. We prescribed oral roxadustatto the patient. After a period, his hemoglobin gradually increased. He did nothave obvious discomfort symptoms, and his tumor did not progress *** roxadustat could achieve good results in treating anemia in cancer patients with ESRD.

关键词： Cancer End-stage renal disease Hemodialysis Anemia Roxadustat Case report