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Neuroprotective Effect of Chunghyuldan(Qing Xue Dan)on Hypoxia-Reoxygenation Induced Damage of Neuroblastoma 2a Cell Lines

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Chinese Journal of Integrative Medicine 2013年第12期19卷 940-944页

作者： Chang-Nam Ko In-Seo Park Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park chulhun kang Ki-Ho Cho Department of Cardiology and Neurology Diseases College of Korean MedicineKyung Hee University Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University

Objectives： Chunghyuldan （CHD）, a combinatorial drug that has anti-hyperlipidemic and anti inflammatory activities, has been shown to reduce infarct volume in a focal ischemia-reperfusion rat model. To explore the molecular basis of CHD＇s neuroprotective effect, we examined whether CHD shows a cell-protective activity and has a regulatory effect on Bax and/or B-cell leukemia/lymphoma 2 （Bcl-2） expression in mouse neuroblastoma 2a （N2a） cells subjected to hypoxia-reoxygenation （H/R）. Methods： In order to evaluate the effects of CHD on the cytotoxicity induced from hypoxia or H/R condition, lactate dehydrogenase （LDH） assay was performed. To explore whether the suppression of neural damage when pre-treated with CHD is associated with its anti-apoptotic effect, the CHD effect on the expression of Bcl-2 and Bax was analyzed by Western blotting analysis. Results： Cytotoxicity of N2a cell line was slightly increased in 42 h hypoxia condition and dramatically increased under the H/R condition. CHD treatment markedly decreased the cytotoxicity in both conditions （P〈0.01, P〈0.05）. H/R markedly increased the expression of the pro-apoptotic protein, Bax, but slightly increased the expression of the anti-apoptotic protein, Bcl-2, compared with the normoxia or hypoxia group. CHD significantly decreased Bax expression （P〈0.01） and slightly decreased Bcl-2 expression （P〉0.05）, resulted in a reduction of Bax/Bcl-2 ratio in N2a cells subjected to H/R. Conclusion： CHD has neuroprotective effect in N2a cells subjected to H/R, which might be derived at least in part from its ability to decrease the expression of the pro-apoptotic protein, Bax.

关键词： apoptosis stroke Chunghyuldan herbal

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Are the release characteristics of Erzhi pills in line with traditional Chinese medicine theory?A quantitative study

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Journal of Integrative Medicine 2021年第1期19卷 50-55页

作者： Jie-yu Zuo chulhun Park Michael Doschak Raimar Lobenberg Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmontonAlberta T6G 2E1Canada

Objective:Traditional Chinese medicine(TCM)has been widely used throughout China to prevent and cure diseases for thousands of years,and now it is a part of the integrative medicine field that is available in Western *** ensure the safety and quality of the herbal medicines that are a major part of the TCM tradition,they must be held to modern pharmaceutical *** pill(EZP)is a Chinese Pharmacopeia-listed herbal preparation that is used in the long-term clinical management of postmenopausal symptoms,osteoporosis and menstrual *** now,whether the drug release mechanism of EZP is in line with its intended TCM usage has not been ***:The release of specnuezhenide from three EZPs(self-made,Leiyunshang and Renhe)in simulated gastric fluid(SGF),acetate buffer(p H 4.5 buffer)and simulated intestinal fluid(SIF)was investigated in a dissolution *** water uptake capacity and erosion extent of the three EZPs were investigated using swelling and erosion *** drug release mechanism was further assessed through statistical model fitting,using DDSolver ***:The release of specnuezhenide from all three EZPs in SGF was less than 50%within a 4 h ***,over 70%of the specnuezhenide was released from each EZP in both p H 4.5 buffer and SIF in the same *** of the swelling and erosion behaviors and the drug release mechanism of the three EZPs confirmed that the release rate from EZP followed a sustained release profile,which was an interactive combination of swelling and ***:This study showed that the release pattern from the pills was in line with the intended TCM use of *** had not only theoretically considered sustained release from the pills,but also formulated them to achieve this release *** establishing quality control standards for pills,the theoretical TCM usage and the actual release patterns need to be considered.

关键词： Traditional Chinese medicine Dosage form Herbal preparation Dissolution Drug release mechanism Erzhi pill

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An oscillator with low phase noise based on active resonator using metamaterial in K-band

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Journal of Measurement Science and Instrumentation 2013年第1期4卷 74-76页

作者： Wooseok Shim Chongmin Lee chulhun Seo Dept.of Electronics Engineering Soongsil UniversitySeoul 156-743Korea

An oscillator(OSC)with a metamaterial resonator based on high-Q is designed to improve the phase noise in *** proposed metamaterial resonator is a lattice structure resonator(LSR)that is designed to be high-Q by a strong coupling of E-field at the resonance *** the output of OSC is about 12.5dBm at the *** phase noise is 109.477dBc/Hz at 100kHz offset frequency.

关键词： metamaterial oscillator(OSC) phase noise

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Design of a Loop Resonator with Improved Power Transmission Efficiency Using a Ferrite Plate

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Journal of Electromagnetic Analysis and Applications 2013年第5期5卷 196-200页

作者： Gangil Byun Sunghwan Ji Byungjun Jang chulhun Seo Hosung Choo Department of Electronic engineering Kookmin University Seoul South Korea Department of Electronics and Computer Engineering Hanyang University Seoul South Korea Department of Telecommunication Soongsil University Seoul South Korea Moasoft Co. Ltd. Seoul South Korea School of Electronic and Electrical Engineering Hongik University Seoul South Korea

We propose a novel resonator that can reduce magnetic field leakage using a ferrite plate. The proposed resonator consists of a rectangular loop, a ferrite plate, and an L-matching network. The ferrite plate is used as an H-field reflector to direct more H-field to each resonator, and the L-matching network is employed to match the 50 Ω of the feed cable at 13.56 MHz. Two identical resonators with dimensions of 30 cm × 15 cm are separated by 50 cm, and the resulting transmission efficiency is about ?12.3 dB at 13.56 MHz. This is about 4.2 dB higher than the resonators without the ferrite plate.

关键词： Ferrite Plate Loop Resonator Wireless Power Transmission

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