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Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer,therapeutic treatment options for platinum-resistant ovarian cancer

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Cancer Drug Resistance 2021年第3期4卷 573-595页

作者： Natasha Rinne Elizabeth LChristie Anastasia Ardasheva chun hei kwok Nikita Demchenko Caroline Low Catherine Tralau-Stewart Christina Fotopoulou Paula Cunnea Department of Surgery&Cancer Imperial College LondonHammersmith campusLondon W120NNUK Peter MacCallum Cancer Centre East MelbourneVictoria 3002Australia Department of Metabolism Digestion&Reproduction Imperial College LondonLondon W120NNUK Takeda Academic Innovation Center for External InnovationTakeda CaliforniaSan DiegoCA 92121USA

The survival rates for women with ovarian cancer have shown scant improvement in recent years,with a 5-year survival rate of less than 40%for women diagnosed with advanced ovarian ***-grade serous ovarian cancer(HGSOC)is the most lethal subtype where the majority of women develop recurrent disease and chemotherapy resistance,despite over 70%-80%of patients initially responding to platinum-based *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signaling pathway regulates many vital processes such as cell growth,survival and ***,this pathway is frequently dysregulated in cancers including different subtypes of ovarian cancer,through amplification or somatic mutations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),amplification of AKT isoforms,or deletion or inactivation of *** evidence indicates a role for the PI3K/AKT/mTOR pathway in the development of chemotherapy resistance in ovarian ***,targeting key nodes of the PI3K/AKT/mTOR pathway is a potential therapeutic *** this review,we outline dysregulation of PI3K signaling in ovarian cancer,with a particular emphasis on HGSOC and platinum-resistant *** review pre-clinical evidence for inhibitors of the main components of the PI3K pathway and highlight past,current and upcoming trials in ovarian cancers for different inhibitors of the *** no inhibitors of the PI3K/AKT/mTOR pathway have thus far advanced to the clinic for the treatment of ovarian cancer,several promising compounds which have the potential to restore platinum sensitivity and improve clinical outcomes for patients are under evaluation and in various phases of clinical trials.

关键词： Ovarian cancer high-grade serous PI3K/AKT/mTOR pathway chemotherapy resistance inhibitors therapeutics

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Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 716-731页

作者： Hsiang-chun Lai Ju-Chien Cheng hei-Tung Yip Long-Bin Jeng Sheng-Teng Huang Graduate Institute of Chinese Medicine School of Chinese MedicineCollege of Chinese MedicineChina Medical UniversityTaichung 404328TaiwanChina Department of Medical Laboratory Science and Biotechnology China Medical UniversityTaichung 404TaiwanChina Management Office for Health Data China Medical University HospitalTaichung 404327TaiwanChina Organ Transplantation Center China Medical University HospitalTaichung 40447TaiwanChina Department of Chinese Medicine China Medical University HospitalSchool of Chinese MedicineChina Medical UniversityTaichung 40447TaiwanChina

BACKGROUND Type 2 diabetes mellitus(DM)is an independent risk factor for hepatocellular carcinoma(HCC),while insulin is a potent *** a new therapeutic modality for preventing insulin users from developing HCC is a critical goal for *** To investigate whether regular herbal medicine use can decrease HCC risk in DM patients with regular insulin *** We used data acquired from the Taiwan,Chinaese National Health Insurance research database between 2000 and *** identified patients with DM who were prescribed insulin for>3 *** herb user group was further defined as patients prescribed herbal medication for DM for>3 months per annum during RESULTS We initially enrolled 657144 DM patients with regular insulin use from 2000 to *** these,46849 patients had used a herbal treatment for DM,and 140547 patients were included as the matched control *** baseline variables were similar between the herb users and *** patients with regular herb use had a 12%decreased risk of HCC compared with the control group[adjusted hazard ratio(aHR)=0.88,95%CI=0.80–0.97].The cumulative incidence of HCC in the herb users was significantly lower than that of the *** with a herb use of>5 years cumulatively exhibited a protective effect against development of HCC(aHR=0.82,P<0.05).Of patients who developed HCC,herb users exhibited a longer survival time than nonusers(aHR=0.78,P=0.0001).Additionally,we report the top 10 herbs and formulas in prescriptions and summarize the potential pharmacological effects of the *** analysis indicated that Astragalus propinquus(Huang Qi)plus Salvia miltiorrhiza Bunge(Dan Shen),and Astragalus propinquus(Huang Qi)plus Trichosanthes kirilowii Maxim.(Tian Hua Fen)were the most frequent combination of single ***,Ji Sheng Shen Qi Wan plus Dan Shen was the most frequent combination of herbs and *** This large-scale retrospective cohort study reveals th

关键词： Hepatocellular carcinoma Diabetes mellitus Insulin Herb Taiwan,Chinaese National health insurance research database

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添加复合乳酸菌和糖蜜对不同水分含量苜蓿青贮品质的影响

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草地学报 2024年第5期32卷 1601-1609页

作者：黑梦琴曹正宇王志远代春辉陈程张文举石河子大学动物科技学院新疆石河子832003 胡杨河市河柒农业科技有限公司新疆胡杨河834034

本文旨在研究水分含量(67.69%,59.43%,47.26%和38.07%)对添加复合乳酸菌和2%糖蜜青贮后紫花苜蓿(Medicago sativa L.)青贮品质的影响。复合乳酸菌由植物乳杆菌和布氏乳杆菌组成,等比添加1×10^(7) cfu·g^(-1) FW。室温厌氧发酵后开袋... 详细信息

本文旨在研究水分含量(67.69%,59.43%,47.26%和38.07%)对添加复合乳酸菌和2%糖蜜青贮后紫花苜蓿(Medicago sativa L.)青贮品质的影响。复合乳酸菌由植物乳杆菌和布氏乳杆菌组成,等比添加1×10^(7) cfu·g^(-1) FW。室温厌氧发酵后开袋对青贮苜蓿营养品质、发酵品质和微生物数量进行测定。结果表明,萎蔫对添加复合乳酸菌和糖蜜的苜蓿青贮后的粗蛋白(Crude protein,CP)、酸性洗涤纤维(Acid detergent fiber,ADF)、氨态氮和有机酸含量均有显著影响(P<0.05);在不同水分条件下使用复合乳酸菌均能显著提高青贮后的乳酸含量(P<0.05),降低酸性洗涤纤维含量、pH值和氨态氮含量(P<0.05);添加复合乳酸菌在一定程度上能改善苜蓿青贮的细菌群落结构。根据主成分分析得出,苜蓿在含水量为59.43%条件下,添加复合乳酸菌青贮效果最佳,可有效提高青贮苜蓿品质。原料含水量为47.26%时添加糖蜜效果最佳。

关键词：紫花苜蓿发酵品质水分复合乳酸菌糖蜜

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闽江河口湿地围垦稻田对土壤铁碳结合特征的影响

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海洋地质与第四纪地质 2024年第1期44卷 44-54页

作者：刘旭阳王纯郭萍萍方云英沈李东胡世文黑杰王亚非胥佳忆王维奇福建师范大学湿润亚热带生态-地理过程教育部重点实验室福州350117 福建闽江河口湿地生态系统国家定位观测研究站(国家林业和草原局) 福州350215 福建闽江河口湿地国家级自然保护区管理处福州350200 格里菲斯大学澳大利亚河流研究所和环境与科学学院南森校区昆士兰4111 南京信息工程大学应用气象学院南京210044 广东省科学院生态环境与土壤研究所广州510650

土壤铁氧化物结合态有机碳是有机碳长期维持的主要途径,但其机理研究仍较为薄弱。为探究河口湿地围垦稻田对土壤铁碳结合特征的影响,本研究选择福建省闽江河口天然芦苇湿地与围垦稻田为研究对象,对两种类型土壤中的铁结合态有机碳(Fe-OC... 详细信息

土壤铁氧化物结合态有机碳是有机碳长期维持的主要途径,但其机理研究仍较为薄弱。为探究河口湿地围垦稻田对土壤铁碳结合特征的影响,本研究选择福建省闽江河口天然芦苇湿地与围垦稻田为研究对象,对两种类型土壤中的铁结合态有机碳(Fe-OC)及其相关指标进行测定与分析。结果显示:①芦苇湿地围垦稻田改变了土壤氧化还原过程,显著影响土壤中铁相的转化。围垦后土壤二价铁[Fe(Ⅱ)]、三价铁[Fe(Ⅲ)]、活性总铁含量(HCl-Fe_(t))及Fe(Ⅲ)/Fe(Ⅱ)分别显著下降了24.68%、52.56%、51.45%、35.68%(P<0.05)。游离态氧化铁(Fe_(d))与无定形态铁(Fe_(o))含量分别显著下降了21.64%和29.24%(P<0.05),络合态铁(Fe_(p))含量则有所增加。②芦苇湿地围垦稻田显著影响土壤碳固存,Fe-OC与土壤有机碳含量(SOC)在围垦稻田后分别显著下降了39.03%和18.42%(P<0.05);芦苇湿地与稻田土壤Fe-OC均主要以吸附途径结合,稻田土壤Fe-OC对土壤有机碳的贡献率(fFe-OC)显著高于芦苇湿地(P<0.05)。③土壤全氮、含水量、电导率、铁以及土壤有机碳、溶解性有机碳与Fe-OC呈显著正相关(P<0.01)。本研究可为退耕还湿、土壤碳增汇提供科学参考。

关键词：铁铁结合态有机碳芦苇湿地稻田闽江河口

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My mother is looking blue

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World Journal of Emergency Medicine 2019年第4期10卷 251-252页

作者： Howard Tat chun Chan Anselm Wang hei Hui Colin Graham Joseph Walline Department of Accident and Emergency Medicine Hong Kong Hospital AuthorityPrince of Wales HospitalShatinHong KongChina Accident and Emergency Medicine Academic Unit The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Dear editor,A 76-year-old Chinese female presented by ambulance to the Emergency Department complaining of dizziness,headache and *** son claimed that the patient“turned blue”three hours prior to onset of the patient’s *** noted the patient’s SpO2 was 83%on room air with no improvement with a nonrebreather *** medical history was signifi cant for diabetes and ***,social and medication history were non-contributory.

关键词： mother looking blue Emergency Department

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Epidemiological Analysis on Reported Hepatitis C Cases in China from 2012 to 2016

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Biomedical and Environmental Sciences 2018年第10期31卷 773-776页

作者： hei Fa Xin YE Shao Dong DING Guo Wei PANG Lin WANG Xiao chun LIU Zhong Fu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention

Viral hepatitis is an important challenge to public health *** hepatitis B is well controlled due to vaccination,the disease burden caused by the spread of hepatitis C has become increasingly *** C is an infectious disease that is mainly *** rate of chronicity ranges from 55% to 85% after people are infected with the hepatitis C virus （HCV）.

关键词： HCV Figure Epidemiological Analysis on Reported Hepatitis C Cases in China from 2012 to 2016

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牙颌面畸形儿童口腔健康、美观程度及正畸治疗需要特征分析和其对自尊的影响

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中国美容医学 2024年第7期33卷 152-155页

作者：高蕾程春黑益玲于竟璟王卿方敏邹英新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科新疆乌鲁木齐830000 新疆医科大学第一附属医院(附属口腔医院)口腔门诊新疆乌鲁木齐830000 新疆医科大学第一附属医院(附属口腔医院)医护办公室新疆乌鲁木齐830000

目的:探究牙颌面畸形儿童口腔健康、美观程度及正畸治疗需要特征及对自尊的影响。方法:选取2020年1月-2023年1月笔者医院收治的120例牙颌面畸形儿童,收集其临床资料,对其口腔健康、美观程度、正畸治疗需要特征进行分析,并探究各指标对... 详细信息

目的:探究牙颌面畸形儿童口腔健康、美观程度及正畸治疗需要特征及对自尊的影响。方法:选取2020年1月-2023年1月笔者医院收治的120例牙颌面畸形儿童,收集其临床资料,对其口腔健康、美观程度、正畸治疗需要特征进行分析,并探究各指标对于患者自尊的影响。结果:120例不同口腔健康严重程度的患儿间比较,自尊水平具有差异,自尊水平:轻度>中度>重度(P中度>重度(P<0.05);对患儿的正畸治疗需要特征进行分析,可知不同牙接触点借位、深覆盖、前牙反[牙合]、开[牙合]间患儿的自尊水平存在差异(P<0.05)。多元线性回归分析结果显示,美观程度、牙接触点错位、深覆盖、前牙反[牙合]、开[牙合]均会对患儿的自尊产生影响(P<0.05)。结论:牙颌面畸形儿童口腔健康的严重程度以及美观程度的不同均与儿童的自尊水平有关,轻度畸形的儿童自尊水平明显高于中度和重度畸形的儿童。此外,不同的口腔问题,如牙接触点错位、深覆盖、前牙反[牙合]、开[牙合]也对自尊水平存在显著影响。

关键词：牙颌面畸形口腔健康美观程度自尊正畸治疗

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M dwarf stars—the by-product of X-ray selected AGN candidates

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Research in Astronomy and Astrophysics 2012年第4期12卷 443-452页

作者： Yu Bai Yan-chun Suni Xiang-Tao hei Yang Chen Jiang-Hua Wui Qing-Kang Li Richard F. Green Wolfgang Voges Department of Astronomy Beijing Normal University Beijing 100875 China Kitt Peak National Observatory NOAO Tucson AZ 85726-6732 USA Max-Planck-Institute fur Extraterrestrische Physik D-85740 Garching Germany

X-ray loud M dwarfs are a major source of by-products （contamination） in the X-ray band of the multiwavelength quasar survey. As a by-product, the low dispersion spectra of 22 M dwarfs are obtained in which the spectra of 16 sources are taken for the first time. The spectral types and distances of the sample are given based on spectral indices CaH2, CaH3, and TiO5. The parameter ζ TiO/CaH is calculated to separate the different metallicity classes among dwarfs, subdwarfs and extreme subdwarfs. We also discuss the distributions in the diagrams of log（L x /L bol ）, the ratio between X-ray and bolometric luminosity versus spectral type and infrared colors.

关键词： spectroscopic — stars: X-rays: M dwarfs

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Introduction to this special issue - "Autophagy and Cancer: current biology and drug development"

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Journal of Cancer Metastasis and Treatment 2019年第8期4卷 1-2页

作者： chun hei Antonio Cheung Department of Pharmacology College of MedicineNational Cheng Kung UniversityTainan 70101Taiwan Institute of Basic Medical Sciences College of MedicineNational Cheng Kung UniversityTainan 70101Taiwan

It is my pleasure,as one of the editorial board members,to introduce the readers of JCMT to this special issue entitled"Autophagy and Cancer:current biology and drug development".Autophagy is a fundamental process for... 详细信息

关键词： Autophagy Cancer drug

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Prevalence of HCV Antibody and its Associated Factors: A Study from Sentinel Hospitals in China

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Biomedical and Environmental Sciences 2023年第4期36卷 334-342页

作者： XU Peng DING Guo Wei WANG Xiao chun YE Shao Dong hei Fa Xin YU Jie Jun YUAN Qing LIU Zhong Fu LI Jian National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Shandong Provincial Qianfoshan Hospital The First Hospital Affiliated with Shandong First Medical UniversityJinan 250014ShandongChina Center for Global Public Health Chinese Center for Disease Control and PreventionBeijing 102206China

Objective The prevalence and related factors of serum anti-HCV in different regions and hospitals have not been studied extensively in China. We used routine screening data to determine the prevalence of HCV antibody in hospital patients, evaluate the epidemic trend of hepatitis C and formulate screening *** Patient information and HCV antibody testing results were collected from January 2017 to December 2019 in 77 HCV sentinel hospitals in China. Univariate and multivariate logistic regression was used to determine the characteristics and *** HCV antibody prevalence rates were distinct among patients in different departments, with a range of 0.33%–6.93%. Patients who were admitted to the liver disease-related departments(aOR =10.76;95% CI, 10.27–11.28), Internal Medicine(aOR = 2.87;95% CI, 2.75–3.00), and Department of Surgery(aOR = 1.95;95% CI, 1.87–2.04), were more likely to be tested for HCV antibody positive. HCV antibody prevalence was associated with patients aged 45 years and older(aOR = 2.74;95% CI,2.69–2.80), testing in infetious disease hospitals(aOR = 2.33;95% CI, 2.26–2.40) and secondary hospitals(aOR = 1.72;95% CI, 1.69–1.75). Patients in sentinel hospitals of the Northeast(aOR = 12.75;95% CI,12.40–13.11), the Central(aOR = 1.65;95% CI, 1.61–1.70), and the West(aOR = 1.78;95% CI, 1.73–1.83)China had higher HCV prevalence than those who were in the Eastern coastal area. Conclusion Those who were over 45 years old and saw doctors for liver diseases, and invasive diagnosis and treatment should be referred to HCV antibody testing.

关键词： Hepatitis C virus HCV antibody test Prevalence of HCV antibody Sentinel hospital

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