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Peripheral leukocyte count and risk of bleeding in patients with non-valvular atrial fibrillation taking dabigatran: a real-world study

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Chinese Medical Journal 2019年第18期132卷 2150-2156页

作者： Wei Zhou Tao Wang Ling-Juan Zhu Ming-Hua Wen Li-Hua Hu Xiao Huang chun-jiao you Ju-Xiang Li Yan-Qing Wu Qing-Hua Wu Hui-Hui Bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China

Background: The association between peripheral leukocyte count and bleeding events in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran remains unclear. This study aimed to explore the association between leukocyte count and bleeding events after excluding other confounders in NVAF patients taking dabigatran. Methods: A total of 851 NVAF patients treated with dabigatran (110 mg bid) were recruited from 12 centers in China from February 2015 to December 2017. Follow-up was completed by May 2018. The exposure and outcome variables were leukocyte count measured at baseline and the number of bleeding events within the subsequent 6 months. Multivariate Cox proportional hazards models were constructed to analyze independent associations, and a Cox proportional hazards regression with cubic spline functions and smooth curve fitting (penalized spline method) was used to address nonlinearity between leukocyte count and bleeding. The inflection point was calculated using a recursive algorithm, and then a two-piecewise Cox proportional hazards model for both sides of the inflection point was constructed. Results: During 6-month follow-up, 87 participants occurred bleeding events. For every 1×10^9/L increase in leukocyte count, the risk of bleeding increased by 11%(hazard ratio [HR]: 1.11, 95% confidence interval [CI]: 0.99–1.25). The smooth curve showed nonlinear relationship between leukocyte count and bleeding events. The inflection point of the leukocyte count was 6.75×10^9/L. For leukocyte counts < 6.75×10^9/L, the HR (95% CI) was 0.88 (0.69–1.13), and for leukocyte counts ≥ 6.75×10^9/L, the HR (95% CI) was 1.28 (1.09–1.51). Conclusion: This study found a J-shaped association between baseline leukocyte count and risk of bleeding in NVAF patients treated with dabigatran.

关键词： Peripheral leukocyte count Bleeding Nonvalvular atrial fibrillation Threshold effect

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Method　of　Direct　Texture　Synthesis　on　Arbitrary　Surfaces

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Journal of Computer Science & Technology 2004年第5期19卷 643-649页

作者： Fu-LiWu chun-HuiMei jiao-YingShi StateKeyLabofCAD＆CG ZhejiangUniversityHangzhou310027P.R.China

A direct texture synthesis method on arbitrary surfaces is proposed in thispaper. The idea is to recursively map triangles on surface to texture space until the surface iscompletely mapped. First, the surface is simplified and a tangential vector field is created overthe simplified mesh. Then, mapping process searches for the most optimal texture coordinates intexture sample for each triangle, and the textures of neighboring triangles are blended on the *** synthesized texture triangles are compressed to an atlas. Finally, the simplified mesh issubdivided to approach the initial surface. The algorithm has several advantages over formermethods: it synthesizes texture on surface without local parameterization; it does not needpartitioning surface to patches; and it does not need a particular texture sample. The resultsdemonstrate that the new algorithm is applicable to a wide variety of texture samples and anytriangulated surfaces.

关键词： texture synthesis texture mapping mesh simplification computer graphics

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Design and development of an ACCT for the Shanghai advanced proton therapy facility

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Nuclear Science and Techniques 2022年第10期33卷 41-52页

作者： Hong Zhang Jun-Zhou Li Rui Hou Sun An Shi-Quan Xu you-chun Liu Peng-jiao Zhang Jie Song Yue-Lin Zhang College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China

The Shanghai advanced proton therapy facility is a proton cancer treatment device designed and built by the Shanghai Institute of applied physics at the Chinese academy of *** accelerator part comprises a proton linear accelerator(linac)injector and a circular *** alternating current current transformer(ACCT)is used for non-intercepting beam current measurement at the drift tube linac *** to the beam characteristics,the ACCT is required to complete real-time beam current and pulse width measurements at currents of3-30 mA,frequencies of 1-10 Hz,and pulse widths of40-400μ*** this paper,we report the design and development of an *** designed ACCT was simulated using CST Microwave Studio,and calibrated using an oscilloscope and signal *** in the output signal of the ACCT were investigated as a function of ceramic gap size,number of coil turns,and *** to the simulation and experimental results,the optimal number of coil turns was found to be *** addition,a low-pass filter was adopted to filter the noise introduced during long-distance signal transmission using a coaxial cable with the length of 20 *** calibration results show that the corresponding rise time of the ACCT is 800 ns with the sensitivity of 8.2 V/A and a droop of less than 1%,meeting the design requirements.

关键词： Beam current monitors ACCT Particle beam diagnostics

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In situ preparation and the characterization of Pt/SnO_2

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Chinese Chemical Letters 2012年第3期23卷 371-374页

作者： Jian She Wang jiao jiao Li Chang chun Yang School of Chemical Engineering and Energy Zhengzhou UniversityZhengzhou 450000China Department of Chemistry Zhengzhou UniversityZhengzhou 450000China

To enhance the cycling stability of Pt-based catalysts,the anti-corrosion property of support and the attachment of Pt with support should both get *** this purpose,a novel method is presented for in situ preparing Pt/SnO_*** structure of Pt/ SnO_2 is characterized by X-ray diffraction（XRD） and transmission electron microscopy（TEM）,confirming the homogeneous deposition of Pt on SnO_*** high resolution TEM（HRTEM） shows the large interfaces between Pt and SnO_*** TEM photos recorded after accelerated durability tests with Pt/SnO_2 show that the agglomeration and size increment of Pt particles is not severe, indicating the good stability of Pt/SnO_*** electrochemical active surface area（EAS） of Pt/SnO_2 keeps increasing during the 1000 cycles of cyclic voltammetric（CV） sweeping in H_2SO_4,while the EAS decayed by 35%when mixing Pt/SnO_2 with carbon nanotubes（CNTs）,indicating the superior anti-corrosion property of SnO_2 in contrast to CNTs.

关键词： Pt-based catalysts Tin dioxide In situ preparation Stability

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Structure and expression of sulfatase and sulfatase modifying factor genes in the diamondback moth,Plutella xylostella

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Insect Science 2018年第6期25卷 946-958页

作者： Xiao-Li Ma Wei-Yi He Wei Chen Xue-jiao Xu Wei-Ping Qi Ming-Min Zou Yan-chun you Simon W.Baxter Ping Wang Min-Sheng you State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry UniversityFuzhouChina. Institute of Applied Ecology Fujian Agriculture and Forestry UniversityFuzhouChina. Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests Fujian Agriculture and Forestry UniversityFuzhouChina. Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops Ministry of AgricultureFuzhouChina. Department of Entomology Comell UniversityNew York State Agricultural Experiment StationGenevaNYUSA . School of Biological Sciences University of AdelaideSouth AustraliaAustralia.

The diamondback moth,Plutella xylostella (L.),uses sulfatases (SULF)to counteract the glucosinolate-myrosinase defensive system that cruciferous plants have evolved to deter insect *** activity is regulated by post-translational modi- fication of a cysteine residue by sulfatase modifying factor 1(SUMF1).We identified 12 SULF genes (PxylSulfs)and two SUMF1 genes (PxylSumfls)in the *** genome. Phylogenetic analysis of SULFs and SUMFs from ***,Bombyx mori,Manduca sexta,Heliconius melpomene,Danaus plexippus,Drosophila melanogaster,Tetranychus urticae and Homo sapiens showed that the SULFs were clustered into five groups,and the SUMFs could be divided into two *** of the expression of PxylSulfs and Pxyl Sumfs by RNA-seq and by quantitative real-time polymerase chain reaction showed that two glucosinolate sulfatase genes (GSS),PxylSulf2and PxylSulf3,were primarily expressed in the midgut of 3rd-and 4th-instar ***,expression of sulfatases PxylSulf2, PxylSulf3 and PxylSulf4 were correlated with expression of the sulfatases modifying fac tor *** findings from this study provide new insights into the structure and expression of SUMF1and PxylSulf genes that are considered to be key factors for the evolutionary success *** as a specialist herbivore of cruciferous plants.

关键词： evolutionary arms race glucosinolate detoxification glucosinolate sulfatase phylogenetie analysis transcriptome analysis

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Study on NiO/Fe interface with X-ray photoelectron spectroscopy

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International Journal of Minerals,Metallurgy and Materials 2010年第6期17卷 777-781页

作者： chun Feng Jing-yan Zhang jiao Teng Fu-ming Wang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China

Different monolayers （ML） of Fe atoms were deposited on NiO （001） substrates or NiO underlayers using molecular beam epitaxy （MBE）, pulse laser deposition （PLD）, and magnetron sputtering （MS）. The magnetic properties and microstructure of the films were studied. The apparent magnetic dead layer （MDL） is found to exist at the NiO/Fe interfaces of the MBE sample （about 2 ML MDL）, the PLD sample （about 3 ML MDL）, and the MS sample （about 4 ML MDL）. X-ray photoelectron spectroscopy indicates the presence of ionic Fe （Fe2＋ or Fe3＋） and metallic Ni at the NiO/Fe interfaces, which may be due to the chemical reactions between Fe and NiO layers. This also leads to the formation of MDL. The thickness of the MDL and the reaction products are related with the deposition energy of the atoms on the substrates. The interfacial reactions are effectively suppressed by inserting a thin Pt layer at the NiO/Fe interface.

关键词： interracial reaction magnetic films X-ray photoelectron spectroscopy magnetic properties microstructure

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Application of CRISPR/Cas9 in plant biology

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Acta Pharmaceutica Sinica B 2017年第3期7卷 292-302页

作者： Xuan Liu Surui Wu jiao Xu chun Sui Jianhe Wei Institute of Medicinal Plant Development Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China

The CRISPR/Cas(clustered regularly interspaced short palindromic repeats/CRISPRassociated proteins) system was first identified in bacteria and archaea and can degrade exogenous substrates. It was developed as a gene editing technology in 2013. Over the subsequent years, it has received extensive attention owing to its easy manipulation, high efficiency, and wide application in gene mutation and transcriptional regulation in mammals and plants. The process of CRISPR/Cas is optimized constantly and its application has also expanded dramatically. Therefore, CRISPR/Cas is considered a revolutionary technology in plant biology. Here, we introduce the mechanism of the type II CRISPR/Cas called CRISPR/Cas9, update its recent advances in various applications in plants, and discuss its future prospects to provide an argument for its use in the study of medicinal plants.

关键词： CRISPR/Cas system Gene editing technology Gene modification Plant biology Transcriptional regulation

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Synthesis of γ-Al2O3 with High Surface Area and Large Pore Volume by Reverse Precipitation- azeotropic Distillation Method

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Chemical Research in Chinese Universities 2013年第2期29卷 206-209页

作者： WU Yu-sheng MA jiao LI Ming-chun HU Fang School of Materials Science and Engineering Shenyang University of Technology Shenyang 110870 P. R. China

γ-Al2O3 with high surface area and large pore volume combined with high thermal stability was synthe- sized by a reverse precipitation-azeotropic distillation method. The effects of azeotropic distillation on the characte- ristics of γ-Al2O3 were studied by means of X-ray diffraction（XRD）, Fourier transform infrared（FTIR） spectroscopy, transmission electron microscopy（TEM） and N2 adsorption-desorption. The results show that γ-Al2O3 dried by azeo- tropic distillation has excellent structure characteristics with a high surface area of 426 m2/g and a large pore volume of 2.56 cm3/g. After calcination at 1100 ℃, the surface area of γ-Al2O3 was still 92 mE/g with a large pore volume of 1.00 cma/g, indicating the potential application in catalyst and petroleum industry.

关键词： Reverse precipitation Azeotropic distillation y-Alumina n-Butyl alcohol Thermal stability

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Syntheses and Vasodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones

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Chemical Research in Chinese Universities 2006年第4期22卷 468-473页

作者： ZHAO Yan-fang ZHAI Xin CHEN jiao-yue GUO Shu-chun GONG Ping School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P.R. China

A series of novel pyrazolo [ 4,3-d ] pyrimidin-7-ones was designed and synthesized in order to find new potent phosphodiesterase 5 inhibitors（PDE5）. The structures of all the compounds were confirmed by IR, ^1H NMR and MS; their in vitro vasodilatory activities were tested on isolated rabbit aortic spiral strips. Among them, compound X3 displays a significant vasodilatory activity, which is more potent than verapamil.

关键词： Pyrazolo[4,3-d]pyrimidin-7-one Synthesis Vasodilatory activity

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Analysis on unit maximum capacity of orthogonal multiple watermarking for multimedia signals in B5G wireless communications

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Digital Communications and Networks 2024年第1期10卷 38-44页

作者： Mianjie Li Senfeng Lai jiao Wang Zhihong Tian Nadra Guizani Xiaojiang Du chun Shan School of Electronics and Information Guangdong Polytechnic Normal UniversityGuangzhou510665China Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China Schoolof Electrical Engineering and Computer Science Washington State UniversityPullmanWA99164USA Department of Computer and Information Science Temple UniversityPhiladelphiaPA19122USA

Beyond-5G(B5G)aims to meet the growing demands of mobile traffic and expand the communication *** that intelligent applications to B5G wireless communications will involve security issues regarding user data and operational data,this paper analyzes the maximum capacity of the multi-watermarking method for multimedia signal hiding as a means of alleviating the information security problem of *** multiwatermarking process employs spread transform dither *** the watermarking procedure,Gram-Schmidt orthogonalization is used to obtain the multiple spreading ***,multiple watermarks can be simultaneously embedded into the same position of a multimedia ***,the multiple watermarks can be extracted without affecting one another during the extraction *** analyze the effect of the size of the spreading vector on the unit maximum capacity,and consequently derive the theoretical relationship between the size of the spreading vector and the unit maximum capacity.A number of experiments are conducted to determine the optimal parameter values for maximum robustness on the premise of high capacity and good imperceptibility.

关键词： B5G Multimedia information security Spread transform dither modulation Spreading vector measurement Unit maximum capacity

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