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Sirtuin1 attenuates acute liver failure by reducing reactive oxygen species via hypoxia inducible factor 1α

World Journal of Gastroenterology 2022年第17期28卷 1798-1813页

作者： Pan Cao Qian Chen chun-Xia shi Lu-Wen Wang Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND The occurrence and development of acute liver failure(ALF)is closely related to a series of inflammatory reactions,such as the production of reactive oxygen species(ROS).Hypoxia inducible factor 1α(HIF-1α)is a key factor that regulates oxygen homeostasis and redox,and the stability of HIF-1αis related to the ROS level regulated by Sirtuin(Sirt)*** activation of Sirt1 will lead to a powerful antioxidant defense system and therapeutic effects in liver ***,little is known about the relationship between HIF-1αand Sirt1 in the process of ALF and the molecular *** To investigate whether HIF-1αmay be a target of Sirt1 deacetylation and what the effects on ALF *** Mice were administrated lipopolysaccharide(LPS)/D-gal and exposed to hypoxic conditions as animal model,and resveratrol was used as an activator of *** cellular model was established with L02 cells stimulated by LPS.N-acetyl-Lcysteine was used to remove ROS,and the expression of Sirt1 was inhibited by *** blotting was used to detect Sirt1 and HIF-1αactivity and related protein *** possible signaling pathways involved were analyzed by immunofluorescent staining,co-immunoprecipitation,dihydroethidium staining,and Western *** Compared with mice stimulated with LPS alone,the expression of Sirt1 decreased,the level of HIF-1αacetylation increased in hypoxic mice,and the levels of carbonic anhydrase 9 and Bcl-2-adenovirus E1B interacting protein 3 increased significantly,which was regulated by HIF-1α,indicating an increase of HIF-1α*** hypoxia,the down-regulation of Sirt1 activated and acetylated HIF-1αin L02 *** inhibition of Sirt1 significantly aggravated this effect and the massive production of *** regulation of ROS was partly through peroxisome proliferatoractivated receptor alpha or AMP-activated protein ***,a Sirt1 activator,effectively relieved ALF aggravated by hypoxia,the production

关键词： Acute liver failure Deacetylation Hypoxia inducible factor 1α Reactive oxygen species Sirtuin1

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Expression and role of specificity protein 1 and collagenⅠin recurrent pterygial tissues

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 223-227页

作者： chun-Sheng shi Yue Wu Na Shu Li-Li Jiang Bo Jiang Department of Ophthalmology Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

AIM:To investigate the expression profiles of the transcription factor specificity protein 1(Sp1)and collagenⅠin recurrent pterygial *** is more,to compare the changes of Sp1 and collagen I among primary pterygial tissue,recurrent pterygial tissue and conjunctival ***:In the prospective study,we collected the pterygial tissues of 40 patients who underwent resection of primary pterygial tissue and recurrent pterygial tissue,and the conjunctival tissues of 10 patients with enucleation due to *** relative expression levels of Sp1 and collagen I were analyzed by reverse transcription quantitative-polymerase chain reaction and Western *** t-test was performed to compare the Sp1 and collagen I of recurrent pterygial tissues,as well as the primary pterygial tissues and conjunctival *** further,Pearson’s hypothesis testing of correlation coefficients was used to compare the correlations of Sp1 and Collagen ***:The content of Sp1 and collagen I m RNA and protein was significantly greater in recurrent pterygial tissue than that was in primary and conjunctival tissue(P<0.05).There was a positive correlation between the m RNA and protein levels of Sp1 and collagen I in recurrent pterygial tissues(protein:r=0.913,P<0.05;m RNA:r=0.945,P<0.05).CONCLUSION:Sp1 and collagen I are expressed in normal conjunctival,primary,and recurrent pterygial tissues,but expression is significantly greater in the ***1 and collagen I may be involved in the regulation of the development of recurrent pterygium.

关键词： recurrent pterygium conjunctiva specificity protein 1 collagenⅠ

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A Single Point Mutation in GmHMA3 Affects Cadimum （Cd） Translocation and Accumulation in Soybean Seeds

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Molecular Plant 2012年第5期5卷 1154-1156页

作者： Yi Wang Kang-Fu Yu Vaino Poysa chun shi Yong-Hong Zhou Greenhouse and Processing Crops Research Centre Agriculture andAgri-Food Canada 2585 County Road 20HarrowOntarioN0R 1G0 Canada Triticeae Research Institute Sichuan Agricultural University Wenjiang 611130Sichuan China

Dear Editor, Soybean can absorb and accumulate Cd from soils in their seed. Consumption, either directly or indirectly, of seed with high levels of Cd could be a human health concern, in 2001, the Codex Committee on Food Additives and Contaminants of the Codex Alimentarius Commission established by the Food and Agriculture Organization and the World Health Organization proposed an upper limit of 0.2 mg kg-1 Cd con- centration in soybean grain （Codex Alimentrius Commission, 2001）. There are cultivar differences in seed Cd concentration in soybean and some cultivars accumulate high Cd concen- trations in seed when grown on Cd-contaminated soils （Arao et al., 2003）. These cultivars can exceed the proposed Codex upper limit. Cdal, a major gene controlling seed Cd accumu- lation, has been mapped on linkage group K by Jegadeesan et al. （2010）. The molecular mechanism of the Cdal gene underlyincl Cd accumulation in soybean seed is unknown.

关键词： Translocation Accumulation Soybean

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Typical atmospheric haze during crop harvest season in northeastern China：A case in the Changchun region

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Journal of Environmental Sciences 2017年第4期29卷 101-113页

作者： Wei Wei Chen Daniel Q.Tong Mo Dan shi chun Zhang Xue Lei Zhang Yue Peng Pan Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changchun 130102 China . Cooperative Institute for Climate & Satellites University of Maryland College Park MD 20740 USA Center for Spatial Information Science and Systems George Mason University Fairfax VA 22030 USA Beijing Municipal Institute of Labor Protection Beijing 100054 China State key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

This study presents the mass concentrations of PM（2.5）,O3,SO2 and NOxat one urban,one suburban and two rural locations in the Changchun region from September 25 to October 272013. Major chemical components of PM（2.5）at the four sites were daily sampled and analyzed. Most of daily concentrations of SO2（7–82 μg/m^3）,O3（27–171 μg/m^3） and NOx（14–213 μg/m^3） were below the limits of the National Ambient Air Quality Standard（NAAQS）in China. However,PM（2.5）concentrations（143–168 μg/m^3） were 2-fold higher than *** PM（2.5）concentrations（~ 150 μg/m^3） were measured during the pre-harvest and harvest at the urban site,while PM（2.5）concentrations significantly increased from 250 to400 μg m^（-3） at suburban and rural sites with widespread biomass burning. At all sites,PM（2.5）components were dominated by organic carbon（OC） and followed by soluble component sulfate（SO4^（2-））,ammonium（NH4~＋） and nitrate（NO3^-）. Compared with rural sites,urban site had a higher mineral contribution and lower potassium（K~＋and K） contribution to PM（2.5）.Severe atmospheric haze events that occurred from October 21 to 23 were attributed to strong source emissions（e.g.,biomass burning） and unfavorable air diffusion ***,coal burning originating from winter heating supply beginning on October 18 increased the atmospheric pollutant emissions. For entire crop harvest period,the Positive Matrix Factorization（PMF） analysis indicated five important emission contributors in the Changchun region,as follows： secondary aerosol（39%）,biomass burning（20%）,supply heating（18%）,soil/road dust（14%） and traffic（9%）.

关键词： Aerosol Air quality Agriculture Biomass burning PM(2.5) PMF

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Improving the simulation of terrestrial water storage anomalies over China using a Bayesian model averaging ensemble approach

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Atmospheric and Oceanic Science Letters 2018年第4期11卷 322-329页

作者： LIU Jian-Guo JIA Bing-Hao XIE Zheng-Hui shi chun-Xiang School of Mathematics and Computational Science and Key Laboratory of Intelligent Control Technology for Wuling-Mountain Ecological Agriculture in Hunan Province Huaihua University State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences National Meteorological Information Center China Meteorological Administration

The ability to estimate terrestrial water storage(TWS)is essential for monitoring hydrological extremes(e.g.,droughts and floods)and predicting future changes in the hydrological ***,inadequacies in model physics and parameters,as well as uncertainties in meteorological forcing data,commonly limit the ability of land surface models(LSMs)to accurately simulate *** this study,the authors show how simulations of TWS anomalies(TWSAs)from multiple meteorological forcings and multiple LSMs can be combined in a Bayesian model averaging(BMA)ensemble approach to improve monitoring and *** using three forcing datasets and two LSMs were conducted over China's Mainland for the period 1979–*** the simulations showed good temporal correlations with satellite observations from the Gravity Recovery and Climate Experiment during 2004–*** correlation coefficient ranged between 0.5 and 0.8 in the humid regions(e.g.,the Yangtze river basin,Huaihe basin,and Zhujiang basin),but was much lower in the arid regions(e.g.,the Heihe basin and Tarim river basin).The BMA ensemble approach performed better than all individual member *** captured the spatial distribution and temporal variations of TWSAs over China's Mainland and the eight major river basins very well;plus,it showed the highest R value(>0.5)over most basins and the lowest root-mean-square error value(<40 mm)in all basins of *** good performance of the BMA ensemble approach shows that it is a promising way to reproduce long-term,high-resolution spatial and temporal TWSA data.

关键词： Terrestrial water storage anomalies multi-forcing and multi-model ensemble simulation Bayesian model averaging spatiotemporal variation uncertainty

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Ultra-high-energy lithium-ion batteries enabled by aligned structured thick electrode design

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Rare Metals 2022年第1期41卷 14-20页

作者： Chao-Chao Zhou Zhi Su Xin-Lei Gao Rui Cao shi-chun Yang Xin-Hua Liu College of Chemistry and Chemical Engineering Xinjiang Normal UniversityUrumqi 830054China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Dyson School of Design Engineering Imperial College LondonSouth Kensington CampusLondon SW72AZUK

Battery manufacturing holds great promise to build highperformance electrodes with fine-controlled microstructure,geometry and ***,thick electrodes face concomitant challenge of the sluggish transport of both electrons and Li ***,we present a thick electrode with an aligned structure,as an alternative to achieve high-energy lithium-ion *** freeze-drying process with the aid of gum binder and single-walled carbon nanotubes(SWCNT)is originally developed for preparing the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2))(NCM811)-based aligned structured thick electrode as the representative cathode electrode *** 1-mm-thick cathode with mass loading of 101 mg·cm^(-2) achieves a high specific capacity of 203.4 mAh·g^(-1).Moreover,the as-prepared ultra-thick electrodes with a high mass loading of 538 mg·cm^(-2) and high active material content of 99.5 wt%are successfully demonstrated,delivering an extremely high areal capacity of 93.4 mAh·cm^(-2),which represents a>30-times improvement compared to that of the commercial *** design opens an effective avenue for greener,scalable and sustainable manufacturing processes toward energy storage devices and other related practical applications.

关键词： Battery electrode lithium

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Investigation on latch-up susceptibility induced by high-power microwave in complementary metal–oxide–semiconductor inverter

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Chinese Physics B 2017年第2期26卷 492-498页

作者： Yu-Hang Zhang Chang-chun Chai Xin-Hai Yu Yin-Tang Yang Yang Liu Qing-Yang Fan chun-Lei shi Key Laboratory of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of Microelectronics Xidian Universitv. Xi＇an 710071 China

The latch-up effect induced by high-power microwave（HPM） in complementary metal–oxide–semiconductor（CMOS） inverter is investigated in simulation and theory in this paper. The physical mechanisms of excess carrier injection and HPM-induced latch-up are proposed. Analysis on upset characteristic under pulsed wave reveals increasing susceptibility under shorter-width pulsed wave which satisfies experimental data, and the dependence of upset threshold on pulse repetitive frequency（PRF） is believed to be due to the accumulation of excess carriers. Moreover, the trend that HPMinduced latch-up is more likely to happen in shallow-well device is ***, the process of self-recovery which is ever-reported in experiment with its correlation with supply voltage and power level is elaborated, and the conclusions are consistent with reported experimental results.

关键词： high-power microwave latch-up repetitive pulse frequency supply voltage dependence

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Physics-based analysis and simulation model of electromagnetic interference induced soft logic upset in CMOS inverter

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Chinese Physics B 2018年第6期27卷 531-538页

作者： Yu-Qian Liu Chang-chun Chai Yu-Hang Zhang chun-Lei shi Yang Liu Qing-Yang Fan Yin-Tang Yang of Microelectronics Xidian University Xi＇ an 710071 China Department of Micro-Nano Electronics Shanghai Jiao Tong University Shanghai 200240 China

The instantaneous reversible soft logic upset induced by the electromagnetic interference（EMI） severely affects the performances and reliabilities of complementary metal–oxide–semiconductor（CMOS） inverters. This kind of soft logic upset is investigated in theory and simulation. Physics-based analysis is performed, and the result shows that the upset is caused by the non-equilibrium carrier accumulation in channels, which can ultimately lead to an abnormal turn-on of specific metal–oxide–semiconductor field-effect transistor（MOSFET） in CMOS inverter. Then a soft logic upset simulation model is introduced. Using this model, analysis of upset characteristic reveals an increasing susceptibility under higher injection powers, which accords well with experimental results, and the influences of EMI frequency and device size are studied respectively using the same model. The research indicates that in a range from L waveband to C waveband, lower interference frequency and smaller device size are more likely to be affected by the soft logic upset.

关键词： electromagnetic interference soft logic upset non-equilibrium carrier upset model

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Gear-like array of (H_2O)_(12) as building blocks in one-dimensional supramolecular assembly

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Chinese Chemical Letters 2007年第11期18卷 1389-1391页

作者： chun Hua Ge Xiang Dong Zhang Yong Chao Ma Lei Guan chun Yue shi Xiao Yan Zhang Ya Nan Guo Qi Tao Liu College of Chemistry Liaoning University Shenyang 110036 China

The preparation and crystal structure of complex Co（Hsae）2·2H2O （1, H2sae = N-salicylidene-2-iminoethanol） are reported. X- ray analysis revealed that every six Co（Hsae）2 forms a cyclic chip and every 12 water forms a novel gear-like cluster. Acting as building blocks, the gear-like water cluster and complex chip are connected in A-B fashion and extend into one-dimensional supramolecular chain. Hydrogen bond is the primary bridging force in the formation of supramolecular framework.

关键词： Co(Ⅱ) complex N-Salicylidene-2-iminoethanol Hydrogen bond Water cluster One-dimensional chain Supramolecular chemistry

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Synthesis and Fluorescence Properties of Eu ^(2+)-Doped KMgF_3 Nanoparticles

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Chemical Research in Chinese Universities 2006年第3期22卷 274-277页

作者： YAN Jing-hui ZHANG Ming LIAN Hong-zhou LIU Jie LI Zhong-tian CAO Jie shi chun-shan College of Materials and Chemical Engineering Changchun University of Science and Technology Changchun 130022 P. R. China Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

The phase diagram of a cetyltrimethyl ammonium bromide （CTAB）/n-butanol/n-octane/KNO3-Mg（ NO3）2 system was drawn. Nanoparticles of Eu^2＋ -doped KMgF3 were prepared from the quaternary microemulsions of cetyltrimethyl ammonium bromide（ CTAB）, a-butanol, n-octane and water. The X-ray diffraction（XRD） patterns were indexed to a pure KMgF3 cubic phase. The environmental scanning electron microscopic（ESEM） images show the presence of spherical Eu^2＋ -doped KMgF3 nanoparticles with a diameter of ca. 20 nm. The emission of KMgF3： Eu^2＋ nanoparticles peaks at 360 nm. The excitation band was observed at 250 nm with a blue shift of ca. 70 nm compared with that of KMgF3： Eu^2＋ single crystal. The preparation method of nano-KMgF3： Eu^2＋/PMMA composite films was inquired into.

关键词： Fluoride Microemulsion phase diagram Nanostructure X-ray diffraction Luminescence

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