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Emerging microfluidics for the modeling and treatment of arthritis

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Engineered Regeneration 2024年第2期5卷 153-169页

作者： Nengjie Yang Chi Sun Chen dong Yuting Huang Yujuan Zhu Zhifeng gu Department of Rheumatology Research Center of ImmunologyAffiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong 226001China Department of Geriatrics Affiliated Hospital of Nantong UniversityNantong UniversityNantong 226001China Department of Dermatology Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong 226001China Research Center of Clinical Medicine Research Center of ImmunologyAffiliated Hospital of Nantong UniversityNantong 226001China

Microfluidic is a technology that allows the precise control of fluid in a *** its advantages of high throughput and low cost,microfluidic technology has achieved good performance in various fields in recent *** is a general term for a variety of joint diseases,which can be clinically manifested as joint pain and swelling,seriously affecting people’s physical and mental *** present,the causes of arthritis disease are still unknown,and existing disease models and treatment methods are still limited,so more treatments need to be *** organ chip is a cutting-edge technology to build a bionic human organ model,which can reflect the structure and function characteristics of human organs by simulating the physiological environment of tissues and cells in *** paper reviews the application of microfluidic technology in the modeling and treatment of arthritis,hoping to open up a new vision for the study of arthritis.

关键词： Microfluidics Arthritis Organ on a chip Drug delivery system Drug screening

The Inherent Law of the Unpredictability of Financial Asset Price Fluctuations: Multistability and Chaos

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Journal of Systems Science & Complexity 2024年第2期37卷 776-804页

作者： gu Enguo Huanghe University of Science and Technology Zhengzhou 450006China

This paper aims at understanding the price dynamics generated by the interaction of traders relying on heterogeneous expectations in an asset pricing *** the present work the authors analyze a financial market populated by five types of boundedly rational speculators-two types of fundamentalists,two types of chartists and trend followers which submit buying/selling orders according to different trading *** authors formulate a stock market model represented as a 2 dimensional piecewise linear discontinuous *** proposed contribution to the existing financial literature is two ***,the authors perform study of the model involving a 2 dimensional piecewise linear discontinuous map through a combination of qualitative and quantitative *** authors focus on the existence conditions of chaos and the multi-stability regions in parameter *** border collision bifurcation curves and basins of multi-attractors are also *** authors find that chaos or quasi-period exists only in the case of fixed point being a saddle(regular or flip)and that the coexistence of multiple attractors may exist when the fixed point is an attractor,but it is common for spiral and flip fixed points.

关键词： BCB curve chaos financial market heterogeneous agents multiple attractors piecewise linear discontinuous map

Anti-N-methyl-D-aspartate receptor type autoimmune encephalitis with severe pneumonia:a case report

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World Journal of Emergency Medicine 2024年第2期15卷 142-146页

作者： Yi gu Xiandong Liu Tiancao dong Qian Yang Xiaowei Bao dongyang Zhao Lunxian Tang Department of Internal Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200120China

Autoimmune encephalitis(AE)is a type of encephalitis caused by autoimmune *** was included on a list of the first batch of 121 rare diseases published by the Chinese National Health Commission on 11^(th)May ***,patients with AE account for 10%-20% of encephalitis cases,with 54%-80% of those cases classified as the anti-N-methyl-D-aspartate receptor(NMDAR)type,which is the most common type.[1]In 2010,China reported the first case of a patient withanti-NMDARtype AE.

关键词： encephalitis autoimmune aspartate

Experimental Investigation on Heat Transfer and Combustion of a Stirling Engine Combustor Fueled by Reformed Gas and Diesel Fuel

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Journal of Thermal Science 2024年第5期33卷 1907-1919页

作者： LAN Jian ZHAO Yanchun LIN guangtao LI Yelin REN Zhe LYU Tian SHEN Mengmeng gu Genxiang HAN dong Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China Shanghai Marine Diesel Engine Research Institute Shanghai 201108China

Thermochemical recuperation heat recovery is an advanced waste heat utilization technology that can effectively recover exhaust waste heat from oxy-fuel Stirling *** novel combustor of a Stirling engine with thermochemical recuperation heat recovery system is expected to utilize both reformed gas and diesel fuels as sources of *** this research,the effects of various factors,including the H_(2)O addition,fuel distribution ratio(FDR),excess oxygen coefficient,and cyclone structure on the temperature distribution in the combustor,combustion emissions,and external combustion system efficiency of the Stirling engine were experimentally *** the increase of steam-to-carbon ratio(S/C),the temperature difference between the upper and lower heating tubes reduces and the circumferential temperature fluctuation decreases,and the combustion of diesel and reformed gas remains close to complete *** S/C=2,the external combustion efficiency is 80.6%,indicating a 1.6%decrease compared to conventional *** the increase of FDR,the temperature uniformity of the heater tube is improved,and the CO and HC emissions ***,the impact of the FDR on the maximum temperature difference and temperature fluctuation across the heater is *** the FDR rises from 21%to 38%,the external combustion efficiency increases from 87.4%to92.3%.The excess oxygen coefficient plays a secondary role in influencing temperature uniformity and temperature difference,and the reformed gas and diesel fuel can be burned efficiently at a low excess oxygen coefficient of *** an increase in the cyclone angle,the heater tube temperature increases,while the maximum temperature difference at the lower part decreases,and the temperature fluctuation ***,the CO and HC emissions increase,and the external combustion efficiency experiences a decrease.A cyclone angle of 30°is found to be an appropriate value for achieving optimal

关键词： Stirling engine fuel reforming synthetic gas oxy-combustion external combustion efficiency

Seasonal Characteristics of Forecasting Uncertainties in Surface PM_(2.5)Concentration Associated with Forecast Lead Time over the Beijing-Tianjin-Hebei Region

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Advances in Atmospheric Sciences 2024年第5期41卷 801-816页

作者： Qiuyan DU chun ZHAO Jiawang FENG Zining YANG Jiamin XU Jun gu Mingshuai ZHANG Mingyue XU Shengfu LIN Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology University of Science and Technology of ChinaHefei 230026China

Forecasting uncertainties among meteorological fields have long been recognized as the main limitation on the accuracy and predictability of air quality ***,the particular impact of meteorological forecasting uncertainties on air quality forecasts specific to different seasons is still not well *** this study,a series of forecasts with different forecast lead times for January,April,July,and October of 2018 are conducted over the Beijing-Tianjin-Hebei(BTH)region and the impacts of meteorological forecasting uncertainties on surface PM_(2.5)concentration forecasts with each lead time are *** increased lead time,the forecasted PM_(2.5)concentrations significantly change and demonstrate obvious seasonal *** general,the forecasting uncertainties in monthly mean surface PM_(2.5)concentrations in the BTH region due to lead time are the largest(80%)in spring,followed by autumn(~50%),summer(~40%),and winter(20%).In winter,the forecasting uncertainties in total surface PM_(2.5)mass due to lead time are mainly due to the uncertainties in PBL heights and hence the PBL mixing of anthropogenic primary *** spring,the forecasting uncertainties are mainly from the impacts of lead time on lower-tropospheric northwesterly winds,thereby further enhancing the condensation production of anthropogenic secondary particles by the long-range transport of natural *** summer,the forecasting uncertainties result mainly from the decrease in dry and wet deposition rates,which are associated with the reduction of near-surface wind speed and precipitation *** autumn,the forecasting uncertainties arise mainly from the change in the transport of remote natural dust and anthropogenic particles,which is associated with changes in the large-scale circulation.

关键词： PM_(2.5) forecasting uncertainties forecast lead time meteorological fields Beijing-Tianjin-Hebei region

Radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field

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Journal of Iron and Steel Research International 2024年第6期31卷 1355-1366页

作者： Sheng-hao Li Ao Huang Fan-bo Zeng Hui Peng Hao-ran Wei Xue-chun Huang Sheng-qiang Song Hua-zhi gu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

High alumina slag will cause severe corrosion at the interface of alumina refractory,and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory *** static magnetic field is a promising solution for improvement in the slag resistance of *** wetting of alumina refractory ceramics with different basicities of high alumina slags under a weak static magnetic field was analyzed,given that a weak static magnetic field can affect the corrosion behavior of refractory *** slag S_(3) as an example,when there was an external static magnetic field of 1.0 mT at 1600 ℃,the thickness of calcium aluminate reaction layer at the interface decreased by 36.7%,the denting depth of interface decreased by 35.6%,and the apparent wetting angle increased by 20%.The living radicals and their formation path in oxide melts were verified by first-principles calculation combined with electron paramagnetic resonance spectroscopy *** influence of the flux density of a weak static magnetic field on the wetting behavior of slags was also *** contact angle of the slags increased owing to the inhibitory effect of magnetic field on the radicalinvolved reaction at the interface of the slag and the alumina refractory *** relationships between the magnetic flux density,diffusion coefficient,slag microstructure(hyperfine coupling constant),and contact angle were *** provides a theoretical basis for the field control of radical involved reactive wetting between inorganic oxide slags and solid oxide ceramics.

关键词： Alumina refractory ceramic Molten slag Weak magnetic field effect Reactive wetting Free radical

Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella(MMAF)and ICSI outcomes

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Asian Journal of Andrology 2024年第1期26卷 91-98页

作者： Zhong-Mei Shao Yu-Tong Zhu Meng gu Sen-Chao guo Hui Yu Kuo-Kuo Li dong-dong Tang Yu-Ping Xu Ming-Rong Lv Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Obstetrics and Gynecology Fuyang Hospital of Anhui Medical UniversityFuyang 236112China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People'sRepublicof ChinaHefei 230032China

Variations in the dynein axonemal heavy chain gene,dynein axonemal heavy chain 6(DNAH6),lead to multiple morphological abnormalities of the *** studies have reported that these deficiencies may result in sperm head ***,whether DNAH6 is also involved in human acrosome biogenesis remains *** purpose of this study was to investigate DNAH6 gene variants and their potential functions in the formation of defective sperm heads and ***-exome sequencing was performed on a cohort of 375 patients with asthenoteratozoospermia from the First Affiliated Hospital of Anhui Medical University(Hefei,China).Hematoxylin and eosin staining,scanning electron microscopy,and transmission electron microscopy were performed to analyze the sperm morphology and *** staining and Western blot analysis were conducted to examine the effects of genetic *** identified three novel deleterious variants in DNAH6 among three unrelated *** absence of inner dynein arms and radial spokes was observed in the sperm of patients with DNAH6 ***,deficiencies in the acrosome,abnormal chromatin compaction,and vacuole-containing sperm heads were observed in these patients with DNAH6 *** decreased levels of the component proteins in these defective structures were further confirmed in sperm from patients with DNAH6 variants using Western *** intracytoplasmic sperm injection(ICSl)treatment,the partner of one patient with a DNAH6 variant achieved successful ***,novel variants in DNAH6 genes that contribute to defects in the sperm head and flagella were identified,and the findings indicated Icsl as an effective clinical treatment for such patients.

关键词： asthenoteratospermia DNAH6 intracytoplasmic sperm injection male infertility

Non-destructive Testing and Intelligent Evaluation of Road Structural Conditions using GPR and FWD

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Zhen Liu Siqi Wang Xingyu gu Qiao dong National Demonstration Center for Experimental Road and Traffic Engineering Education (Southeast University) Department of Roadway Engineering， School of Transportation， Southeast University

Aiming at the assessment of road structural conditions， a method of combining ground penetrating radar (GPR) and falling weight deflectometer (FWD) for assessing the pavement structural integrity and strength was proposed in this study. First， 3D GPR was performed to detect the thickness and internal distress of pavement structural layers using the canny edge detection and you only look once version eight (YOLOv8) detection algorithms. Results showed that the error of thickness extraction was approximately 3%， and the distress detection achieved a mean average precision (mAP) of 0.859 and an inference time of 11.43 ms with a GTX 1070 GPU. Then， the extracted thickness was used for the modulus (E) inversion of pavement structure layers based on FWD test data and regression analysis. Finally， the distress ratio inside pavement structures (DRIPS) was proposed as a structural integrity index. The relationship between E and DRIPS was revealed and showed a good correlation. The greater the DRIPS value， the worse the pavement structural integrity and strength. It provides a reference for the evaluation of road structural conditions. This strategy proved to be reliable for nondestructive testing and evaluation of road structures， which could improve the comprehensiveness and effectiveness for evaluating road structural conditions.

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Valorization of wheat bran arabinoxylan: A review on nutritional and materials perspectives

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Grain & Oil Science and Technology 2024年第3期7卷 196-208页

作者： Muhammad Bilal Dandan Li Chong Xie Runqiang Yang Zhenxin gu dong Jiang Xueming Xu Pei Wang College of Food Science and Technology Whole Grain Food Engineering Research CenterNanjing Agricultural UniversityNanjing 210095JiangsuChina The Sanya Institute of Nanjing Agricultural University Sanya 572024HainanChina National Technique Innovation Center for Regional Wheat Production/Key Laboratory of Crop Physiology Ecologyand ManagementMinistry of Agriculture/National Engineering and Technology Center for Information AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxi 214122JiangsuChina

Wheat bran, a principal byproduct of flour milling, stands as an abundant source of dietary fiber, yet its economic potential remains under-exploited in current forage applications. Arabinoxylan(AX), constituting the core of dietary fiber, emerges as a versatile compound with multifaceted functionalities. Its nutritional significance,coupled with its role in cereal food processing, has prompted a surge of studies focusing on the valorization of wheat bran AX. Moreover, the hydrolyzed derivative, arabinoxylan oligosaccharides(AXOS), demonstrates prebiotic and antioxidant properties, offering potential avenues to mitigate the risk of chronic diseases. This review summarizes current knowledge on the valorization of wheat bran AX in terms of the processing and nutritional properties of AX. Moreover, multiple novel applications of AX in the materials area, including biodegradable food packaging films, delivery of bioactive substances as nanoparticles, and the manufacture of food emulsifiers, are also highlighted to extend the utilization of AX. This review underscores the immense potential of wheat bran AX, advocating for its exploitation not only as a nutritional asset but also as a primary ingredient in advanced materials. The synthesis of nutritional and materials perspectives accentuates the multifaceted utility of wheat bran AX, thereby paving the way for sustainable valorization pathways. By unraveling the latent potential within AX, this paper advocates for the holistic and sustainable utilization of wheat bran in diverse, value-added applications.

关键词： Wheat bran Arabinoxylan Nutrition Biodegradable films Nanoparticles Food emulsifiers