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A phytochemical study on Dichocarpum auriculatum, an endangered medicinal plant peculiar to China

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Chinese Herbal Medicines 2019年第4期11卷 364-368页

作者： Pei Li Shuang-shuang Liu Qing Liu Jie Shen chun-nian He Pei-gen xiao Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China

Objective:Dichocarpum auriculatum,an endangered perennial herb,is endemic to China and has been used as folk medicines for the treatment of cough,hepatitis,scrofula,and ***,there is no phytochemical report on this herbal so *** the resource development and protective importance of this endangered medicinal plant,a phytochemical study was ***:The chemical constituents were purified by silica gel column,Sephadex LH-20 column,and semi-preparative reversed phase *** and MS spectra were used for structural ***:Thirteen compounds were isolated from *** structures were characterized as jatrorrhizine(1),berberine(2),steponine(3),magnoflorine(4),coclauril(5),menisdaurin(6),menisdaurilide(7),aquilegiolide(8),(6 R,9 S)-3-oxo-α-ionol-β-D-glucopyranoside(9),blumenol C glucoside(10),palmitic acid(11),dibutylphthalate(12),and auriculatum A(13).Conclusion:Compound 13 is a new diester terephthalate *** the compounds are obtained from the genus Dichocarpum for the first time,and compounds 9 and 10 have potential chemotaxonomic significance to the genus Dichocarpum.

关键词： benzylisoquinoline alkaloids chemical constituents cyanides Dichocarpum auriculatum(Franch.)W.T Wang et Hsiao megastigmane glycosides

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药师会诊的模拟教学

中国新药杂志 2008年第20期17卷 1805-1807页

作者：叶晓芬蔡映云吕迁洲复旦大学附属中山医院药剂科上海200032 复旦大学附属中山医院老年病科上海200032

通过模拟和互动教学法提高临床药学教学质量。按照临床会诊方式,提供一个模拟病例,组织临床药师培训基地学员与模拟患者沟通并对模拟病例进行讨论,提出会诊意见。模拟药师会诊的教学方法能够培养学员的自学能力,并提高药物治疗临床思维... 详细信息

通过模拟和互动教学法提高临床药学教学质量。按照临床会诊方式,提供一个模拟病例,组织临床药师培训基地学员与模拟患者沟通并对模拟病例进行讨论,提出会诊意见。模拟药师会诊的教学方法能够培养学员的自学能力,并提高药物治疗临床思维和解决实际用药问题的能力。

关键词：模拟药师会诊临床药学教学方法

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复杂微结构三维形貌测量方法的研究

光电子．激光 2006年第1期17卷 98-101页

作者：胡春光胡晓东徐临燕郭彤胡小唐天津大学精密测试技术及仪器国家重点实验室天津300072

微结构三维形貌测量是研究微加工工艺和微尺寸特性的重要测试内容。本文提出一种基于相移显微干涉术、利用干涉图建立二维结构模板指导相位展开的新方法,它不仅适用于静态测量,而且能应用于在动态测量中,特别是微机电系统(MEMS)器件的... 详细信息

微结构三维形貌测量是研究微加工工艺和微尺寸特性的重要测试内容。本文提出一种基于相移显微干涉术、利用干涉图建立二维结构模板指导相位展开的新方法,它不仅适用于静态测量,而且能应用于在动态测量中,特别是微机电系统(MEMS)器件的运动测量。以微谐振器为测试器件,对其运动梳齿结构进行了静态三维形貌测量,实验的离面理论测量精度优于0.5 nm,测试结构内部的面内理论测量精度优于0.5μm,而边缘尺寸因受到边缘提取方法的影响,其测量精度仅在μm量级。对该方法的缺点和发展方向做了探讨。

关键词：微结构三维形貌测量相移显微干涉术二维结构模板生长算法

Rapid prenatal diagnosis of trisomy 21 by fluorescent quantitative multiplex polymerase chain reaction

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Chinese Medical Journal 2006年第6期119卷 514-517页

作者： ZHENG Fang ZHOU Xin ZHANG Yuan-zhen SUN xiao-bo PENG Jian-hong WANG chun-hong XIONG Chen-ling LI Xia Gene Diagnosis Center Zhongnan Hospital of Wuhan UniversityWuhan 430071 China Department of Obstetrics and Gynecology Zhongnan Hospital ofWuhan University Wuhan 430071 China Department of Public Health Wuhan University Wuhan 430071China

Trisomy 21, also named Down syndrome was the most frequent autosomal aneuploidy and the most common cause of mental retardation. Fifty percent patients had congenital heart malformation. Every 20 minutes one case of trisomy 21 was born, and the incidence rate was 1 in 600 to 800 newborns in China.1 In two thirds of cases with trisomy 21, there was a spontaneous abortion, so the actual incidence was higher than that obtained postnatally.

关键词： fluorescent quantitative multiplex polymerase chain reaction prenatal diagnosis Down syndrome heterozygosity

R–fuzzy隶属度粗糙近似集的优势测度理论

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控制理论与应用 2019年第2期36卷 286-294页

作者：李守军马小平杨春雨宿迁学院机电工程学院江苏宿迁223800 中国矿业大学信息与控制工程学院江苏徐州221166

给出了一种R–fuzzy集隶属度的权重比较与量化方法,提出了优势测度概念,解决了粗糙近似集中隶属度的重要性难以确定的问题.首先给出优势测度的定义,然后,研究了优势测度的性质,指出了优势测度1型模糊集的本质属性.优势测度不仅实现了R-f... 详细信息

给出了一种R–fuzzy集隶属度的权重比较与量化方法,提出了优势测度概念,解决了粗糙近似集中隶属度的重要性难以确定的问题.首先给出优势测度的定义,然后,研究了优势测度的性质,指出了优势测度1型模糊集的本质属性.优势测度不仅实现了R-fuzzy集隶属度的量化,而且成为R-fuzzy集与2型模糊集联系的纽带.通过隶属度的优势测度,实现了人类感知领域中的群体共识与个性认识的区分,反过来通过优势测度的可视化,可以对人类不同感知下的隶属度值给出合理的推断与比较.最后,通过声音感知实验研究给出了优势测度可视化的特点及操作方法,讨论了不同职业测试组对于同一声音的理解在隶属度数值上的差异.对于涉及人类感知与模式辨识的应用领域具有较易的操作性与较强的实用性.

关键词： R–fuzzy集粗糙集优势测度智能感知模式分类

Finding optimal basis states for variation after projection nuclear wave functions

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Chinese Physics C 2023年第7期47卷 102-110页

作者：陆晓连占江李雪薇高早春陈永寿 China Institute of Atomic Energy Beijing 102413China

The variation after projection(VAP)method is expected to be an efficient way of obtaining the optimized nuclear wave functions,which can be as close as possible to the exact shell model ***,we found that there are two additional problems that may seriously affect the convergence of the VAP *** first problem is the existence of irrelevant projected basis *** a VAP iteration,the Hill-Wheeler(HW)equation is composed of all updated projected basis *** one of these projected basis states does not mix with a calculated wave function of interest,which is obtained by solving this HW equation,it is likely that this basis state will never mix with this wave function even after the VAP iteration *** other problem is the poor orthonormality among the projected basis states,which seriously affects the accuracy of the calculated VAP wave *** the present work,solutions for these two problems are proposed,and examples are presented to test the *** the present solutions,the most important projected basis states can be reliably obtained,and the fully optimized VAP wave functions can be accurately and efficiently calculated.

关键词： angular momentum projection variation after projection shell model

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“营改增”能否促进企业价值提升

税务与经济 2022年第1期 52-60页

作者：肖春明张文春山西财经大学财政与公共经济学院山西太原030006 中国人民大学财政金融学院北京100872 中国财政金融政策研究中心北京100872

"营改增"通过打通增值税抵扣链条、消除重复征税等,对企业税负降低和专业化分工会产生一定的促进作用,进而能够显著提升企业价值。而交通运输业由于"营改增"前后适用税率差异较大,且固定资产更新周期较长带来的进项抵扣不足,使得"营改增... 详细信息

"营改增"通过打通增值税抵扣链条、消除重复征税等,对企业税负降低和专业化分工会产生一定的促进作用,进而能够显著提升企业价值。而交通运输业由于"营改增"前后适用税率差异较大,且固定资产更新周期较长带来的进项抵扣不足,使得"营改增"对其企业价值的影响程度反而不及现代服务业。与私营企业相比,国有企业更容易受到政府政策干预或扶持,对税收政策的敏感性不及私营企业,即"营改增"对私营企业的企业价值的影响程度显著高于国有企业。鉴于"营改增"对企业价值的促进作用,国家应继续优化增值税体系,保持税收政策在促进企业价值提升时政策红利的延续性;在推行增值税改革的过程中,要增加配套税收优惠政策,以弥补政策效应对某些行业激励不足的短板;此外,要加快国有企业改革,营造公平的营商环境,促进税收中性原则的有效发挥。

关键词：营改增全面试点改革企业价值异质性检验

Corrosion behavior of Mg−Li alloys:A review

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Transactions of Nonferrous Metals Society of China 2021年第11期31卷 3228-3254页

作者： xiao-chun MA Si-yuan JIN Rui-zhi WU Jia-xiu WANG Gui-xiang WANG Boris KRIT Sergey BETSOfen Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China College of Science Heihe UniversityHeihe 164300China Moscow Aviation Institute National Research UniversityMoscow 125993Russia

It has been known that the lack of excellent corrosion resistance is the key problem restricting the wide application of Mg−Li *** on a quantity of literature about corrosion behavior of Mg−Li alloys,this review elaborates the factors affecting the corrosion behavior of Mg−Li alloys and the processing methods for improving corrosion *** corrosion characteristics of Mg−Li alloys are described ***,it is explained that the grain size,orientation,second phase,and surface film strongly influence corrosion performance,which can be tailored by alloying,plastic deformation,and heat *** in-depth discussion about the corrosion mechanisms for Mg−Li alloys was also ***,important points of improving corrosion resistance are suggested.

关键词： Mg−Li alloy corrosion behavior microstructure surface film alloying plastic deformation heat treatment

司他斯汀联合雷公藤多苷片治疗慢性荨麻疹疗效观察

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中国新药杂志 2019年第23期28卷 2857-2859页

作者：肖春才张晨阳郑州大学附属郑州中心医院皮肤科

目的:观察司他斯汀联合雷公藤多苷片治疗慢性荨麻疹的临床疗效。方法:来自我科门诊的80例确诊为慢性荨麻疹的患者,随机分为两组,治疗组40例,对照组40例,两组患者均给予司他斯汀片1 mg·次-1,bid;治疗组在口服司他斯汀的基础上联合雷公... 详细信息

目的:观察司他斯汀联合雷公藤多苷片治疗慢性荨麻疹的临床疗效。方法:来自我科门诊的80例确诊为慢性荨麻疹的患者,随机分为两组,治疗组40例,对照组40例,两组患者均给予司他斯汀片1 mg·次-1,bid;治疗组在口服司他斯汀的基础上联合雷公藤多苷片,20 mg·次-1,tid,治疗12周。结果:治疗12周后,治疗组总有效率为94.9%,明显高于对照组的77.5%(P<0.05)。停药3个月后随访,治疗组和对照组的复发率分别为11.1%和31%,差异有统计学显著性(P<0.05)。结论:司他斯汀联合雷公藤多苷片治疗慢性荨麻疹,能提高治愈率,降低复发率,值得推广应用。

关键词：司他斯汀雷公藤多苷片慢性荨麻疹