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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho Ip Ada Tsui-Lin Ng Yiu-chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health indexting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

Comparative efficacy and safety between endoscopic submucosal dissection,surgery and definitive chemoradiotherapy in patients with cT1N0M0 esophageal cancer

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 72-82页

作者： Shu-Ai Luo Yu-Ying Sun Ya-ting Zeng chun-Yu Huang State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment ***,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain *** To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 *** We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,*** analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up *** Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by *** probability of treatment weighting(IPTW)was used to minimize potential confounding *** We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to *** median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),*** adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and *** For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.

关键词： Retrospective study cT1N0M0 Esophageal squamous cell carcinoma Endoscopic submucosal dissection Surgery Definitive chemoradiotherapy

The cGAS-Sting-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 Sting type I interferon

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多目标视觉追踪中的分组效应及其可加性

生物化学与生物物理进展 2024年第1期51卷 111-122页

作者：王春地李姝婷邓虎北京航空航天大学人文社会科学学院心理系北京100191 北京大学回龙观临床医学院北京回龙观医院北京100096

如何减少注意资源的消耗、提升人类在动态视觉持续性注意任务中的表现,是持续性注意研究关注的重点问题,具有理论和实践的重要意义。多目标追踪任务是研究个体持续性注意的常用实验室方法。多目标追踪任务中,观察者可以利用基于物体特... 详细信息

如何减少注意资源的消耗、提升人类在动态视觉持续性注意任务中的表现,是持续性注意研究关注的重点问题,具有理论和实践的重要意义。多目标追踪任务是研究个体持续性注意的常用实验室方法。多目标追踪任务中,观察者可以利用基于物体特征的分组效应将多个运动目标知觉为一个更大的运动单元,从而减少注意资源的消耗、提高追踪任务表现。为了进一步节省注意资源、提升注意追踪的表现,研究者提出了注意追踪中分组效应的可加性问题。分组效应的可加性表现为基于两个及以上特征的分组对追踪表现的提高优于基于一个特征的分组。可加性的研究对理解不同分组效应的认知机制,个体动态视觉追踪中的注意机制和注意资源分配等具有重要意义。本文对以往的行为以及神经影像学研究进行了汇总,讨论了不同类型分组效应的知觉加工机制及其可加性,系统阐述了基于不同表面特征的不可加性,和基于表面特征与特定时空特征可加性的认知及其神经基础。未来可以从行为学实验角度探究更多基于不同特征分组效应的可加性,或者从注意追踪中基于不同分组效应的神经机制入手,探讨分组效应的可加性问题,为分组效应的分类及可加性研究提供更多认知和神经层面的依据。

关键词：多目标追踪分组效应可加性特征分组

Noncanonical pyroptosis pathway: a promising target of traditional Chinese medicine in the treatment of sepsis-related injury

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Integrative Medicine Discovery 2024年第20期8卷 1-4页

作者： Yan-Yan Cen Pan Wang ting Zhu Ya-Lan Xiong Xi-chun Pan Department of Pharmacology College of PharmacyArmy Medical UniversityChongqing 400038China.

Sepsis is a life-threatening disease of organ failure caused by dysregulated host responses to infection and other infectious ***-organ injury is the leading cause of high mortality and septic shock during *** studies suggest that noncanonical pyroptosis,characterized mainly by the direct activation of caspase-11-gasdermin D-mediated pyroptosis by cytoplastic lipopolysaccharide,is closely related to sepsis-related organ ***,this review summarizes recent advances in the regulatory mechanisms and targeted natural products from traditional Chinese medicine of the noncanonical pyroptosis pathway in sepsis-related injury.

关键词： sepsis-related injury noncanonical pyroptosis caspase-11 gasdermin D

Shugan Jieyu capsule effects on peripheral blood micro-124, micro- 132, and brain-derived neurotrophic factor in patients with mild to moderate depression

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World Journal of Psychiatry 2024年第9期14卷 1354-1363页

作者： Xian Zhang Yang Liu Hua-Fei Tang Feng Jiang chun-Liang Chen ting-ting Wang Hui-Zhong Gu Qiang Zhao Rui Ma Department of Pharmacy The 305 Hospital of People’s Liberation ArmyBeijing 100017China

BACKGROUND To assess the effectiveness of Shugan Jieyu capsules on peripheral blood miR-124,miR-132,and brain-derived neurotrophic factor(BDNF)levels in patients with mild to moderate depression following coronary artery intervention[percuta-neous coronary intervention(PCI)]for coronary heart *** with mild-to-moderate depression of the liver-qi stagnation type after PCI for coronary heart disease at the 305th Hospital of the People’s Liberation Army were enrolled from June 2022 to November 2023 and randomly assigned to two groups:Experimental(treated with Shugan Jieyu capsules)and control(tr-eated with escitalopram oxalate tablets).This study compared the antidepressant effects of these treatments using 17-item Hamilton Rating Scale for Depression(HAMD-17)scores,metabolic equivalents,low-density lipoprotein cholesterol,BDNF,high-sensitivity C-reactive protein levels,miR-124 and miR-132 levels,distribution of immune-related lymphocyte subsets,and traditional Chinese me-dicine syndrome scores before and after 6 weeks of *** No significant difference was observed in any index between the two groups before treatment(P>0.05).After treatment,the total efficacy rates were 93.33%and 90.00%in the experimental and control groups,*** group had significantly lower scores for the main and secondary syndromes compared to the control group(P0.05).The levels of low-density lipoprotein cholesterol,high-sensitivity C-reactive pro-tein,and miR-132 were significantly lower,whereas those of miR-124,BDNF,CD3+T lymphocytes,CD3+CD4+T helper lymphocytes,and CD3+CD4+/CD3+CD8+cells were significantly higher in the experimental group com-pared to the control group(P<0.05).The incidence of adverse reactions during experimental group was signi-ficantly lower than that in control group(P<0.05).CONCLUSION Shugan Jieyu capsu

关键词： Shugan Jieyu capsule Coronary heart disease Depression Escitalopram oxalate tablet Micro-124 Micro-132 Brain-derived neurotrophic factor

至味在人间:城市烟火气游客体验的探索性研究

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旅游学刊 2024年第7期39卷 40-53页

作者：蒋婷苗莉李春济南大学文化和旅游学院山东济南250002 澳门大学工商管理学院中国澳门999078

烟火气是具有中国文化意蕴的词汇,与中国人的生活息息相关,城市烟火气为城市休闲、游客体验注入了新颖活力,然而,目前烟火气尚未受到学术界的关注,这也成为旅游体验理论可进一步深化研究的关键方向。文章透过烟火气这一滤镜去审视城市... 详细信息

烟火气是具有中国文化意蕴的词汇,与中国人的生活息息相关,城市烟火气为城市休闲、游客体验注入了新颖活力,然而,目前烟火气尚未受到学术界的关注,这也成为旅游体验理论可进一步深化研究的关键方向。文章透过烟火气这一滤镜去审视城市游客体验,建构了传统文化意蕴下的烟火气作为城市目的地文化符号的意象和学术内涵,运用深度访谈法获悉游客体验烟火气的过程,基于“认知-情感-行为”体验的框架,构建了城市烟火气游客体验的理论模型,实现了城市旅游体验研究的创新;揭示了烟火气游客体验的过程,丰富了基于游客情感体验的基础性理论;通过发现烟火气感知下的游客“家乡”情结在目的地地方认同形成机理中的关键作用,为城市游客地方感研究的深化作出了理论贡献。此外,该研究也提出了打造烟火气体验消费、创设复合空间等有益的实践启示,以及跨文化情境下烟火气感知差异、美食和民俗活动的关键作用等未来的研究展望。

关键词：烟火气游客体验情感体验食物地方感

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在线代理求助中的不确定性沟通影响患方态度

中国临床心理学杂志 2024年第4期32卷 917-921,849页

作者：吕小康杨婷婷付春野寿春怡南开大学社会学院社会心理学系天津300350 浙江医院外宾诊疗中心杭州310007

目的:本研究探讨在线问诊平台下代理求助行为和医生不确定性沟通方式对患方对医态度的影响。方法:采用2(代理求助:代为问诊vs.信息搜寻)×2(不确定性沟通方式:含蓄vs.直白)×2(疾病严重程度:轻症vs.重症)三因素混合实验设计。结果:代理... 详细信息

目的:本研究探讨在线问诊平台下代理求助行为和医生不确定性沟通方式对患方对医态度的影响。方法:采用2(代理求助:代为问诊vs.信息搜寻)×2(不确定性沟通方式:含蓄vs.直白)×2(疾病严重程度:轻症vs.重症)三因素混合实验设计。结果:代理求助和不确定性沟通方式的主效应显著,代为问诊和含蓄的不确定性沟通方式下的患方态度更积极,即对医信任、对医印象、在线问诊满意度和推荐行为倾向更高。代理求助和不确定性沟通方式对患方态度的交互作用显著:信息搜寻时,相比于直白的不确定性沟通方式,含蓄的不确定性沟通方式下患方态度更积极。结论:在线问诊中的医生用含蓄的不确定性沟通方式可使搜寻信息的代理求助者的对医态度更积极,这为改进在线问诊平台中的医患沟通方式提供了启示。

关键词：在线问诊代理求助不确定性沟通方式医患信任

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甘肃岷县红三叶病害及其对红三叶生长和品质的影响

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草地学报 2024年第5期32卷 1303-1313页

作者：郑荣春南志标段廷玉兰州大学草种创新与草地农业生态系统全国重点实验室兰州大学草地农业科技学院甘肃兰州730020

‘岷山’红三叶(Trifolium pratense ***)是适宜于岷县地区生长的优良豆科牧草品种。前期的调研发现该地区红三叶田间病害发病较重,限制了红三叶的生产,而目前尚缺少该地区病害的系统研究。本研究调查了‘岷山’红三叶在岷县田间的主要... 详细信息

‘岷山’红三叶(Trifolium pratense ***)是适宜于岷县地区生长的优良豆科牧草品种。前期的调研发现该地区红三叶田间病害发病较重,限制了红三叶的生产,而目前尚缺少该地区病害的系统研究。本研究调查了‘岷山’红三叶在岷县田间的主要病害及发生规律,并研究了匍柄霉叶斑病对红三叶生长和品质的影响。该地区红三叶主要田间病害为匍柄霉叶斑病(Stemphylium sarcniforme)、小光壳叶斑病(Leptosphaerulina trifolii)和长隔孢叶斑病(Longiseptatispora meliloti)。其中红三叶匍柄霉叶斑病最为严重,最高发病率26.67%,病情指数8.20。匍柄霉叶斑病显著影响了红三叶的产量和品质,导致鲜重显著下降20.14%、叶绿素含量显著下降20.93%及引起各项营养指标的不同变化。本研究明确了岷县地区红三叶主要病害的发生情况及发病最为严重的匍柄霉叶斑病对红三叶生物量和品质的影响,为该地区的红三叶病害防控提供依据。

关键词： ‘岷山’红三叶田间病害致病性生长指标牧草品质

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四个品种红三叶种带真菌多样性研究

草业学报 2024年第8期33卷 170-180页

作者：郑荣春南志标段廷玉兰州大学草种创新与草地农业生态系统全国重点实验室兰州大学草地农业科技学院甘肃兰州730020

红三叶是一种重要的豆科牧草及绿肥作物,种带真菌会严重影响其种子品质,是限制生产的主要因素之一。本研究以红三叶4个品种为对象,通过室内分离及高通量测序,明确不同红三叶品种种带真菌的种类及多样性。自4个供试品种分离鉴定出种带真... 详细信息

红三叶是一种重要的豆科牧草及绿肥作物,种带真菌会严重影响其种子品质,是限制生产的主要因素之一。本研究以红三叶4个品种为对象,通过室内分离及高通量测序,明确不同红三叶品种种带真菌的种类及多样性。自4个供试品种分离鉴定出种带真菌15属26种,其中岷山红三叶9属14种,瑞德红三叶5属7种,VNS红三叶9属9种,红龙红三叶7属11种。高通量测序法从红三叶4个品种种子样品中共鉴定出30属87种。属水平主要为枝孢菌属、链格孢属、青霉属、曲霉属、匍柄霉属、掷孢酵母属、Filobasidium和Udeniomyces等属。其中匍柄霉属、链格孢属、枝孢菌属、枝顶孢属、葡萄孢属、镰孢菌属及白粉菌属的数个种为潜在致病菌。α和β多样性分析表明品种间真菌群落组成及丰度差异显著,岷山的种带真菌多样性高于其他3个品种。

关键词：红三叶种带真菌高通量测序多样性

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