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Effectiveness of mindfulness-based interventions on the well-being of healthcare workers:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 335-344页

作者： Natasha Yixuan Ong Finn Jing Jie Teo Jane zi Ying Ee Chun En Yau Julian Thumboo Hiang Khoon Tan Qin Xiang ng NUS Yong Loo Lin School of Medicine National University of SingaporeSingapore Health Services Research Unit Singapore General HospitalSingapore SingHealth Duke-NUS Medicine Academic Clinical Programme Duke-NUS Medical SchoolSingapore Singhealth Duke-NUS Global Health Institute Singapore Duke Global Health Institute Duke UniversityDurhamNorth CarolinaUSA Division of Surgery and Surgical Oncology Singapore General HospitalSingapore Saw Swee Hock School of Public Health National University of Singapore and National University Health SystemSingapore

Background Growing evidence attests to the efficacy of mindfulness-based interventions(MBIs),but their effectiveness for healthcare workers remains *** To evaluate the evidence for MBIs in improving healthcare workers’psychological *** A systematic literature search was conducted on Medline,Embase,Cumulative Index for Nursing and Allied Health Literature,PsycINFO and Cochrane Central Register of Controlled Trials up to 31 August 2022 using the keywords‘healthcare worker’,‘doctor’,‘nurse’,‘allied health’,‘mindfulness’,‘wellness’,‘workshop’and‘program’.Randomised controlled trials with a defined MBI focusing on healthcare workers and quantitative outcome measures related to subjective or psychological well-being were eligible for inclusion.R V.4.0.3 was used for data analysis,with the standardised mean difference as the primary outcome,employing DerSimonian and Laird’s random effects *** of Recommendations,Assessment,Development and Evaluation framework was used to evaluate the quality of ***’s Risk of Bias 2 tool was used to assess the risk of bias in the included *** A total of 27 studies with 2506 participants were included,mostly from the USA,involving various healthcare *** such as stress reduction programmes,apps,meditation and training showed small to large effects on anxiety,burnout,stress,depression,psychological distress and job strain outcomes of the *** effects were also seen in self-compassion,empathy,mindfulness and ***,long-term outcomes(1 month or longer postintervention)varied,and the effects were not consistently *** MBIs offer short-term benefits in reducing stress-related symptoms in healthcare *** review also highlights limitations such as intervention heterogeneity,reduced power in specific subgroup analyses and variable study quality.

关键词： nurse sustained workers

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Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 444-453页

作者： Cheng-Cheng Yang Xiu-Xia Yang Xiao-Jing Zhao Heng Wang.zi-Han Guo Kai Jin Yang Liu Bin-Hui Li Department of Ophthalmology the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Ophthalmology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina

●AIM:To evaluate the role of semaphorin 7A(Sema7A)and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells(HCEs).●METHODS:Barrier models of HCEs were treated with recombinant human Sema7A at concentrations of 0,125,250,or 500 ng/mL for 24,48,or 72h in *** electrical resistance(TEER)as well as Dextran-fluorescein isothiocyanate(FITC)permeability assays were conducted to assess barrier *** quantify tight junctions(TJs)such as occludin and zonula occludens-1(ZO-1)at the mRNA level,reverse transcriptionpolymerase chain reaction(RT-PCR)analysis was *** was used to examine the activity of the nuclear factor-kappa B(NF-κB)signaling pathway and the production of TJs *** analyses were employed to localize the ***-linked immunosorbent assay(ELISA)and RT-PCR were utilized to observe changes in interleukin(IL)-1β*** investigate the role of NF-κB signaling activation and IL^(-1)βin Sema7A’s anti-barrier mechanism,we employed 0.1μmol/L IκB kinase 2(IKK2)inhibitor IV or 500 ng/mL IL^(-1)receptor(IL-1R)antagonist.●RESULTS:Treatment with Sema7A resulted in decreased TEER and increased permeability of Dextran-FITC in HCEs through down-regulating mRNA and protein levels of TJs in a time-and dose-dependent manner,as well as altering the localization of ***,Sema7A stimulated the activation of inhibitor of kappa B alpha(IκBα)and expression of IL-1β.The anti-barrier function of Sema7A was significantly suppressed by treatment with IKK2 inhibitor IV or IL-1R antagonists.●CONCLUSION:Sema7A disrupts barrier function through its influence on NF-κB-mediated expression of TJ proteins,as well as the expression of IL-1β.These findings suggest that Sema7A could be a potential therapeutic target for the diseases in corneal epithelium.

关键词： human corneal epithelial barrier function transepithelial electrical resistance zonula occludens-1 occludin nuclear factor-kappa B

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Spinal cord organoids add an extra dimension to traditional motor neuron cultures

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Neural Regeneration Research 2019年第9期14卷 1515-1516页

作者： Winanto zi-Jian Khong Jin-Hui Hor Shi-Yan ng Institute of Molecular and Cell Biology A*STAR Research EntitiesSingaporeSingapore Singapore Singapore(Winanto)School of Biological SciencesNanyang Technological UniversitySingaporeSingapore Department of Biological Sciences National University of SingaporeSingaporeSingapore Yong Loo Lin School of Medicine(Physiology) National University of SingaporeNational Neuroscience InstituteSingaporeSingaporeThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Since Lancaster et al.(2013)first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders,it became evident that three-dimensional(3D)neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in *** use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones,making it a great tool to study neurodevelopment and *** organoids are 3D cell culture systems formed by proliferating,differentiating,migrating and self-organizing pools of neural *** mimic brain structures in their cell type composition,cytoarchitecture,and to some extent maturity and functionality(Lancaster et al.,2013).Because of these unique.

关键词： Since Lancaster neurodevelopment and neurodegeneration these unique

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Comparison of Cognitive Registration Transrectal Ultrasound-Guided Targeted Biopsy of Prostate to Systematic 12-Core Biopsy: A Retrospective, Multicentre Study

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Open Journal of Urology 2024年第7期14卷 381-390页

作者： Kevin Chang Yue Wei Lee Say Bob Devindran Manoharan Liong Men Long Teoh Sze Yong Teo Rui Ling Chua zi Wei Department of Urology Hospital Pulau Pinang George Town Malaysia Department of Urology Georgetown Specialist Hospital George Town Malaysia Department of Radiology Hospital Pulau Pinang George Town Malaysia Department of Radiology Georgetown Specialist Hospital George Town Malaysia

Introduction: Prostate cancer (PCa) is the third most prevalent cancer among Malaysian males, often diagnosed at advanced stages, leading to suboptimal outcomes. While transrectal ultrasound-guided systematic biopsy (TRUS-SB) is the primary diagnostic method, prebiopsy multiparametric magnetic resonance imaging (mpMRI) is gaining popularity in identifying suspicious lesions. This study addresses the lack of comprehensive investigations into the efficacy of cognitive registration TRUS targeted biopsy (COG-TB) compared to conventional TRUS-SB, considering the resource limitations of the Malaysian healthcare system. Materials and Methods: A retrospective cohort study was conducted in two Malaysian healthcare facilities. 116 adult patients with a prostate-specific antigen (PSA) level of more than 4 ng/mL who underwent both COG-TB and TRUS-SB between October 2020 and March 2022 were included. Primary outcomes were cancer detection rate and histopathological outcomes, including Gleason score. Results: COG-TB showed a higher overall cancer detection rate (50%) compared to TRUS-SB (44%). Clinically significant cancer detection rates were similar between COG-TB and TRUS-SB (37.1%). Further analysis revealed that both COG-TB and TRUS-SB detected clinically significant cancer in 30.2% of patients, did not detect it in 56.0%, and had conflicting findings in 16 patients (p Conclusion: COG-TB and TRUS-SB have comparable detection rates for clinically significant prostate cancer, with COG-TB showing a higher tendency to detect insignificant prostate cancer. Further studies comparing these methods are warranted.

关键词： Prostate Cancer Multiparametric MRI Targeted Biopsy Cognitive Fusion Transrectal Ultrasound-Guided Biopsy

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Chylous ascites in colorectal surgery:A systematic review

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World Journal of Gastrointestinal Surgery 2021年第6期13卷 585-596页

作者： zi Qin ng Margaret Han Han Nien Beh Simon Keelan Department of General Surgery St John of God Midland HospitalMidland 6056Western AustraliaAustralia Department of General Surgery Joondalup Health CampusJoondalup 6027Western AustraliaAustralia

BACKGROUND Chylous ascites is a rare complication in colorectal surgery with limited *** To systematically review all available evidence to describe the incidence,clinical presentation,risk factors and management *** The systematic review was performed through PubMed,MEDLINE,EMBASE and Cochrane and cross-checked up to November *** data collated included:Demographics,indications(benign vs malignant),site of disease,surgical approach,extent of lymphadenectomy,day to and method of diagnosis of chylous ascites and management *** A total of 28 studies were included in the final analysis(426 cases).Patient age ranged from 31 to 89 *** except one case were performed for *** the 426 cases,195 were right-colonic,121 left-colonic,103 pelvic surgeries and 7 *** majority were diagnosed during the same inpatient stay by recognition of typical drain appearance and increased *** cases were diagnosed during outpatient visits with increased abdominal distention and subsequently underwent *** cases were managed successfully non-operatively(fasting with prolonged drainage,total parenteral nutrition,somatostatin analogues or a combination of these).Only three cases required surgical intervention after failing conservative management and subsequently resolved *** factors identified include:Right-colonic surgery/tumour location,extent of lymphadenectomy and number of lymph nodes *** Chylous ascites after colorectal surgery is a relatively rare *** the majority of cases resolved without surgical intervention,preventative measures should be undertaken such as meticulous dissection and clipping of lymphatics during lymphadenectomy to prevent morbidity.

关键词： Chylous Chyle Ascites Leak Colon Rectum Lymphadenectomy

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气相色谱法检测红树林湿地土壤中氯/溴代多环芳烃

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中国环境科学 2024年第1期44卷 261-268页

作者：左梓岑张丽倪洁何真杨桂朋中国海洋大学化学化工学院山东青岛266100 自然资源部热带海洋生态系统与生物资源重点实验室广西北海536000

建立了气相色谱-电子捕获检测器(GC-ECD)法检测红树林湿地土壤中18种氯/溴代多环芳烃(Cl/Br-PAHs)同类物,探究了土壤样品的前处理方法,并验证了方法的有效性.该方法的检出限和加标回收率分别为0.21~3.75ng/g dw和64.9%~106.4%,相对标准... 详细信息

建立了气相色谱-电子捕获检测器(GC-ECD)法检测红树林湿地土壤中18种氯/溴代多环芳烃(Cl/Br-PAHs)同类物,探究了土壤样品的前处理方法,并验证了方法的有效性.该方法的检出限和加标回收率分别为0.21~3.75ng/g dw和64.9%~106.4%,相对标准偏差为0.42%~14.13%.与GC-MS方法相比,GC-ECD方法对于多数Cl/Br-PAHs的准确度和灵敏度相当,且该方法稳定性更好,测定成本更低,可以满足湿地土壤中Cl/Br-PAHs的定性定量分析.采用所建立的方法对广西红树林湿地土壤样品进行了检测,结果显示,湿地土壤样品中Cl/Br-PAHs的总含量范围为163.24~244.45ng/g dw.

关键词：氯/溴代多环芳烃(Cl/Br-PAHs) 气相色谱-电子捕获检测器法(GC-ECD) 土壤红树林湿地新污染物

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Predictors for success of non-operative management of adhesive small bowel obstruction

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1116-1124页

作者： zi Qin ng Vivien Hsu William Wei Han Tee Jih Huei Tan Ruwan Wijesuriya Department of General Surgery St John of God Midland HospitalMidland 6056Western AustraliaAustralia Department of Radiology St John of God Midland HospitalMidland 6056Western AustraliaAustralia Department of General Surgery Hospital Sultanah AminahJohor Bahru 80000JohorMalaysia

BACKGROUND Majority of adhesive small bowel obstruction(SBO)cases can be managed ***,a proportion of patients failed non-operative *** To evaluate the predictors of successful non-operative management in adhesive *** A retrospective study was performed for all consecutive cases of adhesive SBO from November 2015 to May *** collated included basic demographics,clinical presentation,biochemistry and imaging results and management *** imaging studies were independently analyzed by a radiologist who was blinded to the clinical *** patients were divided into group A operative(including those that failed initial non-operative management)and group B non-operative for *** Of 252 patients were included in the final analysis;group A(n=90)(35.7%)and group B(n=162)(64.3%).There were no differences in the clinical features between both *** tests of inflammatory markers and lactate levels were similar in both *** the imaging findings,the presence of a definitive transition point[odds ratio(OR)=2.67,95%confidence interval(CI):0.98-7.32,P=0.048],presence of free fluid(OR=2.11,95%CI:1.15-3.89,P=0.015)and absence of small bowel faecal signs(OR=1.70,95%CI:1.01-2.88,P=0.047)were predictive of the need of surgical *** patients that received water soluble contrast medium,the evidence of contrast in colon was 3.83 times predictive of successful non-operative management(95%CI:1.79-8.21,P=0.001).CONCLUSION The computed tomography findings can assist clinicians in deciding early surgical intervention in adhesive SBO cases that are unlikely to be successful with non-operative management to prevent associated morbidity and mortality.

关键词： Small bowel obstruction Adhesive Conservative Non-operative

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成人斯蒂尔病与其他不明原因发热疾病的鉴别诊断指标

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解放军医学杂志 2024年第3期49卷 308-315页

作者：汤影子刘慧敏郭建琼夏杰陆军军医大学第一附属医院感染科重庆400038

目的探讨成人斯蒂尔病(AOSD)与其他不明原因发热(FUO)疾病的鉴别诊断指标。方法收集2010年1月-2021年5月在陆军军医大学第一附属医院住院的177例AOSD患者及163例待鉴别FUO患者的临床资料及实验室指标,随机分为训练组及验证组。通过单因... 详细信息

目的探讨成人斯蒂尔病(AOSD)与其他不明原因发热(FUO)疾病的鉴别诊断指标。方法收集2010年1月-2021年5月在陆军军医大学第一附属医院住院的177例AOSD患者及163例待鉴别FUO患者的临床资料及实验室指标,随机分为训练组及验证组。通过单因素分析提取有统计学意义的变量进行受试者工作特征(ROC)曲线分析并获取变量的最佳截断值,进一步通过多因素logistic回归分析筛选出具有鉴别诊断意义的指标,并构建列线图模型;采用ROC曲线、校准曲线及决策曲线分析列线图的准确性及稳定性。结果单因素分析结果显示,4项临床特征(关节痛、皮疹、咽痛、肌痛)及14项实验室参数[白细胞计数(WBC)、单核细胞百分比、中性粒细胞百分比、淋巴细胞百分比、血小板计数、C反应蛋白、白细胞介素-6(IL-6)、铁蛋白、球蛋白、免疫球蛋白A、免疫球蛋白G(IgG)、肌酸激酶、肌酐、补体C3]差异均有统计学意义(Png/L、铁蛋白≥507.37ng/ml、球蛋白≤36.58g/L、IgG≤13.59g/L、补体C3≥1.27g/L均与AOSD相关(P<0.05)。训练组及验证组的曲线下面积(AUC)分别为0.917[95%可信区间(95%CI)0.883~0.951]、0.869(95%CI0.802~0.936);校准曲线表现出良好的一致性;决策曲线分析表明,训练组及验证组分别在5%~85%、10%~85%广大风险范围内显示出较大的正向收益率。结论该研究建立起一个相对准确的AOSD鉴别诊断模型,关节痛、WBC、IL-6、铁蛋白、球蛋白、IgG及补体C3多指标联合应用有助于鉴别AOSD与其他FUO病因。

关键词：成人斯蒂尔病不明原因发热鉴别诊断

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丹江流域山区地表水-地下水水化学特征及其影响因素

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环境科学 2024年第4期45卷 2107-2117页

作者：张子燕伏永朋王宁涛谭建民刘亚磊中国地质调查局武汉地质调查中心(中南地质科技创新中心) 武汉430205 中国地质大学地质调查研究院武汉430074

丹江流域是南水北调中线工程重要水源涵养区,深入研究丹江流域水化学特征及其影响因素,对区域水资源保护及合理利用具有重要意义.通过对丹江流域水样采集与分析,综合运用描述性统计、Piper三线图、Gibbs图、离子比例系数法及氢氧同位素... 详细信息

丹江流域是南水北调中线工程重要水源涵养区,深入研究丹江流域水化学特征及其影响因素,对区域水资源保护及合理利用具有重要意义.通过对丹江流域水样采集与分析,综合运用描述性统计、Piper三线图、Gibbs图、离子比例系数法及氢氧同位素的方法,分析丹江流域水化学特征及其影响因素.结果表明,丹江流域水体整体呈弱碱性,主要水化学类型为HCO_(3)-Ca型,中游离子质量浓度及水化学类型变化频繁.流域水体均受大气降水补给,地表水受蒸发作用影响明显,水化学组分受岩石风化溶解、离子交换和人类活动共同影响. Ca^(2+)和Mg^(2+)源于方解石、白云石及石膏等碳酸盐和硫酸盐矿物溶解,农业活动是水中硝酸盐的主要来源.地表水与地下水频繁转化和支流汇入影响是丹江干流空间分布特征差异化的主要原因.

关键词：丹江流域水化学特征同位素岩石风化离子交换

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G-四链体二聚体/核酸外切酶Ⅰ辅助信号放大纸芯片检测黄曲霉毒素B1

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分析化学 2024年第8期52卷 1094-1107页

作者：贺璇齐骥余子辉陈燕付秀丽烟台大学化学化工学院中国科学院烟台海岸带研究所海岸带环境工程技术研究与发展中心中国科学院海岸带环境过程与生态修复重点实验室烟台大学物理与电子信息学院山东农业工程学院资源与环境工程学院

本研究利用DNA四面体（TDN）精准调控识别配体的取向和密度，结合核酸外切酶Ⅰ（ExoⅠ）对单链DNA的特异性切割活性，借助G-四链体（G4）二聚体对硫黄素T(ThT)的荧光增强作用，构建了旋转型纸芯片，用于快速高灵敏检测黄曲霉毒素B1(AFB1... 详细信息

本研究利用DNA四面体（TDN）精准调控识别配体的取向和密度，结合核酸外切酶Ⅰ（ExoⅠ）对单链DNA的特异性切割活性，借助G-四链体（G4）二聚体对硫黄素T(ThT)的荧光增强作用，构建了旋转型纸芯片，用于快速高灵敏检测黄曲霉毒素B1(AFB1)。以含有G4二聚体与AFB1识别序列的单链DNA(G4二聚体探针)为识别探针，其中AFB1识别序列与TDN的延伸手臂链通过碱基互补配对形式结合。当AFB1不存在时，G4二聚体探针上的G4二聚体与ThT结合，体系呈现出较强的荧光信号；当AFB1存在时，AFB1与G4二聚体探针结合，使其脱离TDN。此时，ExoⅠ切割脱离的G4二聚体探针，释放出AFB1, AFB1能够再次与TDN上的G4二聚体探针结合，如此循环，使得TDN上的G4二聚体探针减少，导致体系剩余的G4二聚体减少，荧光强度降低。此旋转型纸芯片在AFB1浓度为0.0001～500 ng/mL范围内具有良好的线性关系，检出限为0.1 pg/mL。将本方法用于花生和红酒样品中AFB1的检测，回收率为85.2%～118.2%。本研究开发的的TDN/G4二聚体/ExoⅠ检测策略显著增强了体系的特异性和灵敏度。

关键词：旋转型纸芯片核酸外切酶Ⅰ G-四链体二聚体 DNA四面体黄曲霉毒素B1

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