检索结果-南通市图书馆

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

Growth simulation of Fraxinus chinensis stands damaged by Hyphandria cunea in Beijing area

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2008年第1期10卷 60-63页

作者： BAO Ting-fang, LUO You-qing*, XU Zhi-chun, SHI juan, liu Yu Key Laboratory for Silviculture and Conservation of Ministry of Education, Beijing Forestry University, Beijing 100083, P. R. China Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry University Beijing 100083 P. R. China

Hyphandria cunea is an insect that can damage hundreds of plants in its larval phase and needs to be placed under quarantine at an international level. Its hosts involve 600 plant species, including forest and fruit trees, shrubs, crops, vegetables, weeds and others. In 2006, we surveyed two Fraxinus chinensis Roxb stands, damaged to different degrees, after the invasion of H. cunea in the Changping district of the Beijing area. Given our survey of individual trees and investigation of bio-environmental factors, we provide a preliminarily simulation of the growth situation of F. chinensis stands, damaged by H. cunea, by using the Forest Vegetation Simulator software (FVS), which is supported by the "948" project from the State Forestry Administration of China. The results will provide a valuable reference in forecasting the effect of H. cunea and other invasive pests in China on forest ecological values.

关键词： Hyphandria cunea damage simulation Forest Vegetation Simulator (FVS)

Sora文生视频大模型对学术期刊出版的机遇、挑战及应对

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 79-88页

作者：刘娟新疆师范大学期刊社新疆乌鲁木齐830017

随着Sora文生视频大模型的迅猛发展,学术期刊出版正在经历深刻的变革与重塑。Sora技术的多模态特征与智能化能力,一方面促进学术信息的动态整合与开放获取,推动传统出版模式向协同创新与知识共享的新范式转型;另一方面,赋予著作权归属... 详细信息

随着Sora文生视频大模型的迅猛发展,学术期刊出版正在经历深刻的变革与重塑。Sora技术的多模态特征与智能化能力,一方面促进学术信息的动态整合与开放获取,推动传统出版模式向协同创新与知识共享的新范式转型;另一方面,赋予著作权归属和著作权风险治理等新的价值意蕴。面对Sora文生视频大模型对学术期刊出版带来的机遇和挑战,学术期刊应构建跨学科协作网络、重塑基于价值的学术评价标准、创新人才培养机制,强化全球学术出版治理。文本通过系统分析大语言模型、文生视频大模型驱动下的新兴学术生态,旨在为学术界提供理论视角和实践样态,实现知识生产的原创性与伦理性,推动学术出版在新技术环境中的学术治理现代化及可持续高质量发展。

关键词： Sora 学术期刊出版技术伦理学术伦理学术生态系统

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu liu Shuaipeng Ma Tianjin Shen Yuhua Zou chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

《健康全书》与中世纪西欧养生文化

古代文明（中英文） 2025年第1期19卷 43-49,M0004页

作者：刘娟中国人民大学历史学院北京100872

养生指南是欧洲中世纪兴起的一种指导个人保健的书籍,《健康全书》是其典型代表。“非自然理论”为这类文本提供了理论支撑,它强调个人的主观能动性,同时侧重于对整体健康的关注。作为中世纪养生文化的重要载体,养生指南经历了从上层精... 详细信息

养生指南是欧洲中世纪兴起的一种指导个人保健的书籍,《健康全书》是其典型代表。“非自然理论”为这类文本提供了理论支撑,它强调个人的主观能动性,同时侧重于对整体健康的关注。作为中世纪养生文化的重要载体,养生指南经历了从上层精英向大众广泛传播的过程,其中传达的医学理论不仅成为指导个人规范生活方式的参考,也启发了该时期城市的公共卫生建设。对养生指南的考察,有助于深化对中世纪预防医学发展的认识。

关键词：《健康全书》养生指南非自然因素整体健康

Ni-catalyzed cross-electrophile alkyl-alkyl coupling reactions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Li-Xu You Lan Tian chun-Ling Guo Shun-Xi Li Yu-Cheng liu Yu-Long Li Wei Shu College of Chemistry and Environmental Engineering Key Laboratory of Green Catalysis of Higher Education Institutes of Sichuan Sichuan University of Science and Engineering Guangming Advanced Research Institute Shenzhen Grubbs Institute Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology

Introducing saturated carbon-carbon bonds into organic molecules significantly increases the three-dimensional configuration,thus altering the physical and chemical properties as well as the functions of molecules. Transition-metal-catalyzed carboncarbon cross-couplings represent one of the most straightforward, efficient and modular alternatives to build saturation in a single step. However, the efficient construction of alkyl-alkyl bonds remains a formidable challenge due to the precise manipulation of multiple alkyl metallic intermediates as well as associated competitive side reactions and selectivity control. Over the past years, Ni-catalyzed cross-coupling under reductive conditions has gained more and more attention for alkyl-alkyl crosscoupling partially attributing to the low-valent state of metal centers under reducing conditions, which suppresses the competitive β-hydride elimination process, thus facilitating the formation of alkyl-alkyl bonds. In this review, the initiative and progress of Ni-catalyzed cross-electrophile alkyl-alkyl cross-coupling, including the efforts in racemic and enantioselective formation of alkyl-alkyl bonds, have been summarized and discussed. Moreover, the challenges and further opportunities in this area have also been discussed.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

行政诉讼类型探析——当事人诉讼

山西财经大学学报（高等教育版） 2004年第1期7卷 73-75页

作者：尤春媛刘娟山西大学法学院山西太原030006

重构我国行政诉讼类型是行政法学的热点问题。文章对行政诉讼类型之一的当事人诉讼的基础理论、适用范围、借鉴意义做深入研究,以期对我国行政诉讼类型的完善有所裨益。

关键词：行政诉讼当事人诉讼中国法院司法变更权

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xihan Xu juan-juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于刻蚀处理的池沸腾传热性能实验研究

原子与分子物理学报 2025年第3期42卷 180-188页

作者：王菊萍匡纯纯刘妮上海理工大学制冷技术研究所上海200093

为探究刻蚀处理铜板表面对池沸腾传热性能的改善效果,搭建了可视化实验平台,制备不同刻蚀浓度和刻蚀时间处理的表面,采用去离子水为工质,进行饱和池沸腾实验.结果表明,氨水刻蚀浓度越大,表面的换热性能越强,氨水刻蚀时间越长,表面换热... 详细信息

为探究刻蚀处理铜板表面对池沸腾传热性能的改善效果,搭建了可视化实验平台,制备不同刻蚀浓度和刻蚀时间处理的表面,采用去离子水为工质,进行饱和池沸腾实验.结果表明,氨水刻蚀浓度越大,表面的换热性能越强,氨水刻蚀时间越长,表面换热性能越强.热流密度为43.2 W/cm^(2)时,0.05 mol/L氨水刻蚀4 h表面、0.05 mol/L氨水刻蚀5 h表面、0.05 mol/L氨水刻蚀8 h表面、0.03 mol/L氨水刻蚀4 h表面、0.05 mol/L氨水刻蚀4 h表面和0.10 mol/L氨水刻蚀4 h表面上的换热系数分别提高了46%、92%、105%、36%、45%、78%.此外,对其表面进行表征,结果说明了其优异的沸腾性能.刻蚀处理增强了表面粗糙度,有效面积,从而促进液体的补充,能够在较小的过热度下达到更高的临界热流密度.可视化研究结果表明,刻蚀表面具有更多的成核位点,更小的气泡离开直径和离开频率.这些结果显示出刻蚀表面强化池沸腾换热的潜力.

关键词：池沸腾刻蚀传热性能气泡动力学微纳结构表面

维普期刊数据库博看期刊