检索结果-南通市图书馆

Sequence structure controllable polymerization-induced self-assembly

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第1期67卷 390-397页

作者： Zi-Xuan Chang Ren-Man Zhu chun-Yan hong Wen-Jian Zhang Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Key Laboratory of Environment-Friendly Polymeric Materials of Anhui Province Anhui UniversityHefei 230601China

Polymerization-induced self-assembly(PISA)combines synthesis and self-assembly of artificial polymers in one-pot,which brings us one step closer to emulating ***,the reported PISA formulations primarily focus on developing nano-objects with new chemical compositions and rarely on structural regulation of polymers with specific ***,sequence structure controllable polymerization-induced self-assembly(SCPISA)is reported by using 7-(2-methacryloyloxyethoxy)-4-methylcoumarin(CMA)as a *** the copolymerization of 2-hydroxyethyl methacrylate(HEMA)and CMA,controlled incorporation of CMA units into the polymer chains can be realized by programmable light/heat ***-based P(HEMA-co-CMA)copolymers with the same composition but different sequence structures generate a range of ***,the morphologies of the resultant nano-objects can also be controlled by regulating the feed molar ratio of CMA and HEMA,which is similar to the conventional PISA,but the synthesis procedure is obviously simplified in *** versatility of the methodology is further demonstrated by the fabrication of different functional nano-objects with sequence structure-dependent morphologies in SCPISA systems with different functional monomers.

关键词： polymerization-induced self-assembly sequence-controlled polymers PET-RAFT polymerization

MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： hong-Xia Bai Xue-Mei Qiu chun-hong Xu Jian-Qiang Guo Department of Gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 ***-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family E member 1 Epithelial-mesenchymal transition Proliferation Extracellular signal-regulated kinase-1/2

Mechanism of local solidification time variations with melt rate during vacuum arc remelting process of 8Cr4Mo4V high-strength steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第2期31卷 377-388页

作者： Tao Pan hong-chun Zhu Zhou-hua Jiang Hua-bing Li Rui Zhang Hao Feng School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

A 2D axisymmetric numerical model was established to investigate the variations of molten pool with different melt rates during the vacuum arc remelting of 8Cr4Mo4V high-strength steel,and the ingot growth was simulated by dynamic mesh *** results show that as the ingot grows,the molten pool profile changes from shallow and flat to V-shaped,and both the molten pool depth and the mushy width ***,the variation of both the molten pool shape and the mushy width melt rate is clarified by the thermal equilibrium *** melt rate increases,both the molten pool depth and the mushy width *** is caused by the increment in sensible heat stored in the ingot due to the limitation of the cooling capacity of the *** nonlinear increment in sensible heat leads to a nonlinear increase in the mushy *** addition,as melt rate increases,the local solidification time(LST)of ingot decreases obviously at first and then *** melt rate is controlled in a suitable range,LST is the lowest and the secondary dendrite arm spacing of the ingot is the smallest,which can effectively improve the compactness degree of 8Cr4Mo4V high-strength steel.

关键词： 8Cr4Mo4V high-strength steel Vacuum arc remelting process Melt rate Molten pool Local solidification time

Time-resolved ultra-small-angle X-ray scattering beamline(BL10U1)at SSRF

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第2期35卷 6-19页

作者： Wen-Qiang Hua chun-Ming Yang Ping Zhou Feng Tian Jin-You Lin Yu-Zhu Wang Xiao-Yun Li Xia-Ran Miao chun-Xia hong Qiu-Shi Huang Xin-Tong Zhao Yong-Feng Men Jie Wang Xing-Yu Gao Xiu-hong Li Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Key Laboratory of Advanced Micro Structural Materials MOEInstitute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The construction of a new beamline,BL10U1,was completed at the Shanghai synchrotron radiation facility in *** multipurpose beamline was designed to provide X-ray scattering techniques such as ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),wide-angle X-ray scattering,and microfocus SAXS(μSAXS)for a broad user *** realize fast time-resolved USAXS experiments,the beamline adopted an in-vacuum undulator with a total length of 1.6 m as the photon *** in-house cryogenic-cooled double multilayer monochromator was installed to deliver a photon flux of approximately 10^(13) photons/s at a photon energy of 10 *** three-year successful operation of this beamline demonstrated that the monochromator operated smoothly,as ***10U1 has three end stations in succession:USAXS end station,μSAXS end station,and end station for industrial *** minimum scattering vector q~0.0042 nm^(-1) at 10 keV can be achieved at the USAXS end station equipped with a 28 m-long and 1.8 m-diameter vacuum flight *** theμSAXS end station,a beam spot of less than 10×8μm was achieved for micro-SAXS *** contrast,in situ experimental instruments up to 5 m high and 8 m wide can be mounted at the industrial application end station,which offers industrial scientists the opportunity to use their large industrial ***10U1 opens up a new capability to investigate phenomena such as non-equilibrium and dynamic processes of materials with a wide length scale from angstroms to micrometers with millisecond time *** this paper,we also report beamline design considerations and commissioning results.

关键词： Synchrotron radiation Ultra-small-angle X-ray scattering Micro small-angle X-ray scattering USAXS Time resolved μSAXS

Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-Meng Wang Jian-Ling Jiang Rui Li Juan-Juan Wang chun-hong Gu Jia Zeng Xiao-Hui Wei Mei Chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第3期16卷 979-990页

作者： Yi-Mei Wang Zheng-Wei Luo Yu-Lin Shu Xiu Zhou Lin-Qing Wang chun-hong Liang Chao-Qun Wu Chang-Ping Li Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)is the primary risk factor for gastric cancer(GC),the Wnt/β-Catenin signaling pathway is closely linked to *** has a high mortality rate and treatment cost,and there are no drugs to prevent the progression of gastric precancerous lesions to ***,it is necessary to find a novel drug that is inexpensive and preventive to against *** To explore the effects of *** and Moluodan on the Wnt/β-Catenin signaling pathway and precancerous lesions of GC(PLGC).METHODS Mice were divided into the control,N-methyl-N-nitrosourea(MNU),***+MNU,and Moluodan *** first created an *** infection model in the ***+MNU and Moluodan groups.A PLGC model was created in the remaining three groups except for the control *** was fed to mice in the Moloudan group ad *** general condition of mice were observed during the whole experiment *** tissues of mice were grossly and microscopically *** quantitative real-time PCR(qRT-PCR)and Western blotting analysis,the expression of relevant genes were *** Mice in the ***+MNU group showed the worst performance in general condition,gastric tissue visual and microscopic observation,followed by the MNU group,Moluodan group and the control ***-PCR and Western blotting analysis were used to detect the expression of relevant genes,the results showed that the ***+MNU group had the highest expression,followed by the MNU group,Moluodan group and the control *** *** can activate the Wnt/β-catenin signaling pathway,thereby facilitating the development and progression of *** suppressed the activation of the Wnt/β-catenin signaling pathway,thereby decreasing the progression of PLGC.

关键词： Helicobacter pylori Gastric cancer Wnt/β-catenin signaling pathway Moluodan

Modeling and characterization on electroplastic effect during dynamic deformation of 5182-O aluminum alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2455-2475页

作者： hong-chun SHANG Song-chen WANG Yan-shan LOU School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China

The coupling effects of electrical pulse,temperature,strain rate,and strain on the flow behavior and plasticity of 5182-O aluminum alloy were investigated and *** isothermal tensile test and electrically-assisted isothermal tensile test were performed at the same temperature,and three typical models were further embedded in ABAQUS/Explicit for numerical simulation to illustrate the electroplastic *** results show that electric pulse reduces the deformation resistance but enhances the elongation *** calibration accuracy of the proposed modified Lim−Huh model for highly nonlinear and coupled dynamic hardening behavior is not much improved compared to the modified Kocks−Mecking ***,the artificial neural network model is very suitable to describe the macromechenical response of materials under the coupling effect of different variables.

关键词： machine learning aluminium alloy electroplastic effect coupling effect finite element analysis

在线全文

学校读者我要写书评

暂无评论

日据时期朝鲜半岛汉语会话书中的疑问句

吉林大学社会科学学报 2024年第5期64卷 214-224,240页

作者：李春红吉林大学文学院长春130012

随着域外文献的不断发掘与整理,以明清至民国时期域外汉语文献为语料考察同时期汉语特征的研究方兴未艾。日据时期朝鲜半岛刊行的汉语会话书记录的语法现象呈现出早期现代汉语语法域外传播的同时特征。这些汉语会话书中的疑问句多“以... 详细信息

随着域外文献的不断发掘与整理,以明清至民国时期域外汉语文献为语料考察同时期汉语特征的研究方兴未艾。日据时期朝鲜半岛刊行的汉语会话书记录的语法现象呈现出早期现代汉语语法域外传播的同时特征。这些汉语会话书中的疑问句多“以词带句”呈现,主要包括四大类:以“麽(麼)、嗎、罷”类语气词为标记的是非问句;以“甚麽”类疑问词为标记的特指问句;以“是X(还)是Y”为代表的选择问句;以“VP-Neg-VP”为代表的反复问句等。当时语法学界对疑问句的界定与研究尚未成熟,汉语教科书文献中的疑问句蕴藏着域外汉语教学的句类认知及汉语教育的语法观念,或可为汉语教育教学史及汉语语法学史研究提供更为宽广的全球史视阈。

关键词：域外汉语教育日据时期朝鲜半岛汉语会话书疑问句以词带句

课程思政视域下高中英语大单元教学设计——基于协同教学理论

在线全文

学校读者我要写书评

暂无评论

教育理论与实践 2024年第26期44卷 42-46页

作者：孙春红睢宁县第一中学江苏睢宁221200

当前,高中英语大单元教学中存在着碎片化、表层化和标签化及思想政治教育认知有偏差等倾向,难以形成英语学科与思想政治教育的有效融通。基于协同教学理论,课程思政视域下高中英语大单元教学设计可以从精选课程资源、设定教学目标、整... 详细信息

当前,高中英语大单元教学中存在着碎片化、表层化和标签化及思想政治教育认知有偏差等倾向,难以形成英语学科与思想政治教育的有效融通。基于协同教学理论,课程思政视域下高中英语大单元教学设计可以从精选课程资源、设定教学目标、整合教学内容和优化评价体系等四个维度进行,以促进高中英语大单元教学中的知识传授、能力培养和思政育人三者深度融合,让思政元素有机融入英语教学各环节,从而实现全员全程全方位育人的教育目标。

关键词：课程思政高中英语大单元教学设计协同教学