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Frontiers of Chemical Science and Engineering 2023年第1期17卷 68-81页

作者： chuanhui li li-Long Zhang Hu li Song Yang State Key Laboratory Breeding Base of Green Pesticide&Agricultural Bioengineering Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

Benzimidazole derivatives have wide-spectrum biological activities and pharmacological effects,but remain challenging to be produced from biomass ***,we report a green hydrogen transfer strategy for the efficient one-pot production of benzimidazoles from a wide range of bio-alcohols and o-nitroanilines enabled by cobalt nitride species on hierarchically porous and recyclable nitrogen-doped carbon catalysts(Co/CN_(x)-T,T denotes the pyrolysis temperature)without using an external hydrogen source and base *** the tested catalysts,Co/CN_(x)-700 exhibited superior catalytic performance,furnishing 2-substituted benzimidazoles in 65%–92%*** mechanistic studies manifest that the coordination between Co^(2+)and N with appropriate electronic state on the porous nitrogen-doped carbon having structural defects,as well as the remarkable synergetic effect of Co/N dual sites contribute to the pronounced activity of Co/CN_(x)-700,while too high pyrolysis temperature may cause the breakage of the catalyst Co-N bond to lower down its ***,it is revealed that the initial dehydrogenation of bio-alcohol and the subsequent cyclodehydrogenation are closely correlated with the hydrogenation of nitro *** catalytic hydrogen transfer-coupling protocol opens a new avenue for the synthesis of N-heterocyclic compounds from biomass.

关键词： biomass conversion furanic compounds benzimidazoles hydrogen transfer bifunctional catalysis

基于网络药理学方法和分子对接技术探讨桔梗-苦杏仁药对治疗咳嗽变异性哮喘的作用机制

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山西中医药大学学报 2024年第1期25卷 77-86页

作者：李川徽李英姿刘斌王芳安徽中医药大学第一临床医学院安徽合肥230031 徐州市中医院江苏徐州221000

目的:采用网络药理学方法和分子对接技术探讨“桔梗-苦杏仁”药对治疗咳嗽变异性哮喘(CVA)的作用机制。方法:利用TCMSP数据库获取“桔梗-苦杏仁”药对的有效成分并筛选相关的蛋白靶点。利用GeneCards、OMIM和Drug Bank数据库获取咳嗽变... 详细信息

目的:采用网络药理学方法和分子对接技术探讨“桔梗-苦杏仁”药对治疗咳嗽变异性哮喘(CVA)的作用机制。方法:利用TCMSP数据库获取“桔梗-苦杏仁”药对的有效成分并筛选相关的蛋白靶点。利用GeneCards、OMIM和Drug Bank数据库获取咳嗽变异性哮喘的疾病靶点。将这些数据整合到“中药-成分-靶点”网络中,进行网络拓扑学分析。交叉比较“桔梗-苦杏仁”药对与CVA的靶点,以识别潜在的治疗靶点。对蛋白互作网络(PPI)进行预测,筛选关键靶点。通过GO功能分析和KEGG通路富集分析,探索其在生物学过程及途径中的作用。建立“药物-成分-靶点-通路-疾病”网络图。通过分子对接技术对核心靶点和相关化合物进行验证,计算结合能,初步验证“桔梗-苦杏仁”药对治疗CVA的作用机制。结果:获得“桔梗-苦杏仁”药对25种有效成分和119个作用靶点,CVA疾病靶点1764个。“桔梗-苦杏仁”药对与CVA的交集靶点84个,其中包括AKT1、TP53、IL6、TNF、VEGFA、JUN和CASP3等7个核心靶点。GO功能分析得到497个GO功能模块,KEGG通路富集分析获得180条信号通路,其中磷脂酰肌醇-3-激酶/蛋白激酶B(PI3K-Akt)、白介素-17(IL-17)、肿瘤坏死因子(TNF)、核因子κB(NF-κB)等信号通路与CVA显著相关。“药物-成分-靶点-通路-疾病”网络图提示“桔梗-苦杏仁”药对可能通过“多成分-多靶点-多途径”发挥治疗CVA的作用。分子对接结果显示所有对接组合的结合能均在-5.0kcal/mol以下,具有很好的对接效果。结论:“桔梗-苦杏仁”药对治疗CVA具有多成分、多靶点和多通路的特点,为中药治疗咳嗽变异性哮喘提供了理论基础,有望提高临床治愈率并减少复发率和不良反应。

关键词：咳嗽变异性哮喘桔梗苦杏仁网络药理学分子对接

基于网络药理学和实验验证探讨麦门冬汤治疗特发性肺纤维化的作用机制

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海南医学院学报 2024年第8期30卷 597-606页

作者：马先于明玥周博文李泽峰李传慧辛玲杰贾新华山东中医药大学中医学院山东济南250014 山东中医药大学第一临床医学院山东济南250014 山东大学附属公共卫生临床中心/山东省公共卫生临床中心中西医结合科山东济南250013 山东中医药大学附属医院呼吸与危重症医学科山东济南250014

目的:利用网络药理学方法并结合实验研究,深入探究麦门冬汤对特发性肺纤维化的治疗作用及其机制。方法:采用中药系统药理学数据库TCMSP、中国传统医学百科全书ETCM和SwissADME筛选并确定麦门冬汤中的活性成分。接着利用PubChem、SwissTa... 详细信息

目的:利用网络药理学方法并结合实验研究,深入探究麦门冬汤对特发性肺纤维化的治疗作用及其机制。方法:采用中药系统药理学数据库TCMSP、中国传统医学百科全书ETCM和SwissADME筛选并确定麦门冬汤中的活性成分。接着利用PubChem、SwissTargetPrediction和Uniport数据库挑选出中药活性成分的潜在作用靶标。借助GeneCards和OMIM数据库获取特发性肺纤维化的靶点基因。Venn diagrams绘图工具筛选出中药与疾病的交集靶点,利用Cytoscape3.9.1软件构建“中药-活性成分-疾病-靶点”网络关系图,并通过CytoNCA插件构建蛋白质相互作用网络,筛选得到核心靶点蛋白。运用DAVID进行GO及KEGG通路富集分析。最后使用博来霉素建立SD大鼠肺纤维化模型,观察大鼠肺组织肉眼标本及病理切片,并对其进行实时荧光定量PCR分析,比较治疗组与对照组TGF-β1、α-SMA、IL-4、IFN-γ、LC3-Ⅱ、beclin1的mRNA表达水平。结果:本研究共筛选得到麦门冬汤治疗IPF的作用靶点402个,其中核心靶点50个,对应5种中药的159种有效成分。GO富集分析和KEGG富集分析涉及PI3K-AKT信号通路、MAPK信号通路等信号通路治疗特发性肺纤维化。动物实验结果显示,与模型对照组相比,麦门冬汤治疗组可显著下调TGF-β1、α-SMA、IL-4 mRNA的相对表达水平(Plin1、IFN-γmRNA的相对表达水平(P<0.05)。结论:本研究提示,麦门冬汤中关键活性成分可能在细胞自噬、炎症反应、巨噬细胞极化等生物过程方面发挥作用,发挥改善肺纤维化的作用。

关键词：麦门冬汤特发性肺纤维化网络药理学实验验证自噬

基于相位与幅值补偿的虚拟同步发电机低电压穿越控制

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电力工程技术 2024年第3期43卷 42-51页

作者：陈智勇董新伟李传辉王志超赵明杜秀稳中国矿业大学电气工程学院江苏徐州221008

虚拟同步发电机(virtual synchronous generator,VSG)通过模拟同步发电机的工作原理,引入虚拟惯量与阻尼系数,提高了分布式电源并网的稳定性。但是当电网发生电压跌落时,电压的跌落与恢复均会使电网电压的相位与幅值发生跳变,而传统的VS... 详细信息

虚拟同步发电机(virtual synchronous generator,VSG)通过模拟同步发电机的工作原理,引入虚拟惯量与阻尼系数,提高了分布式电源并网的稳定性。但是当电网发生电压跌落时,电压的跌落与恢复均会使电网电压的相位与幅值发生跳变,而传统的VSG控制策略难以解决该问题。为此,文中提出一种基于相位与幅值补偿的VSG低电压穿越控制方法。首先,分析电网电压跌落与恢复对电网造成的不同影响。其次,在电网电压跌落期间,通过将VSG输出电压和电网电压之间的相位与幅值差控制在允许范围内来实现过流抑制、输出功率的快速稳定以及无功补偿的目的。然后,在电网电压恢复时,通过快速补偿消除VSG输出电压和电网电压之间的相位与幅值差,从而抑制因电网电压跳变而造成的过流等问题。最后,通过MATLAB/Simulink仿真验证所提控制策略的有效性。根据仿真结果可知,文中提出的控制策略可以有效抑制过流的产生并且能够实现无功补偿。

关键词：虚拟同步发电机(VSG) 低电压穿越相位与幅值跳变相位与幅值补偿过流抑制功率稳定无功补偿

益肺通络方对肺纤维化大鼠上皮间质转化的影响

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中医药信息 2024年第8期41卷 20-27,37页

作者：李泽峰李传慧周博文马先刘骅漫贾新华山东中医药大学山东济南250355 山东中医药大学附属医院山东济南250000

目的:探讨益肺通络方干预大鼠肺纤维化的作用机制。方法:56只SD雄性大鼠,随机选取10只大鼠作为空白组(Control组),剩余56只大鼠通过气管内灌注硫酸博来霉素(5 mg/mL)的方法建立肺纤维化动物模型。造模成功后将存活的40只大鼠随机分为模... 详细信息

目的:探讨益肺通络方干预大鼠肺纤维化的作用机制。方法:56只SD雄性大鼠,随机选取10只大鼠作为空白组(Control组),剩余56只大鼠通过气管内灌注硫酸博来霉素(5 mg/mL)的方法建立肺纤维化动物模型。造模成功后将存活的40只大鼠随机分为模型组(Model组)、醋酸泼尼松组(PRED组)、益肺通络方低剂量组(YFTL-L组)、益肺通络方高剂量组(YFTL-H组)。PRED组灌胃1.17 mg/kg醋酸泼尼松片,YFTL-L组、YFTL-H组分别灌胃1.027、2.054 g/mL益肺通络方水煎液,Control组和Model组均灌胃等体积生理盐水,连续给药21 d。治疗结束后计算肺脏系数;HE、Masson染色观察肺组织破坏及胶原沉积情况;EliSA检测血清中羟脯氨酸(Hyp)、TNF-α水平;免疫荧光检测肺组织TGF-β1、Col-I、E-cadherin蛋白水平;免疫组化检测肺组织α-SAM、vimentin蛋白水平。结果:与Model组比较,YFTL-L组、YFTL-H组肺组织结构破坏情况均有改善,胶原沉积减少,大鼠肺脏系数和纤维化评分均降低(P<0.01),血清中Hyp、TNF-α水平降低(P<0.01),肺组织中TGF-β1、Col-I、α-SAM、vimentin蛋白表达下调(P<0.01,P<0.05),E-cadherin蛋白水平升高(P<0.05,P<0.01),且随着灌胃药物浓度升高呈现出一定的剂量依赖效应。结论:益肺通络方可延缓大鼠肺纤维化进展,其作用机制可能是通过缓解肺泡炎症、抑制上皮间质转化机制转化发挥抗纤维化作用。

关键词：益肺通络方肺纤维化上皮间质转化胶原沉积炎症

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Catalytic cascade acetylation-alkylation of biofuran to C_(17)diesel precursor enabled by a budget acid-switchable catalyst

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Chinese Journal of Chemical Engineering 2021年第6期34卷 171-179页

作者： chuanhui li Yuanzhong li Xiaoxiang Luo Zhengyi li Heng Zhang Hu li Song Yang State Key Laboratory Breeding Base of Green Pesticide&Agricultural Bioengineering Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

lignocellulosic biomass is a promising feedstock for the synthesis of value-added chemicals and ***,one of the biggest challenges for producing high-quality diesel fuels is the lack of sufficient carbon-chain length in biomass *** this study,a C_(17)diesel precursor 1,1,1-tris(5-methyl-2-f uryl)ethane(TEMF)with a yield of ca.70%was synthesized from the cascade acetylation-hydroxyalkyla tion/alkylation of bio-based 2-methylfuran(MF)with acetic anhydride(AA)catalyzed by acid-treated montmorillonite with enhanced acidity and improved *** catalytic mechanism of the cascade reaction process was investigated over different types of acid species(Br?nsted acid and Lewis acid),and the influence of in situ formed acetic acid was also examined.A synergistic effect was observed to enable the synthesis of TEMF from the trimerization of MF with AA,in which Lewis acid and weak Br?nsted acid species mainly catalyze the acetylation and hydroxyalkylation processes,while the subsequent alkylation step is mainly catalyzed by strong Br?nsted acid.

关键词： Biomass Diesel Catalysis Biofuranic compound Acetylation-alkylation

Highly stretchable kirigami-patterned nanofiber-based nanogenerators for harvesting human motion energy to power wearable electronics

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Materials Futures 2024年第2期3卷 131-140页

作者： Chuan Ning Shengxin Xiang Xiupeng Sun Xinya Zhao chuanhui Wei Lele li Guoqiang Zheng Kai Dong College of Materials Science and Engineering Key Laboratory of Material Processing and Mold(Ministry of Education)Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Materials Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001People’s Republic of China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

Wearable electronics are advancing towards miniaturization and ***,traditional energy supply methods have largely hindered their *** effective solution to this problem is to convert human mechanical energy into electricity to power wearable electronic ***,it is greatly attractive to design flexible,foldable and even stretchable energy harvesting ***,we use the electrospinning and kirigami approach to develop a type of highly stretchable kirigami-patterned nanofiber-based triboelectric nanogenerator(K-TENG).Due to its innovative structural design,the K-TENG can achieve a tensile strain of 220%,independent of the tensile properties of the material *** a person swings their arms,the K-TENG fixed to the clothing can convert mechanical energy from human movement into electrical *** produced electricity can directly drive 50 LED lights and a digital watch,or be stored in a lithium battery to charge the smartwatch and smartphone,*** study employs a new method to fabricate a stretchable triboelectric nanogenerator and demonstrates its promising applications in wearable power technology.

关键词： stretchable triboelectric nanogenerators kirigami energy harvesting

Defect-manipulated magnetoresistance and above-room-temperature ferromagnetism in two-dimensional BaNi_(2)V_(2)O_(8)

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Chinese Chemical Letters 2024年第3期35卷 523-527页

作者： Pengfei Tan chuanhui Zhu Jinjin Yang Shuang Zhao Tao Xia Mei-Huan Zhao Tao Han Zheng Deng Man-Rong li Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-sen UniversityGuangzhou 510006China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Science Hainan UniversityHaikou 570228China

The intricate correlation between multiple degrees of freedom and physical properties is a fascinating area in solid state chemistry and condensed matter ***,we report a quantum-magnetic system BaNi_(2)V_(2)O_(8)(BNVO),in which the spin correlation was modulated by unusual oxidation state,leading to different magnetic *** BNVO was modified with topochemical reduction(TR)to yield TR-BNVO with partially reduced valance state of Ni^(+)in the two-dimensional NiO_(6)-honeycomb ***,the antiferromagnetic order is suppressed by the introduction of locally interposed Ni^(+)and oxygen vacancies,resulting in a ferromagnetic ground state with the transition temperature up to 710 K.A positive magnetoresistance(7.5%)was observed in the TR-BNVO at 40 K under 7 *** findings show that topological reduction is a powerful approach to engineer low-dimensional materials and accelerate the discovery of new quantum magnetism.

关键词： Layered honeycomb oxide Topochemical reduction Oxygen vacancies Ferromagnetism Magnetoresistance

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo chuanhui Xu linxi li Yunxiang Ji Yezhong Wang Yingjia li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

Perspectives on potential neuroprotective role of albumin in acute ischemic stroke

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Journal of Translational Neuroscience 2023年第2期8卷 1-6页

作者： Yuanyuan liu Xiao Dong Xuehong Chu Ran Meng chuanhui li Chen Zhou Chuanjie Wu Xunming Ji Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology and Stroke Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China China-America Institute of Neuroscience and Beijing Institute of Geriatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China

Albumin is the most abundant protein in plasma and is synthesized primarily in the *** has a variety of biological roles,such as increasing colloid os-motic pressure, and performing antioxidant, anti-inflam-matory,and substance transportation *** studies have confirmed that albumin has neuroprotective effects and it has been used in the treatment of cerebral edema and increased intracranial *** this review we focus on the neuroprotective effects of albumin in ischemic stroke,such as the reduction of cerebral ede-ma, antioxidant effects, protection of neuronal cell mem-branes, and increased cerebral blood flow. In addition, we summarize preclinical and clinical studies of albumin in ischemic stroke. We believe that the neuroprotective role of albumin should be re-investigated in the era of reper-fusion therapy.

关键词： albumin acute ischemic stroke neuro-protection reperfusion therapy