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MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： hong-Xia Bai xue-Mei Qiu chun-hong xu Jian-Qiang Guo Department of Gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 ***-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family E member 1 Epithelial-mesenchymal transition Proliferation Extracellular signal-regulated kinase-1/2

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Numerical simulation of microstructure and microporosity morphology in directional solidification of aluminum-copper alloys:Effect of copper content and withdrawal rate

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China Foundry 2025年第1期22卷 33-44页

作者： Wei Yuan Hai-dong Zhao xu Shen chun Zou Yuan Liu Qing-yan xu National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China Key Laboratory for Advanced Materials Processing Technology(Ministry of Education) Tsinghua UniversityBeijing 100084China

Microporosity formed in the solidification process of Al alloys is detrimental to the alloy properties.A two-dimensional cellular automaton(CA)model was developed to simulate the microstructure and microporosity formation in Al-Cu alloys,considering variations in Cu content and solidification *** results indicate that the Cu content primarily influences the growth of *** validate the model,directional solidification experiments were conducted on Al-Cu alloys with varing Cu contents and withdrawal *** experimental results of dendrites and microporosity characteristics agree well with the predictions from the developed model,thus confirming the validity of the *** alloy’s liquidus temperature,dendrite morphology,and hydrogen saturation solubility arising from different Cu contents have significant effects on microporosity *** withdrawal rate primarily affects the nucleation of hydrogen microporosity by altering cooling rates and dendritic growth rates,resulting in different microporosity characteristics.

关键词： microporosity dendrites cellular automaton Al-Cu alloys directional solidification

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Risk factors for biometry prediction error by Barrett Universal II intraocular lens formula in Chinese patients

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 74-78页

作者： xu-Hao Chen Ying hong Xiang-Han Ke Si-Jia Song Yu-Jie Cen chun Zhang Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Department of OphthalmologyPeking University Third HospitalBeijing 100191China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the influence of postoperative intraocular lens(IOL)positions on the accuracy of cataract surgery and examine the predictive factors of postoperative biometry prediction errors using the Barrett Universal II(BUII)IOL formula for ***:The prospective study included patients who had undergone cataract surgery performed by a single surgeon from June 2020 to April *** collected data included the best-corrected visual acuity(BCVA),corneal curvature,preoperative and postoperative central anterior chamber depths(ACD),axial length(AXL),IOL power,and refractive *** formula was used to calculate the IOL *** mean absolute error(MAE)was calculated,and all the participants were divided into two groups *** t-tests were applied to compare the variables between *** regression analysis was used to analyze the influence of age,AXL,corneal curvature,and preoperative and postoperative ACD on ***:A total of 261 patients were *** 243(93.1%)and 18(6.9%)had postoperative MAE1 D,*** number of females was higher in patients with MAE>1 D(χ^(2)=3.833,P=0.039).The postoperative BCVA(logMAR)of patients with MAE>1 D was significantly worse(t=-2.448;P=0.025).After adjusting for gender in the logistic model,the risk of postoperative refractive errors was higher in patients with a shallow postoperative anterior chamber[odds ratio=0.346;95% confidence interval(CI):0.164,0.730,P=0.005].CONCLUSION:Risk factors for biometry prediction error after cataract surgery include the patient’s sex and postoperative *** with a shallow postoperative anterior chamber are prone to have refractive errors.

关键词： intraocular lens power calculation gender anterior chamber depth biometry prediction error

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Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow hong Zhang Nan Zhang Pinxian Xi Zhichuan J.xu chun‑Hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui hong Su xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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Diagnostic value of traditional Chinese medical dialectical classification in hashimoto's thyroiditis complicated with suspicious nodules

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TMR Theory and Hypothesis 2020年第4期3卷 412-419页

作者： chun-hong xu Qi Liu Zheng Sun Long-Long Li Kai-Lun Ji Depatment of Breast and Thyroid Surgry The Traditional Chinese Medicine Hospital of WeifangShandongChina

Objective:To explore the diagnostic value of traditional Chinese medical(TCM)dialectical classification in Hashimoto's thyroiditis complicated with suspicious ***:The clinical data of patients with Hashimoto's thyroiditis complicated with thyroid nodules in the Department of Breast and thyroid surgery of Weifang Hospital of traditional Chinese Medicine from January 2018 to December 2019 were *** patients were examined by 2 or more experienced TCM doctors,and the four diagnostic data were obtained,and then the relevant syndrome types of the patients were judged according to the *** to the color Doppler ultrasonographic features of thyroid nodules,the patients who met the indication of fine needle aspiration biopsy of thyroid nodules were selected and underwent fine needle aspiration biopsy of thyroid nodules before *** analyze the clinical diagnostic value of that the ultrasonic mode used in this study and thyroid cytopathology Bethesda report system combine dialectical classification of traditional Chinese medicine in Hashimoto's thyroiditis complicated with suspected thyroid ***:A total of 89 patients with Hashimoto's thyroiditis complicated with thyroid nodules were *** to the ultrasonic mode,the difference between different modes was statistically significant(Pxuberant liver fire and heart liver yin *** to the study of different The Bethesda System for Reporting Thyroid Cytopathology(TBSRTC)classification,the dialectical classification of patients with higher TBSRTC classification was more inclined to qi depression and phlegm stagnation,phlegm and blood stasis,and there was significant difference between different clas

关键词： traditional Chinese medical dialectical classification hashimoto's thyroiditis suspicious nodules Qi depression and phlegm obstruction phlegm and blood stasis

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Aligning enhanced feature representation for generalized zero-shot learning

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Science China(Information Sciences) 2025年第2期68卷 74-88页

作者： Zhiyu FANG Xiaobin ZHU chun YANG hongyang ZHOU Jingyan QIN xu-Cheng YIN School of Computer & Communication Engineering University of Science and Technology Beijing

Constructing an effective common latent embedding by aligning the latent spaces of cross-modal variational autoencoders（VAEs） is a popular strategy for generalized zero-shot learning（GZSL）. However, due to the lack of fine-grained instance-wise annotations, existing VAE methods can easily suffer from the posterior collapse problem. In this paper, we propose an innovative asymmetric VAE network by aligning enhanced feature representation（AEFR） for GZSL. Distinguished from general VAE structures, we designed two asymmetric encoders for visual and semantic observations and one decoder for visual reconstruction. Specifically, we propose a simple yet effective gated attention mechanism（GAM） in the visual encoder for enhancing the information interaction between observations and latent variables, alleviating the possible posterior collapse problem effectively. In addition, we propose a novel distributional decoupling-based contrastive learning（D2-CL） to guide learning classification-relevant information while aligning the representations at the taxonomy level in the latent representation space. Extensive experiments on publicly available datasets demonstrate the state-of-the-art performance of our method. The source code is available at https://***/seeyourmind/AEFR.

关键词： generalized zero-shot learning gated attention mechanism contrastive learning multi-modal alignment

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Optimizing frequency allocation for superconducting quantum processors with frequency-tunable qubits

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 23-36页

作者： Bi-Ying Wang Wuxin Liu Xiangyu Chen Shu xu Jiangyu Cui Man-hong Yung Quantum Science Center of Guangdong-hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen518129China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China International Quantum Academy Shenzhen518048China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China Shenzhen Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China

As superconducting quantum processors scale,a key challenge is maintaining high coherence times and fidelity control over numerous *** propose an automatic frequency allocation method for frequency-tunable qubits that equally considers coherence-limited fidelity and crosstalk-induced control errors during the allocation *** employing a weighted average of the objective functions for coherence time and crosstalk,we numerically calculate gate fidelity to establish an open-loop optimization for determining suitable weight *** results in an efficient objective function for frequency *** apply our method to frequency-tunable transmon qubits with tunable couplers,both theoretically and *** numerical results demonstrate significant advantages,including substantial reductions in gate errors and faster operation times,especially at higher qubit ***,our approach successfully achieves approximately 99.9%single-qubit fidelity on a nine-qubit chip.

关键词： frequency allocation transmon qubits superconducting processors

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Skin-Friendly Large Matrix Iontronic Sensing Meta-Fabric for Spasticity Visualization and Rehabilitation Training via Piezo-Ionic Dynamics

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Nano-Micro Letters 2025年第4期17卷 291-307页

作者： Ruidong xu Tong xu Minghua She Xinran Ji Ganghua Li Shijin Zhang Xinwei Zhang hong Liu Bin Sun Guozhen Shen Mingwei Tian Research Center for Intelligent and Wearable Technology College of Textiles and ClothingState Key Laboratory of Bio-Fibers and Eco-TextilesHealth&Protective Smart Textile Research Center of QingdaoQingdao UniversityQingdao 266071People’s Republic of China Academy of Arts&Design of Qingdao University Qingdao 266071People’s Republic of China College of Electronics and Information Qingdao UniversityQingdao 266071People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Rehabilitation training is believed to be an effectual strategy that canreduce the risk of dysfunction caused by ***,achieving visualizationrehabilitation training for patients remains clinically ***,wepropose visual rehabilitation training system including iontronic meta-fabrics withskin-friendly and large matrix features,as well as high-resolution image modules fordistribution of human muscle *** to the dynamic connection and dissociationof the meta-fabric,the fabric exhibits outstanding tactile sensing properties,such as wide tactile sensing range(0~300 kPa)and high-resolution tactile perception(50 Pa or 0.058%).Meanwhile,thanks to the differential capillary effect,the meta-fabric exhibits a“hitting three birds with one stone”property(dryness wearing experience,long working time and cooling sensing).Based on this,the fabrics can be integrated with garmentsand advanced data analysis systems to manufacture a series of large matrix structure(40×40,1600 sensing units)training ***,the tunability of piezo-ionic dynamics of the meta-fabric and the programmability of high-resolution imaging modules allowthis visualization training strategy extendable to various common disease ***,we believe that our study overcomes theconstraint of standard spasticity rehabilitation training devices in terms of visual display and paves the way for future smart healthcare.

关键词： Skin-friendly Large matrix Iontronic meta-fabric Spasticity visualization rehabilitation training

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Predicting the efficiency of arsenic immobilization in soils by biochar using machine learning

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Journal of Environmental Sciences 2025年第1期147卷 259-267页

作者： Jin-Man Cao Yu-Qian Liu Yan-Qing Liu Shu-Dan xue Hai-hong Xiong Chong-Lin xu Qi xu Gui-Lan Duan State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As)pollution in soils is a pervasive environmental *** immobilization offers a promising solution for addressing soil As *** efficiency of biochar in immobilizing As in soils primarily hinges on the characteristics of both the soil and the ***,the influence of a specific property on As immobilization varies among different studies,and the development and application of arsenic passivation materials based on biochar often rely on empirical *** enhance immobilization efficiency and reduce labor and time costs,a machine learning(ML)model was employed to predict As immobilization efficiency before biochar *** this study,we collected a dataset comprising 182 data points on As immobilization efficiency from 17 publications to construct three ML *** results demonstrated that the random forest(RF)model outperformed gradient boost regression tree and support vector regression models in predictive *** importance analysis and partial dependence plots based on the RF model were conducted to identify the most crucial factors influencing As *** findings highlighted the significant roles of biochar application time and biochar pH in As immobilization efficiency in ***,the study revealed that Fe-modified biochar exhibited a substantial improvement in As *** insights can facilitate targeted biochar property design and optimization of biochar application conditions to enhance As immobilization efficiency.

关键词： Biochar Arsenic immobilization Soil Machine learning

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