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Development and assessment of cutting-edge biotechnologies

Journal of Biosafety and Biosecurity 2024年第1期6卷 51-63页

作者： Xiaofeng Hu Baichuan Xu Mingliang Chen Kexin Li Yang Xiao Shengnan Liang chuanfu zhang Hui Ma Hongbin Song Chinese PLA Center for Disease Control and Prevention BeijingChina Army Medical University ChongqingChina Institute of Pathology and Southwest Cancer Centre Southwest HospitalArmy Medical UniversityChongqingChina Department of Chemical Defense Medicine School of Military Preventive MedicineArmy Medical UniversityChongqingChina Institute of Toxicology School of Military Preventive MedicineArmy Medical UniversityChongqingChina China Medical University ShenyangChina Chongqing University Cancer Hospital School of MedicineChongqing UniversityChongqingChina The Nursing Department of PLA General Hospital BeijingChina

The emergence of advanced biotechnologies has intensified in recent *** rapid development of these biotechnologies has had a wide and profound impact globally,with the majority on the frontier of biosecurity *** global biosecurity situation is currently highly challenging,with the characteristics of internationalization,extremely serious harm,and complex *** misuse and abuse of biotechnologies are common,which thereby endanger *** international community and governments have attached great importance to cutting-edge biotechnologies and are implementing laws and regulations to control and prevent biosecurity-related *** tracking the frontier progress of the new technologies generated from gene editing,gene drives,synthetic biology,and related cross-disciplines as applied in the biosecurity field,we analyzed the development trends in biotechnologies and their potential *** the one hand,this paper proposes that there is an urgent need for global cooperation to formulate management,control strategies,and measures for cutting-edge technologies in biosecurity to jointly promote their sound *** the other hand,the international community should jointly shoulder the responsibility for safeguarding biosecurity and restrict the biotechnologies to rational applications within legal and ethical *** paper aims to provide a reference for the prevention of misuse and abuse of biotechnologies and support global cooperation in biosecurity governance.

关键词： Biotechnology Gene drives Gene editing Synthetic biology

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回龙山水电站1 号水轮机主轴工作密封改造

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能源科技 2024年第3期22卷 52-55页

作者：张传富国家能源集团国电电力和禹水电开发公司辽宁本溪117200

回龙山水电站装有2×36 MW的轴流转桨式水轮发电机组,机组安装高程为-8 m,尾水隧洞长为120 m,机组工作密封经过多次改造、检修,止水效果不佳。通过分析历次工作密封改造失败的原因,最终自主研究改造一种填料式与随动式组合的水轮发电机... 详细信息

回龙山水电站装有2×36 MW的轴流转桨式水轮发电机组,机组安装高程为-8 m,尾水隧洞长为120 m,机组工作密封经过多次改造、检修,止水效果不佳。通过分析历次工作密封改造失败的原因,最终自主研究改造一种填料式与随动式组合的水轮发电机工作密封装置,彻底解决了工作密封漏水量大的问题。此密封装置已取得国家实用新型专利。

关键词：轴流转浆式水轮发电机组工作密封新密封结构

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BEHAVIORS OF ACCESSORY ELEMENTS IN COPPER PYROMETALLURGY

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中国有色金属学会会刊：英文版 1998年第1期8卷 115-120页

作者： Tan, Pengfu zhang, chuanfu Central South Univ of Technology Changsha China

ＢＥＨＡＶＩＯＲＳＯＦＡＣＣＥＳＳＯＲＹＥＬＥＭＥＮＴＳＩＮＣＯＰＰＥＲＰＹＲＯＭＥＴＡＬＬＵＲＧＹ①ＴａｎＰｅｎｇｆｕａｎｄＺｈａｎｇＣｈｕａｎｆｕＤｅｐａｒｔｍｅｎｔｏｆＮｏｎｆｅｒｒｏｕｓＭｅｔａｌｕｒｇｙ，Ｃ... 详细信息

ＢＥＨＡＶＩＯＲＳＯＦＡＣＣＥＳＳＯＲＹＥＬＥＭＥＮＴＳＩＮＣＯＰＰＥＲＰＹＲＯＭＥＴＡＬＬＵＲＧＹ①ＴａｎＰｅｎｇｆｕａｎｄＺｈａｎｇＣｈｕａｎｆｕＤｅｐａｒｔｍｅｎｔｏｆＮｏｎｆｅｒｒｏｕｓＭｅｔａｌｕｒｇｙ，ＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒ...

关键词： mathematical model copper smelting accessory element distribution behavior

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聚苯乙烯纳塑料诱导Caco-2细胞氧化应激和线粒体损伤的研究

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生态毒理学报 2024年第4期19卷 284-293页

作者：赵乾秀白淼白宇超曲绍娟张灿张传福安徽医科大学公共卫生学院合肥230032 中国人民解放军疾病预防控制中心北京100071 中国检验检疫科学研究院卫生检验与检疫研究所北京100176

微/纳米塑料的潜在毒理效应及健康风险引起广泛关注。本研究以人结直肠腺癌细胞(Caco-2)为模型,研究聚苯乙烯纳米塑料(polystyrene nanoparticles,PS-NPs)的细胞毒性,从氧化应激和线粒体损伤角度探讨PS-NPs肠道毒性机制。结果表明PS-NP... 详细信息

微/纳米塑料的潜在毒理效应及健康风险引起广泛关注。本研究以人结直肠腺癌细胞(Caco-2)为模型,研究聚苯乙烯纳米塑料(polystyrene nanoparticles,PS-NPs)的细胞毒性,从氧化应激和线粒体损伤角度探讨PS-NPs肠道毒性机制。结果表明PS-NPs暴露导致细胞形态改变,细胞活力下降,乳酸脱氢酶释放增加,确定其最低效应浓度是50μg·mL-1。随着PS-NPs暴露浓度增加,细胞活性氧(reactive oxygen species,ROS)含量和丙二醛水平升高,线粒体膜电位水平降低、Ca^(2+)超载、线粒体膜通透性转换孔开放、二磷酸腺苷/三磷酸腺苷比率(ADP/ATP)上升,最终细胞凋亡率增加。PS-NPs暴露浓度为200μg·mL-1时,ROS含量升高至对照组的3.85倍;线粒体去极化程度降低至对照组的0.63倍;细胞凋亡率达到28.90%(P<0.01)。PS-NPs通过诱导细胞ROS生成,产生氧化应激,过量的ROS会对线粒体造成损伤,最终导致细胞凋亡率升高,因此氧化应激和线粒体损伤是PS-NPs引起细胞毒性的关键机制。本研究结果将为PS-NPs的肠道毒理效应和健康风险评估提供基础数据和科学依据。

关键词：纳米塑料 Caco-2细胞氧化应激线粒体损伤凋亡

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THIOUREA LEACHING OF GOLD FROM A CALCINE OF GOLD-BEARING ARSENICAL PYRITE CONCENTRATE

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Transactions of Nonferrous Metals Society of China 1996年第1期6卷 21-24页

作者： Xu Shengming zhang chuanfu Zhao Tiancong Wu Yanjun Department of Nonferrous Metallurgy Central South University of Technology Changsha 410083 Department of Chemistry Hunan School of Agricultural MechanizationChangsha 410126

The thiourea leaching of gold from the calcine of gold-bearing arsenical pyrite concentrate of Kangjiawan mine was *** effects of the leaching time,the concentrations of thiourea,hydrochloric acid and initial ferric ion on the leaching recovery of gold were investigated,and a regressive model has been established,which showed that the concentrations of thiourea and hydrochloric acid were the most important factors,leaching time the second,and concentration of the initial ferric ion the least・Under the optimal conditions,that is,temperature 50℃,the ratio of liquid to solid 4:1,thiourea 12g/L,hydrochloric acid 1 mol/L,and initial ferric ion 1 g/L,the leaching recoveries of gold and silver were more than 81%and 73%,*** increase of silver recovery and the reduction of thiourea consumption could be attained when sodium sulphite was added.

关键词： gold-bearing arsenical pyrite concentrate calcine thiourea leaching of gold

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FORMATION AND SOLUBILITY OF POTASSIUM ALUMINOSILICATE

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中国有色金属学会会刊：英文版 1998年第1期8卷 121-123页

作者： Liu, Guihua Li, Xiaobin zhang, chuanfu Peng, Zhihong He, Boquan Central South Univ of Technology Changsha China

ＦＯＲＭＡＴＩＯＮＡＮＤＳＯＬＵＢＩＬＩＴＹＯＦＰＯＴＡＳＳＩＵＭＡＬＵＭＩＮＯＳＩＬＩＣＡＴＥ①ＬｉｕＧｕｉｈｕａ，ＬｉＸｉａｏｂｉｎ，ＺｈａｎｇＣｈｕａｎｆｕａｎｄＰｅｎｇＺｈｉｈｏｎｇＤｅｐａｒｔｍｅｎｔｏｆＮ... 详细信息

ＦＯＲＭＡＴＩＯＮＡＮＤＳＯＬＵＢＩＬＩＴＹＯＦＰＯＴＡＳＳＩＵＭＡＬＵＭＩＮＯＳＩＬＩＣＡＴＥ①ＬｉｕＧｕｉｈｕａ，ＬｉＸｉａｏｂｉｎ，ＺｈａｎｇＣｈｕａｎｆｕａｎｄＰｅｎｇＺｈｉｈｏｎｇＤｅｐａｒｔｍｅｎｔｏｆＮｏｎｆｅｒｒｏｕｓＭｅｔａｌｕｒｇ...

关键词： potassium aluminosilicate structure solubility

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Modeling the impact of the viaduct on particles dispersion from vehicle exhaust in street canyons

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Science China(Technological Sciences) 2012年第1期55卷 48-55页

作者： zhang chuanfu WEN Mou ZENG JianRong zhang GuiLin FANG HaiPing LI Yan Key Laboratory of Nuclear Analysis Technique Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

In this paper, the impact of the viaduct on flow and traffic exhausting particles dispersion within urban street canyons was numerically simulated using a computational fluid dynamics （CFD） model. Two-dimensional flow and dispersion of particles from traffic exhausts were modeled using the standard k-e turbulence model. The street canyons with a viaduct at different widths and different heights above the ground are simulated. The results show that the airflow in street canyon is evidently in- fluenced by the viaduct： The position of the main vortex center is changed, especially there are two strong vortexes when the viaduct is placed at 10 m height above the ground. It is found based on the study of the particles number concentrations （PNCs） that the viaduct may mitigate the pollution level in the street canyon sometimes. The impact of the viaduct width on PNCs is stronger than that of the height. The study of PNDs reveals that the mean PNCs at the wall of upwind building increase when a viaduct is placed in street canyon. In addition, it is found based on the study of mean particles residence time （PRT） that the removal of the particles strongly correlates to the mean PNCs. The results indicate that the viaduct is an important factor to influence the flow patterns and particles dispersion in street canyons.

关键词： street canyon viaduct particles number distribution CFD simulation mean particle residence time

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Flame Retardant Material Based on Cellulose Scaffold Mineralized by Calcium Carbonate

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Journal of Renewable Materials 2024年第1期12卷 89-102页

作者： Jinshuo Wang Lida Xing Fulong zhang chuanfu Liu State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510640China

Wood-based functional materials have developed *** the flammability significantly limits its further *** improve the flame retardancy,the balsa wood was delignified by NaClO2 solution to create a cellulose scaffold,and then alternately immersed in CaCl_(2) ethanol solution and NaHCO3 aqueous solution under *** high porosity and wettability resulting from delignification benefited the following mineralization process,changing the thermal properties of balsa wood *** organic-inorganic wood composite showed abundant CaCO_(3) spherical particles under scanning electron *** peak of the heat release rate of delignified balsa-CaCO_(3) was reduced by 33%compared to the native balsa,according to the cone calorimetric *** flame test demonstrated that the mineralized wood was flame retardant and ***,the mineralized wood also displayed lower thermal *** study developed a feasible way to fabricate a lightweight,fire-retardant,self-extinguishing,and heat-insulating wood composite,providing a promising route for the valuable application of cellulosic biomass.

关键词： Cellulose scaffold delignification CaCO_(3) mineralization fire retardancy

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COMPUTER MODEL OF COPPER SMELTING PROCESS AND DISTRIBUTION BEHAVIORS OF ACCESSORY ELEMENTS

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Journal of Central South University 1997年第1期9卷 36-41页

作者： Tan Pengfu zhang chuanfu(Department of Nonferrous Metallurgy. Central South University ofTechnology, Changsha 410083, China) Department of Nonferrous Metallurgy Central South University of Technology Changsha 410083 China

A computer model has been developed to simulate the distribution behaviors of Ni, Co. Sn. Ph,Zn, As, Sb, Bi, An and Ag in copper smelting process. The model assumes that the copper smelting furnaceis in thermodynamic equilibrium. As many as 21 elements (Cu. S, Fe. Ni, Co. Sn, As, Sb. Bi, Ph. ***. Ag. O, N, C, H, Ca, Mg, Al, and St) and 73 compounds are considered. This model accounts forphysical entrainment in the melts. The predictions by the present computer model are compared with theknown commercial data from Guixi Smelter in China, Home Smelter in Canada and Naoshima Smelter inJapan. The agreements between the computer predictions and the commercial data are excellent, so that thepresent computer model can be used to monitor and optimize the actual industrial operations of copper smelting. It is applicable to simulation of almost all copper pyrometallurgical processes.

关键词： simulate distribution behaviors copper smelting computer model

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Overview and prospects of food biosafety

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Journal of Biosafety and Biosecurity 2022年第2期4卷 146-150页

作者： Xiaofeng Hua Baichuan Xu Yang Xiao Shengnan Liang chuanfu zhang Hongbin Song Chinese PLA Center for Disease Control and Prevention BeijingChina Army Medical University ChongqingChina

Biosafety issues have become a major threat to the health of humans,animals,and ecosystems *** problems with food production and the food supply chain have become of greater concern to consumers,issues involving biosafety and food safety from a developmental perspective need to be urgently *** term,food biosafety,is the combination of the core concepts of biosafety and food *** refers to the effective prevention of biological threats to food production and the food supply chain by controlling foodborne diseases arising from the consumption of edible plants and animal products,by preventing the establishment of invasive species,by strictly controlling the use of antibiotics,agricultural chemicals and veterinary drugs in the food supply chain,and by initiating food defense and anti-terrorism measures to protect the health of humans,animals,and ecosystems,thereby maintaining sustainable development in *** article provides theoretical support for the extension of food biosafety to propose an innovative plan for the international co-governance of food safety.

关键词： Dual-use technologies Biosafety Food safety

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