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Magnitude and direction of temperature variability affect hospitalization for myocardial infarction and stroke:population-based evidence from Guangzhou,China

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 1-11页

作者： Zhou yang Murui Zheng Ze-Lin Yan Hui Liu Xiangyi Liu Jie-Qi Jin Jiagang Wu chun-Quan ou State Key Laboratory of Organ Failure Research Department of BiostatisticsGuangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Guangzhou Center for Disease Control and Prevention Guangzhou 510440China

Relationships between nonoptimal temperatures and cardiovascular disease(CVD)mortality have been well ***,evidence of the association between temperature variability(TV)and CVD morbidity is *** study aimed to quantify the risk and burden of CVD-related hospitalization associated with the magnitude and direction of *** on meteorology and population-based hospitalizations for myocardial infarction(MI)and stroke were collected in Guangzhou,China,from 2013 to *** temperature variability(HTV)was measured as the standard deviation of hourly temperature records over specific exposure *** direction(upward or downward)of HTV was defined as the average daily mean temperature change relative to that of the previous day during the exposure ***-Poisson regression was applied to assess the impact of HTV after adjusting for the daily mean temperature,and the hospitalization fractions attributable to HTV were calculated.A 1℃-increase in HTV was significantly associated with a 2.24%and 1.72%increase in hospitalizations for MI and hemorrhagic stroke(HS)at lag 0–1 d,respectively,and a 1.55%increase in hospitalizations for ischemic stroke(IS)at lag 0–3 *** the study period,5.99%,4.64%,and 4.53%of MI,HS,and IS hospitalizations,respectively,were attributable to *** upward TV exerts acute effects on CVD hospital admissions,whereas the impact of downward TV generally *** findings highlight the importance of the magnitude and direction of temperature fluctuations,in addition to the mean level,in assessing the adverse health impacts of temperature variations.

关键词： Hourly temperature variability Cardiovascular Hospitalization Direction China

π-conjugated chromophore functionalized high-nuclearity titanium-oxo clusters containing structural unit of anatase for photocatalytic selective oxidation of sulfides

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Rare Metals 2024年第4期43卷 1736-1746页

作者： Ling-Rong Liao Dong-chun Zheng Pin-Xi ou Qi-Xin Zhao Wei-Min Xuan Qi Zheng State Key Laboratory for Modification of Chemical Fibers and Polymer Materials&College of Materials Science and Engineering Donghua UniversityShanghai201620China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials and College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China

N-doping has significant influence in manipulating the properties of TiO_(2),and this has stimulated the development of N-donor-functionalized titanium-oxo clusters(TOCs)as molecular models to study the structure-property ***,the structural type and photoresponsive application are still limited for such TOCs,especially regarding the high-nuclearity TOCs that contain structure unit of TiO_(2)for ***,we showed the synthesis of a series of high-nuclearity TOCs 1-3 compounds usingπ-conjugated 1,10-phenanthroline(phen)as chromophore and N-donor functional *** 1 features cocrystal structure composed of one[Ti_(26)]~(2+)and half[Ti_(22)]~(2+),which renders it as the first cocrystallized TOC containing two positively charged species and phen-functionalized TOC showing the highest nuclearity up to 37 Ti *** adjusting the synthetic conditions,the individual{Ti_(22)}and{Ti_(26)}clusters can also be isolated as Compounds 2 and 3,*** core structure of{Ti_(22)}is mainly constructed from four lacunary{Ti_(4)}derived from pentagonal{Ti(Ti)_5}unit,while{Ti_(26)}is built from four complete{Ti(Ti)_5}***,a{Ti_8O_(14)}structure unit of anatase TiO_(2)can be identified in{Ti_(26)}.Based on the unique structural features and proper photophysical and photochemical properties of Compounds 1-3,they are applied for photocatalytic *** to the presence of anatase structure unit in{Ti_(26)}and the synergistic effect from{Ti_(22)}and{Ti_(26)},the catalytic performance presents in the order of Compound 1>Compound 3>Compound *** work provides excellent models to understand the structureproperty relationship from the perspective of cocrystallization and Ti-O binding model and will further promote the application of TOCs as functional catalysts for organic transformation.

关键词： Titanium-oxo cluster Molecular model of anatase TiO_(2) High nuclearity π-conjugated chromophore Photocatalytic sulfoxidation

Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection

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Zoological Research 2024年第4期45卷 833-844页

作者： Ying Liu Lin yang Hong-Yong Xiang Ming Niu Jia-Cheng Deng Xue-Yuan Li Wen-Jie Hao Hong-Sheng ou-yang Tong-Yu Liu Xiao-chun Tang Da-Xin Pang Hong-Ming Yuan State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Animal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin 130062China Chifeng Best Genetics Technology Co. Ltd.ChifengNei Mongol 024000China Chongqing Jitang Biotechnology Research Institute Co. Ltd.Chongqing 400015China

Porcine reproductive and respiratory syndrome(PRRS)is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus(PRRSV),resulting in substantial economic losses in the swine *** the CD163 SRCR5 domain,either through deletion or substitution,can eff1ectively confer resistance to PRRSV infection in ***,large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth *** the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant *** the current study,we identified a specific functional amino acid in CD163 that influences PRRSV *** infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV(HP-PRRSV)proliferation by preventing viral binding and ***,individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type(WT)pigs,confirming effective resistance to *** of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G *** findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs,providing novel insights into controlling future PRRSV outbreaks.

关键词： PRRSV CD163 Point mutation E529G Pigs

Association between inflammatory bowel disease and all-cause dementia:A two-sample Mendelian randomization study

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World Journal of Psychiatry 2024年第1期14卷 15-25页

作者： ou-Lan Liao Si-Yuan Xie Jun Ye Qin Du Guo-chun Lou Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Gastroenterology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGRouND Numerous observational studies have documented a correlation between inflammatory bowel disease(IBD)and an increased risk of ***,the causality of their associations remains *** To assess the causal relationship between IBD and the occurrence of all-cause dementia using the two-sample Mendelian randomization(MR)*** Genetic variants extracted from the large genome-wide association study(GWAS)for IBD(the International IBD Genetics Consortium,n=34652)were used to identify the causal link between IBD and dementia(FinnGen,n=306102).The results of the study were validated via another IBD GWAS(United Kingdom Biobank,n=463372).Moreover,MR egger intercept,MR pleiotropy residual sum and outlier,and Cochran's Q test were employed to evaluate pleiotropy and ***,multiple MR methods were performed to estimate the effects of genetically predicted IBD on dementia,with the inverse variance weighted approach adopted as the primary *** The results of the pleiotropy and heterogeneity tests revealed an absence of significant pleiotropic effects or heterogeneity across all genetic variants in outcome *** evidence of a causal effect between IBD and the risk of dementia was identified in the inverse variance weighted[odds ratio(OR)=0.980,95%CI:0.942-1.020,P value=0.325],weighted median(OR=0.964,95%CI:0.914-1.017,P value=0.180),and MR-Egger(OR=0.963,95%CI:0.867-1.070,P value=0.492)*** results were observed in validation *** MR analysis also showed no effect of dementia on the development of ***,MR analysis suggested that IBD and its subtypes did not causally affect allcause dementia and its four subtypes,including dementia in Alzheimer's disease,vascular dementia,dementia in other diseases classified elsewhere,and unspecified *** Taken together,our MR study signaled that IBD and its subentities were not genetically associated with all-cause dementia or its

关键词： Inflammatory bowel disease All-cause dementia Mendelian randomization Causal effect Risk factor©The

资本市场赋能新质生产力形成:理论逻辑、现实问题与升级路径

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深圳大学学报（人文社会科学版） 2024年第2期41卷 66-75页

作者：林春文小鸥辽宁大学金融与贸易学院辽宁沈阳110036

资本市场贯彻新定位、合理发挥枢纽功能对于新质生产力的培育与涌现至关重要。创新激励效应、要素配置效应和产业支撑效应的发挥是资本市场赋能新质生产力形成的重要路径。具体而言,资本市场以层次化的直接融资渠道打破诸多科创活动的... 详细信息

资本市场贯彻新定位、合理发挥枢纽功能对于新质生产力的培育与涌现至关重要。创新激励效应、要素配置效应和产业支撑效应的发挥是资本市场赋能新质生产力形成的重要路径。具体而言,资本市场以层次化的直接融资渠道打破诸多科创活动的资金僵局,加快创新资本的集聚;在创新成果转化中,资本市场通过直接与间接途径发挥要素配置功能,引导新型生产要素与新质主体匹配;作为政策落实的重要载体,资本市场以巩固资金链、分散风险等方式为新兴与未来产业提供发展动能。限于发展历史较短,当前我国资本市场还存在着一些问题,集中表现为金融服务功能尚未充分发挥、创新资本形成渠道狭窄;股价信息含量不高且质量欠佳、要素流动与配置受阻;投融资良性循环尚未形成、资本市场结构协调性不佳。这些问题引发创新资本形成、生产要素配置与中长期资金支撑方面的堵点,导致资本市场对新质生产力形成的赋能路径受阻。未来应多措并举,将资本市场打造成服务实体经济、锻造新质生产力的实质性金融支撑。一是稳步优化金融结构,引导多元化融资渠道互补互促;二是加快完善注册制配套监管机制,提升信息披露质量与传递效率;三是持续推进投资端改革,深层次优化投资者结构治理。

关键词：新质生产力资本市场创新资本生产要素配置新兴与未来产业

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APPLYING PROCESS MINING APPROACH TO SUPPORT THE VERIFICATION OF A MULTI-AGENT SYSTEM

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Journal of Systems Science and Systems Engineering 2010年第2期19卷 131-149页

作者： C.ou-yang Yeh-chun JUAN Depart.of Industrial Management National Taiwan University of Science and Technology Depart.of Industrial Engineering and Management Ming Chi University of Technology

Using agent development tools to construct an agent-based system is a well applied approach. However, the development tools usually do not have the function to check the feasibility about the workflow of the agent system during it implementation stage. Therefore, to develop an evaluation approach to analyze the feasibility of a developing agent system such that the improper workflow of an agent system can be found in the early design stage is a necessary task to reduce the risk of implementation. In this research, a Petri Net （PN） based three-stage evaluation approach was developed. In the conceptual stage, the pitfall of the current agent system developing process was examined and an improvement analysis process was specified. Then, in the system design stage, an evaluation approach which extracted the process log file from a developing agent system into a PN model in terms of a process mining approach-or algorithm was proposed. This model was simulated in a PN simulation package. The agent system performance was evaluated in terms of analyzing the deadlock phenomena of the PN model. Finally, in the implementation stage, the proposed concept was implemented by using an agent developing tool JADE and a PN simulation tool CPN. An agent-based robotic assembly system was used to examine the possible deadlock of the agent system.

关键词： Agent-based systems workflow feasibility process mining Petri Nets

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金融韧性研究进展与展望

经济社会体制比较 2024年第4期 184-195页

作者：林春文小鸥孙英杰辽宁大学金融与贸易学院

在全球经济的复杂性和不确定性逐渐加剧的背景下,金融韧性的“稳定器”作用越发突显,打造有韧性的金融体系已成为新时代发展的重要议题。韧性理论在发展演进中将部分成果应用于金融领域,但金融韧性的概念在学界并未达成统一,且在测度评... 详细信息

在全球经济的复杂性和不确定性逐渐加剧的背景下,金融韧性的“稳定器”作用越发突显,打造有韧性的金融体系已成为新时代发展的重要议题。韧性理论在发展演进中将部分成果应用于金融领域,但金融韧性的概念在学界并未达成统一,且在测度评价方面多依托于已有的韧性研究框架,缺乏高认同度的测算方法与多主体的针对性评价。根据现有研究成果,金融韧性影响因素趋于多元化,但在诸多因素中金融素养、金融创新、金融机构运行与监管的影响相对突出。为加快打造一个有活力、有韧性的金融市场,文章认为理论框架的完善、测评体系的优化、不同主体的开拓以及异质性和应用型研究可作为未来的重点探索方向。

关键词：韧性金融韧性研究进展展望

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石油污染从微观修复到生态调控的生态学转变

环境科学 2024年第8期45卷 4967-4979页

作者：李瑞祥杨雪纯王艳芳李田张晓林高藕叶周启星南开大学环境科学与工程学院南开大学碳中和交叉科学中心环境污染过程与基准教育部重点实验室天津300350 天津博成瑞达环境科技发展有限公司天津300202

石油污染已成为全球较为突出的环境问题,制约了经济与生态环境的协调发展.生物修复虽具备绿色低碳和高效安全等优点,但随着污染的复杂化和严重化,单一的生物修复已难以满足修复目的.而以生物修复为基础的生态修复能够统筹碳中和与生态... 详细信息

石油污染已成为全球较为突出的环境问题,制约了经济与生态环境的协调发展.生物修复虽具备绿色低碳和高效安全等优点,但随着污染的复杂化和严重化,单一的生物修复已难以满足修复目的.而以生物修复为基础的生态修复能够统筹碳中和与生态环境保护,协同推进减污降碳,保证土壤和沉积物履行生态系统服务功能的持续能力,最终实现土壤健康和沉积物健康.因此,从生物修复到生态修复的转变是现阶段环境治理和生态系统维护的最优选择.在此,首先剖析了不同生物修复技术中石油烃微观去除机制,并且从生态学角度探讨了不同生物修复技术的种类及特点.基于此,深入分析了生物修复向生态修复转变的必要性.最后对生态修复发展进行了合理展望,以期为石油污染生态修复的优化提供理论支撑.

关键词：石油污染土壤及沉积物生物修复生态学转变生态修复土壤健康和沉积物健康

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分流导叶垂直轴风力机气动性能研究

热能动力工程 2024年第3期39卷 166-172页

作者：朱致远叶舟欧华浩李春上海理工大学能源与动力工程学院上海200093 上海市动力工程多相流动与传热重点实验室上海200093

为提高垂直轴风力机气动性能,提出一种随相位角变化而改变相对夹角的分流导叶结构。以NACA0021为基础翼型,采用计算流体力学方法对分流导叶作用下垂直轴风力机风能利用系数、单叶片瞬时转矩、压力系数及速度场进行数值分析。结果表明:... 详细信息

为提高垂直轴风力机气动性能,提出一种随相位角变化而改变相对夹角的分流导叶结构。以NACA0021为基础翼型,采用计算流体力学方法对分流导叶作用下垂直轴风力机风能利用系数、单叶片瞬时转矩、压力系数及速度场进行数值分析。结果表明:静态和动态分流导叶均可提高垂直轴风力机气动性能,且动态分流导叶提升效果更为显著;相较于静态分流导叶,动态分流导叶垂直轴风力机在尖速比为2.33时风能利用系数最高可提升23%,在尖速比为2.03时静态分流导叶垂直轴风力机较原始垂直轴风力机风能利用系数提高37%;分流导叶也可使最佳尖速比前移,稳定叶片转矩波动,提升垂直轴风力机的运行稳定性。

关键词：垂直轴风力机主动控制分流导叶尖速比气动性能