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Frontiers of Chemical Science and Engineering 2023年第1期17卷 68-81页

作者： chuanhui li li-Long Zhang Hu li Song Yang State Key Laboratory Breeding Base of Green Pesticide&Agricultural Bioengineering Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

Benzimidazole derivatives have wide-spectrum biological activities and pharmacological effects,but remain challenging to be produced from biomass ***,we report a green hydrogen transfer strategy for the efficient one-pot production of benzimidazoles from a wide range of bio-alcohols and o-nitroanilines enabled by cobalt nitride species on hierarchically porous and recyclable nitrogen-doped carbon catalysts(Co/CN_(x)-T,T denotes the pyrolysis temperature)without using an external hydrogen source and base *** the tested catalysts,Co/CN_(x)-700 exhibited superior catalytic performance,furnishing 2-substituted benzimidazoles in 65%–92%*** mechanistic studies manifest that the coordination between Co^(2+)and N with appropriate electronic state on the porous nitrogen-doped carbon having structural defects,as well as the remarkable synergetic effect of Co/N dual sites contribute to the pronounced activity of Co/CN_(x)-700,while too high pyrolysis temperature may cause the breakage of the catalyst Co-N bond to lower down its ***,it is revealed that the initial dehydrogenation of bio-alcohol and the subsequent cyclodehydrogenation are closely correlated with the hydrogenation of nitro *** catalytic hydrogen transfer-coupling protocol opens a new avenue for the synthesis of N-heterocyclic compounds from biomass.

关键词： biomass conversion furanic compounds benzimidazoles hydrogen transfer bifunctional catalysis

Catalytic cascade acetylation-alkylation of biofuran to C_(17)diesel precursor enabled by a budget acid-switchable catalyst

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Chinese Journal of Chemical Engineering 2021年第6期34卷 171-179页

作者： chuanhui li Yuanzhong li Xiaoxiang Luo Zhengyi li Heng Zhang Hu li Song Yang State Key Laboratory Breeding Base of Green Pesticide&Agricultural Bioengineering Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCenter for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

lignocellulosic biomass is a promising feedstock for the synthesis of value-added chemicals and ***,one of the biggest challenges for producing high-quality diesel fuels is the lack of sufficient carbon-chain length in biomass *** this study,a C_(17)diesel precursor 1,1,1-tris(5-methyl-2-f uryl)ethane(TEMF)with a yield of ca.70%was synthesized from the cascade acetylation-hydroxyalkyla tion/alkylation of bio-based 2-methylfuran(MF)with acetic anhydride(AA)catalyzed by acid-treated montmorillonite with enhanced acidity and improved *** catalytic mechanism of the cascade reaction process was investigated over different types of acid species(Br?nsted acid and Lewis acid),and the influence of in situ formed acetic acid was also examined.A synergistic effect was observed to enable the synthesis of TEMF from the trimerization of MF with AA,in which Lewis acid and weak Br?nsted acid species mainly catalyze the acetylation and hydroxyalkylation processes,while the subsequent alkylation step is mainly catalyzed by strong Br?nsted acid.

关键词： Biomass Diesel Catalysis Biofuranic compound Acetylation-alkylation

Deltaic Sandstone Pinch-out lines Recongnition Based on Seismic Matching Pursuit Instantaneous Spectral Characteristics

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石油地球物理勘探 2012年第A02期47卷 74-81页

作者： Zhang Fanchang li chuanhui Yin Xingyao School of Geoscience China University of Petroleum (East China) QingdaoShandong 266555China

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo chuanhui Xu linxi li Yunxiang Ji Yezhong Wang Yingjia li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

Perspectives on potential neuroprotective role of albumin in acute ischemic stroke

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Journal of Translational Neuroscience 2023年第2期8卷 1-6页

作者： Yuanyuan liu Xiao Dong Xuehong Chu Ran Meng chuanhui li Chen Zhou Chuanjie Wu Xunming Ji Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology and Stroke Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China China-America Institute of Neuroscience and Beijing Institute of Geriatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China

Albumin is the most abundant protein in plasma and is synthesized primarily in the *** has a variety of biological roles,such as increasing colloid osmotic pressure, and performing antioxidant, anti-inflam-matory,and substance transportation *** studies have confirmed that albumin has neuroprotective effects and it has been used in the treatment of cerebral edema and increased intracranial *** this review we focus on the neuroprotective effects of albumin in ischemic stroke,such as the reduction of cerebral edema, antioxidant effects, protection of neuronal cell membranes, and increased cerebral blood flow. In addition, we summarize preclinical and clinical studies of albumin in ischemic stroke. We believe that the neuroprotective role of albumin should be re-investigated in the era of reperfusion therapy.

关键词： albumin acute ischemic stroke neuro-protection reperfusion therapy

Opportunities of endovascular treatment for cerebral venous thrombosis

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Journal of Translational Neuroscience 2024年第2期9卷 9-17页

作者： Na liu Chuanjie Wu Longfei Wu Qingfeng Ma Jian Chen Jiangang Duan Xunming Ji chuanhui li Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Stroke Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Cerebral venous thrombosis(CVT)is a rare condition that can be fatal in severe *** limited occurrence of CVT poses challenges in conducting randomized controlled trials,leading to uncertainty regarding the effectiveness of endovascular thrombectomy(EVT)in specific subgroups of patients with ***,a growing body of new evidence has been published on various aspects of CVT diagnosis and treatment,including studies on prognosis assessment scales and EVT *** remains the primary treatment during the acute phase of CVT,as demonstrated by the thrombolysis or anticoagulation for cerebral venous thrombosis(TOACT)clinical *** study revealed that EVT combined with standard medical care did not improve functional outcomes for patients with severe *** risk screening scores have been developed to predict CVT prognosis,and some of these scales have been shown to perform *** question of whether EVT is beneficial for patients with CVT,and to which subgroups of patients it should be offered,still remains *** global research collaborations should be established to address current challenges and facilitate the execution of clinical trials.

关键词： cerebral venous thrombosis endovascular thrombectomy risk screening tools management

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地震倒谱特征参数谱聚类地震相分析方法

石油地球物理勘探 2021年第1期56卷 38-48,I0008,I0009页

作者：桑凯恒张繁昌李传辉中国石油大学(华东)地球科学与技术学院山东青岛266580 中国地质大学(北京)地球物理与信息技术学院北京100083

常用的地震相分析方法有随机模拟、神经网络、聚类算法和深度学习等。随机模拟结果易受随机模型影响,而且在地质结构复杂地区难以准确划分地震相。神经网络和深度学习具有较强的容错性和泛化能力,但需要海量训练样本数据,同时训练网络... 详细信息

常用的地震相分析方法有随机模拟、神经网络、聚类算法和深度学习等。随机模拟结果易受随机模型影响,而且在地质结构复杂地区难以准确划分地震相。神经网络和深度学习具有较强的容错性和泛化能力,但需要海量训练样本数据,同时训练网络的计算量巨大。K均值聚类、C模糊聚类等经典聚类算法在简单数据集上均获得了理想的聚类结果,但对于非凸数据集并不能实现全局最优。为此,提出一种基于地震数据倒谱特征参数的谱聚类地震相分析方法。该方法以地震倒谱特征参数为谱聚类的输入变量,然后通过井标定,建立地震相与地质体间的对应关系。以图论为基础的谱聚类方法将数据的聚类转化为图的分割问题,通过图的最优分割实现数据的精确聚类。通过优化相似度矩阵计算方法,构建稀疏相似度矩阵,可以解决矩阵维度过大引起的存储和计算量大的问题,使谱聚类更适用于划分三维空间地震相。地震倒谱特征参数一方面能减少数据的维数,降低计算复杂度;另一方面能消除波形的影响,提高划分精度。模型试验和实际数据应用表明,与地震瞬时振幅、多地震属性地震相划分结果相比,所提方法划分的地震相带与古地貌吻合更好,边界更清晰,可解释性也更好,可为油气勘探和油藏评价提供数据支撑。

关键词：谱聚类地震倒谱特征参数地震相反射系数

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政府补贴对跨组织合作创新影响的博弈分析

科技进步与对策 2011年第1期28卷 98-100页

作者：李传辉侯光明北京理工大学管理与经济学院北京100081

跨组织合作创新能够充分发挥不同组织的优势,促进技术创新整体效应的提升。目前,政府对于跨组织合作创新有一定的政策扶持,并给予不同程度的补贴。政府补贴如何激发合作企业的创新投入,影响合作创新的产出是一个重要的研究课题。通过建... 详细信息

跨组织合作创新能够充分发挥不同组织的优势,促进技术创新整体效应的提升。目前,政府对于跨组织合作创新有一定的政策扶持,并给予不同程度的补贴。政府补贴如何激发合作企业的创新投入,影响合作创新的产出是一个重要的研究课题。通过建立两个企业之间跨组织合作创新投入的政府补贴模型,分析了在纳什博弈、合作博弈以及斯坦克尔伯格博弈3种博弈关系下的企业最优投入和政府最优补贴,得出政府在不同条件下的补贴政策和作用。结果表明:政府补贴不仅能激励企业进行合作创新,而且可以调节企业创新投入,使得产出最优。

关键词：合作创新政府补贴博弈分析