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Impact of surgical volume on nationwide hospital mortality after pancreaticoduodenectomy

World Journal of Gastroenterology 2012年第31期18卷 4175-4181页

作者： chul-gyu kim Sungho Jo Jae Sun kim Department of Nursing Cheongju UniversityCheongjuChungbuk 360-764South Korea Department of Surgery Dankook University College of MedicineCheoanChungnam 330-714South Korea Health Insurance Review and Assessment Service Seoul 137-706South Korea

AIM:To evaluate the impact of surgical volume on nationwide hospital mortality after pancreaticoduodenectomy(PD) for periampullary tumors in South ***:Periampullary cancer patients who underwent PD between 2005 and 2008 were analyzed from the database of the Health Insurance Review and Assessment Service of South Korea.A total of 126 hospitals were divided into 5 categories,each similar in terms of surgical volume for each *** used hospital mortality as a quality indicator,which was defined as death during the hospital stay for PD,and calculated adjusted mortality through multivariate logistic models using several confounder ***:A total of eligible 4975 patients were enrolled in this *** annual surgical volume of hospitals was markedly varied,ranging from 215 PDs in the very-high-volume hospital to < 10 PDs in the verylow-volume *** route,type of medical security,and type of operation were significantly different by surgical *** overall hospital mortality was 2.1% and the observed hospital mortality by surgical volume showed statistical *** volume,age,and type of operation were independent risk factors for hospital death,and adjusted hospital mortality showed a similar difference between hospitals with observed *** result of the HosmerLemeshow test was 5.76(P = 0.674),indicating an acceptable appropriateness of our regression ***:The higher-volume hospitals showed lower hospital mortality than the lower-volume hospitals after PD in South Korea,which were clarified through the nationwide database.

关键词： Hospital mortality Pancreaticoduodenecto-my South Korea Databases Factual Logistic models Risk factors

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A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑Young kim Yang Li Guozhen Shen Jong‑chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

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Structural optimization for ball valve made of CF8M stainless steel

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中国有色金属学会会刊：英文版 2009年第B9期19卷 258-261页

作者： Seung-gyu kim Seok-Heum BAEK Young-chul PARK Department of Mechanical Engineering Dong-A University

The mechanical and chemical properties of CF8M were studied through experiments. An application of CF8M in valve body was analyzed by using finite element method(FEM) to evaluate the structural safety. An optimization containing several variables based on the response surface method(RSM) was conducted to find the optimum dimension of the valve. The results show that using this process can save valve mass as well as the computational expense effectively.

关键词：结构优化球阀不锈钢化学性能有限元法结构安全最佳尺寸 FEM

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Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

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Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

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Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

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Mechanical properties of high-strength concrete subjected to high temperature by stressed test

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中国有色金属学会会刊：英文版 2009年第B9期19卷 128-133页

作者： gyu-Yong kim Young-Sun kim Tae-gyu LEE Division of Architecture Engineering Chun gnam National University

Recently, the effects of high temperature on compressive strength and elastic modulus of high strength concrete were experimentally investigated. The present study is aimed to study the effect of elevated temperatures ranging from 20 ℃ to 700 ℃ on the material mechanical properties of high-strength concrete of 40, 60 and 80 MPa grade. During the strength test, the specimens are subjected to a 25% of ultimate compressive strength at room temperature and sustained during heating, and when the target temperature is reached, the specimens are loaded to failure. The tests were conducted at various temperatures (20-700 ℃) for concretes made with W/B ratios of 46%, 32% and 25%, respectively. The results show that the relative values of compressive strength and elastic modulus decrease with increasing compressive strength grade of specimen.

关键词：高强混凝土高温作用力学性能测试抗压强度温度升高弹性模量强度试验

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NLRP3 inflammasome activation and NETosis positively regulate each other and exacerbate proinflammatory responses:implications of NETosis inhibition for acne skin inflammation treatment

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Cellular & Molecular Immunology 2024年第5期21卷 466-478页

作者： Hyo Jeong kim Yun Sang Lee Bok-Soon Lee Chang-Hak Han Sang gyu kim chul-Ho kim Department of Otolaryngology School of MedicineAjou UniversitySuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea

Inflammasomes are multiprotein complexes involved in the host immune response to pathogen ***,inflammasomes participate in many conditions,such as ***,it was shown that NETosis,a type of neutrophil cell death,is induced by bacterial infection and is involved in inflammatory diseases such as delayed wound healing in patients with ***,the relationship between inflammasomes and NETosis in the pathogenesis of inflammatory diseases has not been well *** this study,we determined whether NETosis is induced in ***-induced skin inflammation and whether activation of the nucleotide-binding domain,leucine-rich family,and pyrin domain-containing-3(NLRP3)inflammasome is one of the key factors involved in NETosis induction in a mouse model of acne skin *** found that NETosis was induced in ***-induced skin inflammation in mice and that inhibition of NETosis ameliorated ***-induced skin *** addition,our results demonstrated that inhibiting inflammasome activation could suppress NETosis induction in mouse *** results indicate that inflammasomes and NETosis can interact with each other to induce ***-induced skin inflammation and suggest that targeting NETosis could be a potential treatment for inflammasome-mediated diseases as well as NETosis-related diseases.

关键词： P.acnes NETosis NLRP3 inflammasome Skin inflammation

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Diagnosis of building energy consumption in the 2012 CBECS data using heterogeneous effect of energy variables:A recursive partitioning approach

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Building Simulation 2021年第6期14卷 1737-1755页

作者： Doowon Choi chul kim Department of Industrial and Systems Engineering College of EngineeringTexas A&M UniversityCollege StationTX 77843USA Indoor Air Quality Research Center Korea Institute of Civil Engineering and Building TechnologyGoyang-Si10223R.O.Korea

Numerous previous literature has attempted to apply machine learning techniques to analyze relationships between energy variables in energy ***,most machine learning methods are primarily used for prediction through complicated learning processes at the expense of *** methods have difficulties in evaluating the effect of energy variables on energy consumption and especially capturing their heterogeneous ***,to identify the energy consumption of the heterogeneous relationships in actual buildings,this study applies the MOdel-Based recursive partitioning(MOB)algorithm to the 2012 CBECS survey data,which would offer representative information about actual commercial building characteristics and energy *** resultant tree-structured subgroups,the MOB tree reveals the heterogeneous effect of energy variables and mutual influences on building energy *** results of this study would provide insights for architects and engineers to develop energy conservative design and retrofit in *** buildings.

关键词： CBECS,commercial building decision tree analysis MOdel-Based recursive partitioning(MOB)algorithm recursive partitioning subgroup identification

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