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Adamantiades-Behcet's disease-complicated gastroenteropathy

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World Journal of Gastroenterology 2012年第7期18卷 609-615页

作者： Qing-Jun Wu feng-chun zhang Xuan zhang feng-chun zhang Xuan ZhangDepartmentof RheumatologyPeking Union Medical College HospitalPe-king Union Medical CollegeChinese Academy of Medical Sci-encesBeijing 100730China

Adamantiades-Behcet's disease (ABD) is a chronic,relapsing,systemic vasculitis of unknown *** is more prevalent in populations along the ancient Silk Road from Eastern Asia to the Mediterranean Basin,and most frequently affects young adults between the second and fourth decades of ***-complicated gastroenteropathy is a significant cause of morbidity and mortality,with abdominal pain as the most common *** ileocecal region is affected predominantly,with ulcerations that may lead to penetration and/or perforation,whereas other parts of the gastrointestinal system including the esophagus and stomach can also be *** is useful to locate the site and extent of the lesions,and tissue biopsy is often warranted to examine the histopathology that is often suggestive of underlying vasculitis of small veins/venules or,alternatively in some cases,nonspecific *** wall thickening is the most common finding on computed tomography *** is largely empirical since well-controlled studies are difficult to conduct due to the heterogeneity of the disease,and the unpredictable course with exacerbation and *** with or without other immunosuppressive drugs,such as cyclophosphamide,azathioprine,sulfasalazine,tumor necrosis factor α antagonist or thalidomide should be applied before surgery,except in emergency.

关键词： Adamantiades-Behcet's disease Gastro-enteropathy Ulceration Vasculitis

Primary biliary cirrhosis:What do autoantibodies tell us?

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World Journal of Gastroenterology 2010年第29期16卷 3616-3629页

作者： Chao-Jun Hu feng-chun zhang Yong-Zhe Li Xuan zhang Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100032China

Primary biliary cirrhosis(PBC) is a chronic,progressive,cholestatic,organ-specific autoimmune disease of unknown *** predominantly affects middle-aged women,and is characterized by autoimmune-mediated destruction of small-and medium-size intrahepatic bile ducts,portal inflammation and progressive scarring,which without proper treatment can ultimately lead to fibrosis and hepatic *** autoantibodies are crucial tools for differential diagnosis of *** it is currently accepted that antimitochondrial antibodies are the most important serological markers of PBC,during the last five decades more than sixty autoantibodies have been explored in these patients,some of which had previously been thought to be specific for other autoimmune diseases.

关键词： Primary biliary cirrhosis Autoimmune disease Autoantibody Anti-mitochondrial antibody Antigp210 antibody Anti-sp100 antibody Anti-centromere antibodies

PIV EXPERIMENTAL RESEARCH OF INSTANTANEOUS FLOW CHARACTERISTICS OF CIRCULAR ORIFICE SYNTHETIC JET

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Journal of Hydrodynamics 2007年第4期19卷 453-458页

作者： XU Jing-lei SHA Jiang LIN chun-feng zhang Kun-yuan School of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The instantaneous flow characteristics of circular orifice synthetic jet was experimentally studied by a phase-locked Particle Image Velocimetry （PIV） system. The instantaneous flowfields, including the forming, developing and breaking down of the vortex for the jet were clearly shown by the PIV experimental results. As the basis of the study of the instantaneous flow, 36 images were taken and phase-averaged for each condition. The PIV experiment was mainly focused on the time evolution of the vortex pairs formed in the push cycle, the saddle point existing in the suck cycle, the variation of the centerline velocity in the whole cycle and the cross-stream velocity profiles and their self-similarity. Finally, the orifice depth was changed from 1.5 mm to 2 mm and 3.5 mm in order to study the effect of different orifice depths on the flow structure, which shows that at all stream wise sections, the peak of the mass flux and momentum flux increases as the orifice depth increases. Furthermore, the nondimensional distance of the mass flux from the exit is the maximum, while the nondimensional distance of the centerline velocity peak from the exit is the minimum, and nondimensional distance of the momentum flux from the exit section is between them.

关键词： circular synthetic jet Particle Image Velocimetry (PIV) phase-locked

Two-dimensional finite element mesh generation algorithm for electromagnetic field calculation

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Chinese Physics B 2021年第1期30卷 118-125页

作者： chun-feng zhang Wei Wang Si-Guang An Nan-Ying Shentu Department of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou 310016China

Two-dimensional finite element mesh generation algorithm for electromagnetic field calculation is proposed in this paper to improve the efficiency and accuracy of electromagnetic calculation. An image boundary extraction algorithm is developed to map the image on the geometric domain. Identification algorithm for the location of nodes in polygon area is proposed to determine the state of the node. To promote the average quality of the mesh and the efficiency of mesh generation, a novel force-based mesh smoothing algorithm is proposed. One test case and a typical electromagnetic calculation are used to testify the effectiveness and efficiency of the proposed algorithm. The results demonstrate that the proposed algorithm can produce a high-quality mesh with less iteration.

关键词： mesh generation smoothing function finite element electromagnetic calculation

A Near-Infrared Polymer Acceptor Enables over 15%Efficiency for All-Polymer Solar Cells

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Chinese Journal of Polymer Science 2022年第8期40卷 877-888,I0007页

作者： Tao Wang Rui Sun Xin-Rong Yang Yao Wu Wei Wang Qian Li chun-feng zhang Jie Min The Institute for Advanced Studies Wuhan UniversityWuhan430072China National Laboratory of Solid State Microstructures School of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Beijing National Laboratory for Molecular Sciences Beijing100190China Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationZhengzhou450002China

Finding effective molecular design strategies to enable efficient charge generation,high charge transport,and small energy loss is a longstanding challenge for developing high-performance all-polymer solar cells(all-PSCs).Here,we designed and synthesized a fused-aromatic-ring-constructed near-infrared(NIR)polymer acceptor(PA)PYT-Tz with fused-ring benzotriazole(BTz)-based A’-DAD-A’structure as electron-deficient-core,n-nonane as alkyl-side-chain and thiophene asπ-bridge,and achieved a power conversion efficiency(PCE)of 15.10%for the all-PSCs with PYT-Tz as acceptor and a wide-bandgap PBDB-T as donor.A control PA PYT reported by our lab recently was introduced for investigating the synergistic effect of the electron-deficient-core and alkyl-side-chain on the optoelectronic properties and photovoltaic performance of the n-type *** with PYT,the designed PYT-Tz exhibits intense and red-shifted absorption,upshifted energy levels,high electron mobility and ordered molecular packing in the active layers,and,blended with PBDB-T,yields the efficient hole injection,ultrafast charge generation,and the decreased non-radiative recombination loss of 0.17 *** note is that the PCE of 15.10%is one of the highest PCE values for an all-PSC reported to *** results indicate BTz-based fused-aromatic-ring-constructed PAs are promising NIR acceptors in the all-PSCs.

关键词： Benzotriazole-based A’-DAD-A’structure Near-infrared polymer acceptor High-performance all-polymer solar cells

Numerical Analysis of Perforation during Hydraulic Fracture Initiation Based on Continuous-Discontinuous Element Method

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 2103-2129页

作者： Rui zhang Lixiang Wang Jing Li chun feng Yiming zhang School of Civil and Transportation Engineering Hebei University of TechnologyTianjin300401China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou310018China Jinyun Institute Zhejiang Sci-Tech UniversityLishui321400China

Perforation is a pivotal technique employed to establish main flow channels within the reservoir formation at the outset of hydraulic fracturing *** perforation designs is critical for augmenting the efficacy of hydraulic fracturing and boosting oil or gas *** this study,we employ a hybrid finite-discrete element method,known as the continuous–discontinuous element method(CDEM),to simulate the initiation of post-perforation hydraulic fractures and to derive enhanced design *** model incorporates the four most prevalent perforation geometries,as delineated in an engineering technical ***-world perforations deviate from the ideal cylindrical shape,exhibiting variable cross-sectional profiles that typically manifest as an initial constriction followed by an expansion,a feature consistent across all four perforation *** simulations take into account variations in perforation hole geometries,cross-sectional diameters,and perforation *** findings show that perforations generated by the 39g DP3 HMX perforating bullet yield the lowest breakdown pressure,which inversely correlates with increases in sectional diameter and perforation ***,this study reveals the relationship between breakdown pressure and fracture degree,providing valuable insights for engineers and designers to refine perforation strategies.

关键词： Hydraulic fracturing real perforation shape breakdown pressure perforation layout design CDEM

Analysis of the one-decoy-state SARG04 quantum cryptography protocol in the presence of afterpulse effects

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Communications in Theoretical Physics 2024年第6期76卷 66-71页

作者： Hu Nian Ya-feng Nie chun-Mei zhang Liang-Liang Lu Key Laboratory of Optoelectronic Technology of Jiangsu Province School of Physical Science and TechnologyNanjing Normal UniversityNanjing 210023China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Hefei National Laboratory Hefei 230088China

The SARG04 quantum key distribution protocol can offer greater robustness against photon number splitting attacks than the BB84 protocol that is implemented with weak *** this paper,we propose a tight key analysis for the SARG04 protocol,by considering the one-decoy method and investigating its performance under the influence of a detector *** results demonstrate that an increase in block size leads to a slight increase in both the secure key rate and the maximum transmission ***,the detector afterpulse plays a crucial role in practical applications and has a more pronounced effect on the SARG04 protocol compared to the BB84 protocol.

关键词： Quantum key distribution SARG04 protocol one decoy afterpulse

Large deflection deformation behavior of a Zr-based bulk metallic glass for compliant spinal fixation application

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Journal of Materials Science & Technology 2024年第6期173卷 86-99页

作者： Diao-feng Li chun-Guang Bai Zhi-Qiang zhang Hui-Bo zhang Nan Li Jian Zhao Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

A novel compliant spinal fixation designed based on the concept of compliant mechanisms can reduce the stress-shielding effect and adjacent segment degeneration(ASD)effectively,but propose higher requirements for the properties of the used *** metallic glasses(BMGs),as a kind of young biomaterials,exhibiting excellent comprehensive properties,which are attractive for compliant spinal ***,according to the practical service condition of the basic elements in compliant spinal fixation,large deflection deformation behaviors of Zr_(61)Ti_(2)Cu_(25)Al_(12)(at.%,ZT1)BMG beam,including elastic,yielding and plastic were investigated *** was shown that the theoretical nonlinear analytical solution curve as the benchmark not only with the capacity to predict the nonlinear load-deflection relation within the elastic deformation regime,but also assists to capture the yielding event roughly,which can be used as a powerful design tool for *** capture the beginning of the yielding event exactly,bending proof strength(σ_(p),0.05%)accompanied with tiny permanent strain of 0.05% was proposed and determined for BMGs in biomedical implant applications,which is of significance for setting the allowable operating limits of the basic flexible *** approach of interrupted loading-unloading cycles,plastic deformation driven by the bending moment can be classified into two typical stages:the initial stage which mainly characterized by the nucleation and intense interaction of abundant shear bands when the plastic strain below the critical value,and the second stage which dominated by the progressive propagation of shear bands and coupled with the emergence of shear offsets on tensile *** plasticity of BMG beam structures depends on the BMG's inherent plastic zone size(rp).When the half beam thickness less than that of the rp,the plastic deformation of BMGs will behave in a stable manner,which can be acted as the margin of safety effectiv

关键词： Metallic glasses Biomaterials Compliant spinal fixation Large deflection deformation Plastic deformation

Hsp90-associated DNA replication checkpoint protein and proteasome-subunit components are involved in the age-related macular degeneration

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Chinese Medical Journal 2021年第19期134卷 2322-2332页

作者： Chen Xing Xiao-feng Liu chun-feng zhang Liu Yang Department of Ophthalmology Peking University First HospitalBeijing 100034China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Hepatopancreatobiliary Surgery Department IPeking University Cancer Hospital&InstituteBeijing 100142China Department of Medical Genetics School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Background:Age-related macular degeneration(AMD)is the leading cause of vision loss ***,the mechanisms involved in the development and progression of AMD are poorly *** aimed to explore the critical genes involved in the progression of ***:The differentially expressed genes(DEGs)in AMD retinal pigment epithelial(RPE)/choroid tissues were identified using the microarray datasets GSE99248 and GSE125564,which were downloaded from the gene expression omnibus *** overlapping DEGs from the two datasets were screened to identify DEG-related biological pathways using gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment *** hub genes were identified from these DEGs through protein-protein interaction network *** expression levels of hub genes were evaluated by quantitative real-time polymerase chain reaction following the induction of senescence in ARPE-19 with *** the identification of AMD-related key genes,the potential small molecule compounds targeting the key genes were predicted by ***,a microRNA-gene interaction network was ***:Microarray analyses identified 174 DEGs in the AMD RPE compared to the healthy RPE *** DEGs were primarily enriched in the pathways involved in the regulation of DNA replication,cell cycle,and proteasome-mediated protein *** the top ten hub genes,HSP90AA1,CHEK1,PSMA4,PSMD4,and PSMD8 were upregulated in the senescent ARPE-19 ***,the drugs targeting HSP90AA1,CHEK1,and PSMA4 were *** hypothesize that Hsa-miR-16-5p might target four out of the five key DEGs in the AMD ***:Based on our findings,HSP90AA1 is likely to be a central gene controlling the DNA replication and proteasome-mediated polyubiquitination during the RPE senescence observed in the progression of *** HSP90AA1,CHEK1,PSMA4,PSMD4,and/or PSMD8 genes through specific miRNAs or small molecules mi

关键词： Age-related macular degeneration Retinal pigment epithelium Cell senescence HSP90AA1 DNA damage checkpoint Proteasomal subunit components