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Electroacupuncture and moxibustion promote regeneration of injured sciatic nerve through Schwann cell proliferation and nerve growth factor secretion

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Neural Regeneration Research 2018年第3期13卷 477-483页

作者： Lin-na Hu Jin-xin Tian Wei Gao Jing Zhu Fang-fang Mou Xiao-chun ye Yu-pu Liu Ping-ping Lu Shui-jin Shao Hai-dong Guo Department of Anatomy School of Basic Medicine Shanghai University of Traditional Chinese Medicine Department of Internal Medicine Shanghai Changhang Hospital Department of Gynaecology and Obstetrics Heze Hospital of Traditional Chinese Medicine

Using electroacupuncture and moxibustion to treat peripheral nerve injury is highly efficient with low side effects. However, the electroacupuncture-and moxibustion-based mechanisms underlying nerve repair are still unclear. Here, in vivo and in vitro experiments uncovered one mechanism through which electroacupuncture and moxibustion affect regeneration after peripheral nerve injury. We first established rat models of sciatic nerve injury using neurotomy. Rats were treated with electroacupuncture or moxibustion at acupoints Huantiao （GB30） and Zusanli （ST36）. Each treatment lasted 15 minutes, and treatments were given six times a week for 4 consecutive weeks. Behavioral testing was used to determine the sciatic functional index. We used electrophysiological detection to measure sciatic nerve conduction velocity and performed hematoxylin-eosin staining to determine any changes in the gastrocnemius muscle. We used immunohistochemistry to observe changes in the expression of S100—a specific marker for Schwann cells—and an enzyme-linked immunosorbent assay to detect serum level of nerve growth factor. Results showed that compared with the model-only group, sciatic functional index, recovery rate of conduction velocity, diameter recovery of the gastrocnemius muscle fibers, number of S100-immunoreactive cells,and level of nerve growth factor were greater in the electroacupuncture and moxibustion groups. The efficacy did not differ between treatment groups. The serum from treated rats was collected and used to stimulate Schwann cells cultured in vitro. Results showed that the viability of Schwann cells was much higher in the treatment groups than in the model group at 3 and 5 days after treatment. These findings indicate that electroacupuncture and moxibustion promoted nerve regeneration and functional recovery; its mechanism might be associated with the enhancement of Schwann cell proliferation and upregulation of nerve growth factor.

关键词： nerve regeneration peripheral nerve injury electroacupuncture moxibustion acupuncture serum Schwann cells nerve growth factor proliferation regeneration sciatic functional index neural regeneration

A New Soil Infiltration Technology for Decentralized Sewage Treatment:Two-Stage Anaerobic Tank and Soil Trench System

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Pedosphere 2008年第3期18卷 401-408页

作者： ye chun HU Zhan-Bo KONG Hai-Nan WANG Xin-Ze HE Sheng-Bing School of Environmental Science and Engineering Shanghai Jiaotong University Shanghai 200230 （China） School of Light Industry and Food Engineering Guangxi University Nanning 530004 （China） Research Center of Lake Ecological Environment Chinese Research Academy of Environmental Sciences Beijing 100012（China）

The low removal efficiency of total nitrogen （TN） is one of the main disadvantages of traditional single stage subsurface infiltration system, which combines an anaerobic tank and a soil filter field. In this study, a full-scale, two-stage anaerobic tank and soil trench system was designed and operated to evaluate the feasibility and performances in treating sewage from a school campus for over a one-year monitoring period. The raw sewage was prepared and fed into the first anaerobic tank and second tank by 60% and 40%, respectively. This novel process could decrease chemical oxygen demand with the dichromate method by 89%-96%, suspended solids by 91%-97%, and total phosphorus by 91%-97%. The denitrification was satisfactory in the second stage soil trench, so the removals of TN as well as ammonia nitrogen （NH4^＋-N） reached 68%-75% and 96% 99%, respectively. It appeared that the removal efficiency of TN in this two-stage anaerobic tank and soil trench system was more effective than that in the single stage soil infiltration system. The effluent met the discharge standard for the sewage treatment plant （GB18918-2002） of China.

关键词： decentralized treatment nitrogen removal soil trench system subsurface infiltration

Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis

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Chinese Herbal Medicines 2019年第2期11卷 222-230页

作者： Wan-chun ye Jian-zhong ye Cheng Zheng Xiao-wei He Jia-jie Huang Ren ye Department of Chemotherapy 2 Wenzhou Central Hospital Wenzhou 325000 China State Key Laboratory for Diagnosis and Treatment of Infectious Disease The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310000 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University Hangzhou 310000 China Department of Cardiology The Second Affiliated Hospital Wenzhou Medical University Wenzhou 325000 China Zhuang Medical College Guangxi University of Chinese Medicine Nanning 530000 China Department of Traditional Chinese Medicine The First Affiliated Hospital Wenzhou Medical University Wenzhou 325000 China

Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines,tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy(DN).Methods: A comprehensive research of 12 electronic databases was performed. Data of the included studies were extracted and analyzed independently by two authors, and were synthesized using Review Manager(version 5.2) and Stata(version 12.0).Results: A total of 12 randomized controlled trials(RCTs) involving 829 patients were included. Pooled results showed that the combination therapy significantly increased total efficacy of DN patients [RR = 1.35,95% CI(1.22, 1.50), P 0.05), blood urea nitrogen [MD = 0.25, 95% CI(-0.23, 0.74), P > 0.05], and endogenous creatinine clearance rate[MD =-0.43, 95% CI(-3.48, 2.62), P > 0.05]. However, tripterygium glycosides plus valsartan seemed to exert higher adverse reaction rate than valsartan monotherapy [MD = 3.41, 95% CI(1.34, 8.66), P < 0.05].There were no publication bias for all of the pooled effect ***: Combination therapy of tripterygium glycosides plus valsartan may be effective for the treatment of DN. However, the safety of the combination therapy need to be further confirmed.

关键词： diabetic nephropathy meta-analysis tripterygium glycosides valsartan

Accelerating Data Transfer in Dataflow Architectures Through a Look-Ahead Acknowledgment Mechanism

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Journal of Computer Science & Technology 2022年第4期37卷 942-959页

作者： Yu-Jing Feng De-Jian Li Xu Tan Xiao-chun ye Dong-Rui Fan Wen-Ming Li Da Wang Hao Zhang Zhi-Min Tang State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China Beijing Smartchip Microelectronics Technology Company Limited Beijing 100000China School of Computer and Control Engineering University of Chinese Academy of SciencesBeijing 100190China

The dataflow architecture,which is characterized by a lack of a redundant unified control logic,has been shown to have an advantage over the control-flow architecture as it improves the computational performance and power efficiency,especially of applications used in high-performance computing(HPC).Importantly,the high computational efficiency of systems using the dataflow architecture is achieved by allowing program kernels to be activated in a simultaneous ***,a proper acknowledgment mechanism is required to distinguish the data that logically belongs to different *** solutions include the tagged-token matching mechanism in which the data is sent before acknowledgments are received but retried after rejection,or a handshake mechanism in which the data is only sent after acknowledgments are ***,these mechanisms are characterized by both inefficient data transfer and increased area *** performance of the dataflow architecture depends on the efficiency of data *** order to optimize the efficiency of data transfer in existing dataflow architectures with a minimal increase in area and power cost,we propose a Look-Ahead Acknowledgment(LAA)*** accelerates the execution flow by speculatively acknowledging ahead without *** simulation analysis based on a handshake mechanism shows that our LAA increases the average utilization of computational units by 23.9%,with a reduction in the average execution time by 17.4%and an increase in the average power efficiency of dataflow processors by 22.4%.Crucially,our novel approach results in a relatively small increase in the area and power consumption of the on-chip logic of less than 0.9%.In conclusion,the evaluation results suggest that Look-Ahead Acknowledgment is an effective improvement for data transfer in existing dataflow architectures.

关键词： dataflow model control-flow model high-performance computing application data transfer power efficiency

Scalability of 3D deterministic particle transport on the Intel MIC architecture

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Nuclear Science and Techniques 2015年第5期26卷 88-97页

作者：王庆林刘杰龚春叶邢座程 Science and Technology on Parallel and Distributed Processing Laboratory National University of Defense Technology Science and Technology on Space Physics Laboratory

The key to large-scale parallel solutions of deterministic particle transport problem is single-node computation performance. Hence, single-node computation is often parallelized on multi-core or many-core computer architectures. However, the number of on-chip cores grows quickly with the scale-down of feature size in semiconductor technology. In this paper, we present a scalability investigation of one energy group time-independent deterministic discrete ordinates neutron transport in 3D Cartesian geometry(Sweep3D) on Intel's Many Integrated Core(MIC) architecture, which can provide up to 62 cores with four hardware threads per core now and will own up to 72 in the future. The parallel programming model, Open MP, and vector intrinsic functions are used to exploit thread parallelism and vector parallelism for the discrete ordinates method, respectively. The results on a 57-core MIC coprocessor show that the implementation of Sweep3 D on MIC has good scalability in performance. In addition, the application of the Roofline model to assess the implementation and performance comparison between MIC and Tesla K20 C Graphics Processing Unit(GPU) are also reported.

关键词：计算机体系结构可扩展性粒子输运三维几何英特尔麦克风离散坐标法计算性能

Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2018年第23期24卷 2468-2481页

作者： Jian-Zhong ye Ya-Ting Li Wen-Rui Wu Ding Shi Dai-Qiong Fang Li-Ya Yang Xiao-Yuan Bian Jing-Jing Wu Qing Wang Xian-Wan Jiang Cong-Gao Peng Wan-chun ye Peng-Cheng Xia Lan-Juan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003Zhejiang ProvinceChina Department of Chemotherapy 2 Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina Department of Clinical Laboratory Tai’an Central HospitalTai’an 271000Shandong ProvinceChina

AIM To investigate changes in gut microbiota and metabolism during nonalcoholic steatohepatitis(NASH) development in mice fed a methionine-choline-deficient(MCD) diet. METHODS Twenty-four male C57 BL/6 J mice were equally divided into four groups and fed a methionine-choline-sufficient diet for 2 wk(Control 2 w group,n = 6) or 4 wk(Control 4 w group,n = 6) or the MCD diet for 2 wk(MCD 2 w group,n = 6) or 4 wk(MCD 4 w group,n = 6). Liver injury,fibrosis,and intestinal barrier function were evaluated after 2 and 4 wk of feeding. The fecal microbiome and metabolome were studied using 16 s r RNA deep sequencing and gas chromatography-mass spectrometry. RESULTS The mice fed the MCD diet presented with simple hepatic steatosis and slight intestinal barrier deterioration after 2 wk. After 4 wk of feeding with the MCD diet,however,the mice developed prominent NASH with liver fibrosis,and the intestinal barrier was more impaired. Compared with the control diet,the MCD diet induced gradual gut microbiota dysbiosis,as evidenced by a marked decrease in the abundance of Alistipes and the(Eubacterium) coprostanoligenes group(P < 0.001 and P < 0.05,respectively) and a significant increase in Ruminococcaceae UCG 014 abundance(P < 0.05) after 2 wk. At 4 wk,the MCD diet significantly reduced the promising probiotic Bifidobacterium levels and markedly promoted Bacteroides abundance(P < 0.05,and P < 0.01,respectively). The fecal metabolomic profile was also substantially altered by the MCD diet: At 2 wk,arachidic acid,hexadecane,palmitic acid,and tetracosane were selected as potential biomarkers that were significantly different in the corresponding control group,and at 4 wk,cholic acid,cholesterol,arachidic acid,tetracosane,and stearic acid were selected. CONCLUSION The MCD diet induced persistent alterations in the gut microbiota and metabolome.

关键词： Nonalcoholic steatohepatitis Methioninecholine deficient diet Gut microbiota Metabolome Nonalcoholic fatty liver disease

Chemical Constituents of Streptocaulon juventas

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Chemical Constituents of Streptocaulon juventas

东亚音乐考古学第十届年会暨音乐文化人类学高端论坛会议综述

第十四届全国中药和天然药物学术研讨会

作者： ye chun HAN Na XUE Rui YIN Jun School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

Streptocaulon juventas is a member of Streptocaulon genus in Ascle-piadaceae *** anti-tumor fraction from the 75%ethanol extract of the roots of Streptocaulon juventas was found by bioassay-guided fractionation,and40 compounds including 14 new ones（1-14）together with 26 known ones we-re obtained by HPD100 macroporous adsorption resin column,silica gel colum-n chromatography,Sephedax LH-20 column,ODS column chromatography,MPLC,preparative TLC and preparative *** structures were characterizedby extensive analysis of 1D and 2D NMR and HR-ESIMS data as acovenosig-enin A 3-O-[O--D-glucopyranosyl-（1 6）-O--D-glucopyranosyl-（1 4）-O--D-di-gitalopyranosyl-（1 4）--D-cymaropyranoside]（1）,16-O-acetyl-hydroxyacovenosi-genin 3-O-[O--D-glucopyranosyl-（1 — 6）-O--D-glucopyranosyl-（1 —4）-2-O-acetyl--D-digitalopyranoside（2）,acovenosigenin A 3-O-[O--D-glucopyranosyl-（1 6）-O--D-glucopyranosyl-（1 4）-2-O-acetyl--D-digitalopyranoside]（3）,acovenosige-nin A 3-O-[O--D-glucopyranosyl-（1 6）-O--D-glucopyranosyl-（1 4）--D-cyma-ropyranoside]（4）,periplogenin 3-O-[O--D-glucopyranosyl-（1 4）-O- "-D-glucopy-ranosyl-（1 4）--D-digitoxopyranoside]（5）,periplogenin 3-O-[O--D-glucopyrano-syl-（1 6）-O--D-glucopyranosyl-（14）-2-O-acetyl--D-digitalopyranoside]（6）,16-O-acetyl-hydroxyacovenosigenin（7）,16-O-acetyl-hydroxyperiplogenin3-O--D-di-gitoxopyranoside（8）,1,14-dihydroxy-5-card-20（22）-enolide 3-O-[O--D-glu-copyranosyl-（1 2）--D-digitalopyranoside]（9）,1,3,14-trihydroxy-5-card-16,20（22）-dienolide（10）,digitoxigenin 3-O-[O--D-glucopyranosyl-（1 4）-2-O-a-cetyl--D-digitalopyranoside]（11）,periplogenin 3-O-[O--D-glucopyranosyl-（1 4）-O--D-glucopyranosyl-（1 4）--D-cymaropyranoside]（12）,acovenosigenin A 3-O-[O--D-glucopyranosyl-（1 4）--D-digitalopyranoside]（13）,digitoxigenin 3-O-[O--D-glucopyranosyl-（1 6）-O--D-glucopyranosyl-（1 4）-2-O-acetyl--D-digital-opyranoside]（14）,evonogenin（15）,5-hydroxygitoxigenin（16）,neritaloside（17）,honghelotrioside A（18）,hongheloside G（19）,odoroside H（20）,odoroside G（21）,echunbioside（22）,d

关键词： Streptocaulon juventas chemical constituents activity evaluation anti-tumor

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人民音乐 2019年第5期 39-40页

作者：叶春华南师范大学音乐学院

东亚音乐考古学第十届年会暨音乐文化人类学高端论坛于2018年10月12—13日在华南师范大学举行。自2008年在韩国召开第一届东亚音乐考古学术研讨会至今,学会正好走过十个春秋。在中韩两国学者共同努力下,本着'尊重学术、承担责任、友好... 详细信息

东亚音乐考古学第十届年会暨音乐文化人类学高端论坛于2018年10月12—13日在华南师范大学举行。自2008年在韩国召开第一届东亚音乐考古学术研讨会至今,学会正好走过十个春秋。在中韩两国学者共同努力下,本着'尊重学术、承担责任、友好协商、共同面对'的原则,两国轮流举办了历届年会。在东北亚乃至国际音乐考古学研究中取得了令人瞩目的学术成果,为学科建设和发展做出了重要贡献。

关键词：音乐考古学音乐文化人类学岭南音乐高端论坛

模糊交货期Flow-shop调度问题的改进微粒群算法

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哈尔滨工业大学学报 2009年第1期41卷 145-148页

作者：柳毅叶春明上海理工大学管理学院上海200093 杭州电子科技大学管理科学与信息工程研究所杭州300018

针对企业生产中由定单变化引起的具有模糊交货期性质的连续生产调度问题,提出一种改进的微粒群算法.通过对模糊交货期Flowshop调度问题的模糊机会约束设置惩罚函数,引入自适应变异和交叉等方法来改进算法,仿真结果表明算法具有较好的全... 详细信息

针对企业生产中由定单变化引起的具有模糊交货期性质的连续生产调度问题,提出一种改进的微粒群算法.通过对模糊交货期Flowshop调度问题的模糊机会约束设置惩罚函数,引入自适应变异和交叉等方法来改进算法,仿真结果表明算法具有较好的全局寻优和实用性,优于遗传算法和启发式算法.

关键词：流水车间调度模糊交货期微粒群算法惩罚函数