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Therapeutic effects of four strains of probiotics on experimental colitis in mice

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World Journal of Gastroenterology 2009年第3期15卷 321-327页

作者： Lin-Lin Chen Xue-Hong Wang Yi Cui Guang-hui Lian Jie Zhang chun-hui ouyang Fang-Gen Lu Department of Gastroenterology The Second Xiangya Hospital of Central South University Changsha 410011 Hunan Province China Department of Gastroenterology Zhongshan City People's Hospital Zhongshan 528400 Guangdong Province China

AIM:To investigate the therapeutic effects of four strains of probiotics(***,***,*** and ***) on dextran sulphate sodium(DSS)-induced experimental colitis in Balb/c ***:Eighty Balb/c mice were randomly divided into 8 ***-loss,fecal character,fecal occult blood and hematochezia were recorded *** activity index(DAI) scores were also evaluated *** of colon was measured and histological scores were evaluated on the 13th ***(MPO) activity was ***-1(IL-1) and IL-4 expression was detected by ELISA and ***:The four strains of probiotics relieved the inflammatory condition of DSS-induced experimental colitis in *** loss was slowed down in all probiotics-treated *** weight gain was observed by the end of probiotics *** DAI and histological scores of probiotics-treated mice were lower than those of mice in the control group(1.9 ± 0.2 vs 8.6 ± 0.4,P < 0.05 for ***).The length of colon of probiotics-treated mice was longer than that of mice in the control group(10.3 ± 0.34 vs 8.65 ± 0.77,P < 0.05 for ***).The four strains of probiotics decreased the MP activity and the IL-1 expression,but increased the IL-4 *** had a better effect on DSS-induced experimental colitis in mice than the other three ***:The four strains of probiotics have beneficial effects on experimental colitis in *** has a better effect on DSS-induced experimental colitis in mice than the other three *** of probiotics provides a new therapy for UC.

关键词： Probiotic E faecalis Experimental colitis Interleukin-1 Interleukin-4

Lactobacillus crispatus M206119 exacerbates murine DSS-colitis by interfering with inflammatory responses

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World Journal of Gastroenterology 2012年第19期18卷 2344-2356页

作者： Fu-Xi Zhou Lu Chen Xiao-Wei Liu chun-hui ouyang Xiao-Ping Wu Xue-Hong Wang chun-Lian Wang Fang-Gen Lu Division of Digestive Disease Xiangya Second-HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

AIM： TO investigate the role of Lactobacillus crispatus （L. crispatus） strain China Center for Type Culture Col- lection （CCTCC） M206119 in intestinal inflammation.METHODS： Forty 8-wk-old Balb/c mice （20± 2 g） were divided into four groups of 10 mice each. Three groups that had received dextran sulfate sodium （DSS） were administered normal saline, sulfasalazine or CCTCC M206119 strain, and the fourth group received none of these. We assessed the severity of colitis using a disease activity index, measured the colon length and weight, collected stools and mesenteric lymph nodes for bacterial microflora analysis. One centimeter of the proximal colon, middle colon and distal colon were collected and fixed in 10% buffered formalin, dehydrated in ethanol, and embedded in paraffin. Interleukin （IL）- 1β, IL-6 and tumor necrosis factor （TNF）-α expression was detected using reverse transcription polymerase chain reaction. Protective factors zonula occludens （ZO）-1 and β-defensin 2 were detected by immunoblot-ting. The features of CCTCC M206119 strain were identified based on morphology, biochemical profile, and 16S RNA sequencing.RESULTS： DSS-colitis animals treated with CCTCC M206119 had markedly more severe disease, with greater weight loss, diarrhea, fecal bleeding, and shortened colon length. In addition, the CCTCC-M206119- treated group had comparatively higher histologi- cal scores and more neutrophil infiltration than the controls. Expression of protective factors ZO-1 and β-defensin 2 was downregulated due to destruction of the mucosal barrier after CCTCC M206119 strain treatment. An in vitro assay demonstrated that CCTCC M206119 strain increased the nuclear translocation of nuclear factor-κB in epithelial cells. Intestinal proinflam- matory or anti-inflammatory cytokine responses were evaluated. Proinflammatory colonic cytokine （IL-Iβ, IL-6 and TNF-α） levels were clearly increased in CCTCC- M206119-treated animals, whereas anti-inflammatory colonic cytokine （IL-

关键词： Colitis Lactobacillus crispatus Intestine Dextra sodium sulfate Mice

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防御素与炎症性肠病

世界华人消化杂志 2008年第28期16卷 3204-3207页

作者：吴小平欧阳春晖中南大学湘雅二医院消化内科湖南省长沙市410011

目前普遍认为炎症性肠病是在遗传背景的前提下,环境因素(如感染等)导致肠道免疫紊乱而发病.近年来,防御素(defensin)家族在先天性防御体系中的作用日益受到研究学者的重视.本文就防御素的种类、分布、基因表达调控、其抗微生物作用,以... 详细信息

目前普遍认为炎症性肠病是在遗传背景的前提下,环境因素(如感染等)导致肠道免疫紊乱而发病.近年来,防御素(defensin)家族在先天性防御体系中的作用日益受到研究学者的重视.本文就防御素的种类、分布、基因表达调控、其抗微生物作用,以及其与炎症性肠病的关系和应用前景作一综述.

关键词：防御素炎症性肠病先天免疫鉴别诊断克罗恩病溃疡性结肠炎

低空经济助推新质生产力的运行机理与路径选择

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 118-131页

作者：欧阳日辉中央财经大学中国互联网经济研究院北京100081

低空经济是以低空飞行活动为牵引,以有人驾驶和无人驾驶航空器为主要载体,通过技术创新和模式创新推动相关产业融合发展的新型综合性经济形态。低空经济涉及领域和行业多、应用场景多、创新之处多、产业链条长、带动效应强,具有创新驱... 详细信息

低空经济是以低空飞行活动为牵引,以有人驾驶和无人驾驶航空器为主要载体,通过技术创新和模式创新推动相关产业融合发展的新型综合性经济形态。低空经济涉及领域和行业多、应用场景多、创新之处多、产业链条长、带动效应强,具有创新驱动性、空间依赖性、跨界融合性、辐射带动性等技术—经济特征。低空经济通过场景牵引、跨界融合、协同治理,聚焦应用场景,打造低空多场景应用,推动“低空+”物流配送、“低空+”城市空中交通、“低空+”旅游、“低空+”应急救援等规模化发展,在技术创新与制度创新相互嵌套、协同治理的基础上实现健康发展。当前,各地各部门积极抢占低空经济新赛道,通过建设智能互联高效的基础设施、加快低空智能互联航行技术创新、完善产业链增强低空产业韧性和安全等举措因地制宜打造融合创新的应用场景。为促进低空经济发展,应加强产业政策引导与支持,支持低空经济技术创新与研发,推动跨界融合与应用场景创新,完善产业链配套服务体系。

关键词：低空经济新质生产力应用场景科技创新产业创新

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu hui Hong Wei Quan Xinyu Qiao chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： hui-Yi Hsiao chung-Yi Nien Ruei-Feng Shiu Wei-chun Chin Tzung-Hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

Late veneer and the origins of volatiles of Earth

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Acta Geochimica 2022年第4期41卷 650-664页

作者： chun-hui Li International Research Center for Planetary Science College of Earth SciencesChengdu University of TechnologyChengduChina

Late veneer is an important paradigm in early Earth and planetary *** refers to the late addition of extraterrestrial materials to the Earth’s mantle after the core formation,which leads to the overabundances of highly siderophile elements in the primitive upper *** this review,the origin,evolution,and expansion of the late veneer hypothesis are summarized,including some unresolved problems.I hope this review would be helpful for the new entrants to this field.

关键词： Highly siderophile elements Late veneer Chondrites Primitive mantle Core formation Volatile elements

Boosting energy storage performance of low-temperature sputtered CaBi_(2)Nb_(2)O_(9) thin film capacitors via rapid thermal annealing

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Journal of Advanced Ceramics 2021年第3期10卷 627-635页

作者： Jing YAN Yanling WANG chun-Ming WANG Jun ouyang Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Advanced Energy Materials and Chemistry School of Chemistry and Chemical EngineeringShandong Provincial Key Laboratory of Molecular EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China College of Physics and Electronic Engineering Qilu Normal UniversityJinan 250013China Amperex Technology Limited Ningde 352100China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

CaBi_(2)Nb_(2)O_(9) thin film capacitors were fabricated on SrRuO_(3)-buffered Pt(111)/Ti/Si(100)substrates by adopting a two-step fabrication *** process combines a low-temperature sputtering deposition with a rapid thermal annealing(RTA)to inhibit the grain growth,for the purposes of delaying the polarization saturation and reducing the ferroelectric *** using this method,CaBi_(2)Nb_(2)O_(9) thin films with uniformly distributed nanograins were obtained,which display a large recyclable energy density Wrec≈69 J/cm^(3) and a high energy efficiencyη≈82.4%.A superior fatigue-resistance(negligible energy performance degradation after 10^(9) charge-discharge cycles)and a good thermal stability(from-170 to 150℃)have also been *** two-step method can be used to prepare other bismuth layer-structured ferroelectric film capacitors with enhanced energy storage performances.

关键词： bismuth layer-structured ferroelectrics(BLSFs) calcium bismuth niobate(CaBi_(2)Nb_(2)O_(9)) nanograin films rapid thermal annealing(RTA) energy storage fatigue-resistance

Statistics matters in interpretations of non-traditional stable isotopic data

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Acta Geochimica 2020年第2期39卷 271-279页

作者： chun-hui Li CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026AnhuiChina CAS Center for Excellence in Comparative Planetology Hefei 230026AnhuiChina

Increasing volumes of of non-traditional stable isotope data have brought new opportunities to gain important insights into geochemical and planetary ***,there is a worrysome trend that the isotopic data are interpreted in a fashion that its statistical approaches are chosen *** communication summarizes the rules regarding calculating the mean,standard deviation and relative standard deviation of a population,as well as error propagation and significant *** rules should be used when reporting geochemical data,especially for isotope *** two examples,I show that statistics matters in isotopic data interpretation.

关键词： Isotopic data processing Error propagation Significant digits Difference between means with uncertainties