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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi chun-Hsu pan Hui-Yu Huang Chieh-Hsi Wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

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Hemichorea in patients with temporal lobe infarcts: Two case reports

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World Journal of Clinical Cases 2024年第4期12卷 806-813页

作者： Xu-Dong Wang Xing Li chun-Lian pan Department of Neurology Puren Hospital Affiliated to Wuhan University of Science and TechnologyWuhan 430081Hubei ProvinceChina School of Medicine Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina

BACKGROUND Hemichorea and other hyperkinetic movement disorders are uncommon present-ations of stroke and are usually secondary to deep infarctions affecting the basal ganglia and ***,temporal ischemic lesions causing hemichorea are *** report the cases of two patients with acute ischemic temporal lobe infarct strokes that presented as *** SUMMARY Patient 1:An 82-year-old woman presented with a 1-mo history of involuntary movement of the left extremity,which was consistent with *** diffusion-weighted imaging(DWI)revealed an acute ischemic stroke that predominantly affected the right temporal cortex,and magnetic resonance angiography of the head showed significant stenosis of the right middle cerebral artery(MCA).Treatment with 2.5 mg of olanzapine per day was *** she was discharged from the hospital,her symptoms appeared to have improved compared with those previously ***-seven days after the first admission,she was readmitted due to acute ischemic *** tomogra-phy perfusion showed marked hypoperfusion in the right MCA *** emergency transfemoral cerebral angiogram was performed and showed severe stenosis in the M1 segment of the right *** percutaneous transluminal angioplasty was successfully performed,abnormal movements or other neuro-logic problems did not *** 2:A 76-year-old man was admitted to our hospital for a 7-d history of right-upper-sided involuntary *** showed an acute patchy ischemic stroke in the left temporal lobe without basal ganglia *** diffusion tensor imaging confirmed fewer white matter fiber tracts on the left side than on the opposite *** with 2.5 mg of olanzapine per day improved his condition,and he was *** When acute hemichorea suddenly appears,temporal cortical ischemic stroke should be considered a possible *** addition,hemichorea may be a sign of impending cerebral infarcti

关键词： Acute ischemic stroke Temporal ischemic stroke Movement disorders Cortical hemichorea Case report

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Noncanonical pyroptosis pathway: a promising target of traditional Chinese medicine in the treatment of sepsis-related injury

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Integrative Medicine Discovery 2024年第20期8卷 1-4页

作者： Yan-Yan Cen pan Wang Ting Zhu Ya-Lan Xiong Xi-chun pan Department of Pharmacology College of PharmacyArmy Medical UniversityChongqing 400038China.

Sepsis is a life-threatening disease of organ failure caused by dysregulated host responses to infection and other infectious ***-organ injury is the leading cause of high mortality and septic shock during *** studies suggest that noncanonical pyroptosis,characterized mainly by the direct activation of caspase-11-gasdermin D-mediated pyroptosis by cytoplastic lipopolysaccharide,is closely related to sepsis-related organ ***,this review summarizes recent advances in the regulatory mechanisms and targeted natural products from traditional Chinese medicine of the noncanonical pyroptosis pathway in sepsis-related injury.

关键词： sepsis-related injury noncanonical pyroptosis caspase-11 gasdermin D

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腔室清洗的单臂组合设备初始暂态调度

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控制理论与应用 2024年第2期41卷 303-310页

作者：郭文有潘春荣江西理工大学机电工程学院江西赣州341000

为了提升腔室洁净度,晶圆厂需对组合设备腔室进行清洗操作,从而提高晶圆的加工质量.考虑腔室清洗时间和晶圆驻留时间的约束条件下,本文研究了单臂组合设备的初始暂态调度问题.首先,提出了机械手的初始暂态活动规则,并对机械手活动序列... 详细信息

为了提升腔室洁净度,晶圆厂需对组合设备腔室进行清洗操作,从而提高晶圆的加工质量.考虑腔室清洗时间和晶圆驻留时间的约束条件下,本文研究了单臂组合设备的初始暂态调度问题.首先,提出了机械手的初始暂态活动规则,并对机械手活动序列进行描述,实现了系统的初始暂态可调度性;其次,对机械手在初始暂态和稳态的活动时间进行了建模;然后,根据系统的时间特性,建立了初始暂态调度的线性规划模型;最后,通过实例验证了该方法的有效性.与已有的虚拟晶圆方法相比,该调度方法能有效减少初始暂态的完工时间,提高了组合设备的晶圆生产效率.

关键词：组合设备腔室清洗初始暂态晶圆制造

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Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

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Food Science and Human Wellness 2024年

作者： Qi-Ming Yu Yan Zhu Tao Jiang Ying Gao Nan Ling Na Wang John Shi Wei-chun pan Qi-Zhen Du Jun-Feng Yin Tea Research Institute Chinese Academy of Agricultural Sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture College of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research Center， Agriculture and Agri-Food Canada College of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6J mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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贸易协定如何影响中国进口?——基于条款深度的视角

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上海对外经贸大学学报 2024年第4期31卷 108-124页

作者：廖佳潘春阳上海对外经贸大学国际经贸学院上海201620 华东理工大学商学院上海200237

本文基于2001~2019年107个中国贸易伙伴国的面板数据,运用多维固定效应泊松伪极大似然估计方法 (PPML法)估计了贸易协定及其深度对中国进口的影响。研究发现,贸易协定显著扩大了中国从协定签署国的进口规模,且该结论在考虑贸易协定条款... 详细信息

本文基于2001~2019年107个中国贸易伙伴国的面板数据,运用多维固定效应泊松伪极大似然估计方法 (PPML法)估计了贸易协定及其深度对中国进口的影响。研究发现,贸易协定显著扩大了中国从协定签署国的进口规模,且该结论在考虑贸易协定条款的法律效力和时滞效应并使用工具变量法进行内生性处理及稳健性检验后依然成立。进一步分析发现,不同贸易协定条款对中国进口规模的影响存在异质性。“WTO-plus”条款显著促进了中国进口,其正向促进作用主要来自其中包含的十项边境条款;条款总深度对高科技含量产品和中间品进口存在较显著的正向影响,对中等科技含量产品和最终产品的进口存在较显著的负向影响,其中对中间品进口的促进作用主要来自“WTO-plus”条款,对中等科技含量产品进口的负向影响则主要来自“WTO-extra”条款。本文研究结论为我国通过签署贸易协定主动扩大进口、优化贸易结构提供了实证支撑。

关键词：贸易协定中国进口条款深度贸易模式转型

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Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

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Current Medical Science 2024年第3期44卷 603-610页

作者： Juan YANG Meng-yuan LIANG Yu LI Hao ZHANG Wei LI Jing LV Li-ping DONG Jing-song JIN Cheng YANG Qing-hong ZHANG Li LONG Rong ZOU Yi GAO Dan SONG chun-qin pan Ying YAO Xiao-lin ZHAN Xiao-hui WANG Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First People’s Hospital of GuiyangGuiyang550000China Department of Nephrology The Third Xiangya HospitalCentral South UniversityChangsha410000China Department of Nephrology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Nephrology Wuhan No. 4 HospitalWuhan430033China Department of Nephrology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan430060China Department of Nephrology Central Theater General Hospital of PLAWuhan430064China Department of Nephrology Taihe HospitalShiyan442000China Department of Nephrology Third People’s Hospital of Hubei ProvinceWuhan430033China Department of Nephrology Hubei Province Integrated Traditional Chinese and Western Medicine Hospital of Hubei provinceWuhan430024China Department of Nephrology Xi’an No.3 HospitalAffiliated Hospital of Northwest UniversityXi’an710000China Department of Nephrology Shenzhen Guangming District People’s HospitalShenzhen518000China Department of Nephrology Xiantao First People’s HospitalXiantao433000China Department of Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology Huangshi Central HospitalHuangshi435000China Department of Nephrology The Fifth Hospital of WuhanWuhan430050China

Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal *** A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two *** in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue *** 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two *** After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental ***,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

关键词： Jianpi Shengxue tablet renal anemia randomized open parallel control multicenter clinical study

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基于OBE理念的高职“会计信息系统应用”课程改革与实践

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职业教育研究 2024年第4期 87-91页

作者：潘纯长江工程职业技术学院湖北武汉430212

“会计信息系统应用”是高职会计专业的一门核心课程,对培养学生的会计信息处理和分析能力具有重要意义。然而,传统的课程设置和教学方式已经难以满足现代职业教育的需求,存在教学目标不明确、内容体系滞后、教学模式单一等问题,需要进... 详细信息

“会计信息系统应用”是高职会计专业的一门核心课程,对培养学生的会计信息处理和分析能力具有重要意义。然而,传统的课程设置和教学方式已经难以满足现代职业教育的需求,存在教学目标不明确、内容体系滞后、教学模式单一等问题,需要进行相应的课程改革。文章基于OBE理念,通过重构课程内容体系、反向教学设计、构建线上线下混合教学模式、创新共享财务教学云平台等,探讨如何进行“会计信息系统应用”课程改革与实践。

关键词： OBE理念会计信息系统应用课程改革

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基于产教融合的湖北职教强省建设策略研究

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湖北职业技术学院学报 2024年第1期27卷 6-10页

作者：潘纯长江工程职业技术学院湖北武汉430212

湖北职教强省建设目前实现了校企多元主体深度合作、职教目标契合产业发展目标、教育教学结合社会生产实践等基本目标,但职教服务能力、校企合作效率、职教课程结构都有待优化。主要存在思想认识不到位,产教融合行动乏力,体制机制不健全... 详细信息

湖北职教强省建设目前实现了校企多元主体深度合作、职教目标契合产业发展目标、教育教学结合社会生产实践等基本目标,但职教服务能力、校企合作效率、职教课程结构都有待优化。主要存在思想认识不到位,产教融合行动乏力,体制机制不健全,校企合作效率低下,区域差异化显著,产教融合发展难度较大等不足,对此提出构建产教融合组织架构、制定产教融合培育方案、深化职业教育教学改革、营造产教融合生态环境等应对策略。

关键词：产教融合职教强省湖北问题策略

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基于OBE理念的高职大数据与会计专业人才培养模式创新策略

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长江工程职业技术学院学报 2024年第2期41卷 48-51页

作者：潘纯杜蓓长江工程职业技术学院湖北武汉430212

以高职大数据与会计专业人才培养工作为研究对象,在OBE理念下,围绕高职大数据与会计专业人才培养模式创新展开分析。对OBE理念的概念进行阐述,对现阶段高职大数据与会计专业人才培养存在的问题进行了系统性的梳理,对OBE理念指导下的该... 详细信息

以高职大数据与会计专业人才培养工作为研究对象,在OBE理念下,围绕高职大数据与会计专业人才培养模式创新展开分析。对OBE理念的概念进行阐述,对现阶段高职大数据与会计专业人才培养存在的问题进行了系统性的梳理,对OBE理念指导下的该专业人才培养模式实施要点进行了介绍,提出了基于OBE理念的高职大数据与会计专业人才培养模式创新策略。

关键词： OBE理念大数据与会计专业人才培养模式

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