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Clinical heterogeneity and five phenotypes identified in pediatric Behçet’s syndrome: a cohort study from Shanghai Behçet’s syndrome database

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World Journal of Pediatrics 2024年第8期20卷 801-808页

作者： Dan Hu chun-hui she Hua-Fang Bao Jun Zou Jian-Fei Cai Jing‑Fen Ye Yan shen Hai‑Fen Ma Dan Luo Jian-Long Guan Department of Rheumatology and Immunology Huadong Hospital Affiliated to Fudan University221 Yan’an West Road200040ShanghaiChina

Objectives Behçet’s syndrome(BS)is a rare disease of unknown etiology,with limited reports especially in pediatric *** clinical characteristics and phenotypes of pediatric BS as a highly heterogeneous variable vessel vasculitis were investigated in this *** A cross-sectional study was conducted to compare clinical variables and descriptive characteristics of BS by age of onset and *** analysis was then performed to identify the phenotypes of pediatric *** A total of 2082 BS patients were included in this study,1834 adults and 248 *** with adult-onset BS,pediatric BS had a higher incidence of folliculitis[relative risks(RR)and 95%confidence interval(CI)1.3(1.0–1.5)],uveitis of the left eye[RR and 95%CI 2.3(1.0–5.0)],intestinal ulcer complications[RR and 95%CI 2.1(1.1–4.2)],pericarditis[RR and 95%CI 2.5(1.0–6.2)],and psychiatric disorders[RR and 95%CI 2.8(1.0–7.9)],while the incidence of thrombocytopenia was lower[RR 0.2(0.1–1.0)].Among pediatric BS,females had more genital ulcers,while males were more likely to have skin lesions,panuveitis,vascular involvement,venous lesions,cardiac involvement,and aortic *** analysis classified pediatric BS into five clusters(C1–C5):C1(n=61,24.6%)showed gastrointestinal(GI)involvement;C2(n=44,17.7%)was the central nervous system(CNS)type where 23 cases overlapped joint involvement;in C3(n=35,14.1%),all patients presented with arthritis or arthralgia;all patients in C4(n=29,11.7%)manifested ocular involvement,with a few patients overlapping with GI involvement or joint damage;C5(n=79,31.9%)was the mucocutaneous type,presenting both oral ulcers,genital ulcers,and skin *** The clinical features of pediatric and adult BS differ *** and female pediatric BS also have a distinct *** phenotypes including GI,CNS,joint,ocular,and mucocutaneous types were identified for pediatric BS.

关键词： Behget's syndrome Clinical manifestation Cluster analysis-Pediatric Phenotype

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Vision-Based Adaptive Prescribed-Time Control of UAV for Uncooperative Target Tracking with Performance Constraint

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Journal of Systems Science & Complexity 2024年第5期37卷 1956-1977页

作者： she Xuehua MA hui REN Hongru LI Hongyi School of Automation and the Guangdong Provincial Key Laboratory of Intelligent Decision and Cooperative Control Guangdong University of TechnologyGuangzhou 510006China School of Mathematics and Statistics Guangdong University of TechnologyGuangzhou 510006China College of Electronic and Information Engineering and Chongqing Key Laboratory of Generic Technology and System of Service Robots Southwest UniversityChongqing 400715China

This paper discusses the uncooperative target tracking control problem for the unmanned aerial vehicle(UAV)under the performance constraint and scaled relative velocity constraint,in which the states of the uncooperative target can only be estimated through a vision *** the limited detection range,a prescribed performance function is designed to ensure the transient and steady-state performances of the tracking ***,the scaled relative velocity constraint in the dynamic phase is taken into account,and a time-varying nonlinear transformation is used to solve the constraint problem,which not only overcomes the feasibility condition but also fails to violate the constraint ***,the practically prescribed-time stability technique is incorporated into the controller design procedure to guarantee that all signals within the closed-loop system are *** is proved that the UAV can follow the uncooperative target at the desired relative position within a prescribed time,thereby improving the applicability of the vision-based tracking *** results have been presented to prove the validity of the proposed control strategy.

关键词： Nonlinear transformation performance constraint prescribed-time tracking uncooperative target vision-based measurement

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Positron Emission Tomography Lung Image Respiratory Motion Correcting with Equivariant Transformer

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Computers, Materials & Continua 2024年第5期79卷 3355-3372页

作者： Jianfeng He Haowei Ye Jie Ning hui Zhou Bo she Faculty of Information Engineering and Automation Kunming University of Science and TechnologyYunnan Key Laboratory of Artificial IntelligenceKunming650500China School of Physics and Electronic Engineering Yuxi Normal UniversityYuxi653100China PET/CT Center Affiliated Hospital of Kunming University of Science and TechnologyFirst People’s Hospital of Yunnan ProvinceKunming650031China

In addressing the challenge of motion artifacts in Positron Emission Tomography (PET) lung scans, our studyintroduces the Triple Equivariant Motion Transformer (TEMT), an innovative, unsupervised, deep-learningbasedframework for efficient respiratory motion correction in PET imaging. Unlike traditional techniques,which segment PET data into bins throughout a respiratory cycle and often face issues such as inefficiency andoveremphasis on certain artifacts, TEMT employs Convolutional Neural Networks (CNNs) for effective featureextraction and motion ***’s unique approach involves transforming motion sequences into Liegroup domains to highlight fundamental motion patterns, coupled with employing competitive weighting forprecise target deformation field generation. Our empirical evaluations confirm TEMT’s superior performancein handling diverse PET lung datasets compared to existing image registration networks. Experimental resultsdemonstrate that TEMT achieved Dice indices of 91.40%, 85.41%, 79.78%, and 72.16% on simulated geometricphantom data, lung voxel phantom data, cardiopulmonary voxel phantom data, and clinical data, respectively. Tofacilitate further research and practical application, the TEMT framework, along with its implementation detailsand part of the simulation data, is made publicly accessible at https://***/yehaowei/temt.

关键词： PET lung scans respiratory motion correction triple equivariant motion transformer lie group motion decomposition

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Anomalous response to creep deformation from dislocation density during electrically assisted creep aging

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Rare Metals 2024年第10期43卷 5268-5283页

作者： Chang Zhou Li-Hua Zhan chun-hui Liu Ming-hui Huang College of Mechanical and Electrical Engineering Central South University Light Alloys Research Institute State Key Laboratory of Precision Manufacturing for Extreme Service PerformanceCentral South University

Adding numerous dislocations into metallic materials before the forming stage significantly enhances their deformability. However, this beneficial effect of dislocation defects may not have a simple monotonic relationship with increased dislocation density during electroplastic deformation. This is due to the complex interactions among the drifting electrons, dislocations and solute atoms. This study explores the effect of diverse initial dislocation densities on creep deformation during electrically aided creep aging of an aluminum–lithium alloy. Surprisingly, we discovered a threshold value for the dislocation density that affects electroplastic creep, i.e., an enhanced effect from dislocations weakens when exceeding this density threshold(an anomalous response to creep). Microstructural data also reveal that such an anomalous response originates mainly from differences in various dislocation density-tailored configurations, which can influence the dislocation motions and precipitation kinetics of the strengthening T1precipitates under the same action of pulsed currents. This study provides important insights into the dislocation density-mediated electroplastic creep of an aluminum–lithium alloy.

关键词： Al–Cu–Li alloy Creep aging Dislocation density Pulsed currents

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Optimal investment based on relative performance and weighted utility

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 328-342页

作者： WANG Lei DONG Ying-hui HUA chun-rong Department of Mathematics Suzhou University of Science and TechnologySuzhou 215009China Changshu Institute of Technology Changshu 215500China

This paper studies the optimal portfolio allocation of a fund manager when he bases decisions on both the absolute level of terminal relative performance and the change value of terminal relative performance comparison to a predefined reference point. We find the optimal investment strategy by maximizing a weighted average utility of a concave utility and an Sshaped utility via a concavification technique and the martingale method. Numerical results are carried out to show the impact of the extent to which the manager pays attention to the change of relative performance related to the reference point on the optimal terminal relative performance.

关键词： relative performance weighted utility S-shaped utility concavification

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Insight into the Role of Isolated Gold Atoms-Ceria Conjunction in Catalyzing the Water-Gas Shift Reaction

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Chinese Journal of Chemistry 2024年第6期42卷 636-644页

作者： Xin-Pu Fu hui-Zhao Wei-Wei Wang chun-Jiang Jia Key Laboratory for Colloid and Interface Chemistry Key Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinanShandong250100 China

As the promising catalysts for the water-gas shift(WGS)reaction,the activity of Au-CeO_(2) composites is susceptible to the aggregation size and electronic state of Au *** reports were extensively focused on the discrepancy between nonmetallic Au and metallic Au nanoparticles,whereas the understanding of the authentic role of the isolated Au atoms was ***,we investigated the catalytic behavior and structural information over two types of Au/CeO_(2) catalysts,in which the predominant conjunctions were isolated Au1-CeO_(2) and Aun-CeO_(2),*** on comprehensive characterizations,particularly by in-situ Raman and in-situ DRIFTS,we found that the isolated Au atoms were responsible for enhancing the reducibility of the CeO_(2) *** CO adsorption ability on the isolated Au sites was significantly inferior to clustered Au atoms,especially at relatively high temperatures(>200°C).As a result,the boosted O vacancy on the isolated Au1-CeO_(2) conjunctions could improve the H2O activation ability for the Au-CeO_(2) catalysts and demonstrate a comparable activity to the clustered Aun-CeO_(2) *** work might deepen understanding of the catalytic function for the isolated Au1 site within Au/CeO_(2) systems while catalyzing the WGS reaction.

关键词： Isolated Au atoms Ceria-based catalysts Water-gas shift reaction Defect Adsorption

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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi chun-Hsu Pan hui-Yu Huang Chieh-Hsi Wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

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Electrocatalytic Performance of Carbon Layer and Spherical Carbon/Carbon Cloth Composites Towards Hydrogen Evolution from the Direct Electrolysis of Bunsen Reaction Product

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Chemical Research in Chinese Universities 2024年第1期40卷 109-118页

作者： ZHANG Wanjia GUO Tingyu LIU Yanhua ZHANG Xuewei ZOU Bo ZHAO chun SUO hui WANG hui ZHAO Xu College of Chemistry Jilin UniversityChangchun130012P.R.China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun130012P.R.China Department of Chemical and Biological Engineering University of SaskatchewanSaskatoonSKS7N 5A9Canada

A composite material comprising a carbon layer and spherical carbon/carbon cloth(C-SC/CC)was fabricated using a hydrothermal-pyrolysis method,employing carbon cloth as the substrate and glucose as the carbon *** C-SC/CC electrode was evaluated as an electrocatalytic electrode for hydrogen production by electrolysis of Bunsen reaction *** electrode prepared with 4 g of glucose and annealed at 800°C showed excellent electrocatalytic *** requires only a potential of 185 mV(***)to achieve a current density of 10 mA/***,the electrode demonstrated good stability with a 6%loss in current density after 1000 cycles of scanning from 0.2 V to 1.2 *** results indicate the potential of the SC/CC electrode as an efficient and durable electrocatalyst for the electrolysis of H2SO4 and HI.

关键词： Electrolysis of Bunsen reaction product Carbon material Composite material Hydrogen production

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A possible probe to neutron-skin thickness by fragment parallel momentum distribution in projectile fragmentation reactions

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Nuclear Science and Techniques 2024年第6期35卷 114-119页

作者： chun-Wang Ma Yi-Jie Duan Ya-Fei Guo chun-Yuan Qiao Yu-Ting Wang Jie Pu Kai-Xuan Cheng hui-Ling Wei College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of SciencesZhengzhou 450015China

Neutron-skin thickness is a key parameter for a neutron-rich nucleus;however,it is difficult to *** the framework of the Lanzhou Quantum Molecular Dynamics(LQMD)model,a possible probe for the neutron-skin thickness(δ_(np))of neutron-rich ^(48)Ca was studied in the 140A MeV ^(48)Ca+^(9)Be projectile fragmentation reaction based on the parallel momentum distribution(p∥)of the residual fragments.A Fermi-type density distribution was employed to initiate the neutron density distributions in the LQMD simulations.A combined Gaussian function with different width parameters for the left side(Γ_(L))and the right side(Γ_(R))in the distribution was used to describe the p∥of the residual *** neutron-rich sulfur isotopes as examples,Γ_(L) shows a sensitive correlation withδ_(np) of ^(48)Ca,and is proposed as a probe for determining the neutron skin thickness of the projectile nucleus.

关键词： Neutron-skin thickness Projectile fragmentation Parallel momentum distribution Neutron-rich nucleus Quantum molecular dynamics model

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Thickness dependence of superconductivity in layered GeP_(5)

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Rare Metals 2024年第3期43卷 1323-1328页

作者： Lin Wu Ke-Meng Yang Wei Gan Rui-chun Xiao Ya-Jie Dai Xi Tang Hong Lin hui Han hui Li Information Materials and Intelligent Sensing Laboratory of Anhui Province Institute of Physical Science and Information TechnologyAnhui UniversityHefei230601China

Understanding the relationship between dimensionality and superconductivity has attracted substantial research *** this work,we report the effective modulation of superconductivity in GeP_(5)through *** superconducting phase transition temperature improves by~10%as the thickness of GeP_(5)decreases from bulk to~96 nm,behaving as a unique negative relationship between the superconducting phase transition temperatureand thickness.

关键词： superconductivity dimensionality

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