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磷霉素及其联合用药的药代动力学/药效学研究进展

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中国感染与化疗杂志 2024年第1期24卷 101-107页

作者：张楚晗杨帆刘笑芬张菁复旦大学附属华山医院抗生素研究所上海200040

磷霉素作为“老”药,具有广谱抗菌活性和良好的药代动力学(pharmacokinetics,PK)特征,在临床抗感染治疗中日益受到重视[1]。近年来随着对磷霉素研究的深入,发表了大量相关的研究论文,本综述总结了目前磷霉素PK/药效学(pharmacodynamics,... 详细信息

磷霉素作为“老”药,具有广谱抗菌活性和良好的药代动力学(pharmacokinetics,PK)特征,在临床抗感染治疗中日益受到重视[1]。近年来随着对磷霉素研究的深入,发表了大量相关的研究论文,本综述总结了目前磷霉素PK/药效学(pharmacodynamics,PD)数据,重点关注其联合用药的PK/PD研究新进展,为临床合理应用提供参考。1体外PD磷霉素通过与尿苷二磷酸-N-乙酰氨基葡萄糖烯醇式丙酮酸转移酶不可逆地结合,阻止肽聚糖前体N-乙酰胞壁酸合成,从而破坏细胞壁结构导致细菌裂解死亡。

关键词：磷霉素联合用药药代动力学药效学

珍珠蚌肉二肽基肽酶-IV抑制肽的制备与分离

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食品科学 2024年第17期45卷 63-70页

作者：张楚涵陈寅格马婷翁凌张凌晶张根芳曹敏杰集美大学体育学院福建厦门361021 集美大学海洋食品与生物工程学院福建厦门361021 金华职业技术大学农学院浙江金华321000

目的:以珍珠蚌肉为原料制备对二肽基肽酶(dipeptidyl peptidase,DPP)-IV具有抑制作用的生物活性肽。方法:利用两步酶解法并优化珍珠蚌肉酶解条件,筛选体外DPP-IV抑制活性较高组分进行超滤膜浓缩,Superdex^(TM) peptide 10/300 GL凝胶柱... 详细信息

目的:以珍珠蚌肉为原料制备对二肽基肽酶(dipeptidyl peptidase,DPP)-IV具有抑制作用的生物活性肽。方法:利用两步酶解法并优化珍珠蚌肉酶解条件,筛选体外DPP-IV抑制活性较高组分进行超滤膜浓缩,Superdex^(TM) peptide 10/300 GL凝胶柱层析与反相高效液相色谱(reverse phase-high performance liquid chromatography,RP-HPLC)技术分离纯化出酶解液中的DPP-IV抑制肽,最终通过液相色谱-串联质谱鉴定其氨基酸序列。结果:中性蛋白酶与碱性蛋白酶对珍珠蚌肉均有良好降解效果,经3 kDa超滤膜浓缩后,酶解产物的DPP-IV抑制率可达67.4%。通过凝胶过滤柱和RP-HPLC进一步分离纯化出6个活性较高的肽段,序列分别为FNAPAM、FIPNY、IYNPPTPF、LAMPYP、FFVVMP和LAGMP。进一步,以分子对接的方式分析6个肽段与DPP-IV的相互作用关系。结论:本研究利用珍珠蚌肉制备DPP-IV抑制肽,可为以水产加工副产物为原料制备功能性食品提供理论参考。

关键词：珍珠蚌酶解分离纯化二肽基肽酶-IV 抑制肽

miR-125a靶向转录无调性碱性螺旋环螺旋转录因子8对肺腺癌恶性进展的影响

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中国医科大学学报 2024年第2期53卷 114-120页

作者：姜昌瑞张楚函刘洋李玥中国医科大学附属第一医院胸外科沈阳110001 中国医科大学附属第一医院输血科沈阳110001

目的探讨miR-125a通过靶向转录无调性碱性螺旋环螺旋转录因子8(ATOH8)对肺腺癌恶性进展的影响。方法通过在线数据库UALCAN分析ATOH8在肺腺癌中的表达水平及其与患者生存率的相关性,以及miR-125a在肺腺癌中的表达水平及其与肺癌进展的关... 详细信息

目的探讨miR-125a通过靶向转录无调性碱性螺旋环螺旋转录因子8(ATOH8)对肺腺癌恶性进展的影响。方法通过在线数据库UALCAN分析ATOH8在肺腺癌中的表达水平及其与患者生存率的相关性,以及miR-125a在肺腺癌中的表达水平及其与肺癌进展的关系;提取肺腺癌及癌旁正常组织总RNA,实时PCR分析ATOH8表达水平差异;将ATOH8过表达载体转染至肺腺癌细胞中,CCK-8法检测过表达ATOH8对肺腺癌细胞存活能力的影响;预测与ATOH8的3’非翻译区(UTR)结合的微RNA(miRNA),将miR-125a模拟物和抑制物转染至肺腺癌细胞中,实时PCR和Western blotting检测ATOH8的表达水平变化。结果数据库及实时PCR验证结果显示,ATOH8在肺腺癌组织中显著下调(P<0.01);过表达ATOH8能够显著降低肺腺癌细胞存活能力(P<0.05);高表达ATOH8组患者5年生存率显著升高(P<0.05);miR-125a能够与ATOH8的3’UTR结合,显著抑制其表达(P<0.05)。miR-125a在有吸烟史、中晚期和淋巴转移的肺腺癌患者中显著上调(P<0.05)。结论ATOH8是肺腺癌潜在的抑癌基因,能够抑制肺腺癌细胞存活的能力,影响患者的5年生存率。miR-125a表达水平与吸烟史、肿瘤分期和淋巴转移密切相关。miR-125a能够靶向抑制肺腺癌患者ATOH8表达,是ATOH8在肺腺癌中异常表达的潜在因素。

关键词：无调性碱性螺旋环螺旋转录因子8 肺腺癌 miR-125a 细胞存活

Velocity structure building and ground motion simulation of the 2014 Ludian Ms 6.5 Earthquake

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 719-727页

作者： zhang Lei Xu Yanjie Wang Jinting zhang chuhan State Key Laboratory of Hydroscience and Engineering Tsinghua University

This study constructs a 3 D velocity structure model of the Ludian region in the Yunnan province, southwestern China, and simulates ground motion propagation of the 2014 Ludian Ms 6.5 earthquake. It aims to construct the local velocity structure of the Ludian region in three dimensions and with high precision. The simulation, using the spectral element method, is validated by field data from the Ludian earthquake records. Thus, it demonstrates that the adopted key parameters, such as the seismic source mechanism, propagation medium and geographical features of the engineering site, are appropriated for the simulation. Meanwhile, the simulation generates the ground motion distribution of the study region with an earthquakeinduced landslide in Ludian earthquake.

关键词： wave propagation velocity structure data fusion Ludian earthquake landslide

Accuracy of the half-power bandwidth method with a third-order correction for estimating damping in multi-DOF systems

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Earthquake Engineering and Engineering Vibration 2013年第1期12卷 33-38页

作者： Wang Jinting Lü Dandan Jin Feng zhang chuhan State Key Laboratory of Hydroscience and Engineering Tsinghua University

A third-order correction was recently suggested to improve the accuracy of the half-power bandwidth method in estimating the damping of single DOF *** paper analyzes the accuracy of the half-power bandwidth method with the third-order correction in damping estimation for multi-DOF linear *** ratios in a two-DOF linear system are estimated using its displacement and acceleration frequency response curves,respectively.A wide range of important parameters that characterize the shape of these response curves are taken into *** show that the third-order correction may greatly improve the accuracy of the half-power bandwidth method in estimating damping in a two-DOF *** spite of this,the half-power bandwidth method may significantly overestimate the damping ratios of two-DOF systems in some cases.

关键词： half-power bandwidth method third-order correction damping ratio estimation error two-DOF system

Seismic safety of arch dams with aging effects

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Science China(Technological Sciences) 2011年第3期54卷 522-530页

作者： WANG JinTing JIN Feng zhang chuhan State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China

Arch dams suffer time-varying external loadings and harsh environment that harm their physical properties. With the aging of such dams, damage accumulates and concrete degradation inevitably appears. In this paper, a model is proposed for simulating concrete degradation with aging because of chemo-mechanical damage. The seismic response of an arch dam with aging effects is analyzed using the proposed model. The results show that the damage caused by the aging of arch dams may result in an increase in tensile cantilever stresses during earthquakes. Meanwhile, the dynamic displacement and joint opening also clearly increase in comparison with those without damage. Thus, the seismic safety of arch dams is reduced by aging effects.

关键词： arch dams seismic safety aging damage joint opening

ANALYSIS OF PARAMETERS IN GRANULAR SOLID HYDRODYNAMICS FOR TRIAXIAL COMPRESSION TESTS

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Acta Mechanica Solida Sinica 2014年第1期27卷 15-27页

作者： Shixiong Song Qicheng Sun Feng Jin chuhan zhang State Key Laboratory of Hydroscience and Engineering Tsinghua University

Granular materials are omnipresent in industries and in nature. For small strains, elastic-plastic and hypoplastic constitutive relations are widely used in engineering practice, but they are not a significant reflection of the underlying physics. Under a unified thermodynamics framework explaining the physics of materials, granular solid hydrodynamics （GSH） was an ex- tension towards describing granular materials, not only solid-like, but also fluid-like behaviors. In this paper, the fundamentals of GSH are briefly treated and then simplified to analyze quasi- static deformations in triaxial compressions. The calculated stress-strain relations and volumetric strain are compared with experimental results. The influences of the major parameters in GSH, especially their cross coupling influences, are analyzed and their physical meanings are further clarified. After parameters were calibrated, the calculated stress values in the characteristic stress state are found to be within 22% of tested values. Meanwhile, the energy dissipation during triaxial compression is analyzed. The above results support and partially quantify GSH.

关键词： granular solid hydrodynamics granular materials triaxial compressions non-equilibrium state

Higher-order principal component pursuit via tensor approximation and convex optimization

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Journal of Systems Engineering and Electronics 2014年第3期25卷 523-530页

作者： Sijia Cai Ping Wang Linhao Li chuhan zhang School of Science Tianjin University Center for Applied Mathematics Tianjin University

Recovering the low-rank structure of data matrix from sparse errors arises in the principal component pursuit （PCP）. This paper exploits the higher-order generalization of matrix recovery, named higher-order principal component pursuit （HOPCP）, since it is critical in multi-way data analysis. Unlike the convexification （nuclear norm） for matrix rank function, the tensorial nuclear norm is stil an open problem. While existing preliminary works on the tensor completion field provide a viable way to indicate the low complexity estimate of tensor, therefore, the paper focuses on the low multi-linear rank tensor and adopt its convex relaxation to formulate the convex optimization model of HOPCP. The paper further propose two algorithms for HOPCP based on alternative minimization scheme： the augmented Lagrangian alternating direction method （ALADM） and its truncated higher-order singular value decomposition （ALADM-THOSVD） version. The former can obtain a high accuracy solution while the latter is more efficient to handle the computationally intractable problems. Experimental results on both synthetic data and real magnetic resonance imaging data show the applicability of our algorithms in high-dimensional tensor data processing.

关键词： tensor recovery principal component pursuit alternating direction method tensor approximation.

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阿加曲班在体外膜肺氧合中的应用

中外医疗 2024年第7期43卷 195-198页

作者：章初寒卢安卫浙江中医药大学研究生院浙江杭州310035 浙江树人学院树兰国际医学院浙江杭州310015

在体外膜肺氧合(Extracorporeal Membrane Oxygenation,ECMO)支持过程中,为了有效预防凝血并发症,选择合适的抗凝药物显得尤为关键。阿加曲班作为一种直接凝血酶抑制剂(Direct Thrombin Inhibitor,DTI),以其可控的抗凝监测、出色的抗凝... 详细信息

在体外膜肺氧合(Extracorporeal Membrane Oxygenation,ECMO)支持过程中,为了有效预防凝血并发症,选择合适的抗凝药物显得尤为关键。阿加曲班作为一种直接凝血酶抑制剂(Direct Thrombin Inhibitor,DTI),以其可控的抗凝监测、出色的抗凝效果和良好的安全性等特点,可能相较于传统的肝素(Unfraction-ated heparin,UFH)更为优越。本文综述了阿加曲班在ECMO中的应用,为抗凝治疗提供了更为个体化的选择,进一步丰富了ECMO抗凝策略。

关键词：阿加曲班体外膜肺氧合抗凝