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Cellular & Molecular Immunology 2024年第5期21卷 466-478页

作者： Hyo Jeong kim Yun Sang Lee Bok-Soon Lee Chang-Hak Han Sang Gyu kim chul-ho kim Department of Otolaryngology School of MedicineAjou UniversitySuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea

Inflammasomes are multiprotein complexes involved in the host immune response to pathogen ***,inflammasomes participate in many conditions,such as ***,it was shown that NETosis,a type of neutrophil cell death,is induced by bacterial infection and is involved in inflammatory diseases such as delayed wound healing in patients with ***,the relationship between inflammasomes and NETosis in the pathogenesis of inflammatory diseases has not been well *** this study,we determined whether NETosis is induced in ***-induced skin inflammation and whether activation of the nucleotide-binding domain,leucine-rich family,and pyrin domain-containing-3(NLRP3)inflammasome is one of the key factors involved in NETosis induction in a mouse model of acne skin *** found that NETosis was induced in ***-induced skin inflammation in mice and that inhibition of NETosis ameliorated ***-induced skin *** addition,our results demonstrated that inhibiting inflammasome activation could suppress NETosis induction in mouse *** results indicate that inflammasomes and NETosis can interact with each other to induce ***-induced skin inflammation and suggest that targeting NETosis could be a potential treatment for inflammasome-mediated diseases as well as NETosis-related diseases.

关键词： P.acnes NETosis NLRP3 inflammasome Skin inflammation

GnRH impairs diabetic wound healing through enhanced NETosis

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Cellular & Molecular Immunology 2020年第8期17卷 856-864页

作者： Yun Sang Lee Sung Un Kang Myung-hoon Lee Haeng-Jun kim Chang-Hak Han ho-Ryun Won Young Uk Park chul-ho kim Department of Otolaryngology School of MedicineAjou UniversitySuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea Department of Otolaryngology School of MedicineChungnam National UniversityDaejeonRepublic of Korea Department of Orthopedic Surgery Ajou UniversitySuwonRepublic of Korea

It has been reported that neutrophil extracellular traps(NETs)impair wound healing in diabetes and that inhibiting NET generation(NETosis)improves wound healing in diabetic ***-releasing hormone(GnRH)agonists are associated with a greater risk of ***,the role of GnRH in diabetic wound healing is *** determined whether GnRH-promoted NETosis and induced more severe and delayed diabetic wound healing.A mouse model of diabetes was established using five injections with *** with blood glucose levels>250 mg/dL were then used in the *** agonist treatment induced delayed wound healing and increased NETosis at the skin wounds of diabetic *** contrast,GnRH antagonist treatment inhibited GnRH agonist-induced delayed wound *** expression of NETosis markers PAD4 and citrullinated histone H3 were increased in the GnRH-treated diabetic skin wounds in diabetic mice and *** vitro experiments also showed that neutrophils expressed a GnRH receptor and that GnRH agonist treatment increased NETosis markers and promoted phorbol myristate acetate(PMA)-induced NETosis in mouse and human ***,GnRH antagonist treatment suppressed the expression of NETosis markers and PMA-induced NETosis,which were increased by GnRH *** results indicated that GnRH-promoted NETosis and that increased NETosis induced delayed wound healing in diabetic skin ***,inhibition of GnRH might be a novel treatment of diabetic foot ulcers.

关键词： Neutrophils GnRH Diabetic wound healing NETosis

Numerical Study on the Effect of Rear-diffuser Angle on the Aerodynamic Performance for the Driving Stability of a Blunt Body

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Numerical Study on the Effect of Rear-diffuser Angle on the ...

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

2018中国汽车工程学会年会

作者： SUN Qingzhu chul-ho kim Department of Automotive Engineering Seoul National University of Science and Technology

Rear-diffuser Angle is an important factor influencing the aerodynamic performance of a blunt *** study is performed to evaluate the influence of the Rear-diffuse Angle on aerodynamic,and the relationship between aerodynamic and Rear-diffuser Angle is summarized in this *** flow around the blunt body is analyzed and discussed for detail understanding the effect of the Rear-diffuser Angle to *** vehicle is a typical blunt body,the flow near these types of vehicle markedly influence their aerodynamic *** the past several decades,many investigations of the flow around these vehicles have been carried out on the upper-rear *** et *** an experimental study of the effects of base slant angle of a hatchback shape on the time-averaged properties of the *** proposed a wake vortex system for ***,Nouzawa et *** the flow structure of the notchback type *** structured a flow pattern for notchbacks with no rear diffuser slant Their results indicated that the aerodynamic drag could be increased by generation of the trailing vortex at the trunk-deck and the so-called arch vortex behind the backlight These studies improved our understanding of the influence of the Rear-diffuser Angle on the aerodynamic performance.

关键词： aerodynamic fluid rear-diffuser angle PhoENICS CFD analysis

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑Young kim Yang Li Guozhen Shen Jong‑chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

Large-Scale Production of Microalgal Lipids Containing High Levels of Docosahexaenoic Acid upon Fermentation of <i>Aurantiochytrium</i>sp. KRS101

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Food and Nutrition Sciences 2013年第9期4卷 1-5页

作者： Won-Kyung hong Anna Yu Baek-Rock Oh Jang Min Park chul ho kim Jung-hoon Sohn Akihiko Kondo Jeong-Woo Seo Applied Microbiology Research Center Bio-Materials Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Jeongeup South Korea Department of Chemical Science and Engineering Graduate School of Engineering Kobe University Kobe Japan. Systems and Synthetic Biology Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon South Korea

In this study, large-scale production of microalgal lipid containing high levels of docosahexaenoic acid (DHA) by fermentation of Aurantiochytrium sp. KRS101 was performed. The microalgal strain yielded productivity of docosahex-aenoic acid (DHA) productivity of 1.08 and 1.6 g/L/d by fermentation at 300-L and 5000-L scale stirrer-type bioreactor. The productivity was significantly enhanced upto 5.6 g/L/d by fermentation at 6000-L scale airlift-type bioreactor, probably due to the reduced shearing force. The microalgal lipid could be efficiently recovered by safe extraction methods such as ethanol extraction, hot water extraction or supercritical fluid extraction, promising commercial potential of the microalgal DHA-rich lipid in the food and feed industry.

关键词： Aurantiochytrium sp. Heterotrophic Microalga Large-Scale Cultivation Lipid Docosahexaenoic Acid

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-ho Choi Keun-Young kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

奇异变形杆菌的L-氨基酸脱氢酶在大肠杆菌中的异源表达和鉴定

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生物工程学报 2008年第12期24卷 2129-2129页

作者： in-Oh Baek Jeong-Woo Seo Ohsuk Kwon Su-Il Seong Ik-Hwan kim chul ho kim 韩国生物科学和生物技术研究所(KRIBB)分子生物过程研究中心高丽大学生命科学与生物技术学院 Biotopia公司研发中心

本研究在大肠杆菌中表达了奇异变形杆菌的L-氨基酸脱氢酶,并对产物苯丙酮酸进行了鉴定。奇异变形杆菌的L-氨基酸脱氢酶在大肠杆菌中得到了很好的表达,具有酶活性,并且发现其活性与细胞膜相关。L-氨基酸脱氢酶与细胞膜的密切相关性,对酶... 详细信息

本研究在大肠杆菌中表达了奇异变形杆菌的L-氨基酸脱氢酶,并对产物苯丙酮酸进行了鉴定。奇异变形杆菌的L-氨基酸脱氢酶在大肠杆菌中得到了很好的表达,具有酶活性,并且发现其活性与细胞膜相关。L-氨基酸脱氢酶与细胞膜的密切相关性,对酶活来说可能是必不可少的。

关键词：奇异变形杆菌脱氢酶苯丙氨酸苯丙酮酸苯乳酸

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建筑群中涂料扩散的建模与仿真

土木建筑工程信息技术 2010年第1期2卷 53-58页

作者：倪冬香李超范秦寅金哲晃上海交通大学国家工程数字研究中心上海200030 日本科瑞多软件工程技术股份有限公司

建筑物在进行内部或外部装潢改造时,常常会将毒性很强的涂料直接喷到工件表面作最后处理。在此过程中,有可能出现操作工人或者附近其他人员,吸进这种有毒空气,造成喉痛、咳嗽等呼吸器官病变等事故。为了调查造成事故的原因,本文利用Str... 详细信息

建筑物在进行内部或外部装潢改造时,常常会将毒性很强的涂料直接喷到工件表面作最后处理。在此过程中,有可能出现操作工人或者附近其他人员,吸进这种有毒空气,造成喉痛、咳嗽等呼吸器官病变等事故。为了调查造成事故的原因,本文利用Stream软件对涂料扩散作了仿真分析,再现事故现场,分析涂料的分布规律。

关键词：污染物扩散粒子追踪建筑物 CFD

Exergetical Analysis of Organic Flash Cycle with Two-Phase Expander for Recovery of Finite Thermal Reservoirs

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Journal of Thermal Science 2014年第6期23卷 572-579页

作者： chul ho Han Kyoung hoon kim Department of Intelligent Mechanical Engineering Kumoh National Institute of TechnologyDaehakro 61GumiGyeongbuk 730-701Korea Department of Mechanical Engineering Kumoh National Institute of TechnologyDaehakro 61GumiGyeongbuk 730-701Korea

In this work exergetical performance analysis is carried out based on the second law of thermodynamics for organic flash cycle(OFC) using a two-phase expander instead of throttle expansion in order to recover efficiently finite thermal *** exergy destructions(anergies) at various components of the system are theoretically investigated as well as the exergy *** show that the anergy of heat exchanger or two-phase expander decreases while the anergy of throttle valve increases with increasing flash temperature,and the exergy efficiency has an optimum value with respect to the flash *** the optimal conditions with respect to the flash temperature,exergy efficiency increases with the heating temperature and the component having the largest exergy destruction varies with the flash temperature or heating temperature.

关键词： organic flash cycle(OFC) low grade heat source exergy anecgy

Entransy and Exergy Analyses for Optimizations of Heat-Work Conversion with Carnot Cycle

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Journal of Thermal Science 2016年第3期25卷 242-249页

作者： chul ho Han Kyoung hoon kim Department of Mechanical System Engineering Kumoh National Institute of Technology Department of Mechanical Engineering Kumoh National Institute of Technology

The concept of entransy has been newly proposed in terms of the analogy between heat and electrical conduction and could bc useful in analyzing and optimizing the heat-work conversion systems. This work presents comparative analyses of entransy and exergy for optimizations of heat-work conversion. The work production and heat transfer processes in Carnot cycle system are investigated with the formulations of exergy destruction, entransy loss, work entransy, entransy dissipation, and cfficiencics for both cases of dumping and non-dumping of used source fluid. The effects of source and condensation temperatures on the system performance arc systematically investigated for optimal condition of producing maximum work or work cntransy.

关键词： entransy exergy heat-work conversion Carnot cycle efficiency