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中华医学美学美容杂志 2024年第2期30卷 154-158页

作者：崔传信关小康刘佳音高子涵赵野姜日花李劲然吉林大学中日联谊医院皮肤科长春130033 吉林省人民医院医疗美容科长春130021 吉林大学第二医院皮肤科长春130031

目的探讨非剥脱性1550 nm点阵激光和剥脱性CO_(2)点阵激光治疗面部皱纹的效果和安全性。方法2020年10月至2021年8月,在吉林大学中日联谊医院皮肤科和吉林省人民医院医疗美容科就诊的面部皱纹女性患者47例,年龄26~54(41.9±6.6)岁。对同... 详细信息

目的探讨非剥脱性1550 nm点阵激光和剥脱性CO_(2)点阵激光治疗面部皱纹的效果和安全性。方法2020年10月至2021年8月,在吉林大学中日联谊医院皮肤科和吉林省人民医院医疗美容科就诊的面部皱纹女性患者47例,年龄26~54(41.9±6.6)岁。对同一患者左右面部两侧皱纹区域分别用非剥脱性1550 nm点阵激光和剥脱性CO_(2)点阵激光进行1~4次治疗,每次间隔6~12周。由3名医师对照片皱纹严重程度分级进行评估,判定疗效,记录不良反应。结果非剥脱性1550 nm点阵激光组(非剥脱组)治疗有效38例,占80.9%,剥脱性CO_(2)点阵激光组(剥脱组)治疗有效39例,占83.0%,两组比较差异无统计学意义(P>0.05)。但年龄≤45岁组,两种激光疗效均明显优于>45岁组(均P<0.001);非剥脱组红斑持续时间及结痂脱落时间均小于剥脱组(均P<0.001)。结论非剥脱性1550 nm点阵激光和剥脱性CO_(2)点阵激光治疗面部皱纹均安全有效,非剥脱性1550 nm点阵激光治疗面部皱纹恢复时间更短、不良反应更低。

关键词：激光皱纹 1550 nm点阵激光 CO_(2)点阵激光治疗结果

携带凋亡素基因的溶瘤腺病毒ATV对人宫颈癌HeLa细胞的抑制作用

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中国肿瘤生物治疗杂志 2017年第12期24卷 1356-1361页

作者：尹逊哲陈爽李文杰朱羿龙李一权崔传信李敏崔英丽赵津李善智郑颖孙丽丽李霄郭焱金宁一长春中医药大学药学院吉林长春130117 军事科学院军事兽医研究所分子病毒学与免疫学实验室吉林长春130122 吉林医药学院检验学院吉林吉林132013 吉林省肿瘤医院头颈外一科吉林长春130021 长春中医药大学基础医学院吉林长春130117

目的:探讨携带凋亡素基因(apopptin)的溶瘤腺病毒ATV感染对人宫颈癌HeLa细胞自噬和凋亡的影响。方法:分别用携带凋亡素基因的溶瘤腺病毒ATV与对照病毒Ad-MOCK(均为前期工作构建)感染HeLa细胞后,应用WST-1法检测ATV感染对HeLa细胞增殖的... 详细信息

目的:探讨携带凋亡素基因(apopptin)的溶瘤腺病毒ATV感染对人宫颈癌HeLa细胞自噬和凋亡的影响。方法:分别用携带凋亡素基因的溶瘤腺病毒ATV与对照病毒Ad-MOCK(均为前期工作构建)感染HeLa细胞后,应用WST-1法检测ATV感染对HeLa细胞增殖的影响,流式细胞术检测ATV感染对HeLa细胞凋亡和细胞周期的影响,Western blotting法检测ATV感染对HeLa细胞自噬相关蛋白LC3、P62与mTOR表达的影响,MDC染色法检测ATV感染对HeLa细胞自噬水平的影响。结果:ATV感染后抑制HeLa细胞增殖,并具有一定的时间效应关系;以ATV 100 MOI感染72 h后抑制率达到59.26%,其抑制能力明显强于同时间段对照组(P<0.01)。ATV感染48 h,ATV组HeLa细胞凋亡率显著高于对照组[(38.995±4.009)%vs(14.680±1.174)%,P<0.01]。感染后的HeLa细胞,随着ATV作用时间的延长,S期出现阻滞,48 h阻滞最强,显著高于对照组[(58.490±2.447)%vs(43.235±4.419)%,P<0.05]。与对照组相比,ATV感染HeLa后,LC3表达量6、12 h逐渐增高,12 h达到最大值(P<0.01),24 h表达量最低(P<0.01);P62蛋白在24 h出现最高表达水平(P<0.01);而mTOR随着作用时间延长逐渐降低(48 h时,P<0.01)。荧光显微镜下可见HeLa细胞核周区域MDC阳性染色,随着ATV作用时间延长,自噬小体明显增多;与对照组相比,6、12h自噬小体数量显著增多[(28.000±2.828)vs(8.500±2.121),(37.000±4.243)vs(14.000±1.414);均P<0.01],24 h相对减少[(12.000±2.828)vs(17.000±1.414),P<0.01]。结论:携带凋亡素基因的ATV溶瘤腺病毒可促进人宫颈癌HeLa细胞的凋亡和自噬水平,进而特异性杀伤肿瘤细胞。

关键词：宫颈癌 HeLa细胞凋亡素基因溶瘤腺病毒自噬凋亡

Next-Generation Prosthetic Hand:from Biomimetic to Biorealistic

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Research 2021年第1期2021卷 222-225页

作者： Ning Lan Manzhao Hao chuanxin MNiu He cui Yu Wang Ting Zhang Peng Fang Chih-hong Chou Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghaiChina Laboratory of Neurorehabilitation Engineering School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Rehabilitation Medicine Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Center for Excellence in Brain Science and Intelligent Technology Chinese Academy of SciencesShanghaiChina School of Biological Science and Medical Engineering Beihang UniversityBeijingChina Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina i-lab Key Laboratory of Multifunctional Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenChina

Integrating a prosthetic hand to amputees with seamless neural compatibility presents a grand challenge to neuroscientists and neural engineers for more than half *** anatomical structure or appearance of human hand does not lead to improved neural connectivity to the sensorimotor system of *** functions of modern prosthetic hands do not match the dexterity of human hand due primarily to lack of sensory awareness and compliant ***,progress in restoring sensory feedback has marked a significant step forward in improving neural continuity of sensory information from prosthetic hands to ***,little effort has been made to replicate the compliant property of biological muscle when actuating prosthetic ***,a full-fledged biorealistic approach to designing prosthetic hands has not been contemplated in neuroprosthetic *** this perspective article,we advance a novel view that a prosthetic hand can be integrated harmoniously with amputees only if neural compatibility to the sensorimotor system is *** ongoing research supports that the next-generation prosthetic hand must incorporate biologically realistic actuation,sensing,and reflex functions in order to fully attain neural compatibility.

关键词： neural compatibility primarily

Recent advances in the nanoconfinement of Mg-related hydrogen storage materials:A minor review

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International Journal of Minerals,Metallurgy and Materials 2023年第1期30卷 14-24页

作者： Jingjing Zhang Bing Zhang Xiubo Xie cui Ni chuanxin Hou Xueqin Sun Xiaoyang Yang Yuping Zhang Hideo Kimura Wei Du School of Environmental and Material Engineering Yantai UniversityYantai 264005China

Hydrogen is an ideal clean energy because of its high calorific value and abundance of ***,storing hydrogen in a compact,inexpensive,and safe manner is the main restriction on the extensive utilization of hydrogen ***(Mg)-based hydrogen storage material is considered a reliable solid hydrogen storage material with the advantages of high hydrogen storage capacity(7.6wt%),good performance,and low ***,the high thermodynamic stability and slow kinetics of Mg-based hydrogen storage materials have to be *** this paper,we will review the recent advances in the nanoconfinement of Mg-related hydrogen storage materials by loading Mg particles on different supporting materials,including carbons,metal-organic frameworks,and other *** are also provided for designing high-performance Mg-based materials using nanoconfinement.

关键词： magnesium-based materials hydrogen storage nanoconfinement carbon materials

Recent advances in spinel-type electrocatalysts for bifunctional oxygen reduction and oxygen evolution reactions

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Journal of Energy Chemistry 2021年第2期30卷 290-302,I0010页

作者： Xiao-Meng Liu Xiaoyang cui Kamran Dastafkan Hao-Fan Wang Cheng Tang Chuan Zhao Aibing Chen chuanxin He Minghan Han Qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Chemistry The University of New South WalesSydneyNSW 2052Australia AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory(ChEM-OIL) National Institute of Advanced Industrial Science and Technology(AIST)YoshidaSakyo-kuKyoto 606-8501Japan School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018HebeiChina Shenzhen Key Laboratory of Functional Polymer College of Chemistry and Chemical EngineeringShenzhen UniversityShenzhen 518061GuangdongChina

The demand for efficient and environmentally-benign electrocatalysts that help availably harness the renewable energy resources is growing rapidly. In recent years, increasing insights into the design of water electrolysers, fuel cells, and metal–air batteries emerge in response to the need for developing sustainable energy carriers, in which the oxygen evolution reaction and the oxygen reduction reaction play key roles. However, both reactions suffer from sluggish kinetics that restricts the reactivity. Therefore, it is vital to probe into the structure of the catalysts to exploit high-performance bifunctional oxygen electrocatalysts. Spinel-type catalysts are a class of materials with advantages of versatility, low toxicity, low expense, high abundance, flexible ion arrangement, and multivalence structure. In this review, we afford a basic overview of spinel-type materials and then introduce the relevant theoretical principles for electrocatalytic activity, following that we shed light on the structure–property relationship strategies for spinel-type catalysts including electronic structure, microstructure, phase and composition regulation,and coupling with electrically conductive supports. We elaborate the relationship between structure and property, in order to provide some insights into the design of spinel-type bifunctional oxygen electrocatalysts.

关键词： Spinel electrocatalyst Bifunctional energy electrocatalysis Oxygen evolution reaction Oxygen reduction reaction Structure–property relationship

Neutral color and self-healable electrochromic system based on cui/Cu and I_(3)^(-)/I^(-)conversions

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Nano Research 2024年第5期17卷 4437-4443页

作者： Junsen Zhong Bingkun Huang Kunjie Yang Zuju Ma Lingyu Du Ning Luo Fengjiao Tang chuanxin Hou Fuyi Jiang Litao Kang College of Environment and Materials Engineering Yantai UniversityYantai 264005China School of Energy and Power Engineering Shandong UniversityJinan 250061China Shandong Laboratory of Advanced Materials and Green Manufacturing(Yantai) Yantai 264001China

The electrochromic(EC)mechanisms of inorganic materials are usually based on reversible cation insertion/extraction or metal deposition/dissolution,which are plagued by ion trapping and dendrite growth,*** this paper,a novel conversion-type electrochromic mechanism is proposed,by making good use of the cui/Cu redox *** cui-based electrochromic system shows a neutral color switching from transparent and dim *** simply increasing the bleaching voltage,I_(3)^(-)/I^(-)redox couple can be further *** generated I_(3)^(-)will readily react with Cu,effectively improving the conversion reversibility and thereby rejuvenating the degraded electrochromic *** to the well-designed electrode and the self-healing ability,this conversion electrochromic system achieves rapid response times(tcoloring:23 s,tbleaching:6 s),decant optical modulation amplitude(26.4%),high coloration efficiency(86.15 cm^(2)·C^(-1)),admirable cyclic durability(without performance degradation after 480 cycles)and excellent optical memory ability(transmittance variationcuit storage).The establishment of this conversion-type electrochromism may inspire the exploration of novel electrochromic materials and devices.

关键词： electrochromic cui conversion reaction self-healing neutral color

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深水井精细控压下套管研究

西南石油大学学报（自然科学版） 2021年第4期43卷 175-182页

作者：童传新张海荣徐璧华赵琥崔策中国海洋石油湛江分公司广东湛江524057 南方海洋科学与工程广东省实验室(湛江) 广东湛江524088 油气藏地质及开发工程国家重点实验室·西南石油大学四川成都610500 中海油田服务股份有限公司油田化学研究院河北廊坊065201

深水窄压力窗口地层给下套管带来了巨大挑战,下套管时产生的波动压力将导致井筒压力超过压力窗口上限而出现井漏,大大增加了作业时间,采用传统方法下套管时为了防止波动压力过大而超过安全压力窗口只能降低下套管速度,这样虽然在一定程... 详细信息

深水窄压力窗口地层给下套管带来了巨大挑战,下套管时产生的波动压力将导致井筒压力超过压力窗口上限而出现井漏,大大增加了作业时间,采用传统方法下套管时为了防止波动压力过大而超过安全压力窗口只能降低下套管速度,这样虽然在一定程度上减小漏失风险但增大了作业成本,且这种方式不一定有效。因此,针对深水窄安全压力窗口地层下套管漏失风险问题,基于动态波动压力建立了深水窄安全压力窗口井筒压力控制模型;并在此基础上提出深水精细控压下套管方法。利用建立的模型分析井筒压力影响因素发现,井筒压力随着套管下入深度、最大下入速度、钻井液密度以及钻井液的屈服值、黏度的增大而增大。计算表明,深水精细控压下套管不但降低了漏失风险,还缩短了作业时间,降低了作业成本。

关键词：深水精细控压下套管波动压力井漏

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地铁换乘站坑中坑支护方案优化分析

建筑结构 2022年第S2期52卷 2345-2350页

作者：施鑫荣传新王厚良崔林钊安徽理工大学土木建筑学院淮南232001 安徽建工集团股份有限公司蚌埠233000

在基坑工程中钢支撑相比混凝土支撑具有自重轻、造价低、利于施工等优点。以合肥地铁4、7号线换乘站坑中坑工程为背景对支护方案进行优化,采用加密布置的钢支撑替换原设计混凝土支撑。通过建立三维有限元模型对优化后的基坑分步开挖、... 详细信息

在基坑工程中钢支撑相比混凝土支撑具有自重轻、造价低、利于施工等优点。以合肥地铁4、7号线换乘站坑中坑工程为背景对支护方案进行优化,采用加密布置的钢支撑替换原设计混凝土支撑。通过建立三维有限元模型对优化后的基坑分步开挖、架设内撑等施工全过程进行模拟计算,分析不同工况下的桩体水平位移和支撑轴力。结果表明,可以采用3m间距加密钢支撑替换原有9m间距混凝土支撑,优化后外坑及内坑施工完成时桩体最大水平位移分别为13.19mm和18.10mm,均能满足规范要求。由支撑轴力计算结果可以得出,当开挖面位于外坑区域内时,支撑轴力相对稳定,当开挖底部内坑时,各层支撑轴力均有明显增大趋势。替换后的第二层支撑轴力相对较小,最大值1222kN,能够满足钢支撑稳定性要求。

关键词：基坑工程坑中坑支护优化数值模拟

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上肢康复机器人用于神经康复的研究进展

中国康复医学杂志 2020年第8期35卷 916-920页

作者：牛传欣崔立军鲍勇王继先谢青上海交通大学医学院附属瑞金医院上海市200025 上海市瑞金康复医院

神经康复的目标是为患有神经系统损伤疾病的患者提供康复治疗,使患者摆脱或缓解因神经功能障碍带来的失能。其涉及病种较广,包括血管类疾病、感染类疾病、神经创伤、结构或神经肌肉紊乱、功能性异常、退行性异常等。神经康复的患者出现... 详细信息

神经康复的目标是为患有神经系统损伤疾病的患者提供康复治疗,使患者摆脱或缓解因神经功能障碍带来的失能。其涉及病种较广,包括血管类疾病、感染类疾病、神经创伤、结构或神经肌肉紊乱、功能性异常、退行性异常等。神经康复的患者出现上肢功能障碍的比例很高[1],手部的感觉运动控制能力尤为精细复杂,使得上肢的神经康复面临特殊的挑战。以脑卒中为例,患者肢体运动功能障碍的比例高达60%—80%[2—3],然而仅有约16.7%的患者得到了康复治疗[4],其中上肢运动障碍得到及时康复的比例更低。

关键词：上肢功能障碍神经功能障碍神经康复肢体运动功能障碍神经创伤神经系统损伤神经肌肉上肢康复机器人