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Science in China,Ser.A 1978年第4期 533-540页

作者：罗茀荪袁钧苏杨善璐端木肇夏张香桐 shanghai Institute of Physiology

Pain evoked’ unit discharges in the parafaseieular nucleus eould be inhibited by direct electrieal stimulation of the ceatromedian nueleus of thalamus, with residual inhibitory effeet lasting for several minutes after eessation of stimulation. The optimal frequeucy of stimulation for produetion of the inhibitory effeet was found to be 4—8 pulses per seeond. The diuration of inhibition following eacen stimulating pulse lasted for 100—170 msec. Analysis of oscillographic reeords shows that there exists before the onset of the inhibition of parafascicular discharges a latent period of 10—20 msec which far cxceeds the time required for impulse conduction between the two closely related structures, suggesting that a long tortuous neuronal circuit is involved in elaboration and transmission of the inhibitory effect.

关键词： INHIBITION OF NOCICEPTIVE DISCHARGES OF PARAFASCICULAR NEURONS BY DIRECT ELECTRICAL STIMULATION OF NUCLEUS CENTRUM MEDIANUM

大鼠性别及血清保存条件对生化检测结果的影响研究

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标记免疫分析与临床 2017年第3期24卷 326-330,313页

作者：刘婷刘师卜单纯张露勇中国食品药品检定研究院北京100050

目的研究大鼠不同性别、血清样本放置条件及时间对生化检验结果的影响。方法 80只大鼠编号后一次性取静脉血,放置30min后离心,每只鼠血清分成8份。首次(1h)检测后,所有血清至于-80℃冰箱保存,一份于1、2、4、7、11、23、40d时间点重复... 详细信息

目的研究大鼠不同性别、血清样本放置条件及时间对生化检验结果的影响。方法 80只大鼠编号后一次性取静脉血,放置30min后离心,每只鼠血清分成8份。首次(1h)检测后,所有血清至于-80℃冰箱保存,一份于1、2、4、7、11、23、40d时间点重复解冻、检测后复存于-80℃冰箱;其余七份分别于以上时间点单次解冻、检测后丢弃;检测项目均为谷草转氨酶(AST)、谷丙转氨酶(ALT)、尿素(UREA)、肌酐(CREA)、胆固醇(CHO)、甘油三酯(TG)、血糖(Glu)、总蛋白(TP)、白蛋白(ALB)。结果雄性、雌性大鼠血清样本-80℃冰箱保存至40d 9个生化指标均与1h差异无统计学意义;雌性大鼠血清样本保存-80℃在1d、2d、4d、7d 4个时间点重复解冻,部分生化指标逐步显示差异有统计学意义,且随解冻次数及保存时间的增加,差异具有统计学意义的生化指标项数增加,第4次(7d)解冻后ALT、TP指标结果与1h测定结果比较差异具有统计学意义(均Plu、TP、ALB指标结果与1h测定结果比较差异具有统计学意义(均P0.05)。雄性大鼠血清样本保存-80℃重复解冻1~5次9个生化指标均与1h测定结果比较差异无统计学意义,第6次(23d)解冻TP指标测定结果比较差异具有统计学意义(P0.05)。结论不同性别大鼠血清-80℃条件下保存40d以内单次解冻后测定以及在大鼠血清解冻3次以内对生化指标测定值无影响;但重复解冻4次以上部分生化指标有显著差异,且不同性别大鼠血清指标差异情况不同,血清样本放置条件及时间及解冻次数会对大鼠生化检测指标造成影响。

关键词：大鼠性别保存条件生化检测影响

High-flow nasal cannula oxygen therapy and noninvasive ventilation for preventing extubation failure during weaning from mechanical ventilation assessed by lung ultrasound score: A single-center randomized study

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World Journal of Emergency Medicine 2021年第4期12卷 274-280页

作者： shan-xiang Xu chun-shuang Wu Shao-yun Liu Xiao lu Emergency Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND: We sought to demonstrate the superiority of a targeted therapy strategy involving high-flow nasal cannula oxygen(HFNCO_(2)) therapy and noninvasive ventilation(NIV) using lung ultrasound score(luS) in comparison with standard care among patients in the intensive care unit(ICU) who undergo successful weaning to decrease the incidence of extubation failure at both 48 hours and seven ***: During the study period, 98 patients were enrolled in the study, including 49 in the control group and 49 in the treatment group. Patients in the control group and patients with an luS score lure) in the treatment group were extubated and received standard preventive care without NIV or HFNCO_(2). Patients with an luS score ≥14 points(at high risk of extubation failure) in the treatment group were extubated with a second review of the therapeutic optimization to identify and address any persisting risk factors for postextubation respiratory distress;patients received HFNCO2 therapy combined with sessions of preventive NIV(4-8 hours per day for 4-8 sessions total) for the first 48 hours after ***: In the control group, 13 patients had the luS scores ≥14 points, while 36 patients had scores luS scores ≥14 points, while 33 patients had scores luS score ≥14 points, the extubation failure rate within 48 hours was 30.8% in the control group and 12.5% in the treatment group, constituting a statistically significant difference(PluS score lure(P=0.61). The length of ICU stay(9.4±3.1 days vs. 7.2±2.4 days) was significantly different and the re-intubation rate(at 48 hours: 18.4% vs. 10.2%;seven days: 22.4% vs. 12.2%) significantly varied between the two groups(P<0.05). There was no significan

关键词： High-flow nasal cannula oxygen Noninvasive ventilation lung ultrasound Extubation

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue shang Ying Chen Meng Tian Cheng-Yu Jin Xin lu Bing-chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Novel analysis and improvement of Yahalom protocol

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The Journal of China Universities of Posts and Telecommunications 2009年第2期16卷 80-83页

作者： CHEN chun-ling YU Han lu Heng-shan WANG Ru-chuan College of Software Nanjing University of Posts and Telecommunications Nanjing 210003 China Department of Mathematics College of Art and Science University of Wyoming Laramie Wyoming 82072 USA College of Computer Nanjing University of Posts and Telecommunications Nanjing 210003 China

The modified version of Yahalom protocol improved by Burrows, Abradi, and Needham （BAN） still has security drawbacks. This study analyzed such flaws in a detailed way from the point of strand spaces, which is a novel method of analyzing protoeol＇s security. First, a mathematical model of BAN-Yahalom protocol is constructed. Second, penetrators＇ abilities are restricted with a rigorous and formalized definition. Moreover, to increase the security of this protocol against potential attackers in practice, a further improvement is made to the protocol. Future application of this re-improved protocol is also discussed.

关键词： strand spaces BAN-Yahalom protocol ideal minimal element

The Maximum Surplus before Ruin and Related Problems in a Jump-Diffusion Renewal Risk Process

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Acta Mathematica Sinica,English Series 2011年第12期27卷 2379-2394页

作者： shan shan WANG chun Sheng ZHANG Department of Mathematics Tianjin Polytechnic University Tianjin 300160 P. R. China School of Mathematics and LPMC Nankai University Tianjin 300071 P. R. China

In this paper, we investigate a Sparre Andersen risk model perturbed by diffusion with phase-type inter-claim times. We mainly study the distribution of maximum surplus prior to ruin. A matrix form of integro-differential equation for this quantity is derived, and its solution can be expressed as a linear combination of particular solutions of the corresponding homogeneous integro-differential equations. By using the divided differences technique and nonnegative real part roots of lundberg＇s equation, the explicit Laplace transforms of particular solutions are obtained. Specially, we can deduce closed-form results as long as the individual claim size is rationally distributed. We also give a concise matrix expression for the expected discounted dividend payments under a barrier dividend strategy. Finally, we give some examples to present our main results.

关键词： Sparre Andersen risk model phase-type inter-claim times maximum surplus before ruin,expected present value of dividends barrier dividend strategy diffusion integro-differential equation

The Impact of Nonlinear Stochastic Perturbation on Dynamical Behavior of an HIV Infection System

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Journal of Systems Science & Complexity 2023年第2期36卷 632-655页

作者： SUN Guanzhen lu chun Department of Environmental Science School of Environment and Municipal EngineeringQingdao University of TechnologyQingdao 266520China Department of Mathematics Qingdao University of TechnologyQingdao266520China

In this paper,the authors develop and study an HIV infection system with two distinct cell subsets and nonlinear stochastic ***,the authors obtain that the solution of the system is positive and ***,for the corresponding linear case,the authors derive a critical condition R0S similar to deterministic *** R0S>1,the authors establish sufficient conditions for the existence and uniqueness of an ergodic stationary distribution to the stochastic system,***,the authors give sufficient criterions for extinction of the *** proposed work provides a new method in overcoming difficulty conduced by nonlinear stochastic perturbation.

关键词： HIV model nonlinear stochastic perturbation stationary distribution two distinct cell subsets

发芽糙米特征营养、食味品质提升及功能性评价研究进展

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食品科学 2025年第1期46卷 284-292页

作者：任传英洪滨张珊袁迪冯俊然山珊张竞一管立军李波黄文功卢淑雯黑龙江省农业科学院食品加工研究所黑龙江省食品加工重点实验室黑龙江省全谷物营养食品工程技术研究中心黑龙江哈尔滨150086 黑龙江省农业科学院农产品质量安全研究所黑龙江哈尔滨150086

发芽糙米作为一种全谷物,保留了完整的皮层和胚,集中了大部分营养素和功能性活性物质,但由于皮层纤维结构致密,蒸饭过程中阻碍了吸水速率、吸水量和淀粉糊化,与大米相比,其蒸煮性和食用品质较差,且难以同煮同熟,因此一直以来未被广大消... 详细信息

发芽糙米作为一种全谷物,保留了完整的皮层和胚,集中了大部分营养素和功能性活性物质,但由于皮层纤维结构致密,蒸饭过程中阻碍了吸水速率、吸水量和淀粉糊化,与大米相比,其蒸煮性和食用品质较差,且难以同煮同熟,因此一直以来未被广大消费者接受。本文综述糙米发芽的生理代谢反应及发芽过程中营养成分、活性成分和食味品质的变化,总结发芽糙米胁迫富集γ-氨基丁酸(γ-aminobutyric acid,GABA)技术和发芽糙米的功能特性研究现状。糙米发芽过程中,多种生物活性物质在酶促反应下富集,尤其是特征成分GABA含量显著提升。多种逆境胁迫均可通过改变Ca^(2+)、H^(+)或底物水平促进GABA富集,一些预处理技术可进一步提升发芽糙米的食味品质。GABA与其他营养成分和活性成分发挥协同作用,赋予发芽糙米抗高血脂、抗高血糖、保护心脏、改善睡眠、抗炎和抗氧化等一系列功效与作用。

关键词：发芽糙米特征营养食味品质功能性

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Effect of Quantum Fluctuation on Two-Dimensional Spatially Anisotropic Heisenberg Antiferromagnet with Integer Spin

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Communications in Theoretical Physics 2006年第6期45卷 1137-1146页

作者： JI An-chun TIAN Guang-shan School of Physics Peking University Beijing 100871 China

In the present paper, we calculate the Gaussian correction to the critical value J^c⊥ caused by quantum spin fluctuation in a two-dimensional spatially anisotropic Heisenberg antiferromagnet with integer spin S. Previously, some authors computed this quantity by the mean-field theory based on the Sehwinger boson representation of spin operators. However, for S = 1, their result is much less than the one derived by numerical calculations. By taking the effect of quantum spin fluctuation into consideration, we are able to produce a greatly improved result.

关键词： spatially anisotropic Heisenberg model functional integration Schwinger boson representation

Dimethyl Sulfoxide Is Feasible for Plant Tubulin Assembly In vitro： A Comprehensive Analysis

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Journal of Integrative Plant Biology 2005年第4期47卷 457-466页

作者： chun-HuaXU shan-JinHUANG MingYUAN StateKeyLaboratoryofPlantPhysiologyandBiochemistry CollegeofBiologicalSciencesChinaAgriculturalUniversityBeijing100094China

Abstract: It is much more difficult for tubulin from plant sources to polymerize in vitro than tubulin from animal sources. Taxol, a most widely used reagent in microtubule studies, enhances plant microtubule assembly, but hinders microtubule dynamics. Dimethyl sulfoxide (DMSO), a widely used reagent in animal microtubule studies, is a good candidate for the investigation of plant microtubule assembly in vitro. However, proper investigation is lacking about the effects of DMSO on plant microtubule assembly in vitro. In the present study, DMSO was used to establish optimal conditions for the polymerization of plant tubulin. Tubulin, purified from lily pollen, polymerizes into microtubules at a critical concentration of 1.2 mg/mL in the presence of 10% DMSO. The polymers appear to have a normal microtubule structure, as revealed by electron microscopy. In the presence of 10% DMSO, microtubule polymerization decreases when the pH of the medium is increased from 6.5 to 7.4. Both the polymerization rate and the mass of the polymers increase as temperature increases from 25 to 40 °C. Tubulin polymerizes and depolymerizes along with cycling of temperature, from 37 to 4 °C, or following the addition to or the removal of Ca2+ from the medium. When incubated with nuclei isolated from tobacco BY-2 suspension cells, tubulin assembles onto the nuclear surface in the presence of 10% DMSO. Labeling lily pollen tubulin with 5- (and 6-) carboxytetramethyl-rhodamine succinimidyl ester (NHS-rhodamine) was performed successfully in the presence of 10% DMSO. Labeled tubulin assembles into a radial structure on the surface of BY-2 nuclei. The polymerization of lily pollen tubulin is also enhanced by microtubule-associated proteins from animal sources in the presence of 10% DMSO. All the experimental results indicate that plant tubulin functions normally in the presence of DMSO. Therefore, DMSO is an appropriate reagent for plant tubulin polymerization and investigation of plant microtubu

关键词： dimethyl sulfoxide Lilium davidii Duch. tubulin labeling tubulin polymerization tubulin purification