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G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment

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World Journal of Gastroenterology 2021年第8期27卷 677-691页

作者： Ming Yang chun-ye Zhang Department of Surgery University of MissouriColumbiaMO 65212United States Department of Veterinary Pathobiology University of MissouriColumbiaMO 65212United States

Nonalcoholic fatty liver disease(NAFLD)is a broad-spectrum disease,ranging from simple hepatic steatosis to nonalcoholic steatohepatitis,which can progress to cirrhosis and liver *** hepatic lipid accumulation is the major manifestation of this disease,and lipotoxicity promotes NAFLD *** addition,intermediate metabolites such as succinate can stimulate the activation of hepatic stellate cells to produce extracellular matrix proteins,resulting in progression of NAFLD to fibrosis and even cirrhosis.G protein-coupled receptors(GPCRs)have been shown to play essential roles in metabolic disorders,such as NAFLD and obesity,through their function as receptors for bile acids and free fatty *** addition,GPCRs link gut microbiota-mediated connections in a variety of diseases,such as intestinal diseases,hepatic steatosis,diabetes,and cardiovascular *** latest findings show that gut microbiota-derived acetate contributes to liver lipogenesis by converting dietary fructose into hepatic acetyl-CoA and fatty *** agonists,including peptides and natural products like docosahexaenoic acid,have been applied to investigate their role in liver *** such as probiotics and GPCR agonists may be applied to modulate GPCR function to ameliorate liver metabolism *** review summarizes the current findings regarding the role of GPCRs in the development and progression of NAFLD and describes some preclinical and clinical studies of GPCR-mediated ***,understanding GPCR-mediated signaling in liver disease may provide new therapeutic options for NAFLD.

关键词： Nonalcoholic fatty liver disease G protein-coupled receptors Metabolism Bile acids Short-chain fatty acids Gut microbiota

A continuing 30-year decline in water quality of Jiaojiang Estuary, China

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Water Science and Engineering 2015年第1期8卷 20-29页

作者： chun-ye Wang Bin Zhou Bei Huang College of Marine Science Shanghai Ocean University College of Science Hangzhou Normal University Zhejiang Provincial Zhoushan Ocean Ecological Environment Monitoring Station

A quantitative description of a long-term series of aquatic environmental factors and their spatial distributions was generated using measured data from the Jiaojiang Estuary from 1982 to 2011. The aquatic environmental factors included suspended matter, salinity, and nutrients. Based on these factors, the aquatic ecosystem health in the Jiaojiang Estuary over the last 30 years was analyzed. The results indicated that the suspended matter concentration in the estuary was mainly affected by the amounts of suspended sediment and solid waste, with the value fluctuating over a long period, and the range of high concentration expanded continually; the salinity was mainly affected by precipitation and surface water resources, showing an overall decreasing trend, and the region with low salinity moved seaward and toward the reclamation areas; and the nutritional status, mainly affected by discharge of industrial wastewater and domestic sewage, was satisfactory in the 1980s and 1990s, but the status became severe in recent years. Reclamation had a great influence on these three factors： high reclamation strength led to a significant increase in the suspended matter concentration and a deterioration of the nutritional status, and the reclamation rate was negatively related with the salinity in the estuary. There was a significant positive correlation between the health status of the aquatic ecosystem and salinity, with a correlation coefficient of 0.93. The correlation coefficient between the health status and nutritional status was -0.71, while the correlation between the suspended matter concentration and health status was not as significant as that of the other two factors. The dynamics of the aquatic environment could be divided into four stages： sustainable health from the 1980s to the 1990s, continued deterioration from 2000 to 2003, improvement from 2004 to 2005, and secondary deterioration from 2006 to 2011. The Jiaojiang Estuary is faced with imminent environmental

关键词： Water quality decline Aquatic ecosystem health Aquatic environmental factor Suspended matter concentration Salinity Nutritional status Jiaojiang Estuary

Diagnostic biomarkers for pancreatic cancer:An update

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World Journal of Gastroenterology 2021年第45期27卷 7862-7865页

作者： Ming Yang chun-ye Zhang Department of Surgery University of MissouriColumbiaMO 65212United States Department of Veterinary Pathobiology University of MissouriColumbiaMO 65212United States

Pancreatic ductal adenocarcinoma accounts for the primary type of pancreatic cancer(PC)with a 5-year survival rate of only about 10%in the United *** diagnosis will improve chances for curative *** date,a broadly used serum marker for PC diagnosis is carbohydrate antigen 19-9,which is the only approved biomarker currently by the United States Food and Drug ***,it has low specificity;therefore,development of novel biomarkers is urgently *** trials are ongoing to evaluate candidate biomarkers for PC diagnosis,and the use of a multi-biomarker panel with current PC diagnostic biomarkers appears promising.

关键词： Pancreatic ductal adenocarcinoma Diagnosis Biomarkers Panel Clinical trials

Effect of Development Stage on the Artemisinin Content and the Sequence Characterized Amplified Region （SCAR） Marker of High-Artemisinin Yielding Strains of Artemisia annua L.

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Journal of Integrative Plant Biology 2006年第9期48卷 1054-1062页

作者： Long Zhang He-chun ye Guo-Feng Li Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Guangdong Key Laboratory of Biotechnology for Plant Development College of Life Sciences South China Normal University Guangzhou 510631 China

The effects of development states on the artemisinin content of clone S1 of Artemisia anuua L. grown in a greenhouse were investigated in the present study. The artemisinin content increased gradually during the phase of vegetative growth and reached its highest level at 8-9 mg/g dry weight （DW） when the S1 was 6 months old on a long day （LD） photoperiod. Treatment with 9-18 d of short day （SD） photoperiod resulted in the artemisinin content reaching and being maintained at a higher level （2.059-2.289 mg/g DW）, twofold that of control plants and plants of S1 presented at the pro-flower budding and flower-budding stages. The artemisinin content varied in different parts of the plant. The artemisinin content of leaves was higher than that of florets and branches. The artemisinin content in middle leaves was higher than that of bottom leaves, and then top leaves. Different densities of capitate glands （the storage organ of artemisinin） located on the surface of leaves, florets, and branches explained the variations in artemisinin content in these parts of the plant. The correlation coefficient between artemisinin content and density of capitate glands on the surface of different organs was 0.987. The genetic marker for artemisinin content was screened using random amplified polymorphic DNA （RAPD） and sequence characterized amplified region （SCAR） techniques. The random primer OPAl5 （5＇-TTCCGAACCC-3＇） could amplify a specific band of approximately 1 000 bp that was present in all high-artemisinin yielding strains, but absent in all low-yielding strains in three independent replications. This specific band was cloned and its sequence was analyzed. This RAPD marker was converted into a SCAR marker to obtain a more stable marker.

关键词： Artemisia annua artemisinin capitate gland random amplified polymorphic DNA (RAPD) sequence characterized amplified region (SCAR)

Roles of fibroblast growth factors in the treatment of diabetes

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World Journal of Diabetes 2024年第3期15卷 392-402页

作者： chun-ye Zhang Ming Yang Bond Life Sciences Center University of MissouriColumbiaMO 65211United States Department of Surgery University of MissouriColumbiaMO 65212United States NextGen Precision Health Institution University of MissouriColumbiaMO 65212United States

Diabetes affects about 422 million people worldwide,causing 1.5 million deaths each ***,the incidence of diabetes is increasing,including several types of *** 1 diabetes(5%-10%of diabetic cases)and type 2 diabetes(90%-95%of diabetic cases)are the main types of diabetes in the *** evidence shows that the fibroblast growth factor(FGF)family plays important roles in many metabolic disorders,including type 1 and type 2 *** consists of 23 family members(FGF-1-23)in ***,we review current findings of FGFs in the treatment of diabetes and management of diabetic *** FGFs(e.g.,FGF-15,FGF-19,and FGF-21)have been broadly investigated in preclinical studies for the diagnosis and treatment of diabetes,and their therapeutic roles in diabetes are currently under investigation in clinical ***,the roles of FGFs in diabetes and diabetic complications are involved in numerous ***,FGF intervention can prevent high-fat diet-induced obesity and insulin resistance and reduce the levels of fasting blood glucose and triglycerides by regulating lipolysis in adipose tissues and hepatic glucose ***,modulation of FGF expression can inhibit renal and cardiac fibrosis by regulating the expression of extracellular matrix components,promote diabetic wound healing process and bone repair,and inhibit cancer cell proliferation and ***,FGFs can regulate the activation of glucoseexcited neurons and the expression of thermogenic genes.

关键词： Fibroblast growth factors Type 1 diabetes Type 2 diabetes Metabolic disorders Treatment Clinical trials

Regulatory T cells and their associated factors in hepatocellular carcinoma development and therapy

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World Journal of Gastroenterology 2022年第27期28卷 3346-3358页

作者： chun-ye Zhang Shuai Liu Ming Yang Department of Veterinary Pathobiology University of MissouriColumbiaMO 65211United States The First Affiliated Hospital Zhejiang UniversityHangzhou 310006Zhejiang ProvinceChina Department of Surgery University of MissouriColumbiaMO 65211United States

Liver cancer is the third leading cause of cancer-related death worldwide with primary type hepatocellular carcinoma(HCC).Factors,including carcinogens,infection of hepatitis viruses,alcohol abuse,and non-alcoholic fatty liver disease(NAFLD),can induce HCC initiation and promote HCC *** prevalence of NAFLD accompanying the increased incidence of obesity and type 2 diabetes becomes the most increasing factor causing HCC ***,the benefit of current therapeutic options is still *** immunity plays critically important roles in HCC initiation,development,and *** T cells(Tregs)and their associated factors such as metabolites and secreting cytokines mediate the immune tolerance of the tumor microenvironment in ***,targeting Tregs and blocking their mediated factors may prevent HCC *** review summarizes the functions of Tregs in HCC-inducing factors including alcoholic and NAFLD,liver fibrosis,cirrhosis,and viral ***,a better understanding of the role of Tregs in the development and progression of HCC provides treatment strategies for liver cancer treatment.

关键词： Hepatocellular carcinoma Regulatory T cells Alcoholic fatty liver disease Non-alcoholic fatty liver disease Treatment Clinical trials

Crosstalk between gut microbiota and COVID-19 impacts pancreatic cancer progression

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1456-1468页

Pancreatic cancer(PC)is one of the most common causes of cancer-associated death worldwide,with a low rate of 5-year ***,the pathogenesis of PC is complicated,with no efficient *** disease 2019(COVID-19)disease caused by severe acute respiratory syndrome coronavirus 2 further exacerbates the challenge of patients with *** alteration of gut microbiota caused by COVID-19 infection may impact PC progression in patients via immune *** expression of inflammatory immune mediators such as interleukin(IL)-6,IL-8,and IL-10 has been found to increase in both PC and COVID-19 patients,which is associated with the disease severity and prognostic *** microbiome serves as a critical connector between viral infection and *** can regulate host systemic immune response and impact the efficacy of ***,we first demonstrated the features of inflammatory cytokines in both diseases and their impact on disease ***,we demonstrated the importance of immunotherapeutic *** includes the immune modulation that targets a single or dual receptors using a single agent or their combinations for the treatment of PC in patients who get infected with ***,we explored the possibility of managing the disease by regulating gut ***,modulation of the lung-gut-pancreases axis can boost anti-cancer immunotherapy and reduce adverse prognostic outcomes.

关键词： COVID-19 SARS-CoV-2 Gut microbiota Pancreatic cancer Interleukin-6 Interleukin-8 Interleukin-10 Monoclonal antibodies Modulatory treatment

Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options

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World Journal of Gastroenterology 2022年第48期28卷 6827-6845页

作者： chun-ye Zhang Shuai Liu Ming Yang Christopher S.Bond Life Sciences Center University of MissouriColumbiaMO 65211United States The First Affiliated Hospital Zhejiang UniversityHangzhou 310006Zhejiang ProvinceChina Department of Surgery University of MissouriColumbiaMO 65211United States

Pancreatic cancer(PC)is the third-leading cause of cancer *** overall 5-year survival rate of PC is 9%,and this rate for metastatic PC is below 3%.However,the PC-induced death cases will increase about 2-fold by *** factors such as genetic and environmental factors and metabolic diseases can drive PC development and *** most common type of PC in the clinic is pancreatic ductal adenocarcinoma,comprising approximately 90%of PC *** pathogenic processes including but not limited to inflammation,fibrosis,angiogenesis,epithelial-mesenchymal transition,and proliferation of cancer stem cells are involved in the initiation and progression of *** diagnosis is essential for curable therapy,for which a combined panel of serum markers is very *** some mono or combined therapies have been approved by the United States Food and Drug Administration for PC treatment,current therapies have not shown promising ***,the development of novel immunotherapies,such as oncolytic viruses-mediated treatments and chimeric antigen receptor-T cells,combined with therapies such as neoadjuvant therapy plus surgery,and advanced delivery systems of immunotherapy will improve therapeutic outcomes and combat drug resistance in PC ***,the pathogenesis,molecular signaling pathways,diagnostic markers,prognosis,and potential treatments in completed,ongoing,and recruiting clinical trials for PC were reviewed.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma Molecular mechanisms Diagnostic and prognostic markers Treatment Clinical trials

A New Xanthanolide from Carpesium longifolium

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Chinese Chemical Letters 2003年第5期14卷 483-484页

作者： Chao YANG Meng chun ye Zhong Jian JIA Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

A new xanthanolide was isolated from the aerial parts of Carpesium longifolium. Its structure was elucidated as 1, 4-epoxy-5?hydroxy-10酘-xantha-11(13)-en-12, 8?olide by spectral methods (HRMS, 1D and 2D NMR).

关键词： Carpesium longifolium Compositae xanthanolide.