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Experimental Trypanosoma brucei infection at immediate post partum period:effects on dam and the offspring

Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 531-534页

作者： Izuchukwu S Ochiogu chukwuka n uchendu John I Ihedioha Department of Veterinary Obstetrics and Reproductive Diseases University of NigeriaNsukkaEnugu StateNigeria Department of Veterinary Physiology and Pharmacology University of NigeriaNsukkaEnugu StateNigeria Department of Veterinary Pathology and Microbiology University of NigeriaNsukkaEnugu StateNigeria

Objective:To investigate the effects of immediate post-partum infection with Trypanosoma brucei（***） on dam and ***:Sixty female Albino rats（Rattus norvegicus） weighing between 130-170 g were used as animal *** animals were divided as follows: 25 infected between 1-5 days post partum;10 infected unbred as positive controls;and 25 uninfected as negative *** following parameters were evaluated:packed cell volume （PCV）,level of parasitaemia,survival time,litter size and litter weight at birth and on days 7, 14 and 21 post delivery,using conventional *** trans-mammary transmission of infection to litter through milk was also ***:The results showed a comparatively （Pn PCV value for the uninfected negative control on the 8 day post infection compared with the infected groups which corresponded with the increasing level of parasitaemia in the two infected *** litter size and litter weights were higher（Pn the uninfected controls on the 21st *** time in the infected groups were *** evidence of trans-mammary transfer of infection was ***:*** infection during immediate post partum period is detrimental to the dam and impairs growth of the offspring.

关键词： Trypanosoma brucei Post-partum Infection Litter Parasitaemia.

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Buruli ulcer in nigeria:results of a pilot case study in three rural districts

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Infectious Diseases of Poverty 2016年第1期5卷 328-336页

作者： Kingsley n.Ukwaja Anthony O.Meka Alphonsus chukwuka Kingsley B.Asiedu Kristina L.Huber Miriam Eddyani Joseph n.Chukwu Moses C.Anyim Charles C.nwafor Daniel C.Oshi nelson O.Madichie ngozi Ekeke Martin njoku Kentigern ntana Department of Medicine Federal Teaching HospitalFMC RdAbakalikiEbonyi StateNigeria Medical Department German Leprosy and TB Relief AssociationEnuguEnugu StateNigeria St Benedict’s Tuberculosis and Leprosy Rehabilitation Hospital OgojaCross River StateNigeria Global Buruli Ulcer Initiative Department of Control of Neglected Tropical DiseasesWorld Health OrganizationGenevaSwitzerland Department of Infectious Diseases and Tropical Medicine University HospitalLudwig-Maximilians UniversityMunichGermany Mycobacteriology Unit Department of MicrobiologyInstitute of Tropical MedicineAntwerpBelgium

Background:Buruli ulcer(BU),also known as Mycobacterium ulcerans disease,is the third most common mycobacterial disease *** BU disease has been diagnosed among nigerians in neighbouring West African countries,data on the burden of the disease in nigeria itself are *** study aimed to assess the magnitude and epidemiology of BU in the South South region of ***:We conducted a cross-sectional survey in the Ogoja territory(comprising 31 communities).We undertook sensitisation programmes centred on BU in 10 of the *** were asked to identify community members with long-standing ulcers,who were then invited for *** also contacted traditional healers to refer their clients who had non-healing *** suspected cases had a full clinical evaluation and laboratory *** cases were given treatment in a referral hospital in the ***:We diagnosed 41 clinical BU cases;36(87.8%)of which were confirmed by quantitative polymerase chain reaction(qPCR).These 36 PCR-confirmed cases were diagnosed in a total population of 192,169 ***,the estimated crude prevalence of BU was 18.7 per 100,000 population,varying from 6.0 to 41.4 per 100,000 in the districts *** majority(66.7%)of the cases were *** 92%of the BU lesions were located on the patients’*** differences were observed between the sexes in terms of the location of the *** age of the patients ranged from four to 60 years,with a median age of 17 *** 35(100%)patients who consented to treatment completed chemotherapy as *** the treated cases,29(82.9%)needed and received *** cases healed,but 29(82.9%)had some limitations in *** with limitations in movement occurred in 18/19(94.7%)and 8/10(80.0%)of patients with lesions>15 cm(Category III)and 6–15 cm in diameter(Category II),*** median duration of treatment was 130(87–164)days for children and

关键词： Buruli ulcer Mycobacterium ulcerans Epidemiology Case finding Endemicity Ogoja Cross River State nigeria

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Modulations in Anti-Oxidant Activities of Selected Gastro-Intestinal Tissues in Alloxan-Induced, Silymarin Treated Diabetic Wistar Rats

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Open Journal of Gastroenterology 2019年第5期9卷 73-90页

作者： Johnson Uyovwiesevwa Ataihire Eze Kingsley nwangwa John chukwuka Igweh Department of Human Physiology Faculty of Basic Medical Sciences College of Health Sciences Delta State University Abraka Nigeria

Diabetes mellitus (DM) is reportedly the commonest metabolic disorder with multi organ involvement. By inducing DM (with Alloxan) in Wistar rats, current study investigated the changes in antioxidant activities of selected gastrointestinal (GI) tissues [stomach, duodenum, pancreas and liver], upon treatment with Silymarin and/or Vitamin C. One hundred and twenty five (125) adult male wistar rats of between 130 to 180 grams were procured for the study. Five units of one control and four experimental units were designated with twenty five (25) rats per group (n = 25);Unit 1: Control rats, Unit 2 were DM induced, Silymarin untreated rats, and Units 3, 4 and 5 were DM induced, vitamin C, Silymarin and Vitamin C + Silymarin treated respectively. Following four (4) weeks of administration of test substance(s), rats were euthanized and blood samples obtained for biochemical and antioxidant assay on aforementioned GI tissues. One way analysis of variance (AnOVA) and Students t-test at p p n of extract treated unit to control. Study also observed a significant change in pancreatic, liver, and duodenal anti-oxidant marker levels with Vitamin C, Silymarin and Vitamin C + Silymarin co-administrations to diabetic rats. It can therefore be said, that DM caused a destructive alteration pancreatic histo-architecture with improved functional capabilities in wistar rats at administration of Silymarin and vitamin C. Thus, Silymarin posed antioxidant potentials, with ameliorated pancreatic dysfunctions.

关键词： Silymarin Antioxidant Diabetes Mellitus

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